智媒时代中国对外传播研究的认知革新与生态优化

党的二十大报告提出“增强中华文明传播力影响力”的要求,明确了国际传播能力建设的历史性目标。以CSSCI文献的关键词为起点,借助工具软件对中国对外传播既有研究成果进行计量分析,研究发现,近十年来中国对外传播研究总体呈上升趋势,研究热点频出、活跃度高,但也存在深层机理考察不足、对新的媒介生态和技术逻辑认识不足、对政策制定反哺不足以及学术共同体建设不足等困境。在新时代和智能化背景下,有必要革新认知、优化传播策略:第一,加强研究的问题意识和机理探索,在回应政策需要的同时,就中国对外传播的对象、特点、模式、动力机制等进行深入系统研究;第二,跳出具体的对外传播议题,以更加开放宏观的视野重新审视智能化背景下传播活动的底层逻辑,增强对智媒传播特点与生态的认识;第三,超越既有对外传播及其研究的某些惯性,关注“观念政治”,构建全球格局;第四,增加学术交流,打造学术共同体,在量的基础上重视研究的可持续性及引领性,推进符合中国语境和独特道路的高质量学术探索。

Evaluation of the effect and profitability of gene-assisted selection in pig breeding system

Objective:To evaluate the effect and profitability of using the quantitative trait loci (QTL)-linked direct marker (DR marker) in gene-assisted selection (GAS). Methods: Three populations (100, 200, or 300 sows plus 10 boars within each group) with segregating QTL were simulated stochastically. Five economic traits were investigated, including number of born alive (NBA), average daily gain to 100 kg body weight (ADG), feed conversion ratio (FCR), back fat at 100 kg body weight (BF) and intramuscular fat (IMF). Selection was based on the estimated breeding value (EBV) of each trait. The starting frequencies of the QTL's favorable allele were 0.1, 0.3 and 0.5, respectively. The economic return was calculated by gene flow method. Results: The selection efficiency was higher than 100% when DR markers were used in GAS for 5 traits. The selection efficiency for NBA was the highest, and the lowest was for ADG whose QTL had the lowest variance. The mixed model applied DR markers and obtained higher extra genetic gain and extra economic returns. We also found that the lower the frequency of the favorable allele of the QTL, the higher the extra return obtained. Conclusion: GAS is an effective selection scheme to increase the genetic gain and the eco- nomic returns in pig breeding.

Screening and comprehensive analysis of key genes in liver hepatocellular carcinoma based on bioinformatics

Objective:To search and analyze the related genes of liver hepatocellular carcinoma(LIHC)by using bioinformatics technology.Methods:Gene expression omnibus(GEO)was used to retrieve the entry of"Liver hepatocellular carcinoma",and GSE109903 chip data was downloaded.The differentially expressed genes in the control group and liver hepatocellular carcinoma group were screened by bioinformatics analysis.GO enrichment analysis,KEGG pathway analysis,differential gene expression analysis and visualization processing were performed for the differentially expressed genes;Protein interaction network analysis and visualization processing were used to screen core genes EEF1A1 and HK2 with strong correlation with liver hepatocellular carcinoma.GEPIA,Kaplan-Meier plotter,GeneMANIA and Timer 2.0 databases were used to analyze the differential expression,prognostic value and immune cell infiltration of key genes in LIHC.Results:A total of 1059 differentially expressed genes were screened,including 637 up-regulated genes and 872 downregulated genes.Functional analysis showed that differentially expressed genes were mainly involved in the process of positive transcription regulation,nucleosome function,chromatin function and RNA binding.Pathway analysis showed that differentially expressed genes were involved in systemic lupus erythematosus,alcoholism and RNA polymerase I promoter opening pathway.The analysis of differential gene expression showed that the drugs with similar gene characteristics were mainly CDC inhibitors,prostaglandins,serotonin receptor antagonists,BAF transcriptional repression inhibitors,tyrosine phosphatase inhibitors,etc;Protein interaction network analysis showed that the main genes associated with LIHC were EEF1A1,HK2,FAM38A and LAMB3;EEF1A1 and HK2 genes were further analyzed by GEPIA.The results showed that the expression of EEF1A1 and HK2 mRNA in LIHC tissues was higher than that in normal tissues,and was significantly correlated with the pathological stage,overall survival rate and disease-free survival rate of LIHC patients.EEF1A1 and HK2 may be potential prognostic biomarkers for LIHC patients.In addition,the functions of EEF1A1 and HK2 were mainly related to translation factor activity,molecular chaperone mediated autophagy and carbohydrate catabolism,and purine nucleoside diphosphate metabolism,respectively.Immunocyte infiltration showed that the expression of EEF1A1 and HK2 was significantly correlated with the infiltration of a variety of immune cells,including six types of immune cells:CD4+T cells,macrophages,neutrophils,B cells,CD8+T cells and dendritic cells.Conclusion:By screening differentially expressed genes,we can identify the key genes in the development of liver hepatocellular carcinoma,and screen potential prognostic biomarkers for the survival of patients with liver hepatocellular carcinoma.At the same time,this study provides new ideas and programs for clinical treatment of liver hepatocellular carcinoma.

