目的本研究拟探讨程序性死亡受体1(Programmed cell death 1,PD-1)抑制剂联合抗血管生成药物及化疗二线治疗晚期肺腺癌的临床对比分析。方法回顾性分析河北北方学院附属第一医院2017年1月1日—2020年12月31日期间收治的99例晚期肺腺癌...目的本研究拟探讨程序性死亡受体1(Programmed cell death 1,PD-1)抑制剂联合抗血管生成药物及化疗二线治疗晚期肺腺癌的临床对比分析。方法回顾性分析河北北方学院附属第一医院2017年1月1日—2020年12月31日期间收治的99例晚期肺腺癌患者临床资料,根据不同治疗方法将患者分为单纯化疗组(n=35)、化疗联合抗血管生成药物组(n=34)和化疗联合抗血管生成药物联合免疫治疗组(n=30)。比较三组患者治疗后的临床疗效及不良反应发生情况。结果三组的疾病控制率(Disease control rate,DCR)分别为48.6%、55.9%和80.0%,差异有统计学意义(P=0.028);客观缓解率(Objective response rate,ORR)分别为11.4%、8.8%和23.3%,差异无统计学意义(P=0.273)。三组中位无进展生存期(Progression-free survival,PFS)分别为2.4个月、4.3个月和6.2个月,差异有统计学意义(P<0.001)。治疗期间三组最常见的不良反应有白细胞减少、恶心呕吐、转氨酶升高、乏力等,大多为1~2级。单因素分析显示临床分期是影响PFS的独立因素。在考虑分组因素情况下,多因素Cox回归分析显示脑转移是PFS的独立影响因素。结论三组对比分析显示二线应用PD-1抑制剂联合抗血管生成药物及化疗治疗晚期肺腺癌的疗效确切且安全性良好。展开更多
The current research of vehicle electrical power supply system mainly focuses on electric vehicles(EV) and hybrid electric vehicles(HEV).The vehicle electrical power supply system used in traditional fuel vehicles...The current research of vehicle electrical power supply system mainly focuses on electric vehicles(EV) and hybrid electric vehicles(HEV).The vehicle electrical power supply system used in traditional fuel vehicles is rather simple and imperfect;electrical/electronic devices(EEDs) applied in vehicles are usually directly connected with the vehicle's battery.With increasing numbers of EEDs being applied in traditional fuel vehicles,vehicle electrical power supply systems should be optimized and improved so that they can work more safely and more effectively.In this paper,a new vehicle electrical power supply system for traditional fuel vehicles,which accounts for all electrical/electronic devices and complex work conditions,is proposed based on a smart electrical/electronic device(SEED) system.Working as an independent intelligent electrical power supply network,the proposed system is isolated from the electrical control module and communication network,and access to the vehicle system is made through a bus interface.This results in a clean controller power supply with no electromagnetic interference.A new practical battery state of charge(So C) estimation method is also proposed to achieve more accurate So C estimation for lead-acid batteries in traditional fuel vehicles so that the intelligent power system can monitor the status of the battery for an over-current state in each power channel.Optimized protection methods are also used to ensure power supply safety.Experiments and tests on a traditional fuel vehicle are performed,and the results reveal that the battery So C is calculated quickly and sufficiently accurately for battery over-discharge protection.Over-current protection is achieved,and the entire vehicle's power utilization is optimized.For traditional fuel vehicles,the proposed vehicle electrical power supply system is comprehensive and has a unified system architecture,enhancing system reliability and security.展开更多
There is no accurate analytical approach for the acoustic performance prediction of Helmholtz resonator with conical neck,which has broad band acoustic attenuation performance in the low frequency range.To predict the...There is no accurate analytical approach for the acoustic performance prediction of Helmholtz resonator with conical neck,which has broad band acoustic attenuation performance in the low frequency range.To predict the acoustic performance of the resonator accurately,a general theory model based on the one-dimensional analysis approach with acoustic length corrections is developed.The segmentation method is used to calculate the acoustic parameters for sound propagation in conical tubes.And then,an approximate formula is deduced to give accurate correction lengths for conical tubes with difierent geometries.The deviations of the resonance frequency between the transmission loss results obtained by the general theory with acoustic lengths correction and the results from the finite element method and experiments are less than 2 Hz,which is much better than the results from one-dimensional approach without corrections.The results show that the method of acoustic length correction for the conical neck greatly improved the accuracy of the one-dimensional analysis approach,and it will be quick and accurate to predict the sound attenuation property of Helmholtz resonator with conical neck.展开更多
