To study whether Bmi-l maintained cardiac function and prevents senescence associated pathological cardiac hypertrophy(PCH)and whether Bmi-1-RING1B promoted GATA4 ubiquitination and its autophagic degradation for prev...To study whether Bmi-l maintained cardiac function and prevents senescence associated pathological cardiac hypertrophy(PCH)and whether Bmi-1-RING1B promoted GATA4 ubiquitination and its autophagic degradation for preventing senescence-related PCH,Bmi^(-/-)deficient(Bmi^(-/-))mice and WT littermates were directly observed for PCH;Bmi-1+,Bmi^(-/-)overexpression transgenic(Bmi1^(TM))and WT mice were indirectly subcutaneously infused AngⅡto recur the development of PCH and observed;A utophagy agonist metformin or rapamycin was administered to Bmi^(-/-)and WT mice infused with AngⅡ.Mouse embryonic cardiomyocyte(ECM)and human myocardial AC16 cells were used for experiments.Phenotypes of cardiac and cardiomyocytes and GATA4-autophagic degradation were analyzed.展开更多
The intrinsic compliance of soft materials endows soft robots with great advantages to achieve large deformation and adaptive interactions in grasping tasks.However,current soft grippers usually focus on the in-plane ...The intrinsic compliance of soft materials endows soft robots with great advantages to achieve large deformation and adaptive interactions in grasping tasks.However,current soft grippers usually focus on the in-plane large deformation and load capacity but ignore the effect of out-of-plane external loads,which may lead to instability in practical scenarios.This problem calls for stiffness design along multiple directions to withstand not only in-plane interacting forces with objects,but also unexpected outof-plane loads.In this paper,we design a new type of soft finger by embedding an endoskeleton inside the widely-used PneuNets actuator,and the endoskeleton layout is optimized to achieve a remarkable bending deflection and limited lateral deflection under combined external in-plane and out-of-plane loads.Based on the multi-objective topology optimization approach,the key structural features of the optimized endoskeleton are extracted and parameterized.The multi-material soft fingers are fabricated by the silicone compound mold method.Static and dynamic experiment results validate that the soft gripper with endoskeleton embedded exhibits remarkably improved out-of-plane stiffness,without sacrificing the in-plane bending flexibility,and leads to more stable grasping.展开更多
文摘To study whether Bmi-l maintained cardiac function and prevents senescence associated pathological cardiac hypertrophy(PCH)and whether Bmi-1-RING1B promoted GATA4 ubiquitination and its autophagic degradation for preventing senescence-related PCH,Bmi^(-/-)deficient(Bmi^(-/-))mice and WT littermates were directly observed for PCH;Bmi-1+,Bmi^(-/-)overexpression transgenic(Bmi1^(TM))and WT mice were indirectly subcutaneously infused AngⅡto recur the development of PCH and observed;A utophagy agonist metformin or rapamycin was administered to Bmi^(-/-)and WT mice infused with AngⅡ.Mouse embryonic cardiomyocyte(ECM)and human myocardial AC16 cells were used for experiments.Phenotypes of cardiac and cardiomyocytes and GATA4-autophagic degradation were analyzed.
基金supported by the National Natural Science Foundation of China (Grant Nos.52275026 and 91948302)the State Key Laboratory of Structural Analysis for Industrial Equipment (Grant No.GZ21117)。
文摘The intrinsic compliance of soft materials endows soft robots with great advantages to achieve large deformation and adaptive interactions in grasping tasks.However,current soft grippers usually focus on the in-plane large deformation and load capacity but ignore the effect of out-of-plane external loads,which may lead to instability in practical scenarios.This problem calls for stiffness design along multiple directions to withstand not only in-plane interacting forces with objects,but also unexpected outof-plane loads.In this paper,we design a new type of soft finger by embedding an endoskeleton inside the widely-used PneuNets actuator,and the endoskeleton layout is optimized to achieve a remarkable bending deflection and limited lateral deflection under combined external in-plane and out-of-plane loads.Based on the multi-objective topology optimization approach,the key structural features of the optimized endoskeleton are extracted and parameterized.The multi-material soft fingers are fabricated by the silicone compound mold method.Static and dynamic experiment results validate that the soft gripper with endoskeleton embedded exhibits remarkably improved out-of-plane stiffness,without sacrificing the in-plane bending flexibility,and leads to more stable grasping.
