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海洋源的活性物质抑制小胶质细胞活化的研究进展
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作者 徐晓萌 杨隆河 +1 位作者 林祥志 王昭凯 《中南药学》 CAS 2018年第5期669-674,共6页
小胶质细胞是中枢神经系统中关键免疫效应细胞,激活后的小胶质细胞有M1和M2两种形态,当小胶质细胞受到过度刺激时会打破两者之间的平衡,导致过度活化,从而引起或加剧神经退行性疾病中的神经损伤。因此找到抑制活化的物质对于神经退行性... 小胶质细胞是中枢神经系统中关键免疫效应细胞,激活后的小胶质细胞有M1和M2两种形态,当小胶质细胞受到过度刺激时会打破两者之间的平衡,导致过度活化,从而引起或加剧神经退行性疾病中的神经损伤。因此找到抑制活化的物质对于神经退行性疾病的治疗具有重要意义。本世纪以来,海洋源生物活性物质得到广泛运用,海洋生物已经成为药物重要来源之一,其中一些物质具有抑制小胶质细胞活化的作用。本文综述了小胶质细胞活化与神经退行性疾病之间的关系以及目前海洋源抑制小胶质细胞活化活性物质的研究状况,为进一步药物开发和机制研究提供参考。 展开更多
关键词 小胶质细胞 活化状态 神经退行性疾病 海洋源活性物质
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Compact Single-Mode Distributed Bragg Reflector Fiber Laser
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作者 XUE Yi-Yuan AN Hong-lin +2 位作者 FU Li-Bin lin xiang-zhi LIU Hong-Du 《Chinese Physics Letters》 SCIE CAS CSCD 2000年第2期109-111,共3页
A compact single-mode distributed Bragg reflector (DBR) fiber laser with narrow spectral linewidth is investigated. Firstly, based on our theoretical analysis the single longitudinal mode operation domain is obtained.... A compact single-mode distributed Bragg reflector (DBR) fiber laser with narrow spectral linewidth is investigated. Firstly, based on our theoretical analysis the single longitudinal mode operation domain is obtained. Then, a single-mode DBR fiber laser of 7.9cm long with master oscillator power amplifier (MOPA) configuration is designed and constructed to operate in the single-mode domain. The fiber laser is pumped by a semiconductor laser at 975.5nm. The master oscillator operates at 1556.91 nm with a cw output power of 1.43mW for a pump power of 55.35 mW. Its slope efficiency is 2.7% and the spectral linewidth is less than 1.2MHz (instrument resolution limited). With the MOPA configuration the laser output power and slope efficiency are increased to 7.8mW and 16.9%, respectively. 展开更多
关键词 FIBER AMPLIFIER PUMPED
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New Method to Obtain Strain Gradient Chirped Fiber Bragg Gratings
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作者 WANG ling FU Li-bin +3 位作者 XU Wan-jin AN Hong-lin lin xiang-zhi LIU Hong-du 《Chinese Physics Letters》 SCIE CAS CSCD 1999年第12期902-904,共3页
We describe a new method for applying a strain gradient with different profiles to convert uniform fiber Bragg gratings into linear or non-linear chirped ones. The chirping profile and the chirp rate of the fiber grat... We describe a new method for applying a strain gradient with different profiles to convert uniform fiber Bragg gratings into linear or non-linear chirped ones. The chirping profile and the chirp rate of the fiber gratings can be controlled by simply varying the tension applied. Both the theory and experimental results are presented. 展开更多
关键词 FIBER CHIRP CONVERT
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Electrically Tunable Optical Fiber Mach- Zehnder Interferometer
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作者 XING Jie FU Li-bin +6 位作者 XU Wan-jing lin xiang-zhi LIU Hong-du LI Yi-jun SHAO Yan-bin HU Dan-ping CHEN Yan-chuan 《Chinese Physics Letters》 SCIE CAS CSCD 1999年第7期516-517,共2页
An electrically tunable optical fibre Macli-Zehnder interferometer is reported,based on the magnetostrictive effect.The period and peak wavelength of the interference spectrum can be electrically tuned to match the In... An electrically tunable optical fibre Macli-Zehnder interferometer is reported,based on the magnetostrictive effect.The period and peak wavelength of the interference spectrum can be electrically tuned to match the International Telecommunication Union standard wavelength grid and so it is promising to be used in dense wavelength division multiplexing technology. 展开更多
关键词 INTERFEROMETER TUNABLE effect.
