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Dataset of Comparative Observations for Land Surface Processes over the Semi-Arid Alpine Grassland against Alpine Lakes in the Source Region of the Yellow River 被引量:2
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作者 Xianhong MENG Shihua LYU +13 位作者 Zhaoguo LI Yinhuan AO lijuan wen Lunyu SHANG Shaoying WANG Mingshan DENG Shaobo ZHANG Lin ZHAO Hao CHEN Di MA Suosuo LI Lele SHU Yingying AN Hanlin NIU 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第6期1142-1157,共16页
Thousands of lakes on the Tibetan Plateau(TP) play a critical role in the regional water cycle, weather, and climate. In recent years, the areas of TP lakes underwent drastic changes and have become a research hotspot... Thousands of lakes on the Tibetan Plateau(TP) play a critical role in the regional water cycle, weather, and climate. In recent years, the areas of TP lakes underwent drastic changes and have become a research hotspot. However, the characteristics of the lake-atmosphere interaction over the high-altitude lakes are still unclear, which inhibits model development and the accurate simulation of lake climate effects. The source region of the Yellow River(SRYR) has the largest outflow lake and freshwater lake on the TP and is one of the most densely distributed lakes on the TP. Since 2011,three observation sites have been set up in the Ngoring Lake basin in the SRYR to monitor the lake-atmosphere interaction and the differences among water-heat exchanges over the land and lake surfaces. This study presents an eight-year(2012–19), half-hourly, observation-based dataset related to lake–atmosphere interactions composed of three sites. The three sites represent the lake surface, the lakeside, and the land. The observations contain the basic meteorological elements,surface radiation, eddy covariance system, soil temperature, and moisture(for land). Information related to the sites and instruments, the continuity and completeness of data, and the differences among the observational results at different sites are described in this study. These data have been used in the previous study to reveal a few energy and water exchange characteristics of TP lakes and to validate and improve the lake and land surface model. The dataset is available at National Cryosphere Desert Data Center and Science Data Bank. 展开更多
关键词 field observation dataset lake-atmosphere interaction energy and water exchanges the source region of the Yellow River Tibetan Plateau
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Numerical simulation of the climate effect of high-altitude lakes on the Tibetan Plateau 被引量:1
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作者 YinHuan Ao ShiHua Lyu +2 位作者 ZhaoGuo Li lijuan wen Lin Zhao 《Research in Cold and Arid Regions》 CSCD 2018年第5期379-391,共13页
Lakes regulate the water and heat exchange between the ground and the atmosphere on different temporal and spatial scales. However, studies of the lake effect in the high-altitude Tibetan Plateau(TP) rarely have been ... Lakes regulate the water and heat exchange between the ground and the atmosphere on different temporal and spatial scales. However, studies of the lake effect in the high-altitude Tibetan Plateau(TP) rarely have been performed until recently, and little attention has been paid to modelling of frozen lakes. In this study, the Weather Research and Forecasting Model(WRF v. 3.6.1) is employed to conduct three numerical experiments in the Ngoring Lake Basin(the original experiment, an experiment with a tuned model, and a no-lake experiment) to investigate the influences of parameter optimization on the lake simulation and of the high-altitude lake on the regional climate. After the lake depth, the roughness lengths, and initial surface temperature are corrected in the model, the simulation of the air temperature is distinctly improved. In the experiment using a tuned model, the simulated sensible-heat flux(H) is clearly improved, especially during periods of ice melting(from late spring to early summer) and freezing(late fall). The improvement of latent-heat flux(LE) is mainly manifested by the sharp increase in the correlation coefficient between simulation and observation, whereas the improvement in the average value is small. The optimization of initial surface temperature shows the most prominent effect in the first year and distinctly weakens after a freezing period. After the lakes become grassland in the model, the daytime temperature clearly increases during the freezing and melting periods; but the nocturnal cooling appears in other stages, especially from September to October. The annual mean H increases by 6.4 times in the regions of the Ngoring Lake and the Gyaring Lake, and the LE declines by 56.2%. The sum of H and LE increases from 71.2 W/m2(with lake) to 84.6 W/m2(no lake). For the entire simulation region, the sum of H and LE also increases slightly. After the lakes are removed, the air temperature increases significantly from June to September over the area corresponding to the two lakes, and an abnormal convergence field appears; at the same time, the precipitation clearly increases over the two lakes and surrounding areas. 展开更多
