BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is uncertain.This Mendelian randomization(MR)study investigated th...BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is uncertain.This Mendelian randomization(MR)study investigated the bidirectional causal relationship between systemic iron parameters and LV structure and function in a preserved ejection fraction population.METHODS Transferrin saturation(TSAT),total iron binding capacity(TIBC),and serum iron and ferritin levels were extracted as instrumental variables for iron parameters from meta-analyses of public genome-wide association studies.Individuals without myocardial infarction history,HF,or LV ejection fraction(LVEF)<50%(n=16,923)in the UK Biobank Cardiovascular Magnetic Resonance Imaging Study constituted the outcome dataset.The dataset included LV end-diastolic volume,LV endsystolic volume,LV mass(LVM),and LVM-to-end-diastolic volume ratio(LVMVR).We used a two-sample bidirectional MR study with inverse variance weighting(IVW)as the primary analysis method and estimation methods using different algorithms to improve the robustness of the results.RESULTS In the IVW analysis,one standard deviation(SD)increased in TSAT significantly correlated with decreased LVMVR(β=-0.1365;95%confidence interval[CI]:-0.2092 to-0.0638;P=0.0002)after Bonferroni adjustment.Conversely,no significant relationships were observed between other iron and LV parameters.After Bonferroni correction,reverse MR analysis showed that one SD increase in LVEF significantly correlated with decreased TSAT(β=-0.0699;95%CI:-0.1087 to-0.0311;P=0.0004).No heterogeneity or pleiotropic effects evidence was observed in the analysis.CONCLUSIONS We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejection fraction population.展开更多
目的探讨针灸联合生物反馈电刺激治疗产后压力性尿失禁(postpartum stress urinary incontinence,PSUI)的疗效及对国际尿失禁咨询委员会尿失禁问卷表(Incontinence Questionnaire of the International Incontinence Advisory Committee...目的探讨针灸联合生物反馈电刺激治疗产后压力性尿失禁(postpartum stress urinary incontinence,PSUI)的疗效及对国际尿失禁咨询委员会尿失禁问卷表(Incontinence Questionnaire of the International Incontinence Advisory Committee,ICI-Q-SF)评分和盆底肌表面电信号的影响。方法选取2022年6月—2023年6月于本院就诊的PSUI患者264例,随机分为对照组(n=132)和研究组(n=132),对照组采取生物反馈电刺激治疗,研究组采取针灸联合生物反馈电刺激治疗,均治疗8周,观察两组治疗疗效,对比治疗前后漏尿量、盆底功能、肌力、肌纤维疲劳度、ICI-Q-SF得分、盆底肌表面电信号、尿动力学水平[最大尿道闭合压(MUCP)、最大尿流率(MFR)、达峰时间(Tmax)、咳嗽点膀胱内压(CLPP)]。采用GEE模型评价两种治疗方法对患者ICI-Q-SF评分和盆底肌表面电信号的影响。结果对照组总有效率为74.24%,研究组总有效率为91.67%,两组临床疗效比较差异有统计学意义(P<0.05)。与治疗前比较,治疗4周、6周、8周后两组患者阴道收缩压、静息压、盆底肌表面电信号水平(活力)及尿动力学水平均有显著升高,而膀胱颈活动度、尿道旋转角度、漏尿量、ICI-Q-SF评分、盆底肌表面电信号水平(峰值)显著降低(P<0.05),且研究组优于对照组(P<0.05)。治疗4周、6周、8周后,研究组盆底肌力情况及盆底Ⅰ类、Ⅱ类肌纤维疲劳度均优于对照组,差异均有统计学意义(P<0.05)。采用GEE模型结果显示,治疗时间、治疗方案及两者的交互作用比较差异有统计学意义(P<0.05)。结论针灸联合生物反馈电刺激在治疗产后压力性尿失禁方面具有很好的应用前景,可显著改善患者的ICI-Q-SF评分和盆底肌表面电信号,应用价值较高。展开更多
基金funded by the Key Research and Development of the Gansu Province(No.20YF8FA 079)the Construction Project of the Gansu Clinical Medical Research Center(No.18JR2FA003).
文摘BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is uncertain.This Mendelian randomization(MR)study investigated the bidirectional causal relationship between systemic iron parameters and LV structure and function in a preserved ejection fraction population.METHODS Transferrin saturation(TSAT),total iron binding capacity(TIBC),and serum iron and ferritin levels were extracted as instrumental variables for iron parameters from meta-analyses of public genome-wide association studies.Individuals without myocardial infarction history,HF,or LV ejection fraction(LVEF)<50%(n=16,923)in the UK Biobank Cardiovascular Magnetic Resonance Imaging Study constituted the outcome dataset.The dataset included LV end-diastolic volume,LV endsystolic volume,LV mass(LVM),and LVM-to-end-diastolic volume ratio(LVMVR).We used a two-sample bidirectional MR study with inverse variance weighting(IVW)as the primary analysis method and estimation methods using different algorithms to improve the robustness of the results.RESULTS In the IVW analysis,one standard deviation(SD)increased in TSAT significantly correlated with decreased LVMVR(β=-0.1365;95%confidence interval[CI]:-0.2092 to-0.0638;P=0.0002)after Bonferroni adjustment.Conversely,no significant relationships were observed between other iron and LV parameters.After Bonferroni correction,reverse MR analysis showed that one SD increase in LVEF significantly correlated with decreased TSAT(β=-0.0699;95%CI:-0.1087 to-0.0311;P=0.0004).No heterogeneity or pleiotropic effects evidence was observed in the analysis.CONCLUSIONS We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejection fraction population.
文摘目的探讨针灸联合生物反馈电刺激治疗产后压力性尿失禁(postpartum stress urinary incontinence,PSUI)的疗效及对国际尿失禁咨询委员会尿失禁问卷表(Incontinence Questionnaire of the International Incontinence Advisory Committee,ICI-Q-SF)评分和盆底肌表面电信号的影响。方法选取2022年6月—2023年6月于本院就诊的PSUI患者264例,随机分为对照组(n=132)和研究组(n=132),对照组采取生物反馈电刺激治疗,研究组采取针灸联合生物反馈电刺激治疗,均治疗8周,观察两组治疗疗效,对比治疗前后漏尿量、盆底功能、肌力、肌纤维疲劳度、ICI-Q-SF得分、盆底肌表面电信号、尿动力学水平[最大尿道闭合压(MUCP)、最大尿流率(MFR)、达峰时间(Tmax)、咳嗽点膀胱内压(CLPP)]。采用GEE模型评价两种治疗方法对患者ICI-Q-SF评分和盆底肌表面电信号的影响。结果对照组总有效率为74.24%,研究组总有效率为91.67%,两组临床疗效比较差异有统计学意义(P<0.05)。与治疗前比较,治疗4周、6周、8周后两组患者阴道收缩压、静息压、盆底肌表面电信号水平(活力)及尿动力学水平均有显著升高,而膀胱颈活动度、尿道旋转角度、漏尿量、ICI-Q-SF评分、盆底肌表面电信号水平(峰值)显著降低(P<0.05),且研究组优于对照组(P<0.05)。治疗4周、6周、8周后,研究组盆底肌力情况及盆底Ⅰ类、Ⅱ类肌纤维疲劳度均优于对照组,差异均有统计学意义(P<0.05)。采用GEE模型结果显示,治疗时间、治疗方案及两者的交互作用比较差异有统计学意义(P<0.05)。结论针灸联合生物反馈电刺激在治疗产后压力性尿失禁方面具有很好的应用前景,可显著改善患者的ICI-Q-SF评分和盆底肌表面电信号,应用价值较高。
