Through utilizing water flow monitoring, rock scratching, soil wood piles and radionuclide ^(137)Cs tracing in the Longhe karst ecological experimental site(hereinafter referred to"Longhe site"), Pingguo Cou...Through utilizing water flow monitoring, rock scratching, soil wood piles and radionuclide ^(137)Cs tracing in the Longhe karst ecological experimental site(hereinafter referred to"Longhe site"), Pingguo County, Guangxi Province, the features and values of soil erosion and soil leakage in different geomorphologic locations and land uses in the karst peak-cluster depressions are showed clearly. There are four kinds of geomorphologic locations in the karst peak-cluster depression, namely peaks, strip, slopes and depression. The soil leakage modulus in the peaks and strips respectively occupy 92.43% and 96.24% of the total mean soil erosion modulus at experimental sites. On the slope, soil leakage accounted for about 75%. At the bottom of depression, surface water was the main factor of soil erosion, and at last most soil leaked into underground rivers from sinkholes. The total soil erosion modulus and the contribution rates of relative surface soil erosion in regard of peaks, slopes and depressions gradually increased. There are also five major types of land use in the karst peak-cluster depressions, farmland, Kudingcha tea plantations, young Lignum Sappan fields, shrub-grassland and pastures. The soil erosion modulus of slope farmland has the highest value with an increasing trend year by year. But soil erosion modulus of other four land use types decreased by year, which shows the "grain for green" will result in better soil protection. By handling with rocky desertification and ecological rehabilitation in Longhe site, the mean soil erosion modulus of the karst peak-cluster depression has decreased about 80% from 2003 to 2015.展开更多
The distribution of trace metals in remote alpine region is an effective way to understand the impacts of regional human activity and vegetation on the alpine ecosystem. In this study, the concentrations of cadmium(Cd...The distribution of trace metals in remote alpine region is an effective way to understand the impacts of regional human activity and vegetation on the alpine ecosystem. In this study, the concentrations of cadmium(Cd), copper(Cu), lead(Pb), and zinc(Zn) in the soils of Gongga Mountain, Eastern Tibetan Plateau, were investigated to reveal their seasonal and spatial distribution and enrichment state, and to decipher the effects of atmospheric deposition and vegetation on their distributions among five vegetation zones. The results showed that the concentrations of Cd, Pb, and Zn were higher in the O horizon than in other horizons despite the seasonal changes, whereas Cu was enriched in the C horizon. The enrichment states of the metals studied in the soils decreased in the order of Cd > Pb > Zn > Cu. Cd and Pb were mainly sourced from atmospheric deposition; Zn was from both atmospheric deposition and parent materials, whereas Cu was mainly from parent materials.Seasonally, the trace metals were generally higher in May and December but lower in September, implying the impact of vegetation on the distribution of trace metals under the plant uptake and the litter decomposition. Spatially, the higher enrichment of Cu, Pb, and Zn in the soils existed in the mixed broadleafconiferous forests and coniferous forests(approximately 3000 m above sea level). The results suggested that atmospheric deposition and biological processes are main factors controlling the seasonal and spatial distribution of trace metals in the soils of the remote alpine ecosystem.展开更多
Background Retinopathy of prematurity (ROP) has become one of the leading causes of visual loss in children. Vascular endothelial growth factor A (VEGF-A) is the principal stimulator of angiogenesis. VEGF was diff...Background Retinopathy of prematurity (ROP) has become one of the leading causes of visual loss in children. Vascular endothelial growth factor A (VEGF-A) is the principal stimulator of angiogenesis. VEGF was differentially spliced from exon 8 to exons 8a and 8b to form two families: the pro-angiogenic VEGFxxx family and the anti-angiogenic VEGFxxxb family. Previous research has shown variable effeteness of bevacizumab in inhibiting retinal neovascularization in ROP. This study aimed to investigate whether the effectiveness of this inhibition depends on the relative ratio of the two VEGF isoforms. Methods Intravitreal bevacizumab injection (IVB) was performed in the oxygen-induced-retinopathy (OIR) mice on postnatal day 12 (P12) (intravitreal phosphate buffered saline (PBS) injection as control). The Evans blue perfused retina were used to test the retinal neovascularization-leakage (NVL) area and non-perfusion (NP) area. Results The retinal NVL and NP area in the IVB group were significantly smaller than the intravitreal PBS injection group (IVP group). On P17, the protein level of total VEGF isoforms was significantly inhibited compared to IVP group (P 〈0.05) while VEGFls5b isoform was slight reduced (P 〉0.05). The switch from pro-angiogenic isoforms to anti-angiogenic isoforms after IVB could be found. The relative protein expression of VEGF165b isoform was significantly higher in IVB group than in IVP group (P 〈0.05) on P17 which was correlated with the reduced ischemia-induced angiogenesis in OIR mice after IVB. Conclusions The anti-angiogenic effectiveness might depend on the relative high expression of VEGF165b after intravitreal bevacizumab injection. Anti-angiogenic therapy is a more effective therapy for ROP.展开更多
