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丹参酮ⅡA对急性心肌梗死大鼠心脏功能和心肌线粒体自噬的影响 被引量:30
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作者 王佳南 林建安 杜苗苗 《中国免疫学杂志》 CAS CSCD 北大核心 2019年第4期418-423,共6页
目的:探究丹参酮ⅡA(TSⅡA)对急性心肌梗死(AMI)大鼠心脏功能的作用及机制。方法:将60只大鼠随机分为对照(Ctrl)组、心肌梗死(MI)组、TSⅡA(20)组、TSⅡA(50)组和TSⅡA(100)组。除对照组外,其余组采用冠状动脉结扎术建立急性心肌梗死模... 目的:探究丹参酮ⅡA(TSⅡA)对急性心肌梗死(AMI)大鼠心脏功能的作用及机制。方法:将60只大鼠随机分为对照(Ctrl)组、心肌梗死(MI)组、TSⅡA(20)组、TSⅡA(50)组和TSⅡA(100)组。除对照组外,其余组采用冠状动脉结扎术建立急性心肌梗死模型,TSⅡA(20)组、TSⅡA(50)组和TSⅡA(100 mg)组腹腔注射20 mg/kg、50 mg/kg和100 mg/kg的TSⅡA,其余两组给予生理盐水。21 d后检测大鼠平均动脉压(MAP)、心率(HR)和左心室收缩压(LVSP),并分离心肌,计算心肌梗死面积,HE染色检测心肌病理损伤,Tunel染色检测细胞凋亡,试剂盒检测血清超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽(GSH)浓度,Western blot检测肌红蛋白(Mb)、肌酸激酶同工酶(CK-MB)、肌酐蛋白Ⅰ(c TnⅠ)及Beclin 1、P62和LC3的表达。结果:与对照组比较,心肌梗死组大鼠MAP、HR和LVSP均明显降低,心肌组织Mb、CK-MB和c TnⅠ表达明显增多;与心肌梗死组比较,TSⅡA(20、50、100)组大鼠MAP、HR和LVSP均明显升高,Mb、CK-MB和c TnⅠ蛋白表达明显被抑制。同时,心肌梗死组大鼠心肌损伤与对照组比较明显加重,细胞凋亡明显增多,心肌梗死面积均明显增大; TSⅡA(20、50、100)组大鼠心肌损伤情况与心肌梗死组比较明显减轻,凋亡细胞明显减少,心肌梗死面积明显减小。此外,心肌梗死能显著降低大鼠血清SOD和GSH浓度,升高MDA浓度,还能显著升高LC3Ⅱ/LC3Ⅰ比值和Beclin 1的表达水平,抑制P62表达; TSⅡA(20、50、100)能明显诱导SOD和GSH分泌,降低血清MDA浓度,还能显著下调LC3Ⅱ/LC3Ⅰ比值和Beclin 1的表达水平,促进P62表达。结论:丹参酮ⅡA(TSⅡA)可能通过抑制心肌线粒体自噬促进心肌梗死大鼠心肌功能的恢复。 展开更多
关键词 心肌梗死 氧化应激 细胞凋亡 线粒体自噬
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Effects of Plasma Density and Toroidal Magnetic Field on Lower Hybrid Current Drive Efficiencv on HT-7 Tokamak 被引量:1
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作者 DING Bo-jiang KUANG Guang-li +19 位作者 LIU Yue-xiu LIU Deng-Cheng ZHENG Guang-hua WU Jun-Shuan LIU Fu-kun SHEN Wei-ci lin jian-an YANG Chun-sheng XU Han-Dong YU Jia-Wen HUANG Yi-yun SHANG Lian-Quan SHI Yue-Jiang WU Zhen-wei ZHANG Jin-Song YIN Fu-Xian ZHANG Xiao-Dong LIU Xiao-ning XIE Ji-Kang WAN Yuan-Xi 《Chinese Physics Letters》 SCIE CAS CSCD 2000年第7期519-521,共3页
Lower hybrid current drive experiments on the HT-7 device have been carried out by scanning the following parameters: central line averaged electron density (ne = 0.6 - 2.0 × 1019m-3) and toroidal magnetic field ... Lower hybrid current drive experiments on the HT-7 device have been carried out by scanning the following parameters: central line averaged electron density (ne = 0.6 - 2.0 × 1019m-3) and toroidal magnetic field (Bt = 1.62 - 2.0 T). The dependence of current drive efficiency on these parameters has been studied and the experimental curves of current drive efficiency as a function of ne and Bt have also been obtained. From these experimental results, it can be seen that current drive efficiency rises with the increase of toroidal magnetic field. As plasma density increases, the current drive efficiency first increases to a certain value, then gradually decreases, that is, there exists an optimized density regime where a better drive efficiency can be obtained. The analysis shows that the current drive efficiency is mainly affected by wave accessibility and impurity concentration, and the competition of these two factors determines the current drive efficiency. 展开更多
