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Boosting oxygen reduction activity and CO_(2) resistance on bismuth ferrite-based perovskite cathode for low-temperature solid oxide fuel cells below 600℃
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作者 Juntao Gao Zhiyun Wei +5 位作者 Mengke Yuan Zhe Wang Zhe Lü Qiang Li lingling xu Bo Wei 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第3期600-609,I0013,共11页
Developing efficient and stable cathodes for low-temperature solid oxide fuel cells(LT-SOFCs) is of great importance for the practical commercialization.Herein,we propose a series of Sm-modified Bi_(0.7-x)Sm_xSr_(0.3)... Developing efficient and stable cathodes for low-temperature solid oxide fuel cells(LT-SOFCs) is of great importance for the practical commercialization.Herein,we propose a series of Sm-modified Bi_(0.7-x)Sm_xSr_(0.3)FeO_(3-δ) perovskites as highly-active catalysts for LT-SOFCs.Sm doping can significantly enhance the electrocata lytic activity and chemical stability of cathode.At 600℃,Bi_(0.675)Sm_(0.025)Sr_(0.3)FeO_(3-δ)(BSSF25) cathode has been found to be the optimum composition with a polarization resistance of 0.098 Ω cm^2,which is only around 22.8% of Bi_(0.7)Sr_(0.3)FeO_(3-δ)(BSF).A full cell utilizing BSSF25 displays an exceptional output density of 790 mW cm^(-2),which can operate continuously over100 h without obvious degradation.The remarkable electrochemical performance observed can be attributed to the improved O_(2) transport kinetics,superior surface oxygen adsorption capacity,as well as O_(2)p band centers in close proximity to the Fermi level.Moreover,larger average bonding energy(ABE) and the presence of highly acidic Bi,Sm,and Fe ions restrict the adsorption of CO_(2) on the cathode surface,resulting in excellent CO_(2) resistivity.This work provides valuable guidance for systematic design of efficient and durable catalysts for LT-SOFCs. 展开更多
关键词 Low-temperature solid oxide fuel cell Perovskite cathode DFT calculations CO_(2) tolerance
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Preparation and Performance of n-Dodecane Microencapsulated Phase Change Cold Storage Materials
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作者 Pan Zhang lingling xu +2 位作者 Xin Shi Zemeng Guo Jiajia Cheng 《Journal of Renewable Materials》 SCIE EI 2023年第2期689-705,共17页
Cold chain transportation is currently a hot research topic.Since the traditional refrigeration methods lead to the consumption of large amounts of energy,the search for new energy storage materials is a major trend.I... Cold chain transportation is currently a hot research topic.Since the traditional refrigeration methods lead to the consumption of large amounts of energy,the search for new energy storage materials is a major trend.In the present contribution,n-dodecane/PMMA microencapsulated phase change materials were prepared by suspension polymerization for ice-temperature cold chain transportation and their preparation parameters were explored using the encapsulation ratio as optimization indicator.The results show that the n-dodecane-containing microcapsules have a maximum encapsulation ratio of 93.2%when using a core-to-wall ratio of 3:1,5%of emulsifier,30%of crosslinker,and 2000 rpm of emulsification speed.The phase transition temperature and enthalpy are-2℃and 195.9 kJ/kg,respectively.The microcapsules prepared with the optimized process parameters have good microscopic morphology,high energy storage efficiency,uniform particle size and good thermal stability,making them ideal materials for cold chain transportation. 展开更多
关键词 Phase change microcapsules N-DODECANE suspension polymerization cold storage
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Low ambient temperature and air pollution are associated with hospitalization incidence of coronary artery disease:Insights from a cross-sectional study in Northeast China
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作者 Rui Jiang lingling xu +4 位作者 Yue Liu Guangna Zhao Chun Xing Youyuan Li Yongchen Wang 《Frigid Zone Medicine》 2023年第4期232-241,I0007-I0013,共17页
