目的:通过文献计量学方法探究中医药治疗乳腺癌的国内外研究的知识结构和研究热点。方法:在Web of Science核心合集(WoSCC)数据库检索2003年1月1日至2022年12月31日有关中医药治疗乳腺癌的相关文献,采用VOSviewer、CiteSpace和R包“bibl...目的:通过文献计量学方法探究中医药治疗乳腺癌的国内外研究的知识结构和研究热点。方法:在Web of Science核心合集(WoSCC)数据库检索2003年1月1日至2022年12月31日有关中医药治疗乳腺癌的相关文献,采用VOSviewer、CiteSpace和R包“bibliometrix”进行文献计量分析。结果:共检索到中医药治疗乳腺癌的相关文献2 150篇,其中2003年至2007年年均发文量30.6篇,呈一个较低的且平稳的状态,2008年以后随着时间的推移,年发文量逐年上升,近5年(2018—2022)年均发文量达到了212.8篇。发文量最多的国家是中国,其次是美国、韩国、英国等,中国和美国的合计发文量占总发文量的77.07%。从文献的机构分布情况看,发表相关研究论文最多的是上海中医药大学。Evidence-based Complementary and Alternative Medicine和Journal of Ethnopharmacology为最受欢迎的两本期刊。被引频次最高的期刊是Journal of Clinical Oncology,其次是Journal of Ethnopharmacology、Cancer Research和Evidence-based Complementary and Alternative Medicine。被引期刊中,CA:A Cancer Journal for Clinicians的影响因子最高(IF=254.7),其次是The Journal of the American Medical Association(IF=120.7)。Drug Metabolism And Disposition、Journal of Pharmacology and Experimental Therapeutics、Journal of Clinical Oncology、Cancer Research、New England Journal Of Medicine、Journal of Ethnopharmacology等期刊间具有正向共被引关系。中医药治疗乳腺癌的研究中细胞凋亡、细胞自噬、炎症等机制研究是近年来的热点,“Trial”“epithelial mesenchymal transition”“network pharmacology”“Identification”“Mechanism”“Survival”等是主要的关键词。结论:中医药治疗乳腺癌研究的国际合著比例不高,以同国籍合著为主,作者之间的合作较少,研究还不够深入,疗效尚未被高质量期刊所认可,今后应严谨研究设计、注重质量控制、加强国际合作,开展更多的大样本、多中心的临床研究,以发表更多高水平的研究论文。展开更多
The Indosinian post-collisional Wulong pluton intruded into the Mesoproterozoic Fuping Group, South Qinling, central China. In the southern part of the pluton, some mafic enclaves have sharp or gradational contact rel...The Indosinian post-collisional Wulong pluton intruded into the Mesoproterozoic Fuping Group, South Qinling, central China. In the southern part of the pluton, some mafic enclaves have sharp or gradational contact relationships with the host biotite granodiorite. Geochemistry, zircon LA-ICP MS （laser ablation inductively-coupled plasma mass spectrometry） U-Pb chronology and Sr- Nd-Pb isotope geochemistry of the pluton are reported in this paper. The biotite granodiorite shows close compositional similarities to high-silica adakite. Its chondrite-normalized REE patterns are characterized by strong HREE depletion （Yb = 0.33--0.96 10-6 and Y = 4.77-11.19 ×10^-6）, enrichment of Ba （775-1386 x 10-6） and Sr （643-1115 × 10^-6） and high Sr/Y （57.83-159.99） and Y/Yb （10.99-14.32） ratios, as well as insignificant Eu anomalies （6Eu = 0.70-0.83）, suggesting a feldspar-poor, garnet±amphibole-rich residual mineral assemblage. The mafic enclaves have higher MgO （4.15- 8.13%）, Cr （14.79-371.31 × 10-6）, Ni （20.00-224.24× 10^-6） and Nb/Ta （15.42-21.91） than the host granodiorite, implying that they are mantle-derived and might represent underplated mafic magma. Zircon LA-ICP MS dating of the granodiorite yields a ^206pb/^238U weighted mean age of 208±2 Ma （MSWD=0.50, 1σ）, which is the age of emplacement of the host biotite granodiorite. This age indicates that the Wulong pluton formed during the late-orogenic or post-collisional stage （〈242±21 Ma） of the South Qinling belt. The host biotite granodiorite displays ^87Sr/^86Sr = 0.7059-0.7062, Isr = 0.7044-- 0.7050,^143Nd/^144Nd = 0.51236-0.51238, εNd（t）= -2.26 to -2.66 to ^206Pb/^204pb = 18.099-18.209, ^207pb/^204pb = 15.873-15.979 and ^208pb/^204pb = 38.973-39.430. Those ratios are similar to those of the Mesoproterozoic Yaolinghe Group in the South Qinling. Furthermore, its Nd isotopic model age （-1.02 Ga） is consistent with the age （-1.1 Ga） of the Yaolinghe Group. Based on the integrated geological and geochemical studies, coupled with previous