芳构化是有机化合物成岩作用的重要过程,形成萘、菲等环状芳烃化合物。成岩芳构化产物常作为研究样品热成熟度（Mackineze et al.,1981,1982）的生物标志化合物,其中常见的芳烃为——单芳甾烷和三芳甾烷直至菲。而芳构化的藿烷类化合物...芳构化是有机化合物成岩作用的重要过程,形成萘、菲等环状芳烃化合物。成岩芳构化产物常作为研究样品热成熟度（Mackineze et al.,1981,1982）的生物标志化合物,其中常见的芳烃为——单芳甾烷和三芳甾烷直至菲。而芳构化的藿烷类化合物并不常见,其芳构化作用的研究相对较少。展开更多
Glioblastoma is a devastating malignancy with a dismal survival rate.Currently,there are limited prognostic markers of glioblastoma including IDH1,ATRX,MGMT,PTEN,EGFRv Ⅲ,and others.Although these biomarkers for tumor...Glioblastoma is a devastating malignancy with a dismal survival rate.Currently,there are limited prognostic markers of glioblastoma including IDH1,ATRX,MGMT,PTEN,EGFRv Ⅲ,and others.Although these biomarkers for tumor prognosis are available,a surgical biopsy must be performed for these analyses,which has morbidity involved.A non-invasive and readily available biomarker is sought after which provides clinicians prognostic information.Sodium is an electrolyte that is easily and quickly obtained through analysis of a patient's serum.Hyponatremia has been shown to have a predictive and negative prognostic indication in multiple cancer types,but the role of glioblastoma patients' serum sodium at the time of diagnosis in predicting glioblastoma patient survival has not been determined.We assessed whether hyponatremia at the time of glioblastoma diagnosis correlates to patient survival and show that in our cohort of 200 glioblastoma patients,sodium,at any level,did not significantly correlate to glioblastoma survival,unlike what is seen in multiple other cancer types.We further demonstrate that inducing hyponatremia in an orthotopic murine model of glioblastoma has no effects on tumor progression and survival.展开更多
文摘Glioblastoma is a devastating malignancy with a dismal survival rate.Currently,there are limited prognostic markers of glioblastoma including IDH1,ATRX,MGMT,PTEN,EGFRv Ⅲ,and others.Although these biomarkers for tumor prognosis are available,a surgical biopsy must be performed for these analyses,which has morbidity involved.A non-invasive and readily available biomarker is sought after which provides clinicians prognostic information.Sodium is an electrolyte that is easily and quickly obtained through analysis of a patient's serum.Hyponatremia has been shown to have a predictive and negative prognostic indication in multiple cancer types,but the role of glioblastoma patients' serum sodium at the time of diagnosis in predicting glioblastoma patient survival has not been determined.We assessed whether hyponatremia at the time of glioblastoma diagnosis correlates to patient survival and show that in our cohort of 200 glioblastoma patients,sodium,at any level,did not significantly correlate to glioblastoma survival,unlike what is seen in multiple other cancer types.We further demonstrate that inducing hyponatremia in an orthotopic murine model of glioblastoma has no effects on tumor progression and survival.
