Twenty-seven novel chaicone derivatives were designed and synthesized as neuraniinidase(NA) inhibitors. A concise suitable synthetic strategy was employed in the target compounds? synthesis with relatively high yields...Twenty-seven novel chaicone derivatives were designed and synthesized as neuraniinidase(NA) inhibitors. A concise suitable synthetic strategy was employed in the target compounds? synthesis with relatively high yields. The synthesized compounds were evaluated for their inhibitory activities against the NA of influenza A virus in vitro. The results show that compound 9b possesses the most potent NA inhibitory activity. Structure-activity relationship studies indicate that the chaicone system and hydrogen bond donor substituent are significant for the NA inhibitory activity. And the chaicone derivatives containing pyran ring have better NA inhibitory activity than those without the pyran ring. In addition, molecular docking studies reveal that compounds 9b and 9u are in the good binding mode with Zanamivir binding sites. This study indicates that compound 9b could be selected as a potent compoxind for further structural optimization and development of novel NA inhibitors.展开更多
基金the Hunan Provincial Natural Science Foundation,China(No.2019JJ40030)the National Natural Science Foundation of China(No.81673480).
文摘Twenty-seven novel chaicone derivatives were designed and synthesized as neuraniinidase(NA) inhibitors. A concise suitable synthetic strategy was employed in the target compounds? synthesis with relatively high yields. The synthesized compounds were evaluated for their inhibitory activities against the NA of influenza A virus in vitro. The results show that compound 9b possesses the most potent NA inhibitory activity. Structure-activity relationship studies indicate that the chaicone system and hydrogen bond donor substituent are significant for the NA inhibitory activity. And the chaicone derivatives containing pyran ring have better NA inhibitory activity than those without the pyran ring. In addition, molecular docking studies reveal that compounds 9b and 9u are in the good binding mode with Zanamivir binding sites. This study indicates that compound 9b could be selected as a potent compoxind for further structural optimization and development of novel NA inhibitors.