基于生物信息学的乳腺癌关键基因筛选及实验验证

目的:通过利用生物信息学技术,筛选乳腺细胞癌组织与正常组织间的差异表达基因,明确其潜在治疗药物,为将来临床乳腺癌的免疫靶向治疗及药物治疗提供参考。方法:利用基因表达数据库(gene expression omnibus,GEO)检索关键词“乳腺癌”,下载GSE79586芯片数据,通过生信技术筛选对照组及乳腺癌模型组差异表达基因并对其进行基因本体(GO)功能分析、京都基因与基因组百科全书(KEGG)分析、差异基因特征表达分析以及蛋白互作网络(PPI)分析,对分析结果进一步可视化处理。通过GEPIA、GeneMANIA、Timer2.0数据库分别进行预后分析、相关功能预测以及免疫浸润分析。最终通过Connectivity Map(CMap)明确对乳腺癌具有潜在治疗作用的化合物。采用蛋白质印迹法及实时荧光定量PCR(RT-PCR)对核心基因及相关性最高的潜在治疗药物吉非替尼进行体外验证。结果:共筛选到包括1786个上调基因和2130个下调基因在内的3916个差异表达基因;GO结果显示差异基因主要参与磷酸化的正向调节、分泌囊泡、外消旋酶和差向异构酶活性等功能;KEGG结果显示差异基因主要参与系统性红斑狼疮、酒精中毒、粘着斑、阿米巴痢疾等疾病通路与Ras信号通路等;差异基因特征表达分析显示MEK抑制剂、HSP90抑制剂以及信号转导通路激酶抑制剂等是与差异基因相似的药物;PPI结果显示H2AFJ、TFF1、GATA3、FOXA1、CDH1等是与乳腺癌相关的核心基因;进一步选取相关性最高的H2AFJ、TFF1两个核心基因进行GEPIA分析。分析结果显示,原发性乳腺癌细胞组织中H2AFJ与TFF1 mRNA表达显著高于正常组织,并且与原发性乳腺癌细胞患者的病理分期、总生存率以及无病生存率存在显著相关性(P<0.01);H2AFJ与TFF1可能是影响乳腺癌细胞患者生存的潜在预后生物标志物;差异表达的H2AFJ与TFF1功能主要分别与激素受体结合、上皮结构维持和基因表观遗传负调控、参与转录负调控的染色质组织等过程有关;免疫浸润结果显示,H2AFJ与TFF1的表达与巨噬细胞、中性粒细胞、单核细胞、CD4^(+)T、CD8^(+)T以及B淋巴细胞等免疫细胞的浸润存在着显著相关性;CMap结果显示吉非替尼、阿培利西、索拉菲尼、舒尼替尼等化合物对乳腺癌具有潜在的治疗作用。Western blot和RT-PCR结果显示,H2AFJ与TFF1在乳腺癌细胞中显著高表达,吉非替尼可明显抑制乳腺癌细胞中H2AFJ与TFF1的表达(P<0.05,P<0.01)。结论:本研究通过生物信息学手段筛选出乳腺细胞癌组织与正常组织间差异表达基因,明确在乳腺癌发病进程中的关键基因及具有潜在治疗效果的化合物,进一步通过实验验证了所筛选药物对乳腺癌的有效性。为今后临床针对乳腺癌的新药研发提供参考,以便开发更有效的治疗方案。