关键词 Lake-surface temperature roughness length turbulent flux Ngoring Lake Tibetan Plateau
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Regulation of pathological blood-brain barrier for intracranial enhanced drug delivery and anti-glioblastoma therapeutics
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作者 KAI WANG FENGTIAN ZHANG +5 位作者 CHANGLONG wen ZHIHUA HUANG ZHIHAO HU YUwen ZHANG FUQIANG HU lijuan wen 《Oncology Research》 SCIE 2021年第5期351-363,共13页
The blood-brain barrier(BBB)is an essential component in regulating and maintaining the homeostatic microenvironment of the central nervous system(CNS).During the occurrence and development of glioblastoma(GBM),BBB is... The blood-brain barrier(BBB)is an essential component in regulating and maintaining the homeostatic microenvironment of the central nervous system(CNS).During the occurrence and development of glioblastoma(GBM),BBB is pathologically destroyed with a marked increase in permeability.Due to the obstruction of the BBB,current strategies for GBM therapeutics still obtain a meager success rate and may lead to systemic toxicity.Moreover,chemotherapy could promote pathological BBB functional restoration,which results in significantly reduced intracerebral transport of therapeutic agents during multiple administrations of GBM and the eventual failure of GBM chemotherapy.The effective delivery of intracerebral drugs still faces severe challenges.However,strategies that regulate the pathological BBB to enhance the transport of therapeutic agents across the barrier may provide new opportunities for the effective and safe treatment of GBM.This article reviews the structure and function of BBB in physiological states,the mechanisms underlying BBB pathological fenestration during the development of GBM,and the therapeutic strategies of GBM based on BBB intervention and medicinal drugs transporting across the BBB. 展开更多
关键词 Blood-brain barrier PHYSIOLOGICAL PATHOLOGICAL GLIOBLASTOMA INTERVENTION
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A case of 46, XY/47, XYY mosaicism
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作者 Yanwei Guo lijuan wen Huimin Zhao 《Discussion of Clinical Cases》 2017年第2期27-28,共2页
In some clinical features, the failure of the couple to reproduce may be related to the chromosome abnormality of the patient. This report was based on one example about the topic.
关键词 CHROMOSOME CHIMERA ABNORMAL GENE
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Regulation of pathological BBB restoration via nanostructured ROS-responsive glycolipid-like copolymer entrapping siVEGF for glioblastoma targeted therapeutics 被引量:2
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作者 lijuan wen Yu Peng +6 位作者 Kai Wang Zhihua Huang Shiying He Ruiwen Xiong Longping Wu Fengtian Zhang Fuqiang Hu 《Nano Research》 SCIE EI CSCD 2022年第2期1455-1465,共11页
Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative treatments.Abnormally elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)wi... Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative treatments.Abnormally elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)with an increased permeability,resulting in poor outcome and prognosis.RNAi interference has shown strong potential to inhibit VEGF expression,thus it is necessary to development an effective and safe gene delivery system possessing the ability to cross the BBB and target GBM cells.This study aims to explore the anti-GBM effect of angiopep-2(Ap)peptide modified reactive oxygen species(ROS)cleavable thioketal(TK)linked glycolipid-like nanocarrier(CSTKSA)delivering anti-VEGF siRNA(R),termed as Ap-CSTKSA/R complexes.Ap functionalized modification produced an enhanced cellular uptake and a stronger bio-distribution of Ap-CSTKSA/R complexes in U87 MG cells and brain tumor tissues,respectively.Ap-CSTKSA/R complexes exhibited great superiority in GBM growth inhibition and finally translated into the longest survival period mainly via receptor-mediated targeting delivery,VEGF gene silencing accompanied with remarkable angiogenesis inhibition,and suppressed expression of caveolin-1 which is involved in BBB functional regulation in the occurrence and treatment of GBM.The study indicated that Ap functionalization on ROS-responsive glycolipid-like copolymer exhibits a promising and effective gene delivery platform for GBM targeted treatment. 展开更多
关键词 GLIOBLASTOMA ROS-responsive siRNA blood brain barrier COPOLYMER
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