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长链非编码RNA MEF2C-AS1调控成骨细胞功能的机制研究 被引量:2
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作者 何洋洋 王力刚 赵玉驰 《中国现代医学杂志》 CAS 2020年第10期6-13,共8页
目的探讨长链非编码RNA MEF2C-AS1通过肌细胞增强因子2C(MEF2C)基因对成骨细胞的影响。方法培养人成骨细胞系hFOB1.19,转染过表达MEF2C-AS1质粒,检测过表达MEF2C-AS1组的碱性磷酸酶(ALP)活性变化;通过小干扰RNA沉默MEF2C-AS1,用qRT-PCR... 目的探讨长链非编码RNA MEF2C-AS1通过肌细胞增强因子2C(MEF2C)基因对成骨细胞的影响。方法培养人成骨细胞系hFOB1.19,转染过表达MEF2C-AS1质粒,检测过表达MEF2C-AS1组的碱性磷酸酶(ALP)活性变化;通过小干扰RNA沉默MEF2C-AS1,用qRT-PCR、Western blotting检测MEF2C-AS1水平变化对MEF2C、SOST基因的mRNA、蛋白水平的影响,再同时过表达MEF2C-AS1、MEF2C,检测SOST基因表达水平变化。结果过表达MEF2C-AS1组MEF2C、SOST mRNA和蛋白相对表达量较对照组低(P<0.05)。过表达MEF2C-AS1组ALP活性较对照组高(P<0.05)。沉默MEF2C-AS1组MEF2C、SOST mRNA和蛋白相对表达量较对照组高(P<0.05)。过表达MEF2C-AS1组SOST mRNA和蛋白相对表达量较对照组低(P<0.05)。过表达MEF2C-AS1+MEF2C组SOST mRNA和蛋白相对表达量较过表达MEF2C-AS1组高(P<0.05)。结论MEF2C-AS1可通过抑制MEF2C进一步抑制SOST基因的表达,促进成骨细胞的分化成熟。 展开更多
关键词 骨质疏松症 成骨细胞 肌细胞增强因子2C/基因 骨硬化蛋白/蛋白 长链非编码RNA
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Beam Shaping and Displacement in Single- and Multi-layered Structures Containing Meta-materials and Dielectric Media
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作者 li-gang wang Shi-yao Zhu 《量子光学学报》 CSCD 北大核心 2006年第B08期74-74,共1页
关键词 束修正 单层结构 多层结构 电介质 量子论
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Atom-field dynamics in curved spacetime
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作者 Syed Masood A.S.Bukhari li-gang wang 《Frontiers of physics》 SCIE CSCD 2024年第5期1-34,共34页
Some aspects of atom-field interactions in curved spacetime are reviewed.Of great interest are quantum radiative and entanglement processes arising out of Rindler and black hole spacetimes,which involve the role of Ha... Some aspects of atom-field interactions in curved spacetime are reviewed.Of great interest are quantum radiative and entanglement processes arising out of Rindler and black hole spacetimes,which involve the role of Hawking-Unruh and dynamical Casimir effects.Most of the discussion surrounds the radiative part of interactions.For this,we specifically reassess the conventional understandings of atomic radiative transitions and energy level shifts in curved spacetime.We also briefly outline the status quo of entanglement dynamics study in curved spacetime,and highlight literature related to some novel insights,like entanglement harvesting.On one hand,the study of the role played by spacetime curvature in quantum radiative and informational phenomena has implications for fundamental physics,notably the gravity-quantum interface.In particular,one examines the viability of the Equivalence Principle,which is at the heart of Einstein’s general theory of relativity.On the other hand,it can be instructive for manipulating quantum information and light propagation in arbitrary geometries.Some issues related to nonthermal effects of acceleration are also discussed. 展开更多
关键词 atom-field interactions general relativity Minkowski and curved spacetime quantum field theory in curved spacetime light-matter interactions spontaneous excitations
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Diffraction limit of light in curved space
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作者 JINGXUAN ZHANG CHENNI XU +1 位作者 PATRICK SEBBAH li-gang wang 《Photonics Research》 SCIE EI CAS CSCD 2024年第2期235-243,共9页
Overcoming the diffraction limit is crucial for obtaining high-resolution images and observing fine microstructures.With this conventional difficulty still puzzling us and the prosperous development of wave dynamics o... Overcoming the diffraction limit is crucial for obtaining high-resolution images and observing fine microstructures.With this conventional difficulty still puzzling us and the prosperous development of wave dynamics of light interacting with gravitational fields in recent years,how spatial curvature affects the diffraction limit is an attractive and important question.Here we investigate the issue of the diffraction limit and optical resolution on two-dimensional curved space—surfaces of revolution(SORs)with constant or variable spatial curvature.We show that the diffraction limit decreases and the resolution is improved on SORs with positive Gaussian curvature,opening a new avenue to super-resolution.The diffraction limit is also influenced by the propagation direction,as well as the propagation distance in curved space with variable spatial curvature.These results provide a possible method to control the optical resolution in curved space or equivalent waveguides with varying refractive index distribution and may allow one to detect the presence of the nonuniform strong gravitational effect by probing locally the optical resolution. 展开更多
关键词 LIMIT curved CURVATURE
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Associations of autozygosity with economic important traits in a cross of Eurasian pigs
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作者 Lin Tao li-gang wang +9 位作者 Adeniyi C.Adeola Long-Chao Zhang Lian-Wei Li Qing-Long Li Dao-Ji Cen Chen Yan Zhan-Shan Ma Li-Xian wang Hai-Bing Xie Ya-Ping Zhang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2023年第3期216-220,共5页