基于秾大云上(超星学习通)的混合式教学探索——以“遗传学”课程为例

随着高等教育信息化的不断推进,为了给学生创建连贯丰富的学习体验,从而达到高效、高质的学习效果,“遗传学”课程也需要紧跟科技发展、把握前沿学科,不断探索创新。基于秾大云上平台(超星学习通),结合“遗传学”课程及学生特点,开展混合式教学实践,提升教学效果。实践表明,该课程混合式教学的开展搭建了良好的师生交流互动平台,促进了师生共同成长与进步,不仅有效激发了学生的学习积极性和主动性,实现了专业素质与创新能力的协同培养,而且对教师课程开发及提高教学水平具有较强的促进作用,为进一步建设“遗传学”课程做出了贡献。

COF复合金纳米粒子用于乙酰胆碱的SERS检测

乙酰胆碱(ACh)是一种神经递质,其浓度与阿尔茨海默病、帕金森病、重症肌无力和精神分裂症等疾病密切相关,因此,实现乙酰胆碱的灵敏检测具有重要意义。本研究制备了一种基于金纳米颗粒修饰的共价有机框架复合材料(COF@AuNPs),其具有类似于硝基还原酶的强催化性能以及大量拉曼“热点”的优势,能高效催化对硝基苯酚(4-NPH)还原,ACh作为电子受体能够抑制4-NPH的还原过程。以4-NPH作为SERS标记物,结合SERS光谱,可以对ACh进行高灵敏度检测。本方法对ACh的最低检测浓度为1 pmol·L^(-1)。

Bioinformatics screening of breast cancer-related genes and potential drug research

Objective:To search the the differentially expressed genes between breast cell carcinoma tissues and normal tissues by using bioinformatics technology,and the potential therapeutic drugs for breast cancer were identified,which can provide reference for clinical immune targeted therapy and drug therapy of breast cancer in the future.Methods:"Breast cancer"was searched by using Gene Expression Omnibus(GEO),and GSE79586 chip data was downloaded.The differentially expressed genes in the control group and the breast cancer model group were screened by using bio-communication technology and subjected to GO function analysis,KEGG pathway analysis,differential gene characteristic expression analysis and protein-protein interaction network(PPI)analysis,and the analysis results were further visualized.Prognosis analysis,related function prediction and immune infiltration analysis were performed using the GEPIA,GeneMANIA,and Timer2.0 databases,respectively.Finally,the compounds with potential therapeutic effects on breast cancer are identified through Connectivity Map(CMap).Western blotting and real-time PCR(RT-PCR)were used to verify the core genes and potential therapeutic agents with the highest correlation in vitro.Results:A total of 3916 differentially expressed genes including 1786 up-regulated genes and 2130 down-regulated genes were screened.GO analysis showed that the differential genes were mainly involved in the positive regulation of phosphorylation,secretory vesicles,racemase and epimerase activities.KEGG analysis showed that differential genes were involved in systemic lupus erythematosus,alcoholism,sticky spots,amoebic dysentery Ras signal pathways and other disease pathways.The characteristic expression analysis of differential genes showed that MEK inhibitors,HSP90 inhibitors and signal transduction pathway kinase inhibitors were drugs similar to the differential genes.PPI results showed that H2AFJ,TFF1,GATA3,FOXA1,and CDH1 were core genes related to breast cancer.Two core genes of H2AFJ and TFF1 with the highest correlation were further selected for GEPIA analysis.The results of the analysis showed that the mRNA expression levels of H2AFJ and TFF1 in breast cancer cells were significantly higher than those in normal tissues,and there was a significant correlation with the pathological staging,overall survival rate and disease-free survival rate of breast cancer patients.H2AFJ and TFF1 may be potential prognostic biomarkers for survival of breast cancer patients.The functions of differentially expressed H2AFJ and TFF1 are mainly related to hormone receptor binding,epithelial structure maintenance and epigenetic negative regulation of genes,chromatin tissue involved in negative regulation of transcription,etc.The results of immune infiltration showed that the expressions of H2AFJ and TFF1 had a significant correlation with the infiltration of macrophages,neutrophils,monocytes,CD4+T,CD8+T,B lymphocytes and other immune cells.CMap results showed that compounds such as Gefitinib,Alpelisib,Sorafenib,and Sunitinib had potential therapeutic effects on breast cancer.Western blot and RT-PCR results showed that H2AFJ and TFF1 were significantly overexpressed in breast cancer cells.Gefitinib significantly inhibited the expression of H2AFJ and TFF1 in breast cancer cells(P<0.05,P<0.01).Conclusion:In this study,differentially expressed genes between breast cell carcinoma tissues and normal tissues were screened out by bioinformatics means to further identify key genes and compounds with potential therapeutic effects in the onset process of breast cancer and to further verify the effectiveness of the screened drugs on breast cancer through experiments.It will provide reference for clinical research and development of new drugs against breast cancer in the future in order to develop more effective treatment options.