Background:Previous studies have established a link between fluctuations in climate and increased mortality due to coronary artery disease(CAD).However,there remains a need to explore and clarify the evidence for asso... Background:Previous studies have established a link between fluctuations in climate and increased mortality due to coronary artery disease(CAD).However,there remains a need to explore and clarify the evidence for associations between meteorological changes and hospitalization incidences related to CAD and its subtypes,especially in cold regions.This study aimed to systematically investigate the relationship between exposure to meteorological changes,air pollutants,and hospitalization for CAD in cold regions.Methods:We conducted a cross-sectional study using hospitalization records of 86,483 CAD patients between January 1,2009,and December 31,2019.Poisson regression analysis,based on generalized additive models,was applied to estimating the influence of hospitalization for CAD.Results:Significant associations were found between low ambient temperature[-10℃,RR=1.65;95%CI:(1.28-2.13)]and the incidence of hospitalization for CAD within a lag of 0-14 days.Furthermore,O_(3)[95.50μg/m^(3),RR=12;95%CI:(1.03-1.21)]and NO_(2)[48.70μg/m^(3),RR=1.0895%CI:(1.01-1.15)]levels were identified as primary air pollutants affecting the incidence of CAD,ST-segment-elevation myocardial infarction(STEMI),and non-STEMI(NSTEMI)within the same lag period.Furthermore,O_(3)[95.50μg/m^(3),RR=1.12;95%CI:(1.03-1.21)]and NO_(2)[48.70μg/m^(3),RR=1.0895%CI:(1.01-1.15)]levels were identified as primary air pollutants affecting the incidence of CAD,ST-segment-elevation myocardial infarction(STEMI),and non-STEMI(NSTEMI)within the same lag period.The effect curve of CAD hospitalization incidence significantly increased at lag days 2 and 4 when NO_(2)and O_(3)concentrations were higher,with a pronounced effect at 7 days,dissipating by lag 14 days.No significant associations were observed between exposure to PM,SO_(2),air pressure,humidity,or wind speed and hospitalization incidences due to CAD and its subtypes.Conclusion:Our findings suggest a positive correlation between short-term exposure to low ambient temperatures or air pollutants(O_(3)and NO_(2))and hospitalizations for CAD,STEMI,and NSTEMI.These results could aid the development of effective preparedness strategies for frequent extreme weather events and support clinical and public health practices aimed at reducing the disease burden associated with current and future abnormal weather events. 展开更多
关键词 meteorological changes ambient temperature air pollution coronary heart disease Poisson regression analysis
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A Hybrid Biofuel and Triboelectric Nanogenerator for Bioenergy Harvesting
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作者 Hu Li Xiao Zhang +9 位作者 Luming Zhao Dongjie Jiang lingling xu Zhuo Liu Yuxiang Wu Kuan Hu Ming‑Rong Zhang Jiangxue Wang Yubo Fan Zhou Li 《Nano-Micro Letters》 SCIE EI CAS CSCD 2020年第4期53-64,共12页
Various types of energy exist everywhere around us,and these energies can be harvested from multiple sources to power micro-/nanoelectronic system and even personal electronic products.In this work,we proposed a hybri... Various types of energy exist everywhere around us,and these energies can be harvested from multiple sources to power micro-/nanoelectronic system and even personal electronic products.In this work,we proposed a hybrid energy-harvesting system(HEHS)for potential in vivo applications.The HEHS consisted of a triboelectric nanogenerator and a glucose fuel cell for simultaneously harvesting biomechanical energy and biochemical energy in simulated body fluid.These two energy-harvesting units can work individually as a single power source or work simultaneously as an integrated system.This design strengthened the flexibility of harvesting multiple energies and enhanced corresponding electric output.Compared with any individual device,the integrated HEHS outputs a superimposed current and has a faster charging rate.Using the harvested energy,HEHS can power a calculator or a green light-emitting diode pattern.Considering the widely existed biomechanical energy and glucose molecules in the body,the developed HEHS can be a promising candidate for building in vivo self-powered healthcare monitoring system. 展开更多