基金the financial support by IGCP 661, CAGS Research Fund (Grant No. YYWF201725)the National Natural Science Foundation of China (Grant No.41571203)+1 种基金the Ministry of Science and Technology of China (Grant No. 2016YFC0502403-2) the Bureau of Science and Technology of Guangxi (Grant No. 2014GXNS FAA118280)
文摘Through utilizing water flow monitoring, rock scratching, soil wood piles and radionuclide ^(137)Cs tracing in the Longhe karst ecological experimental site(hereinafter referred to"Longhe site"), Pingguo County, Guangxi Province, the features and values of soil erosion and soil leakage in different geomorphologic locations and land uses in the karst peak-cluster depressions are showed clearly. There are four kinds of geomorphologic locations in the karst peak-cluster depression, namely peaks, strip, slopes and depression. The soil leakage modulus in the peaks and strips respectively occupy 92.43% and 96.24% of the total mean soil erosion modulus at experimental sites. On the slope, soil leakage accounted for about 75%. At the bottom of depression, surface water was the main factor of soil erosion, and at last most soil leaked into underground rivers from sinkholes. The total soil erosion modulus and the contribution rates of relative surface soil erosion in regard of peaks, slopes and depressions gradually increased. There are also five major types of land use in the karst peak-cluster depressions, farmland, Kudingcha tea plantations, young Lignum Sappan fields, shrub-grassland and pastures. The soil erosion modulus of slope farmland has the highest value with an increasing trend year by year. But soil erosion modulus of other four land use types decreased by year, which shows the "grain for green" will result in better soil protection. By handling with rocky desertification and ecological rehabilitation in Longhe site, the mean soil erosion modulus of the karst peak-cluster depression has decreased about 80% from 2003 to 2015.
基金supported by National Natural Science Foundation of China (Grant No. 41402313, Grant No. 41272200)National Key Research and Development Program of China (2016YFC0502401)the Fundamental Research Funds of Institute of Karst Geology, Chinese Academy of Geological Sciences (No. 2017008)
文摘The distribution of trace metals in remote alpine region is an effective way to understand the impacts of regional human activity and vegetation on the alpine ecosystem. In this study, the concentrations of cadmium(Cd), copper(Cu), lead(Pb), and zinc(Zn) in the soils of Gongga Mountain, Eastern Tibetan Plateau, were investigated to reveal their seasonal and spatial distribution and enrichment state, and to decipher the effects of atmospheric deposition and vegetation on their distributions among five vegetation zones. The results showed that the concentrations of Cd, Pb, and Zn were higher in the O horizon than in other horizons despite the seasonal changes, whereas Cu was enriched in the C horizon. The enrichment states of the metals studied in the soils decreased in the order of Cd > Pb > Zn > Cu. Cd and Pb were mainly sourced from atmospheric deposition; Zn was from both atmospheric deposition and parent materials, whereas Cu was mainly from parent materials.Seasonally, the trace metals were generally higher in May and December but lower in September, implying the impact of vegetation on the distribution of trace metals under the plant uptake and the litter decomposition. Spatially, the higher enrichment of Cu, Pb, and Zn in the soils existed in the mixed broadleafconiferous forests and coniferous forests(approximately 3000 m above sea level). The results suggested that atmospheric deposition and biological processes are main factors controlling the seasonal and spatial distribution of trace metals in the soils of the remote alpine ecosystem.
文摘Background Retinopathy of prematurity (ROP) has become one of the leading causes of visual loss in children. Vascular endothelial growth factor A (VEGF-A) is the principal stimulator of angiogenesis. VEGF was differentially spliced from exon 8 to exons 8a and 8b to form two families: the pro-angiogenic VEGFxxx family and the anti-angiogenic VEGFxxxb family. Previous research has shown variable effeteness of bevacizumab in inhibiting retinal neovascularization in ROP. This study aimed to investigate whether the effectiveness of this inhibition depends on the relative ratio of the two VEGF isoforms. Methods Intravitreal bevacizumab injection (IVB) was performed in the oxygen-induced-retinopathy (OIR) mice on postnatal day 12 (P12) (intravitreal phosphate buffered saline (PBS) injection as control). The Evans blue perfused retina were used to test the retinal neovascularization-leakage (NVL) area and non-perfusion (NP) area. Results The retinal NVL and NP area in the IVB group were significantly smaller than the intravitreal PBS injection group (IVP group). On P17, the protein level of total VEGF isoforms was significantly inhibited compared to IVP group (P 〈0.05) while VEGFls5b isoform was slight reduced (P 〉0.05). The switch from pro-angiogenic isoforms to anti-angiogenic isoforms after IVB could be found. The relative protein expression of VEGF165b isoform was significantly higher in IVB group than in IVP group (P 〈0.05) on P17 which was correlated with the reduced ischemia-induced angiogenesis in OIR mice after IVB. Conclusions The anti-angiogenic effectiveness might depend on the relative high expression of VEGF165b after intravitreal bevacizumab injection. Anti-angiogenic therapy is a more effective therapy for ROP.