studies, the authors suggest that the Wulong adakitic biotite granodiorite was probably generated by dehydration melting of the Yaolinghe Group-like thickened mafic crust, triggered by underplating of mafic magma at the boundary of the thickened mafic crust and hot lithospheric mantle, and that the Wulong adakitic biotite granodiorite may have resulted from thinning and delamination of the lower crust or breakoff of the subducting slab of the Mianlue ocean during the Indosinian post-collisional orogenic stage of the Qinling orogenic belt.展开更多
Objective The Yanshan Fold Belt is located within the northern margin of the North China platform and contains welldeveloped and widespread Neoproterozoic and Mesoproterozoic sedimentary units with a total thickness o...Objective The Yanshan Fold Belt is located within the northern margin of the North China platform and contains welldeveloped and widespread Neoproterozoic and Mesoproterozoic sedimentary units with a total thickness of up to 9000 m.Previous studies identified many oil seedlings as well as asphalt and ancient hydrocarbon reservoirs in Northern Hebei depression and western Liaoning depression.This research indicates that the Mesoproterozoic and Neoproterozoic sedimentary units are ideally suited for the formation of significant oil and gas resources.The Niu D1 well was drilled by the China Geological Survey(CGS)in the Niuyingzi area and intercepted oil immersions and oil-and gas-bearing units within a limestone reservoir in the middle Proterozoic Gaoyuzhuang Formation(Fig.1).This study presents new biomarker compound and carbon isotope data that indicate that the oil within this formation was derived from hydrocarbon source rocks of the Hongshuizhuang Formation,part of the Mesoproterozoic Jixian Series,and the reservoir type is overthrust fault fractured anticline hydrocarbon reservoir.The oil reservoir within the Gaoyuzhuang Formation limestone might represent the oldest oil reservoir discovered to date within the Yanliao faulted depression zone.展开更多
文摘目的:通过文献计量学方法探究中医药治疗乳腺癌的国内外研究的知识结构和研究热点。方法:在Web of Science核心合集(WoSCC)数据库检索2003年1月1日至2022年12月31日有关中医药治疗乳腺癌的相关文献,采用VOSviewer、CiteSpace和R包“bibliometrix”进行文献计量分析。结果:共检索到中医药治疗乳腺癌的相关文献2 150篇,其中2003年至2007年年均发文量30.6篇,呈一个较低的且平稳的状态,2008年以后随着时间的推移,年发文量逐年上升,近5年(2018—2022)年均发文量达到了212.8篇。发文量最多的国家是中国,其次是美国、韩国、英国等,中国和美国的合计发文量占总发文量的77.07%。从文献的机构分布情况看,发表相关研究论文最多的是上海中医药大学。Evidence-based Complementary and Alternative Medicine和Journal of Ethnopharmacology为最受欢迎的两本期刊。被引频次最高的期刊是Journal of Clinical Oncology,其次是Journal of Ethnopharmacology、Cancer Research和Evidence-based Complementary and Alternative Medicine。被引期刊中,CA:A Cancer Journal for Clinicians的影响因子最高(IF=254.7),其次是The Journal of the American Medical Association(IF=120.7)。Drug Metabolism And Disposition、Journal of Pharmacology and Experimental Therapeutics、Journal of Clinical Oncology、Cancer Research、New England Journal Of Medicine、Journal of Ethnopharmacology等期刊间具有正向共被引关系。中医药治疗乳腺癌的研究中细胞凋亡、细胞自噬、炎症等机制研究是近年来的热点,“Trial”“epithelial mesenchymal transition”“network pharmacology”“Identification”“Mechanism”“Survival”等是主要的关键词。结论:中医药治疗乳腺癌研究的国际合著比例不高,以同国籍合著为主,作者之间的合作较少,研究还不够深入,疗效尚未被高质量期刊所认可,今后应严谨研究设计、注重质量控制、加强国际合作,开展更多的大样本、多中心的临床研究,以发表更多高水平的研究论文。