关键词 SELF-POWERED Triboelectric nanogenerator Glucose fuel cell Hybrid energy harvester BIOENERGY
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Correction to:A Hybrid Biofuel and Triboelectric Nanogenerator for Bioenergy Harvesting
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作者 Hu Li Xiao Zhang +9 位作者 Luming Zhao Dongjie Jiang lingling xu Zhuo Liu Yuxiang Wu Kuan Hu Ming-Rong Zhang Jiangxue Wang Yubo Fan Zhou Li 《Nano-Micro Letters》 SCIE EI CAS CSCD 2020年第7期191-191,共1页
In the original publication,the authors’contribution is missing in the acknowledgment section.The correct acknowledgement is provided in this correction.Also,in Fig.4,the second(c)after figure(d)should be read as(e).... In the original publication,the authors’contribution is missing in the acknowledgment section.The correct acknowledgement is provided in this correction.Also,in Fig.4,the second(c)after figure(d)should be read as(e).In Fig.5(i),the Y-axis label“Current(μA)”should be read as“Voltage”. 展开更多
关键词 section. GENERATOR KNOWLEDGE
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QUANTIFYING THE SHORT LIFETIME WITH TCSPC-FLIM:FIRST MOMENT VERSUS FITTING METHODS
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作者 lingling xu ZHONG-CHAO WEI +1 位作者 SHAOQUN ZENG ZHEN-LIHU ANG 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2013年第4期1-10,共10页
Combing the time corelated single photon counting(TCSPC)with fuorescence lifetime imaging microscopy(FLIM)provides promising opportunities in revealing important information on the microenvironment of cells and tissue... Combing the time corelated single photon counting(TCSPC)with fuorescence lifetime imaging microscopy(FLIM)provides promising opportunities in revealing important information on the microenvironment of cells and tissues,but the applications are thus far mainly limited by the accuracy and precision of the TCSPC-FLIM technique.Here we present a comprehensive in-vestigation on the perforance of two data analysis methods,the first moment(M_(1))method and the conventional least squares(Fitting)method,in quantifying fuorescence lifetime.We found that the Mp method is more superior than the Fitting method when the lifetime is short(70-400ps)or the signal intensity is weak(<10^(3) photons). 展开更多
关键词 Fluorescence lifetimne imaging tim-correlated single photon counting the distribution of the first moment(M_(1))
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Chromosome 6q deletion mapping in human ovarian tumor: a common deletion region between D6S1649 and D6S311
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作者 Yufei Shen lingling xu +3 位作者 Yongning Zhai Jing Tian Hong Xia Lasko W 《Journal of Nanjing Medical University》 2006年第5期307-311,共5页
Objective: To explore the loss of heterozygosity(LOH) on chromosome 6q in ovarian cancer, and localize a minimum area in deletion region. Methods: 93 ovarian tumors were analyzed for LOH studies with 10 microsatel... Objective: To explore the loss of heterozygosity(LOH) on chromosome 6q in ovarian cancer, and localize a minimum area in deletion region. Methods: 93 ovarian tumors were analyzed for LOH studies with 10 microsatellite markers spanning chromosome 6q. To further localize a minimum area in deletion region. Nineteen microsatellite markers were used to refined a minimum area. Results: Forty three tumors (46%) were demonstrated allelic losses, which spanned less than two megabase areas, franked by a distal marker D6S311 and a proximal marker D6S1649, and likely harbored ovarian tumor suppressor gene (s). With analysis of density of LOH, increased DNA copy number at loci of 6q was demonstrated between D6S1649 and D6S311. Conclusion: It is possible that duplication after the allelic loss might be a main mechanism that leads to carcinogenesis in ovarian tumor. The refinement of these candidate tumor suppressor genes loci might facilitate future loss of heterozygosity studies and enable the isolation of candidate genes from this region. 展开更多
关键词 OVARY CANCER loss of heterozygosity chromosome 6q
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Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China