文摘目的本研究拟探讨程序性死亡受体1(Programmed cell death 1,PD-1)抑制剂联合抗血管生成药物及化疗二线治疗晚期肺腺癌的临床对比分析。方法回顾性分析河北北方学院附属第一医院2017年1月1日—2020年12月31日期间收治的99例晚期肺腺癌患者临床资料,根据不同治疗方法将患者分为单纯化疗组(n=35)、化疗联合抗血管生成药物组(n=34)和化疗联合抗血管生成药物联合免疫治疗组(n=30)。比较三组患者治疗后的临床疗效及不良反应发生情况。结果三组的疾病控制率(Disease control rate,DCR)分别为48.6%、55.9%和80.0%,差异有统计学意义(P=0.028);客观缓解率(Objective response rate,ORR)分别为11.4%、8.8%和23.3%,差异无统计学意义(P=0.273)。三组中位无进展生存期(Progression-free survival,PFS)分别为2.4个月、4.3个月和6.2个月,差异有统计学意义(P<0.001)。治疗期间三组最常见的不良反应有白细胞减少、恶心呕吐、转氨酶升高、乏力等,大多为1~2级。单因素分析显示临床分期是影响PFS的独立因素。在考虑分组因素情况下,多因素Cox回归分析显示脑转移是PFS的独立影响因素。结论三组对比分析显示二线应用PD-1抑制剂联合抗血管生成药物及化疗治疗晚期肺腺癌的疗效确切且安全性良好。
基金Supported by Collaborative Innovation Center of Intelligent New Energy Vehicle of U.S.and China-Clean Energy Research Center,Fund of China Scholarship Council(Grant No.201406215015)
文摘The current research of vehicle electrical power supply system mainly focuses on electric vehicles(EV) and hybrid electric vehicles(HEV).The vehicle electrical power supply system used in traditional fuel vehicles is rather simple and imperfect;electrical/electronic devices(EEDs) applied in vehicles are usually directly connected with the vehicle's battery.With increasing numbers of EEDs being applied in traditional fuel vehicles,vehicle electrical power supply systems should be optimized and improved so that they can work more safely and more effectively.In this paper,a new vehicle electrical power supply system for traditional fuel vehicles,which accounts for all electrical/electronic devices and complex work conditions,is proposed based on a smart electrical/electronic device(SEED) system.Working as an independent intelligent electrical power supply network,the proposed system is isolated from the electrical control module and communication network,and access to the vehicle system is made through a bus interface.This results in a clean controller power supply with no electromagnetic interference.A new practical battery state of charge(So C) estimation method is also proposed to achieve more accurate So C estimation for lead-acid batteries in traditional fuel vehicles so that the intelligent power system can monitor the status of the battery for an over-current state in each power channel.Optimized protection methods are also used to ensure power supply safety.Experiments and tests on a traditional fuel vehicle are performed,and the results reveal that the battery So C is calculated quickly and sufficiently accurately for battery over-discharge protection.Over-current protection is achieved,and the entire vehicle's power utilization is optimized.For traditional fuel vehicles,the proposed vehicle electrical power supply system is comprehensive and has a unified system architecture,enhancing system reliability and security.
基金supported by the National Nature Science Foundation of China(51275262,51345007)
文摘There is no accurate analytical approach for the acoustic performance prediction of Helmholtz resonator with conical neck,which has broad band acoustic attenuation performance in the low frequency range.To predict the acoustic performance of the resonator accurately,a general theory model based on the one-dimensional analysis approach with acoustic length corrections is developed.The segmentation method is used to calculate the acoustic parameters for sound propagation in conical tubes.And then,an approximate formula is deduced to give accurate correction lengths for conical tubes with difierent geometries.The deviations of the resonance frequency between the transmission loss results obtained by the general theory with acoustic lengths correction and the results from the finite element method and experiments are less than 2 Hz,which is much better than the results from one-dimensional approach without corrections.The results show that the method of acoustic length correction for the conical neck greatly improved the accuracy of the one-dimensional analysis approach,and it will be quick and accurate to predict the sound attenuation property of Helmholtz resonator with conical neck.