It can not provide dynamic view mechanism in previous dataspace information system. In this paper, the dynamic extendable view mechanism provided by object deputy model is proposed for personalized dataspace informati...It can not provide dynamic view mechanism in previous dataspace information system. In this paper, the dynamic extendable view mechanism provided by object deputy model is proposed for personalized dataspace information system which can provide rich semantics and enough flexibility. The flexible inheritance avoids a lot of data redundancy. The cross class query mechanism allows users to find more related data based on complex relationships. The personalized dataspace service provides less storage space consumption and shorter query response time. The experiment result shows that our approach is more feasible and efficient than the traditional one.展开更多
目的评估玻璃体内注射雷珠单抗联合激光光凝(IVR+Laser)与单用玻璃体内注射雷珠单抗(IVR)治疗糖尿病性黄斑水肿(DME)的疗效和安全性。方法采用meta分析方法,检索有关IVR+Laser疗法与单用IVR治疗DME的随机对照试验(RCT)文献进行二次分析...目的评估玻璃体内注射雷珠单抗联合激光光凝(IVR+Laser)与单用玻璃体内注射雷珠单抗(IVR)治疗糖尿病性黄斑水肿(DME)的疗效和安全性。方法采用meta分析方法,检索有关IVR+Laser疗法与单用IVR治疗DME的随机对照试验(RCT)文献进行二次分析,检索文献范围包括Cochrane Library、PubMed、EMbase、Web of Science、中国生物医学文献数据库、中国知网、维普网、万方数据,检索时间均从建库起至2022年4月。由2位研究员按照纳入和排除标准独立进行文献筛选、资料提取、质量评价并交叉核对后,采用RevMan5.4.1软件进行meta分析,比较不同方法治疗后最佳矫正视力(BCVA)、黄斑中心凹厚度(CMT)、平均注射次数和不良事件的差异。结果共纳入12篇RCT,共1695眼。meta分析结果显示,随访结束时,IVR+Laser组患者BCVA和CMT改善情况优于IVR组,2个组BCVA变化和CMT变化差异均有统计学意义(WMD=-0.66,95%CI:-1.11~-0.21,P<0.01;WMD=-5.05,95%CI:-9.21~-0.89,P=0.02)。随访结束时,IVR+Laser组平均注射次数明显少于IVR组,差异有统计学意义(WMD=-1.16,95%CI:-2.07~-0.25,P=0.01)。2个组不良事件发生率比较,差异均无统计学意义(均P>0.05)。结论IVR+Laser联合治疗DME疗效优于单独IVR治疗,安全性与单独IVR治疗相当,且平均注射次数较少。展开更多
基金Supported by the National Natural Science Foundation of China (60573095)the Program for New Century Excellent Talents at Univer-sity of China (NCET-04-0675)+2 种基金the National High Technology Research and Development Program of China (2006AA12Z210)Specialized Research Fund for the Doctoral Program of Higher Education of China (20050486024)State Key Laboratory of Software Engineering (SKLSE05-01)
文摘It can not provide dynamic view mechanism in previous dataspace information system. In this paper, the dynamic extendable view mechanism provided by object deputy model is proposed for personalized dataspace information system which can provide rich semantics and enough flexibility. The flexible inheritance avoids a lot of data redundancy. The cross class query mechanism allows users to find more related data based on complex relationships. The personalized dataspace service provides less storage space consumption and shorter query response time. The experiment result shows that our approach is more feasible and efficient than the traditional one.
文摘目的评估玻璃体内注射雷珠单抗联合激光光凝(IVR+Laser)与单用玻璃体内注射雷珠单抗(IVR)治疗糖尿病性黄斑水肿(DME)的疗效和安全性。方法采用meta分析方法,检索有关IVR+Laser疗法与单用IVR治疗DME的随机对照试验(RCT)文献进行二次分析,检索文献范围包括Cochrane Library、PubMed、EMbase、Web of Science、中国生物医学文献数据库、中国知网、维普网、万方数据,检索时间均从建库起至2022年4月。由2位研究员按照纳入和排除标准独立进行文献筛选、资料提取、质量评价并交叉核对后,采用RevMan5.4.1软件进行meta分析,比较不同方法治疗后最佳矫正视力(BCVA)、黄斑中心凹厚度(CMT)、平均注射次数和不良事件的差异。结果共纳入12篇RCT,共1695眼。meta分析结果显示,随访结束时,IVR+Laser组患者BCVA和CMT改善情况优于IVR组,2个组BCVA变化和CMT变化差异均有统计学意义(WMD=-0.66,95%CI:-1.11~-0.21,P<0.01;WMD=-5.05,95%CI:-9.21~-0.89,P=0.02)。随访结束时,IVR+Laser组平均注射次数明显少于IVR组,差异有统计学意义(WMD=-1.16,95%CI:-2.07~-0.25,P=0.01)。2个组不良事件发生率比较,差异均无统计学意义(均P>0.05)。结论IVR+Laser联合治疗DME疗效优于单独IVR治疗,安全性与单独IVR治疗相当,且平均注射次数较少。