基于坚果表型性状的新疆核桃种质资源多样性与分类

【目的】揭示新疆核桃坚果表型性状所表征的种质遗传多样性水平,以期为新疆核桃种质资源的分类鉴定和挖掘利用提供依据。【方法】基于对新疆人工栽培的乡土核桃种质资源的全面综合考察,对165份核桃种质其坚果表型数量性状指标和质量性状多态性指标进行数据釆集,采用Simpson指数(D)、Shannon-Weaver指数(H')对I3个表型质量性状多态性指标进行多样性分析,并基于18个坚果表型性状指标应用系统聚类方法对供试核桃种质进行分类。【结果】坚果5个表型数量性状指标K-S检验符合正态分布,纵径、横径、侧径三径均值变异范围为19.14-46.59 mm;坚果表型质量性状多态性指标中沿缝合线纵切面形状、垂直于缝合线纵切面形状、果基形状和果肩形状等的较高;供试核桃种质可分为9类,分类结果与坚果大小、形状、核壳特征等表型性状相关,不完全与其地理分布相关。【结论】坚果表型性状多样性分析可为新疆核桃种质资源多样性评价提供基础,并显示出新疆乡土核桃种质资源坚果表型性状多样性水平高,蕴藏着丰富的遗传资源,具有较大的挖掘利用潜力。

坚果表型性状在核桃种质鉴定中的应用

【目的】本文探了索坚果表型性状在核桃种质鉴定中的应用。【方法】采集52份核桃种质其坚果表型性状指标数据,对其采用非加权组平均法(UPGMA)进行聚类分析后进行聚类锐度测试,并构建热图。在此基础上,采用多元回归树(MRT)方法构建多元回归树,对鉴定供试核桃种质所需的最少坚果表型性状进行量化。【结果】52份供试核桃种质坚果数量性状、质量性状变异类型丰富,聚类分析显示供试种质可分为20类,热图直观地显示坚果表型性状在各种质中的分布情况,并且多元回归树显示15个坚果表型性状能够区分52份供试种质。【结论】52份供试核桃种质坚果表型多样性丰富,沿缝合线纵切面形状、垂直于缝合线纵切面形状、横切面形状、脊分布、单果重、果形、核壳厚度、出仁率等性状是种质鉴定中重要的指标性状。同时R语言在统计分析中的应用,为今后核桃种质形态与遗传变异研究提供了新的数据分析方法。

