基于超声造影参数构建列线图模型预测肝细胞癌分化程度的应用研究

目的通过软件定量分析超声造影灌注参数与原发性肝细胞癌(HCC)病理分级间的相关性,进而预测肝细胞癌的病理分化程度。方法收集在吉林大学中日联谊医院接受超声造影检查(CEUS)并通过肝穿刺活检且病理证实为原发性肝细胞癌的患者128例,以Edmondson-Steiner病理分级为金标准,将其分为低级别组和高级别组。分析B型超声(BMUS)和CEUS的特征。通过软件进行DCE-US分析得到定量参数,并与HCC病理分级进行对比分析研究,构建logistic回归方程及Nomogram预测模型,并通过绘制ROC曲线、校准曲线、DCA曲线来评价模型的诊断效果。结果单因素分析中mTTI、FT、单病灶最大直径大小具有统计学差异(P<0.05)。多因素二元回归得到的方程为:Y=-2.360+1.674χ_(1)+1.019χ_(2)+0.753χ_(3(2))+1.570χ_(3(3)),其AUC为0.831,敏感度为82.0%,特异度为79.5%。结论联合多参数构建的回归模型可有效提高CEUS对HCC不同病理分化程度的诊断效能,为CEUS作为术前诊断HCC病理分化程度的影像学方法提供临床依据和数据支撑。

全球有缆海底观测网概述

近期有缆海底观测网发展迅猛,世界各国包括加拿大、美国、日本和欧洲国家都依据自己的科学目标,建立了相应的有缆海底观测网。文章针对不同国家有缆海底观测网系统的组成和建设分别做了概述和评论。从1978年开始到现在,日本成功建设了10条有缆海底地震观测网,从早期同轴电缆作为主干电缆,发展到使用光电缆连接水下设施。加拿大成功建成近岸尺度和区域尺度两条有缆海底观测网。美国2012年成功建成目前世界上最长的一条区域海底观测网(约900km)。欧洲国家也正在开展在10个海区建立有缆观测网。跟随国外的步伐,我国和我国台湾地区也建立了自己的海底观测站(东海小衢山)和有缆观测网(中国台湾妈祖)。文章依据世界上已经建立的有缆海底观测网,分析认为与全球有缆观测网布设有关的遥控水下机器人是关键技术,并探讨了海底观测网今后的发展和面临的挑战。

Relationship between phytoplankton composition and environmental factors in the surface waters of southern South China Sea in early summer of 2009

Horizontal distributions of phytoplankton abundance,species composition as well as environmental factors were investigated in the surface waters of southern South China Sea (SCS) in early summer (May 16 to June 7) of 2009.In most areas of southern SCS,the concentrations of nitrogen and phosphorus were very low and DIN/DIP ratios usually were lower than the Redfield N/P Ratio of 16∶1.Nitrogen nutrients were significant lower in the upwelling region off Vietnam.A total of 144 taxa of phytoplankton were identified in the study area.The dominant genera were Prorocentrum,Gonyaulax,Gyrodinium,Scrippsiella and Chaetoceros,respectively.Spatial patterns of early-summer phytoplankton abundance and species composition should be mainly controlled by the upwelling off Vietnam and the discharge of Mekong River in the southern SCS.Diatoms dominated in the nutritious Mekong River Estuary or upwelling region off Vietnam; while dinoflagellates dominated in the oligotrophic pelagic region.The canonical correspondence analysis (CCA) indicates that most of diatoms favor higher levels of silicate and phosphorus,as well as lower temperature; while most of dinoflagellates favor the lower silicate and phosphorous and higher temperature.Correlation and CCA results indicate that silicate,nitrate and temperature were the most relevant environmental factors to regulate the horizontal pattern of early-summer phytoplankton in the surface waters of southern SCS.

Distribution patterns of appendicularians and copepods and their relationship on the northwest continental shelf of South China Sea during summer

The potential suppression of copepods on appendicularians was found in field and experimental conditions. The abundance and distribution of appendicularians and planktonic copepods were studied with reference to their correlations during summer on the northwest continental shelf of the South China Sea （SCS）. Based on the topography and water mass of the surveyed region, it was divided into three sub-regions： Region I （inshore waters of the east Leizhou Peninsula） with low temperature, salinity and high chlorophyll a （Chl a） concentration, Region II （inshore waters of the east and southeast Hainan Island） with low temperature, high salinity and moderate Chl a concentration and Region III （offshore waters from the Leizhou Peninsula to Hainan Island） with high temperature, high salinity and low Chl a concentration. The species richness of appendicularians and copepods increased from the inshore to offshore waters, and high values were observed in Region III. The distribution of appendicularian and copepod abundance decreased generally from the inshore to offshore waters, with the highest values at Region I. Our results suggest that the distribution patterns of appendicularians and copepods differed significantly, as a result of the influence of physical and biological factors. The negative impact of pelagic copepods on appendicularians was not found based on in situ data in the northwest continental shelf of SCS.

Variations in Dissolved Oxygen Induced by a Tropical Storm Within an Anticyclone in the Northern South China Sea

Tropical storms(TSs)can induce sea surface cooling,freshening,and phytoplankton blooms.The dissolved oxygen(DO)concentration response to TSs within an anticyclone is still unclear due to the rarity of in situ observations.In this study,we investi-gate the variations in DO concentration attributed to TS‘Haitang’within an anticyclonic eddy in the northern South China Sea based on Chinese underwater glider data.DO concentrations have a higher value at the edge of eddy than at the core.Influenced by TS,DO concentrations decrease remarkably in the subsurface layer in all three regions(inside,edge,and outside of the anticyclonic eddy).The mean DO concentrations decrease more at the edge of the anticyclone than those inside the anticyclone.The recovery time of DO concentration after TS is around one week at the edge of the anticyclone and is>10 days within the eddy.Our observations show that the DO concentrations decrease above the subsurface chlorophyll a maxima layer.Quantitative analysis shows that variations in DO concentration are dominated by horizontal advection and vertical advection terms in the subsurface layer.

肉瘤样肝癌误诊为肝脓肿1例

患者男,47岁,15 d前无明显诱因出现间断右上腹部疼痛,5 d前间断性发热,最高体温达39.5℃,伴寒战,就诊于当地医院,经抗炎对症治疗后未见明显好转。为求进一步诊治就诊吉林大学中日联谊医院,门诊以"肝脓肿"收入院,患者既往体健,无肝炎及肿瘤病史。入院实验室检查:降钙素原(PCT)0.55μg/L,白细胞计数(WBC)15.6×109/L,中性粒细胞(NEUT)86.4%,余实验室检查结果均正常。