Inbreeding depression(ID)refers to the undesirable effects of inbreeding(mating of relatives)on fitness-associated phenotypes(Charlesworth and Willis,2009).ID on production,reproduction,and health traits is relevant t... Inbreeding depression(ID)refers to the undesirable effects of inbreeding(mating of relatives)on fitness-associated phenotypes(Charlesworth and Willis,2009).ID on production,reproduction,and health traits is relevant to industrial profitability,making it important in animal management.Runs of homozygosity(ROH)is a good measure of inbreeding and autozygosity(the inheritance of two copies of an ancestral allele)(Alkuraya,2013). 展开更多
关键词 Eurasian PROFIT REPRODUCTION
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Theory of light propagation in arbitrary two-dimensional curved space 被引量:3
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作者 CHENNI XU li-gang wang 《Photonics Research》 SCIE EI CAS CSCD 2021年第12期2486-2493,共8页
As an analog model of general relativity,optics on some two-dimensional(2 D)curved surfaces has received increasing attention in the past decade.Here,in light of the Huygens-Fresnel principle,we propose a theoretical ... As an analog model of general relativity,optics on some two-dimensional(2 D)curved surfaces has received increasing attention in the past decade.Here,in light of the Huygens-Fresnel principle,we propose a theoretical frame to study light propagation along arbitrary geodesics on any 2 D curved surfaces.This theory not only enables us to solve the enigma of"infinite intensity"that existed previously at artificial singularities on surfaces of revolution but also makes it possible to study light propagation on arbitrary 2 D curved surfaces.Based on this theory,we investigate the effects of light propagation on a typical surface of revolution,Flamm’s paraboloid,as an example,from which one can understand the behavior of light in the curved geometry of Schwarzschild black holes.Our theory provides a convenient and powerful tool for investigations of radiation in curved space. 展开更多
关键词 space. curved ARBITRARY
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Sustainable development of China's commercial vehicles 被引量:2
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作者 li-gang wang Ning Zhang 《Advances in Manufacturing》 SCIE CAS CSCD 2015年第1期37-41,共5页
Automobiles are the major contributor to fuel consumption and emission of pollutants. The growth of the vehicle fleet has also placed enormous pressure on China's energy supply and environment. Thus sustainable devel... Automobiles are the major contributor to fuel consumption and emission of pollutants. The growth of the vehicle fleet has also placed enormous pressure on China's energy supply and environment. Thus sustainable development of the Chinese automotive industry must pay significant attention to fuel-saving and emission-reduction of vehicles. Although commercial vehicles make up only about 20% of the entire automobile fleet, their contribution to energy-consumption and emission of pollutants is significant. Thus, priority should be given to fuel-saving and emission-reduction of commercial vehicles. As a result of concerted efforts by Chinese government, industry and enterprises, great progress has been made in technologies concerning new-energy, intelligent and lightweight auto- mobiles. However, compared with developed countries, the level of lightweighting of commercial vehicles produced in China remains comparably low. This means that great potential for development of lightweight commercial vehicles in China exists and it will be an efficient path towards fuel-saving and emission-reduction. 展开更多
关键词 Commercial vehicles. Fuel-saving.Emission-reduction - Lightweight
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Spatial-dependent probe transmission based high-precision two-dimensional atomic localization
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作者 Muhammad Idrees Humaira Kalsoom +2 位作者 Bakth Amin Bacha Arif Ullah li-gang wang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2021年第4期69-74,共6页
Herein,we propose a scheme for the realization of two-dimensional atomic localization in aλ-type three-level atomic medium such that the atom interacts with the two orthogonal standing-wave fields and a probe field.B... Herein,we propose a scheme for the realization of two-dimensional atomic localization in aλ-type three-level atomic medium such that the atom interacts with the two orthogonal standing-wave fields and a probe field.Because of the spatially dependent atom-field interaction,the information about the position of the atom can be obtained by monitoring the probe transmission spectra of the weak probe field for the first time.A single and double sharp localized peaks are observed in the one-wavelength domain.We have theoretically archived high-resolution and high-precision atomic localization within a region smaller thanλ/25×λ/25.The results may have potential applications in the field of nano-lithography and advance laser cooling technology. 展开更多
关键词 2D atomic localization probe transmission spectra standing-wave fields three-level atomic medium
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