麻醉前应用抗胆碱能药物的广东省专家共识(2021版)

抗胆碱能药物在临床应用历史悠久,最初被应用于呼吸系统疾病的治疗。目前,抗胆碱能药物作为重要的术前用药,其术前应用是保证临床麻醉安全实施的重要措施,在促进患者术后快速康复中扮演重要角色。目前抗胆碱能药物种类较多,作用机制不同,术前规范并合理使用抗胆碱能药物可防范麻醉及手术因素所致的风险,保证患者围手术期安全,提高围手术期麻醉管理质量。为进一步规范术前抗胆碱能药物使用,受广东省医学会麻醉学分会的委托,本专家共识邀请省内相关领域麻醉专家,根据国内外最新研究进展和专家共识及指南,结合各中心术前应用抗胆碱能药物的临床实践经验,从抗胆碱能药物在临床麻醉中的应用及在围手术期的应用、麻醉前应用抗胆碱能药物的选择与考虑、抗胆碱能药物的用法用量及注意事项等方面,对术前应用抗胆碱能药物的要点进行阐述。

基于星点设计-效应面法优化红花多糖提取工艺研究

目的:运用星点设计-效应面法探讨红花多糖的最佳提取技术工艺,并对其进行质量评价。方法:以红花多糖的提取率为指标,以料液比、提取时间、提取温度、提取次数为考察因素,在单因素试验的基础上,采用星点设计-效应面法优选出红花多糖的最佳提取工艺并验证。结果:以红花多糖提取率为因变量Y,料液比、提取时间和提取温度为自变量X,P<0.0001建立效应面模型。最佳提取技术工艺为料液比1∶16.69,提取温度91.39℃,提取工作时间89.78 min。在此条件下红花多糖提取率可达7.45%,验证实验结果显示相对标准偏差(RSD)为1.05%,证明该模型能较好地预测实验结果。结论:星点设计-效应面法优化红花多糖的提取率较高,工艺操作简便有效合理、稳定性高、精确度高,可充分发展应用于红花多糖的资源管理开发利用。

Wnt/β-catenin通路在动脉粥样硬化发生中的作用

动脉粥样硬化(atherosclerosis,AS)是心血管病中最常见、最重要的病理基础,其主要特点是动脉管壁增厚变硬、弹性降低、管腔缩小,使得心肌血流量减少,导致胸痛、心绞痛甚至心肌梗死,对人类的健康造成了严重的危害。AS的发生是一个多步骤的病理过程,始于脂质沉积和内皮细胞功能障碍。随后单核细胞聚集可引发炎症反应,单核细胞进一步分化为巨噬细胞并通过摄取修饰低密度脂蛋白转化为泡沫细胞。同时,随着血管平滑肌细胞的浸润,增殖细胞外基质沉积在内膜下,最终形成斑块。Wnt信号通路是高度保守的信号通路,它参与调节细胞的分化、增殖和凋亡的过程。Wnt/β-catenin通路是一种经典的Wnt通路,近些年Wnt/β-catenin信号通路在AS的中所起到的作用成为研究热点。本文对近年来Wnt/β-catenin信号通路在AS病理生理中的作用机制所取得的研究进展论述。

