A green and efficient synthesis of 3-pyrazolyl indoles was developed by the eye 1 ocondensation reactionof β-ethylthio-β-indolyl-α,β-unsaturated ketones with semi carbazide hydrochloride as hydrazine equivalent in...A green and efficient synthesis of 3-pyrazolyl indoles was developed by the eye 1 ocondensation reactionof β-ethylthio-β-indolyl-α,β-unsaturated ketones with semi carbazide hydrochloride as hydrazine equivalent in thepresence of 3 equiv. of PEG400(la/PEG mole ratio of 1:3) in reflux water. This procedure did not require toxichydrazine and product purification, eliminating the use of toxic liquid chemicals.展开更多
A cost-effective and environmentally compliance FeCl3·6H2O catalyzed Friedel-Crafts alkylation of cyclic ketene dithioacetals with alcohols was developed. The reaction was efficient in the presence of catalyst lo...A cost-effective and environmentally compliance FeCl3·6H2O catalyzed Friedel-Crafts alkylation of cyclic ketene dithioacetals with alcohols was developed. The reaction was efficient in the presence of catalyst loading as low as 5%（molar fraction） in CH2Cl2 solvent at room temperature or under reflux conditions. A wide range of alkylated ketene dithioacetals were synthesized in excellent yields.展开更多
The oxidant iodosobenzene diacetate was combined with the cheap,environment-friendly FeCl3 as a chloride source to produce an efficient chlorinating agent for α-chlorination of ketene dithioacetals through direct C(s...The oxidant iodosobenzene diacetate was combined with the cheap,environment-friendly FeCl3 as a chloride source to produce an efficient chlorinating agent for α-chlorination of ketene dithioacetals through direct C(sp2)-H chlorination.Furthermore,the synthetic utility of α-chlorinated ketene dithioacetals was verified by the intermolecular cyclization with hydrazine hydrate,leading to the synthesis of pyrazoles,in which a 1,2-sulfur migration was involved.展开更多
基金Supported by the National Natural Science Foundation of China(No.20902010)the Foundation of Science and Technology Research Projects of the 13th Five-year Plan of Jilin Provincial Department of Education,China(No,2016037).
文摘A green and efficient synthesis of 3-pyrazolyl indoles was developed by the eye 1 ocondensation reactionof β-ethylthio-β-indolyl-α,β-unsaturated ketones with semi carbazide hydrochloride as hydrazine equivalent in thepresence of 3 equiv. of PEG400(la/PEG mole ratio of 1:3) in reflux water. This procedure did not require toxichydrazine and product purification, eliminating the use of toxic liquid chemicals.
基金Supported by the National Natural Science Foundation of China（No,20902010）, the Foundation of Liaoning Provincial Education Administration, China（No.L2015003） and the Science Foundation of Anshan City, China（Nos.2012KJ02, 2014KJ05）.
文摘A cost-effective and environmentally compliance FeCl3·6H2O catalyzed Friedel-Crafts alkylation of cyclic ketene dithioacetals with alcohols was developed. The reaction was efficient in the presence of catalyst loading as low as 5%（molar fraction） in CH2Cl2 solvent at room temperature or under reflux conditions. A wide range of alkylated ketene dithioacetals were synthesized in excellent yields.
基金supported by the National Natural Science Foundation of China (20902010 and 21172029)the Fundamental Research Funds for the Central Universities (10JCXK005)
文摘The oxidant iodosobenzene diacetate was combined with the cheap,environment-friendly FeCl3 as a chloride source to produce an efficient chlorinating agent for α-chlorination of ketene dithioacetals through direct C(sp2)-H chlorination.Furthermore,the synthetic utility of α-chlorinated ketene dithioacetals was verified by the intermolecular cyclization with hydrazine hydrate,leading to the synthesis of pyrazoles,in which a 1,2-sulfur migration was involved.
