Tibetan Plateau(TP) lakes are important water resources,which are experiencing quick expansion in recent decades.Previous researches mainly focus on analyzing the relationship between terrestrial water storage(TWS) ch...Tibetan Plateau(TP) lakes are important water resources,which are experiencing quick expansion in recent decades.Previous researches mainly focus on analyzing the relationship between terrestrial water storage(TWS) change and lake water storage(LWS) change in the total inner TP,it is still lack of researches about the spatial difference and the characteristic of sub-region in the inner TP.In this study,we estimated the area change of 34 lakes by using Landsat images in the northeastern TP during 1976–2013,and LWS change by using the Shuttle Radar Topography Mission(SRTM).The results suggested that LWS had shrunk from 1976 to 1994,and then expanded quickly until 2013.LWS had a serious decrease by 13.6 Gt during 1976–1994,and then it increased quickly by 35.4 Gt during 1994–2013.We estimated TWS change,soil moisture change,and permafrost degradation based on the satellite data and related models during 2003–2013.The results indicated that their changing rates were 1.86 Gt/y,0.22 Gt/y,and –0.19 Gt/y,respectively.We also calculated the change of groundwater based on the mass balance with a decreasing trend of –0.054 Gt/y.The results suggested that the cause of TWS change was the increase of LWS.We analyzed the cause of lake change according to water balance,and found that the primary cause of lake expansion was the increasing precipitation(80.7%),followed by glacier meltwater(10.3%) and permafrost degradation(9%).The spatial difference between LWS change and TWS change should be studied further,which is important to understand the driving mechanism of water resources change.展开更多
The effect of Glycyrrhiza uralensis Fisch (GRZ) aqueous extract and one of its active principles Glycyrrhetinic acid (GRT) on hepatic cytochrome P450 in mice were investigated. Oral administration of GRZ at 10g/kg/d o...The effect of Glycyrrhiza uralensis Fisch (GRZ) aqueous extract and one of its active principles Glycyrrhetinic acid (GRT) on hepatic cytochrome P450 in mice were investigated. Oral administration of GRZ at 10g/kg/d or GRT at 50 mg/kg/d for 7 days was foulld to increase the P450 contents up to 4.6 fold compared with the controls. The activities of aryl hydrocarbon hydroxylase (AHH,3. 1 and 3. 3 fold), aminopyrine N-demethylase (ADM, 4. 2 and 3. 2 folds), and 7-ethoxycumarin O-deethylase (ECOD, 2. 8 and 2. 5 fold) were also shown to be increased. Westem blot analysis showed that the subtypes of P450 isoforms induced selectively by GRZ and GRT included CYP1A1 (1. 8 and 1. 5 fold over that of the control, respectively), CYP2B1 (both 1.3 fold), and CYP2C11(3 .2 and 3 .0 fold). Moreover, significant positive correlation between the P450 content or the isoforms and the corresponding enzyme activities mentioned above was observed.展开更多
基金funded by the Strategic Priority Research Program of Chinese Academy of Sciences,Pan-Third Pole Environment Study for a Green Silk Road (Pan-TPE) (XDA20040501)the second Tibetan Plateau Scientific Expedition and Research Program (STEP) (2019QZKK0605)the National Natural Science Foundation of China (41501073)。
文摘Tibetan Plateau(TP) lakes are important water resources,which are experiencing quick expansion in recent decades.Previous researches mainly focus on analyzing the relationship between terrestrial water storage(TWS) change and lake water storage(LWS) change in the total inner TP,it is still lack of researches about the spatial difference and the characteristic of sub-region in the inner TP.In this study,we estimated the area change of 34 lakes by using Landsat images in the northeastern TP during 1976–2013,and LWS change by using the Shuttle Radar Topography Mission(SRTM).The results suggested that LWS had shrunk from 1976 to 1994,and then expanded quickly until 2013.LWS had a serious decrease by 13.6 Gt during 1976–1994,and then it increased quickly by 35.4 Gt during 1994–2013.We estimated TWS change,soil moisture change,and permafrost degradation based on the satellite data and related models during 2003–2013.The results indicated that their changing rates were 1.86 Gt/y,0.22 Gt/y,and –0.19 Gt/y,respectively.We also calculated the change of groundwater based on the mass balance with a decreasing trend of –0.054 Gt/y.The results suggested that the cause of TWS change was the increase of LWS.We analyzed the cause of lake change according to water balance,and found that the primary cause of lake expansion was the increasing precipitation(80.7%),followed by glacier meltwater(10.3%) and permafrost degradation(9%).The spatial difference between LWS change and TWS change should be studied further,which is important to understand the driving mechanism of water resources change.
文摘The effect of Glycyrrhiza uralensis Fisch (GRZ) aqueous extract and one of its active principles Glycyrrhetinic acid (GRT) on hepatic cytochrome P450 in mice were investigated. Oral administration of GRZ at 10g/kg/d or GRT at 50 mg/kg/d for 7 days was foulld to increase the P450 contents up to 4.6 fold compared with the controls. The activities of aryl hydrocarbon hydroxylase (AHH,3. 1 and 3. 3 fold), aminopyrine N-demethylase (ADM, 4. 2 and 3. 2 folds), and 7-ethoxycumarin O-deethylase (ECOD, 2. 8 and 2. 5 fold) were also shown to be increased. Westem blot analysis showed that the subtypes of P450 isoforms induced selectively by GRZ and GRT included CYP1A1 (1. 8 and 1. 5 fold over that of the control, respectively), CYP2B1 (both 1.3 fold), and CYP2C11(3 .2 and 3 .0 fold). Moreover, significant positive correlation between the P450 content or the isoforms and the corresponding enzyme activities mentioned above was observed.