基于生物信息学筛选并综合分析肝细胞癌关键基因

目的:通过生物信息技术,检索肝细胞癌(LIHC)相关基因及对相关基因进行深入分析。方法:利用基因数据表达库(GEO)检索“LIHC“词条,下载GSE109903芯片数据,通过生信分析筛选对照组及组差异表达基因,对所获得差异表达基因进行GO功能分析、KEGG通路分析、差异基因特征表达分析并作可视化处理;蛋白互作网络分析并作可视化处理,筛选与LIHC相关性较强的核心基因EEF1A1与HK2。通过GEPIA、Kaplan-Meier plotter、GeneMANIA、Timer2.0数据库进行分析,明确LIHC关键基因的差异表达、预后价值和免疫细胞浸润情况。结果:共筛选到1 059个差异表达基因,包括637个上调基因、872个下调基因;功能分析显示差异基因主要参与以DNA为模版的正向转录调控、核体功能、核染色质功能、RNA结合等过程;通路分析显示差异基因参与系统性红斑狼疮、酒精中毒等疾病通路与RNA聚合酶Ⅰ启动子开放通路等;差异基因特征表达分析显示与差异基因特征相似的药物主要有CDC抑制剂、前列腺素、血清素受体拮抗剂、BAF转录阻遏抑制剂、酪氨酸磷酸酶抑制剂等;蛋白互作网络分析显示与LIHC相关的基因主要有EEF1A1、HK2、FAM38A、LAMB3等;选取EEF1A1与HK2两个基因进一步进行GEPIA分析,分析结果显示EEF1A1与HK2 mRNA在LIHC癌组织中表达较正常组织中高,并且与LIHC患者的病理分期和总生存率、无病生存率呈显著相关;EEF1A1与HK2可能是LIHC患者生存的潜在预后生物标志物;此外,差异表达的EEF1A1与HK2功能主要分别与翻译因子活性、分子伴侣介导的自噬和碳水化合物分解代谢过程、嘌呤核苷二磷酸代谢过程有关;免疫细胞浸润情况显示EEF1A1与HK2的表达与多种免疫细胞的浸润显著相关,包括6种类型的免疫细胞:CD4^(+)T细胞、巨噬细胞、中性粒细胞、B细胞、CD8^(+)T细胞和树突状细胞。结论:通过筛选差异表达基因,明确在LIHC发展过程中关键基因,为LIHC患者生存筛选潜在的预后生物标志物,同时本研究为LIHC临床治疗提供新思路和方案。

轻比重腰麻在老年骨科手术中的应用

目的探讨轻比重腰麻在老年骨科手术中的应用。方法选择2018年1～10月在江西省吉安市第一人民医院治疗的60例下肢骨科手术患者作为研究对象,将其随机分为观察组与对照组,每组各30例。观察组患者采用轻比重罗哌卡因麻醉,对照组患者采用重比重罗哌卡因麻醉。比较两组患者的感觉阻滞起效时间、平面固定时间、感觉阻滞持续时间、运动阻滞起效时间、最大运动阻滞时间、最大Bromage评分,麻醉前、麻醉后10、30 min及手术结束后心率(HR)、收缩压(SBP)、舒张压(DBP)及麻醉效果。结果观察组患者的感觉阻滞起效时间、平面固定时间、运动阻滞起效时间、最大运动阻滞时间均显著长于对照组,差异有统计学意义(P<0.05);观察组患者的最大Bromage评分显著低于对照组,差异有统计学意义(P<0.05);两组患者的感觉阻滞持续时间比较,差异无统计学意义(P<0.05)。两组患者麻醉前的HR、血压比较,差异无统计学意义(P>0.05);观察组患者麻醉后10、30 min以及手术结束后的HR、SBP、DBP与麻醉前比较,差异无统计学意义(P>0.05);对照组患者手术结束后的HR、SBP、DBP与麻醉前比较,差异无统计学意义(P>0.05);对照组患者麻醉后10、30 min的HR、SBP、DBP均显著低于麻醉前,差异有统计学意义(P<0.05);观察组患者麻醉后10、30 min的HR、SBP、DBP均显著高于对照组,差异有统计学意义(P<0.05)。两组患者的麻醉优良率比较,差异无统计学意义(P>0.05)。结论轻比重腰麻用于老年骨科手术,虽然麻醉起效时间相对延迟,但两组的麻醉效果相似,且轻比重对老年患者血压、HR的影响小,安全性更高。

