Background Curcumin, an active ingredient of turmeric with antioxidant and anti-inflammatory properties has recently been reported to have anticonvulsant effects in several animal models of epilepsy. This study aimed ...Background Curcumin, an active ingredient of turmeric with antioxidant and anti-inflammatory properties has recently been reported to have anticonvulsant effects in several animal models of epilepsy. This study aimed to investigate the effects of curcumin on the pilocarpine rat model of status epilepticus. Methods The effect of intraperitoneal administration of curcumin （30, 100, and 300 mg/kg） on pilocarpine-induced seizures in rats was tested. The correlation between seizure activity and hippocampal levels of nitric oxide synthase and free radicals was quantified. Whether curcumin treatment modulated these parameters was also investigated. Results Curcumin significantly increased seizure threshold at doses of 100 and 300 mg/kg. Rats with pilocarpine- induced seizures showed significantly elevated levels of malonaldehyde, nitric oxide synthase, and lactate dehydrogenase, but decreased levels of superoxide dismutase and glutathione compared with normal control rats. At doses of 100 and 300 mg/kg, curcumin reversed the effects of pilocarpine-induced seizures on nitric oxide synthase, lactate dehydrogenase, glutathione, and superoxide dismutase. However, curcumin did not restore the elevated malonaldehyde levels. Conclusion Curcumin has anticonvulsant activity in the pilocarpine rat model of seizures, and that modulation of free radicals and nitric oxide synthase may be involved in this effect.展开更多
Background Curcumin can reduce the severity of seizures induced by kainate acid （KA）, but the role of curcumin in amygdaloid kindled models is still unknown. This study aimed to explore the effect of curcumin on the...Background Curcumin can reduce the severity of seizures induced by kainate acid （KA）, but the role of curcumin in amygdaloid kindled models is still unknown. This study aimed to explore the effect of curcumin on the development of kindling in amygdaloid kindled rats. Methods With an amygdaloid kindled Sprague-Dawley （SD） rat model and an electrophysiological method, different doses of curcumin （10 mg·kg^-1·d^-1 and 30 mg·kg^-1·d^-1 as low dose groups, 100 mg·kg^-1·d^-1 and 300 mg·kg^-1·d^-1 as high dose groups） were administrated intraperitoneally during the whole kindling days, by comparison with the course of kindling, afterdischarge （AD） thresholds and the number of ADs to reach the stages of class I to V seizures in the rats between control and experimental groups. One-way or two-way ANOVA and Fisher＇s least significant difference post hoc test were used for statistical analyses. Results Curcumin （both 100 mg·kg^-1·d^-1 and 300 mg·kg^-1·d^-1 ） significantly inhibited the behavioral seizure development in the （19.80±2.25） and （21.70±2.21） stimulations respectively required to reach the kindled state. Rats treated with 100mg·kg^-1·d^-1 curcumin 30 minutes before kindling stimulation showed an obvious increase in the stimulation current intensity required to evoke AD from （703.3±85.9） μA to （960.0±116.5） μA during the progression to class V seizures. Rats treated with 300 mg·kg^-1·d^-1 curcumin showed a significant increase in the stimulation current intensity required to evoke AD from （735.0±65.2） μA to （867.0±93.4） μA during the progression to class V seizures. Rats treated with 300mg·kg^-1·d^-1 curcumin required much more evoked ADs to reach the stage of class both IV （as （199.83±12.47） seconds） and V seizures （as （210.66±10.68） seconds）. Rats treated with 100 mg·kg^-1·d^-1 curcumin required much more evoked ADs to reach the stage of class V seizures （as （219.56±18.24） seconds）. Conclusion Our study suggests that curcumin has a potential antiepileptogenic effect on kindling-induced epileptogenesis.展开更多
文摘Background Curcumin, an active ingredient of turmeric with antioxidant and anti-inflammatory properties has recently been reported to have anticonvulsant effects in several animal models of epilepsy. This study aimed to investigate the effects of curcumin on the pilocarpine rat model of status epilepticus. Methods The effect of intraperitoneal administration of curcumin （30, 100, and 300 mg/kg） on pilocarpine-induced seizures in rats was tested. The correlation between seizure activity and hippocampal levels of nitric oxide synthase and free radicals was quantified. Whether curcumin treatment modulated these parameters was also investigated. Results Curcumin significantly increased seizure threshold at doses of 100 and 300 mg/kg. Rats with pilocarpine- induced seizures showed significantly elevated levels of malonaldehyde, nitric oxide synthase, and lactate dehydrogenase, but decreased levels of superoxide dismutase and glutathione compared with normal control rats. At doses of 100 and 300 mg/kg, curcumin reversed the effects of pilocarpine-induced seizures on nitric oxide synthase, lactate dehydrogenase, glutathione, and superoxide dismutase. However, curcumin did not restore the elevated malonaldehyde levels. Conclusion Curcumin has anticonvulsant activity in the pilocarpine rat model of seizures, and that modulation of free radicals and nitric oxide synthase may be involved in this effect.
文摘Background Curcumin can reduce the severity of seizures induced by kainate acid （KA）, but the role of curcumin in amygdaloid kindled models is still unknown. This study aimed to explore the effect of curcumin on the development of kindling in amygdaloid kindled rats. Methods With an amygdaloid kindled Sprague-Dawley （SD） rat model and an electrophysiological method, different doses of curcumin （10 mg·kg^-1·d^-1 and 30 mg·kg^-1·d^-1 as low dose groups, 100 mg·kg^-1·d^-1 and 300 mg·kg^-1·d^-1 as high dose groups） were administrated intraperitoneally during the whole kindling days, by comparison with the course of kindling, afterdischarge （AD） thresholds and the number of ADs to reach the stages of class I to V seizures in the rats between control and experimental groups. One-way or two-way ANOVA and Fisher＇s least significant difference post hoc test were used for statistical analyses. Results Curcumin （both 100 mg·kg^-1·d^-1 and 300 mg·kg^-1·d^-1 ） significantly inhibited the behavioral seizure development in the （19.80±2.25） and （21.70±2.21） stimulations respectively required to reach the kindled state. Rats treated with 100mg·kg^-1·d^-1 curcumin 30 minutes before kindling stimulation showed an obvious increase in the stimulation current intensity required to evoke AD from （703.3±85.9） μA to （960.0±116.5） μA during the progression to class V seizures. Rats treated with 300 mg·kg^-1·d^-1 curcumin showed a significant increase in the stimulation current intensity required to evoke AD from （735.0±65.2） μA to （867.0±93.4） μA during the progression to class V seizures. Rats treated with 300mg·kg^-1·d^-1 curcumin required much more evoked ADs to reach the stage of class both IV （as （199.83±12.47） seconds） and V seizures （as （210.66±10.68） seconds）. Rats treated with 100 mg·kg^-1·d^-1 curcumin required much more evoked ADs to reach the stage of class V seizures （as （219.56±18.24） seconds）. Conclusion Our study suggests that curcumin has a potential antiepileptogenic effect on kindling-induced epileptogenesis.