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作者 Ziyi Lin Xiaolong Fan +8 位作者 Gaojie Chen Youwei Hong Mengren Li lingling xu Baoye Hu Chen Yang Yanting Chen Zhiqian Shao Jinsheng Chen 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第4期561-571,共11页
To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As... To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,Xiamen.The concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and Zn.Based on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping emission.According to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace elements.During the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain times.Health risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future. 展开更多
关键词 PM_(2.5)-bound trace elements Seasonal variations Source appointment Health risks Traffic-related source
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Atmospheric oxidation capacity and O_(3) formation in a coastal city of southeast China:Results from simulation based on four-season observation
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作者 Gaojie Chen Taotao Liu +9 位作者 Jinsheng Chen lingling xu Baoye Hu Chen Yang Xiaolong Fan Mengren Li Youwei Hong Xiaoting Ji Jinfang Chen Fuwang Zhang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第2期68-80,共13页
The pollution of atmospheric ozone in China shows an obvious upward trend in the past decade.However,the studies on the atmospheric oxidation capacity and O_(3)formation in four seasons in the southeastern coastal reg... The pollution of atmospheric ozone in China shows an obvious upward trend in the past decade.However,the studies on the atmospheric oxidation capacity and O_(3)formation in four seasons in the southeastern coastal region of China with the rapid urbanization remain limited.Here,a four-season field observation was carried out in a coastal city of southeast China,using an observation-based model combining with the Master Chemical Mechanism,to explore the atmospheric oxidation capacity(AOC),radical chemistry,O_(3)formation pathways and sensitivity.The results showed that the average net O_(3)production rate(14.55 ppbv/hr)in summer was the strongest,but the average O_(3)concentrations in autumn was higher.The AOC and ROx levels presented an obvious seasonal pattern with the maximum value in summer,while the OH reactivity in winter was the highest with an average value of 22.75 sec^(-1).The OH reactivity was dominated by oxygenated VOCs(OVOCs)(30.6%-42.8%),CO(23.2%-26.8%),NO_(2)(13.6%-22.0%),and alkenes(8.4%-12.5%)in different seasons.HONO photolysis dominated OH primary source on daytime in winter,while in other seasons,HONO photolysis in the morning and ozone photolysis in the afternoon contributed mostly.Sensitivity analysis indicated that O_(3)production was controlled by VOCs in spring,autumn and winter,but a VOC-limited and NOx-limited regime in summer,and alkene and aromatic species were the major controlling factors to O_(3)formation.Overall,the study characterized the atmospheric oxidation capacity and elucidated the controlling factors for O_(3)production in the coastal area with the rapid urbanization in China. 展开更多
关键词 Atmospheric oxidation capacity Radical chemistry Ozone production Sensitivity analysis
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MODIFIED STOCHASTIC EXTRAGRADIENT METHODS FOR STOCHASTIC VARIATIONAL INEQUALITY
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作者 Ling Zhang lingling xu 《Journal of Computational Mathematics》 SCIE CSCD 2024年第2期390-414,共25页
In this paper,we consider two kinds of extragradient methods to solve the pseudo-monotone stochastic variational inequality problem.First,we present the modified stochastic extragradient method with constant step-size... In this paper,we consider two kinds of extragradient methods to solve the pseudo-monotone stochastic variational inequality problem.First,we present the modified stochastic extragradient method with constant step-size(MSEGMC)and prove the convergence of it.With the strong pseudo-monotone operator and the exponentially growing sample sequences,we establish the R-linear convergence rate in terms of the mean natural residual and the oracle complexity O(1/ǫ).Second,we propose a modified stochastic extragradient method with adaptive step-size(MSEGMA).In addition,the step-size of MSEGMA does not depend on the Lipschitz constant and without any line-search procedure.Finally,we use some numerical experiments to verify the effectiveness of the two algorithms. 展开更多