关键词 DENSITY PLASMA LOWER
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乳鼠心肌细胞原代培养方法的再改良 被引量:4
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作者 王佳南 林建安 杜苗苗 《中外医疗》 2018年第33期29-31,共3页
目的探求优化的原代培养乳鼠心肌细胞方法。方法 2017年6月1日—2017年6月2日选取泉州市医学高等专科学校提供6只出生24 h内Wistar乳鼠,采用2种不同消化心肌组织的方法,对照组予0.125%胰酶+0.05%I型胶原酶+0.1%Ⅱ型胶原酶逐次消化心肌组... 目的探求优化的原代培养乳鼠心肌细胞方法。方法 2017年6月1日—2017年6月2日选取泉州市医学高等专科学校提供6只出生24 h内Wistar乳鼠,采用2种不同消化心肌组织的方法,对照组予0.125%胰酶+0.05%I型胶原酶+0.1%Ⅱ型胶原酶逐次消化心肌组织;试验组予0.05%I型胶原酶+0.1%Ⅱ型胶原酶消化数次后再单予0.125%胰酶快速消化心肌组织;比较两组取得的心肌细胞数量以及存活率,免疫荧光测肌钙蛋白鉴定纯度。结果 2种方法均得到心肌细胞数量多[对照组(103.3±4.4),试验组(105.8±5.0)],差异无统计学意义(t=-0.911,P=0.384);细胞即刻存活率试验组明显高于对照组,试验组达91.87%,对照组即刻存活率仅68.07%,差异有统计学意义(χ~2=81.0,P=0.025)。试验组存活率明显高于对照组。结论再改良方法提取心肌细胞,可获得存活率高、活力好的心肌细胞。 展开更多
关键词 心肌细胞 原代培养 乳鼠
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Lower Hybrid Current Drive Effects on HT-7 Superconducting Tokamak
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作者 KUANG Guang-li XU Wei-hua +17 位作者 ZHANG Xiang-qin SHAN Jia-fang LIU Yue-xiu LIU Deng-cheng ZHENG Guang-hua LIU Fu-kun lin jian-an WU Jun-shuan JIN Qian-chun DING Bo-jiang YANG Chun-sheng ZHOU Yuan-wei SHANG Lian-quan XU Han-dong FAN Heng-yu FANG Yu-de XIE Ji-kang WAN Yuan-xi 《Chinese Physics Letters》 SCIE CAS CSCD 1998年第6期435-437,共3页
Lower hybrid current drive(LHCD)experiments have been done on the superconducting Tokamak HT-7 by using a new developed long pulse megawatt lower hybrid wave system.An LHCD efficiency of 0.5×10^(19)A·m^(-2)/... Lower hybrid current drive(LHCD)experiments have been done on the superconducting Tokamak HT-7 by using a new developed long pulse megawatt lower hybrid wave system.An LHCD efficiency of 0.5×10^(19)A·m^(-2)/W in a pulse length of several hundreds of milliseconds has been achieved.After boronization of the tokamak vacuum vessel,considerable improvements of plasma energy confinement and particle confinement during LHCD phase have been achieved by adjusting wave spectra.An energy transfer from the lower hybrid wave to plasma bulk electrons has been demonstrated experimentally.A computer simulation of the LHCD experiments by using a ray tracing code combined with a two dimensional Fokker-Planck code is in good accordance with experimental measurements and suggests an important role of plasma current profile. 展开更多
关键词 WAVE hundreds ENERGY
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