文摘The Indosinian post-collisional Wulong pluton intruded into the Mesoproterozoic Fuping Group, South Qinling, central China. In the southern part of the pluton, some mafic enclaves have sharp or gradational contact relationships with the host biotite granodiorite. Geochemistry, zircon LA-ICP MS （laser ablation inductively-coupled plasma mass spectrometry） U-Pb chronology and Sr- Nd-Pb isotope geochemistry of the pluton are reported in this paper. The biotite granodiorite shows close compositional similarities to high-silica adakite. Its chondrite-normalized REE patterns are characterized by strong HREE depletion （Yb = 0.33--0.96 10-6 and Y = 4.77-11.19 ×10^-6）, enrichment of Ba （775-1386 x 10-6） and Sr （643-1115 × 10^-6） and high Sr/Y （57.83-159.99） and Y/Yb （10.99-14.32） ratios, as well as insignificant Eu anomalies （6Eu = 0.70-0.83）, suggesting a feldspar-poor, garnet±amphibole-rich residual mineral assemblage. The mafic enclaves have higher MgO （4.15- 8.13%）, Cr （14.79-371.31 × 10-6）, Ni （20.00-224.24× 10^-6） and Nb/Ta （15.42-21.91） than the host granodiorite, implying that they are mantle-derived and might represent underplated mafic magma. Zircon LA-ICP MS dating of the granodiorite yields a ^206pb/^238U weighted mean age of 208±2 Ma （MSWD=0.50, 1σ）, which is the age of emplacement of the host biotite granodiorite. This age indicates that the Wulong pluton formed during the late-orogenic or post-collisional stage （〈242±21 Ma） of the South Qinling belt. The host biotite granodiorite displays ^87Sr/^86Sr = 0.7059-0.7062, Isr = 0.7044-- 0.7050,^143Nd/^144Nd = 0.51236-0.51238, εNd（t）= -2.26 to -2.66 to ^206Pb/^204pb = 18.099-18.209, ^207pb/^204pb = 15.873-15.979 and ^208pb/^204pb = 38.973-39.430. Those ratios are similar to those of the Mesoproterozoic Yaolinghe Group in the South Qinling. Furthermore, its Nd isotopic model age （-1.02 Ga） is consistent with the age （-1.1 Ga） of the Yaolinghe Group. Based on the integrated geological and geochemical studies, coupled with previous studies, the authors suggest that the Wulong adakitic biotite granodiorite was probably generated by dehydration melting of the Yaolinghe Group-like thickened mafic crust, triggered by underplating of mafic magma at the boundary of the thickened mafic crust and hot lithospheric mantle, and that the Wulong adakitic biotite granodiorite may have resulted from thinning and delamination of the lower crust or breakoff of the subducting slab of the Mianlue ocean during the Indosinian post-collisional orogenic stage of the Qinling orogenic belt.
基金funded by the China Geological Survey Project(Grant No.DD20190098).
文摘Objective The Yanshan Fold Belt is located within the northern margin of the North China platform and contains welldeveloped and widespread Neoproterozoic and Mesoproterozoic sedimentary units with a total thickness of up to 9000 m.Previous studies identified many oil seedlings as well as asphalt and ancient hydrocarbon reservoirs in Northern Hebei depression and western Liaoning depression.This research indicates that the Mesoproterozoic and Neoproterozoic sedimentary units are ideally suited for the formation of significant oil and gas resources.The Niu D1 well was drilled by the China Geological Survey(CGS)in the Niuyingzi area and intercepted oil immersions and oil-and gas-bearing units within a limestone reservoir in the middle Proterozoic Gaoyuzhuang Formation(Fig.1).This study presents new biomarker compound and carbon isotope data that indicate that the oil within this formation was derived from hydrocarbon source rocks of the Hongshuizhuang Formation,part of the Mesoproterozoic Jixian Series,and the reservoir type is overthrust fault fractured anticline hydrocarbon reservoir.The oil reservoir within the Gaoyuzhuang Formation limestone might represent the oldest oil reservoir discovered to date within the Yanliao faulted depression zone.