关键词 Stochastic variational inequality Pseudo-monotone Modified stochastic ex-tragradient methods Adaptive step-size
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江苏省盐城市滨海县社区糖尿病患者慢性肾功能不全发病率及危险因素分析
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作者 徐玲玲 周阳 +2 位作者 李冬玲 刘瑾 杨俊伟 《中华糖尿病杂志》 CAS CSCD 北大核心 2023年第12期1237-1243,共7页
目的探讨江苏省盐城市滨海县社区糖尿病患者慢性肾功能不全(CRI)的发病率及其危险因素。方法为回顾性队列研究。选取江苏省盐城市滨海县2018年1月1日—12月31日参与居民健康体检,并连续4年(截至2021年12月31日)完成每年1次体检随访的糖... 目的探讨江苏省盐城市滨海县社区糖尿病患者慢性肾功能不全(CRI)的发病率及其危险因素。方法为回顾性队列研究。选取江苏省盐城市滨海县2018年1月1日—12月31日参与居民健康体检,并连续4年(截至2021年12月31日)完成每年1次体检随访的糖尿病患者为研究对象。收集患者一般资料(性别、年龄)、血液学指标[空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、肌酐],尿蛋白定性结果(阴性、微量、1+、2+或3+;其中,中等量蛋白尿定义为尿蛋白1+,大量蛋白尿被定义为尿蛋白≥2+),并根据慢性肾脏病流行病学协作公式(CKD-EPI)计算估算的肾小球滤过率(eGFR)。CRI诊断标准为患者肾功能不全[eGFR<60 ml·min^(-1)·(1.73 m^(2))^(-1)]病史持续≥3个月。终点事件设定为患者在随访期间,首次出现肾功能不全,并通过后续门诊、查询电子病历系统或电话随访,调取参与者至少2次血清肌酐水平,证实患者符合CRI诊断。采用Poisson回归模型计算患者CRI发病率,采用多因素Cox回归分析评估糖尿病患者发生CRI的独立危险因素。结果最终纳入8244例糖尿病患者。基线时,患者年龄(62.2±9.1)岁,男性占39.3%(3238/8244)。中位随访时间为3.4(3.3,3.5)年,8.7%(715/8244)患者在随访期内发生CRI,CRI发病率为2.64(95%CI 2.60~2.67)/百人年。多因素Cox回归分析显示,女性(HR=1.634,95%CI 1.389~1.921)、TG增加(每增加1 mmol/L,HR=1.044,95%CI 1.014~1.075)、FPG增加(每增加1 mmol/L,HR=1.063,95%CI 1.040~1.087)、中等量蛋白尿(HR=1.290,95%CI 1.003~1.667)及大量蛋白尿(HR=2.086,95%CI 1.645~2.644)是新发CRI风险的独立危险因素。基线eGFR水平与CRI患病风险独立负相关[每增加5 ml·min^(-1)·(1.73 m^(2))^(-1),HR=0.623,95%CI 0.604~0.642]。结论社区糖尿病患者CRI发病率较高。女性、TG及FPG的升高、中等及大量蛋白尿、低eGFR与新发CRI风险独立相关。 展开更多
关键词 糖尿病 肾功能不全 慢性 发病率 危险因素
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有晶状体眼人工晶状体不同植入方向旋转稳定性的比较 被引量:1
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作者 李帅飞 游昌涛 +2 位作者 徐玲玲 陈东栋 王铮 《中华眼视光学与视觉科学杂志》 CAS CSCD 2023年第7期518-523,共6页
目的:比较水平、斜向、垂直植入有晶状体眼人工晶状体(ICL)及水平植入散光型人工晶状体(TICL)在术后1个月、1年的旋转稳定性。方法:回顾性临床研究。连续性收集2020年1月至2021年6月在郑州爱尔眼科医院屈光手术专科行ICL(V4c)植入术的... 目的:比较水平、斜向、垂直植入有晶状体眼人工晶状体(ICL)及水平植入散光型人工晶状体(TICL)在术后1个月、1年的旋转稳定性。方法:回顾性临床研究。连续性收集2020年1月至2021年6月在郑州爱尔眼科医院屈光手术专科行ICL(V4c)植入术的屈光不正患者92例(184眼)。根据术后1 d的人工晶状体(IOL)轴向分为ICL水平组、ICL斜向组、ICL垂直组和TICL水平组,分别为59、33、36、56眼。记录术后1 d、1个月和1年的裸眼视力、眼压、拱高及IOL轴向等,并计算术后1个月、1年的有效性指数和IOL旋转角度和方向。4组间术后各时间点有效性指数、眼压等计量资料的比较采用重复测量方差分析,IOL旋转角度组间比较采用Kruskal-Wallis检验,IOL旋转方向组间比较采用Pearsonχ^(2)检验。采用Spearman秩相关分析及多元线性回归分析术后1年IOL旋转角度与年龄、性别等指标之间的相关性。结果:ICL水平组、ICL斜向组、ICL垂直组与TICL水平组在术后1个月、1年组间有效性指数、眼压、拱高及角膜内皮细胞密度差异均无统计学意义(均P>0.05)。在术后1个月、1年,4组间IOL旋转角度差异均无统计学意义(H=6.36,P=0.095;H=4.82,P=0.185);IOL旋转方向差异亦无统计学意义(χ^(2)=4.44,P=0.617;χ^(2)=6.03,P=0.420)。术后1年IOL旋转角度与患者年龄、性别等指标均无相关性(均P>0.05)。结论:ICL水平、斜向、垂直植入与TICL水平植入在术后1个月和1年均可获得相对一致的手术效果和旋转稳定性。 展开更多
关键词 人工晶状体植入术 有晶状体眼 植入方向 旋转稳定性
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Genetic Architecture and Functional Implications of the CSF‑Contacting Nucleus 被引量:1
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作者 Siyuan Song Yumin Yuan +7 位作者 lingling xu Jun Jiang Ying Li Yao Yan Qing Li Fang Zhou Junli Cao Licai Zhang 《Neuroscience Bulletin》 SCIE CSCD 2023年第11期1638-1654,共17页
We previously identified a unique nucleus,the cerebrospinal fluid(CSF)-contacting nucleus.This study aims to understand its gene architecture and preliminarily suggest its functions.The results showed that there were ... We previously identified a unique nucleus,the cerebrospinal fluid(CSF)-contacting nucleus.This study aims to understand its gene architecture and preliminarily suggest its functions.The results showed that there were about 19,666 genes in this nucleus,of which 913 were distinct from the dorsal raphe nucleus(non-CSF contacting).The top 40 highly-expressed genes are mainly related to energy metabolism,protein synthesis,transport,secretion,and hydrolysis.The main neurotransmitter is 5-HT.The receptors of 5-HT and GABA are abundant.The channels for Cl–,Na+,K+,and Ca2+are routinely expressed.The signaling molecules associated with the CaMK,JAK,and MAPK pathways were identified accurately.In particular,the channels of transient receptor potential associated with nociceptors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed.The relationship between the main genes of the nucleus and life activities is preliminarily verified. 展开更多
