A genome-wide association study recently showed that genetic variants in human leukocyte antigen (HLA)-DP loci were strongly associated with a risk of persistent infection of hepatitis B virus (HBV) in Japanese and Th...A genome-wide association study recently showed that genetic variants in human leukocyte antigen (HLA)-DP loci were strongly associated with a risk of persistent infection of hepatitis B virus (HBV) in Japanese and Thai individuals and variants in interleukin 28B (IL-28B) have been associated with responses to anti-hepatitis C virus (HCV) treatment. The aim of this study was to investigate whether the HLA-DP loci and IL-28B were associated with different outcomes of chronic HBV infection (CHB) in Chinese subjects. The rs9277535 near HLA-DPB1,rs3077 near HLA-DPA1, and rs12979860 near IL-28B were genotyped by direct sequencing in 185 CHB patients and 193 self-limited hepatitis B virus (SLHBV)-infected subjects who recovered from HBV infection. The rs9277535 near HLA-DPB1 was strongly associated with CHB (P=0.000 018 1, OR=1.905). This association was observed independent of HBV e antigen (HBeAg) status and HBV viral loads in HBeAg-positive CHB patients (P=0.000 4, OR=1.956), in HBeAg-negative CHB patients (P=0.000 9, OR=1.857), and in HBeAg-negative CHB individuals without detectable levels of HBV DNA in serum (P=0.001 1, OR=2.05). The rs3077 near HLA-DPA1 was associated with CHB (P=0.020 6, OR=0.686 5) and HBeAg-positive CHB infection status (P=0.014 3, OR=0.604 7). Meanwhile, a genetic variation of insertion-deletion (INDEL) polymorphism (rs361527, -/ATAAATGTTGA) near HLA-DPA1 was found to be associated with CHB (P=0.030 7, OR=0.702 8) and HBeAg-positive CHB infection status (P=0.023 3, OR=0.619). However,the rs12979860 genotype near IL-28B had no correlation with CHB. This study demonstrated that in the Han Chinese populations, HLA-DP loci, but not IL-28B, were associated with persistence of infection in different outcomes of HBV-infected patients; however, the mechanism needs to be further investigated.展开更多
In this paper,the best final EMS frequency for bloom continuous casting is proposed.For 280×380 bloom,the best frequency is in the range of 4;Hz.Simulation results also show that,with this frequency,the electroma...In this paper,the best final EMS frequency for bloom continuous casting is proposed.For 280×380 bloom,the best frequency is in the range of 4;Hz.Simulation results also show that,with this frequency,the electromagnetic force in the molten steel in the bloom reaches stronger and the electromechanical transformation rate of the stirring equipment is higher.The flow fields in the bloom with the various stirring parameters are simulated also.The final EMS parameters for bloom are optimized base on the simulation results.The experimental results show that,for high carbon steel,the best stirring frequency is 7 Hz and the current is 500A.In order to alleviate negative segregation of the low and medium carbon steel,the stirring frequency and the current should be 4Hz and 430A,respectively.展开更多
基金sponsored by the National Key Technologies R&D Program of China during the Eleventh Five-Year Plan Period(2008ZX10002-007 and 2009ZX10004-314)the National High Technology Research and Development Program(2006AA02A411)
文摘A genome-wide association study recently showed that genetic variants in human leukocyte antigen (HLA)-DP loci were strongly associated with a risk of persistent infection of hepatitis B virus (HBV) in Japanese and Thai individuals and variants in interleukin 28B (IL-28B) have been associated with responses to anti-hepatitis C virus (HCV) treatment. The aim of this study was to investigate whether the HLA-DP loci and IL-28B were associated with different outcomes of chronic HBV infection (CHB) in Chinese subjects. The rs9277535 near HLA-DPB1,rs3077 near HLA-DPA1, and rs12979860 near IL-28B were genotyped by direct sequencing in 185 CHB patients and 193 self-limited hepatitis B virus (SLHBV)-infected subjects who recovered from HBV infection. The rs9277535 near HLA-DPB1 was strongly associated with CHB (P=0.000 018 1, OR=1.905). This association was observed independent of HBV e antigen (HBeAg) status and HBV viral loads in HBeAg-positive CHB patients (P=0.000 4, OR=1.956), in HBeAg-negative CHB patients (P=0.000 9, OR=1.857), and in HBeAg-negative CHB individuals without detectable levels of HBV DNA in serum (P=0.001 1, OR=2.05). The rs3077 near HLA-DPA1 was associated with CHB (P=0.020 6, OR=0.686 5) and HBeAg-positive CHB infection status (P=0.014 3, OR=0.604 7). Meanwhile, a genetic variation of insertion-deletion (INDEL) polymorphism (rs361527, -/ATAAATGTTGA) near HLA-DPA1 was found to be associated with CHB (P=0.030 7, OR=0.702 8) and HBeAg-positive CHB infection status (P=0.023 3, OR=0.619). However,the rs12979860 genotype near IL-28B had no correlation with CHB. This study demonstrated that in the Han Chinese populations, HLA-DP loci, but not IL-28B, were associated with persistence of infection in different outcomes of HBV-infected patients; however, the mechanism needs to be further investigated.
基金Item Sponsored by the Postdoctoral gathering project in Liaoning Province(No.2011921003)
文摘In this paper,the best final EMS frequency for bloom continuous casting is proposed.For 280×380 bloom,the best frequency is in the range of 4;Hz.Simulation results also show that,with this frequency,the electromagnetic force in the molten steel in the bloom reaches stronger and the electromechanical transformation rate of the stirring equipment is higher.The flow fields in the bloom with the various stirring parameters are simulated also.The final EMS parameters for bloom are optimized base on the simulation results.The experimental results show that,for high carbon steel,the best stirring frequency is 7 Hz and the current is 500A.In order to alleviate negative segregation of the low and medium carbon steel,the stirring frequency and the current should be 4Hz and 430A,respectively.