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Hydrogen Concentration Dependence of Bragg Wavelength of UV-Written Fiber Grating
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作者 FU Li-bin TAN Gu +2 位作者 XU Wan-jin lin xiang-zhi LIU Hong-du 《Chinese Physics Letters》 SCIE CAS CSCD 1998年第12期886-888,共3页
Hydrogen loading provides highly enhanced photosensitivity in Ge-doped fiber. But the Bragg wavelength of UV-written fiber grating will shift from its initial value as the remaining hydrogen diffuses out of such fiber... Hydrogen loading provides highly enhanced photosensitivity in Ge-doped fiber. But the Bragg wavelength of UV-written fiber grating will shift from its initial value as the remaining hydrogen diffuses out of such fiber. A simple model to calculate the index change of hydrogenated fibers is presented. The theoretical model is in good agreement with experimental results and it can well predict the final wavelength position of UV-written weak fiber grating. 展开更多
关键词 FIBER fibers VALUE
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Photosensitivity and Hydroxyl in Hydrogenated Silica Fibers
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作者 TAN Gu lin xiang-zhi +3 位作者 LIU Hong-du FU Li-bin E.Y.B.Pun P.S.Chung 《Chinese Physics Letters》 SCIE CAS CSCD 1998年第9期657-658,共2页
Optical loss spectra and refractive index changes have been measured in the hydrogenated standard telecommu-nication fiber and photosensitive fiber.The index changes due to ultraviolet exposure were found to be closel... Optical loss spectra and refractive index changes have been measured in the hydrogenated standard telecommu-nication fiber and photosensitive fiber.The index changes due to ultraviolet exposure were found to be closely related with the OH formation in both types of fibers.A direct photolyticd model is proposed to explain the effect of hydrogen loading on the enhancement of the photosensitivity in silica fibers. 展开更多
关键词 LOADING ULTRAVIOLET EFFECT
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Loss Increase Induced by H_(2) Loading in GeO_(2) Doped Optical Fiber
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作者 AN Hong-lin CUI Xiao-ming +4 位作者 WEN Peng-yue lin xiang-zhi LIU Hong-du E.Y.B.Pun P.S.Chung 《Chinese Physics Letters》 SCIE CAS CSCD 1997年第3期187-189,共3页
The increase of absorption loss in photosensitivity enhanced optical fiber via H_(2) loading induced in the making process of fiber grating was measured.From the results it can be seen that hydroxyl induced by exposin... The increase of absorption loss in photosensitivity enhanced optical fiber via H_(2) loading induced in the making process of fiber grating was measured.From the results it can be seen that hydroxyl induced by exposing the H_(2) loaded GeO_(2)-doped optical fiber to 248nm light causes large absorption loss at 1.4μm.A reaction model is postulated to describe the process that leads to the loss increase and photosensitivity enhancement in GeO_(2)-doped optical fiber. 展开更多
关键词 fiber optical ABSORPTION
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Antipyretic and anti-inflammatory activities of Thais luteostoma extracts and underlying mechanisms 被引量:16
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作者 LIU Xin TANG Yu-Ping +7 位作者 LIU Rui JIN Yi GUO Jian-Ming ZHAO Jin-Long DING Shao-Xiong lin xiang-zhi lin Ru-Rong DUAN Jin-Ao 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2015年第3期192-198,共7页
Thais luteostoma has been utilized as a crude drug whose shell and soft tissue have been widely used for the treatment of heat syndrome in China for thousands of years. The present study was designed to investigate th... Thais luteostoma has been utilized as a crude drug whose shell and soft tissue have been widely used for the treatment of heat syndrome in China for thousands of years. The present study was designed to investigate the antipyretic and anti-inflammatory activities of T. luteostoma. T. luteostoma was divided into shell (TLSH) and soft tissue (TLST) samples in the present study. The rat model of yeast-induced fever was used to investigate their antipyretic effects; and the rat model of hind paw edema induced by carrageenan was utilized to study their anti-inflammatory activities, and at the same time, the concentration variations of the central neurotransmitter [prostaglandin E2 (PGE2) and cyclic adenosine monophosphate (cAMP)], inflammatory mediators [tumor necrosis factor (TNFα), interleukin-1β (IL-1), interleukin-2 (IL-2) and interleukin-6 (IL-6)] and ion (Na^+ and Ca^2+) were also tested. The results showed that TLSH and TLST extracts significantly inhibited yeast-induced pyrexia in rats (P 〈 0.05), and exhibited more lasting effects as compared to aspirin, and TLSH had the better antipyretic activity than TLST, and that TLSH and TLST could significantly prevent against carrageenan induced paw edema in rats (P 〈 0.05); and markedly reduced levels of PGE2, cAMP, TNFα, IL-1β, IL-2, IL-6, and Na^+/Ca^2+. In fever model, TLST could significantly reduce the levels of PGE2 (P 〈 0.01) in rats' homogenate and TNF a (P 〈 0.05), IL-113 (P 〈 0.01) in the plasma than TLSH, whereas TLSH could reduce the content of IL-2 (P 〈 0.01) and IL-6 (P 〈 0.01) in plasma and increase the content of Ca2+ (P 〈 0.01) in plasma and homogenate more significantly than TLST. In conclusion, T. luteostoma extract has antipyretie and anti-inflammatory activities, which may be mediated through the suppression of production of PGE2, cAMP, Na^+/Ca^2+ , TNF a, IL-1β, IL-2, and IL-6. 展开更多
关键词 Marine organism Thais luteostoma ANTIPYRETIC ANTI-INFLAMMATORY Inflammatory mediator
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