关键词 Gene architecture Cerebrospinal fluidcontacting nucleus(CSF-contacting nucleus) Biological function
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Highly lipophilic coumarin fluorophore with excimer-monomer transition property for lipid droplet imaging
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作者 Xiang Shi Ge Gao +4 位作者 Xiaoyang Liu lingling xu Yu Deng Rui Wang Gaolin Liang 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第3期367-371,共5页
Lipid droplet(LD) fluorescent imaging plays an important role in the detection of lipid-related diseases.Due to their poor photostability and low hydrophobicity of currently available LD imaging fluorophores,LD imagin... Lipid droplet(LD) fluorescent imaging plays an important role in the detection of lipid-related diseases.Due to their poor photostability and low hydrophobicity of currently available LD imaging fluorophores,LD imaging is limited by its short imaging period and low imaging contrast. Herein, we reasonably designed a highly lipophilic compound Cou-Flu with excellent photostability and excimer-monomer transition property. It exhibited weak excimer emission in cytoplasm, but strong monomer emission in LDs,enabling high contrast LD imaging and LD movement tracing in cells. Zebrafish imaging study demonstrated that Cou-Flu was also suitable for in vivo LD detection with excellent sensitivity. We anticipate that Cou-Flu could be widely applied to understand LD-related intracellular activities and even LD-related diseases in the future. 展开更多
关键词 Excimer-monomer transition Fluorescent probe Hydrophobicity Lipid droplets Monomer emission
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Intrapulse coherence degradation suppressing method of echo signal in coherent lidar
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作者 从海胜 孙建锋 +7 位作者 卢智勇 贺红雨 任伟杰 姜玉鑫 许玲玲 李超洋 张龙坤 张正伟 《Chinese Optics Letters》 SCIE EI CAS CSCD 2023年第7期7-15,共9页
Aiming at coherence degradation during target detection,a suppressing method based on frequency-modulated continuous wave coherent lidar is proposed.Combined with a random iteration algorithm,a long-pulse echo signal ... Aiming at coherence degradation during target detection,a suppressing method based on frequency-modulated continuous wave coherent lidar is proposed.Combined with a random iteration algorithm,a long-pulse echo signal with coherent degradation is matched with random phase noise of a certain frequency and achieves coherence restoration.Simulation and field experiment results show that this proposed method can recover the intrapulse coherence in long-pulse echo signals.In addition,for the real target echo signal at 4.2 and 19.8 km,the peak signal-to-noise ratio processed by this method is increased by 0.35 times and 4 times after pulse compression,respectively. 展开更多
关键词 coherent lidar long-pulse signal coherent degradation frequency modulation continuous wave
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雷公藤红素抑制成人T细胞白血病细胞增殖及机制 被引量:6
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作者 方金勇 衣凯宁 +3 位作者 宋早文 陈梦云 徐玲玲 赵铁军 《生物工程学报》 CAS CSCD 北大核心 2018年第9期1491-1499,共9页
本研究旨在分析雷公藤红素对成人T细胞白血病细胞增殖、凋亡的影响,并探讨其分子机制。使用不同浓度的雷公藤红素溶液处理多种成人T细胞白血病细胞株,通过四唑盐比色法(MTT)、克隆形成实验检测细胞的增殖情况;Annexin V/PI双染检测细胞... 本研究旨在分析雷公藤红素对成人T细胞白血病细胞增殖、凋亡的影响,并探讨其分子机制。使用不同浓度的雷公藤红素溶液处理多种成人T细胞白血病细胞株,通过四唑盐比色法(MTT)、克隆形成实验检测细胞的增殖情况;Annexin V/PI双染检测细胞凋亡情况;最后通过Western blotting及双荧光素酶报告基因技术探究雷公藤红素抑制成人T细胞白血病细胞生长的调控机制。结果表明雷公藤红素能显著抑制成人T细胞白血病细胞增殖并诱导其凋亡,随着雷公藤红素浓度的增加Bax/Bcl-2蛋白比率明显升高,凋亡途径中Caspase-3/7蛋白也随之被切割活化,同时病毒编码的癌蛋白Tax的表达也明显受到抑制。以上结果表明,雷公藤红素通过调控Bcl-2家族蛋白,激活了Caspase途径诱导细胞凋亡,并通过抑制病毒关键蛋白Tax的表达,从而有效抑制了成人T细胞白血病细胞的增殖。该研究为临床应用雷公藤红素治疗成人T细胞白血病提供了实验依据。 展开更多
关键词 雷公藤红素 成人T细胞白血病 增殖 凋亡 TAX蛋白
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Pollution characteristics of organic and elemental carbon in PM_(2.5) in Xiamen,China 被引量:28
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作者 Fuwang Zhang Jinping Zhao +2 位作者 Jinsheng Chen Ya xu lingling xu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2011年第8期1342-1349,共8页
