目的:系统评价玻璃酸钠联合复方倍他米松对比玻璃酸钠治疗膝关节骨性关节炎(KOA)的疗效,为临床用药提供循证参考。方法:计算机检索Cochrane图书馆、PubMed、Embase、Web of Science、中国知网数据库、万方数据库、维普数据库、百度学术...目的:系统评价玻璃酸钠联合复方倍他米松对比玻璃酸钠治疗膝关节骨性关节炎(KOA)的疗效,为临床用药提供循证参考。方法:计算机检索Cochrane图书馆、PubMed、Embase、Web of Science、中国知网数据库、万方数据库、维普数据库、百度学术数据库,收集玻璃酸钠联合复方倍他米松(观察组)对比玻璃酸钠(对照组)治疗KOA的随机对照试验(RCT)。筛选文献、提取资料后采用Jadad量表对纳入文献质量进行评价,采用Rev Man 5.3软件进行Meta分析。结果:共纳入24项RCT,共计2 929例患者。Meta分析结果显示,观察组患者总有效率[OR=5.33,95%CI(3.85,7.38),P<0.000 01]、美国特种外科医院膝关节评分[SMD=1.63,95%CI(1.32,1.93),P<0.000 01]、膝关节功能评分[SMD=1.22,95%CI(0.84,1.59),P<0.000 01]均显著高于对照组,视觉模拟评分[SMD=-1.44,95%CI(-1.76,-1.11),P<0.000 01]显著低于对照组。结论:玻璃酸钠联合复方倍他米松治疗KOA的疗效显著优于单用玻璃酸钠,且能显著改善膝关节功能。展开更多
Malignant tumors are complex organs consisting of tumor cells and their microenvironment. Increasing evidence has shown that the tumor microenvironment is critical to the initiation and progression of tumors. Rational...Malignant tumors are complex organs consisting of tumor cells and their microenvironment. Increasing evidence has shown that the tumor microenvironment is critical to the initiation and progression of tumors. Rational design of tumor therapies via targeting the tumor microenvironment to inhibit tumor growth is thus becoming a consensus strategy. Gd@C 82 (OH) 22 nanoparticles, as novel endohedral hydroxylated metallofullerenes, have been demonstrated to be a potent antitumor nanomedicine via targeting multiple factors in the tumor microenvironment. Gd@C 82 (OH) 22 nanoparticles possess excellent biocompatibility and remarkable antineoplastic activity, as a result not of direct tumor cytotoxicity but of their diverse biological effects, including antioxidation, immune activation, angiogenesis inhibition, imprisoning cancer cells, and reversal of drug-resistance. In this article, we summarize the unique nanoscale physiochemical properties and the antineoplastic activities of Gd@C 82 (OH) 22 nanoparticles, and focus on the mechanisms underlying their regulation of the tumor microenvironment.展开更多
文摘目的:系统评价玻璃酸钠联合复方倍他米松对比玻璃酸钠治疗膝关节骨性关节炎(KOA)的疗效,为临床用药提供循证参考。方法:计算机检索Cochrane图书馆、PubMed、Embase、Web of Science、中国知网数据库、万方数据库、维普数据库、百度学术数据库,收集玻璃酸钠联合复方倍他米松(观察组)对比玻璃酸钠(对照组)治疗KOA的随机对照试验(RCT)。筛选文献、提取资料后采用Jadad量表对纳入文献质量进行评价,采用Rev Man 5.3软件进行Meta分析。结果:共纳入24项RCT,共计2 929例患者。Meta分析结果显示,观察组患者总有效率[OR=5.33,95%CI(3.85,7.38),P<0.000 01]、美国特种外科医院膝关节评分[SMD=1.63,95%CI(1.32,1.93),P<0.000 01]、膝关节功能评分[SMD=1.22,95%CI(0.84,1.59),P<0.000 01]均显著高于对照组,视觉模拟评分[SMD=-1.44,95%CI(-1.76,-1.11),P<0.000 01]显著低于对照组。结论:玻璃酸钠联合复方倍他米松治疗KOA的疗效显著优于单用玻璃酸钠,且能显著改善膝关节功能。
文摘Malignant tumors are complex organs consisting of tumor cells and their microenvironment. Increasing evidence has shown that the tumor microenvironment is critical to the initiation and progression of tumors. Rational design of tumor therapies via targeting the tumor microenvironment to inhibit tumor growth is thus becoming a consensus strategy. Gd@C 82 (OH) 22 nanoparticles, as novel endohedral hydroxylated metallofullerenes, have been demonstrated to be a potent antitumor nanomedicine via targeting multiple factors in the tumor microenvironment. Gd@C 82 (OH) 22 nanoparticles possess excellent biocompatibility and remarkable antineoplastic activity, as a result not of direct tumor cytotoxicity but of their diverse biological effects, including antioxidation, immune activation, angiogenesis inhibition, imprisoning cancer cells, and reversal of drug-resistance. In this article, we summarize the unique nanoscale physiochemical properties and the antineoplastic activities of Gd@C 82 (OH) 22 nanoparticles, and focus on the mechanisms underlying their regulation of the tumor microenvironment.