新工科背景下《机器视觉》课程教学模式改革

为适应当前新产业、新技术、新模式下的新经济形态,要以新工科为引导,培养具有崇高职业道德、扎实专业知识、良好工程实践素养的高素质应用型人才。《机器视觉》课程是交叉融合与工程性极强的一门新兴课程,当前教学中存在内容泛而不精、重理论轻实践、教学方法滞后和考核机制不全等问题。对此,通过更新教学理论、线上线下混合教学、项目制教学和过程考核机制等改革措施,提高了学生的学习效率,激发了学生的实践创新能力。

《宠物美容》课程高职教学的实践与探讨

《宠物美容》是宠物养护与驯导专业的核心课程。教学过程通过“教、训、练、赛”有机结合,以职业教育理念深化宠物美容教育改革的探索,按“由浅入深,循序渐进”的原则,设计了“四维课堂”。通过“一维连线画初稿、二维成面练剪刀、三维立体剪假犬、四维定时修造型”引导学生克服“怕咬、怕苦、怕累、怕脏”的四怕现象;通过“以赛促教、以赛促学”及“社团宣传、社区公益、店面践行、上门服务”锻炼学生“少信心、少耐心、少匠心、少上进心”的四少问题。借助宠物社团、双创项目、宠物美容工作室、行业内大赛四大平台的延伸,全面提升教学质量,培养本领过硬的高素质专门人才和拔尖创新人才目标。

一例京巴犬多次复发膀胱结石的诊治分析

在宠物临床上,犬的尿结石中以膀胱结石最为多见,手术治疗后,如不采取针对性的防治措施,该病的复发率很高。本文通过对一例京巴犬多次复发膀胱结石的诊治分析,以期为犬膀胱结石病例的临床诊断及治疗提供参考。

精氨酸谷氨酸盐注射液对慢性肝病伴高血氨患者的临床安全性与有效性研究

目的:探讨精氨酸谷氨酸盐注射液治疗慢性肝病伴高血氨患者的有效性和安全性。方法:选取2020年6月-2021年4月广汉市人民医院收治的慢性肝病伴高血氨患者100例,采用随机数字表法分为两组,各50例。对照组给予盐酸精氨酸注射液治疗,研究组给予精氨酸谷氨酸盐注射液治疗,比较两组治疗效果。结果:两组血氨下降的百分率及治疗总效率比较,差异均无统计学意义(P>0.05);研究组治疗1周后临床症状及体征积分均低于对照组,差异有统计学意义(P<0.05);研究组临床症状及体征积分改善总有效率明显高于对照组,差异有统计学意义(P<0.05);两组均未见药物相关不良反应。结论:精氨酸谷氨酸盐注射液治疗慢性肝病伴血氨升高,可显著降低血氨水平,改善患者临床症状和体征,且具有较高的安全性。

教育大数据视域下幸福感提升策略的应用路径

在研究与分析教育大数据的基础上,从国内外研究现状与存在的问题出发,进而研究教育大数据中大学生幸福数据的收集、教育大数据中大学生幸福数据的理论分析、大学生幸福感的影响因素分析等几个方面的应用路径基础,最后针对教育大数据中得出的影响幸福教育相关因素提出大学生幸福提升策略,以期帮助大学生获得幸福感,自信满满面对生活,充满激情解决问题,让我们的国家栋梁能全面、健康地发展。

犬乳头瘤病毒研究概况

犬病毒性乳头瘤(Canine viral papillomatosis)是由犬乳头瘤病毒(Canine papillomavirus,CPV)引起的一种犬传染病,主要感染犬皮肤和黏膜的鳞状上皮(如口腔、唇周、生殖器及皮肤),表现为疣或“花椰菜样”的乳头状瘤,恶化时可转化为鳞状细胞癌。目前国内外对于该病毒的基础、预防及临床研究甚少,对该病毒及所致疾病的认识不足,因此,对CPV的基本生物学特性、现有报道的流行情况、临床症状、检测方法以及目前预防性疫苗研发状况进行综述,为未来深入研究CPV理论基础、临床检测和疫苗研发提供参考。