Xiamen, located on the southeastern coastal line of China, is undergoing rapid urbanization and industrialization, so its air quality has a trend of degradation. However, studies on level, temporal and spatial changes... Xiamen, located on the southeastern coastal line of China, is undergoing rapid urbanization and industrialization, so its air quality has a trend of degradation. However, studies on level, temporal and spatial changes of fine particles (PM2.5) and their carbonaceous fractions are scarce. In this article, abundance, sources, seasonal and spatial variations, distribution of organic carbon (OC) and elemental carbon (EC) in PM2.5, were studied at suburban, urban and industrial sites in Xiamen during four season-representative months in 2009-2010. PM2.5 samples were collected with middle volume sampler and were analyzed for OC and EC with thermal optical transmittance (TOT) method. Results showed that the annual average PM2.5 concentrations were 63.88-74.80 Ixg/m3 at three sites. While OC and EC concentrations were in the range of 15.81-19.73 [xg/m3 and 2.74-3.49 ~tg/m3, respectively, and clearly presented the summer minima and winter maxima in this study. The carbonaceous aerosol accounted for 42.8%-47.3% of the mass of PMzs. The annual average of secondary organic carbon (SOC) concentrations in Xiamen were 9.23-11.36 ~g/m3, accounting for approximately 56% of OC. Strong correlations between OC and EC was found in spring (R2 = 0.50) and autumn (R2 = 0.73), suggesting that there were similar emission and transport processes for carbonaceous aerosols in these two seasons, while weak correlations were found in summer (R2 = 0.33) and winter (R2 = 0.41). The OCI'EC ratios in PM2.5 varied from 2.1 to 8.7 with an annual average of 5.7, indicating that vehicle exhaust, coal smoke and biomass burning were main source apportionments of carbonaceous fractions in Xiamen. 展开更多
关键词 fine particle carbonaceous aerosol organic carbon elemental carbon XIAMEN
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Chemical compositions of PM_(2.5) aerosol during haze periods in the mountainous city of Yong'an, China 被引量:19
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作者 LiqianYin Zhenchuan Niu +3 位作者 Xiaoqiu Chen Jinsheng Chen lingling xu Fuwang Zhang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2012年第7期1225-1233,共9页
Haze phenomena were found to have an increasing tendency in recent years in Yong'an, a mountainous industrial city located in the center part of Fujian Province, China. Atmospheric fine particles (PM2.5) in the urb... Haze phenomena were found to have an increasing tendency in recent years in Yong'an, a mountainous industrial city located in the center part of Fujian Province, China. Atmospheric fine particles (PM2.5) in the urban area during haze periods in three seasons (spring, autumn and winter) from 2007 to 2008 were collected, and the mass concentrations and chemical compositions (seventeen elements, water soluble inorganic ions (WSIIs) and carbonaceous species) of PM2.5 were determined. PM2.5 mass concentrations did not show a distinct difference among the three seasons. The carbonaceous species organic carbon (OC) and elemental carbon (EC) constituted up to 19.2%-30.4% of the PM2.5 mass during sampling periods, while WSIIs made up 25.3%-52.5% of the PM2.5 mass. The major ions in PM2.5 were SO42-, NO3- and NH4~, while the major elements were Si, K, Pb, Zn, Ca and A1. The experimental results (from data based on three haze periods with a 10-day sampling length for each period) showed that the crustal element species was the most abundant component of PM2.5 in spring, and the secondary ions species (SO42-, NO3-, NH4+, etc.) was the most abundant component in PM2.5 in autumn and winter. This indicated that dust was the primary pollution source for PM2.5 in spring and combustion and traffic emissions could be the main pollution sources for PM2.5 in autumn and winter. Generally, coal combustion and traffic emissions were considered to be the most prominent pollution sources for this city on haze days. 展开更多
关键词 PM2.5 HAZE metal elements water soluble inorganic ions carbonaceous species Yong'an City
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Rapid reconstitution of NK1 cells after allogeneic transplantation is associated with a reduced incidence of graft-versus-host disease 被引量:10
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作者 Xingxing Yu lingling xu +2 位作者 Yingjun Chang Xiaojun Huang Xiangyu Zhao 《Science China(Life Sciences)》 SCIE CAS CSCD 2018年第8期902-911,共10页
The balance between immunostimulation and immunoregulation in T cell immunity is achieved by maintaining specific ratios of Th1, Th2, Th3 and Tr1 cells. Here, we investigate levels of type 1(IFN-gamma; NK1), type 2(IL... The balance between immunostimulation and immunoregulation in T cell immunity is achieved by maintaining specific ratios of Th1, Th2, Th3 and Tr1 cells. Here, we investigate levels of type 1(IFN-gamma; NK1), type 2(IL-13; NK2), type 3(TGF-beta;NK3) and regulatory(IL-10; NKr) cytokines in peripheral blood to assess the cytokine profiles of natural killer(NK) cells following human allogeneic hematopoietic stem cell transplantation(allo-HSCT). NK2 and NK3 cell expansion was observed after allo-HSCT; levels of NKr cells reached donor levels at day 15, though levels of NK1 cells were consistently lower than donor levels until day 60 after allo-HSCT. Multivariate analysis showed that a higher level of NK1 cells by day 15 was associated with a lower overall risk of acute graft-versus-host disease(GVHD)(HR 0.157, P=0.010) as well as II-IV acute GVHD(HR0.260, P=0.059). Furthermore, higher levels of NK1 cells by day 15 were correlated with lower rates of cytomegalovirus(CMV)reactivation(HR 0.040, 0.005–0.348, P=0.003). These results indicate that rapid reconstitution of NK cells, especially NK1 cells,can help prevent the development of GVHD as well as CMV reactivation after allogeneic transplantation. 展开更多
关键词 干细胞移植 房间 疾病 CYTOKINES 宪法 白天 CMV 施主
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Aerosol light absorption in a coastal city in Southeast China:Temporal variations and implications for brown carbon 被引量:5
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作者 Yuqing Qiu Xin Wu +5 位作者 Yanru Zhang lingling xu Youwei Hong Jinsheng Chen Xiaoqiu Chen Junjun Deng 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2019年第6期257-266,共10页
Light-absorbing carbonaceous aerosols including black carbon(BC) and brown carbon(BrC)play significant roles in atmospheric radiative properties. One-year measurements of aerosol light absorption at multi-wavelength w... Light-absorbing carbonaceous aerosols including black carbon(BC) and brown carbon(BrC)play significant roles in atmospheric radiative properties. One-year measurements of aerosol light absorption at multi-wavelength were continuously conducted in Xiamen,southeast of China in 2014 to determine the light absorption properties including absorption coefficients(σabs) and absorption ?ngstr?m exponent(AAE) in the coastal city.Light absorptions of BC and BrC with their contributions to total light absorption were further quantified. Mean σabsat 370 nm and 880 nm were 56.6 ± 34.3 and 16.5 ± 11.2 Mm-1,respectively. σabspresented a double-peaks diurnal pattern with the maximum in the morning and the minimum in the afternoon. σabswas low in warm seasons and high in cold seasons. AAE ranged from 0.26 to 2.58 with the annual mean of 1.46, implying that both fossil fuel combustion and biomass burning influenced aerosol optical properties. σabsof BrC at 370 nm was 24.0 ± 5.7 Mm-1, contributing 42% to the total absorption. The highest AAE(1.52 ± 0.02) and largest BrC contributions(47% ± 4%) in winter suggested the significant influence of biomass burning on aerosol light absorption. Long-distance air masses passing through North China Plain and the Yangtze River Delta led to high AAE and BrC contributions. High AAE value of 1.46 in July indicated that long-range transport of the air pollutants from intense biomass burning in Southeast Asia would affect aerosol light absorption in Southeast China. The study will improve the understanding of light absorption properties of aerosols and the optical impacts of BrC in China. 展开更多
关键词 LIGHT ABSORPTION BROWN CARBON Black CARBON ABSORPTION ANGSTROM exponent Biomass burning Western Taiwan STRAIT
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