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百合乌药蒲公英汤对肝纤维化的改善作用及机制研究 被引量:1
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作者 刘恒旭 王寰 +6 位作者 王瑞 冯欣怡 贾晓冬 郝思钰 盛奕菲 岳志伟 齐亚娟 《食品安全质量检测学报》 CAS 北大核心 2023年第5期300-307,共8页
目的 评价百合乌药蒲公英汤(decotion of Baihe Wuyao Pugongying,DBWP)对肝纤维化(liver fibrosis,LF)的保护作用,并揭示其相关机制。方法 通过四氯化碳诱导6~8周龄雄性昆明种小鼠LF模型并随机分为5组,给予6周不同剂量DBWP进行体内实... 目的 评价百合乌药蒲公英汤(decotion of Baihe Wuyao Pugongying,DBWP)对肝纤维化(liver fibrosis,LF)的保护作用,并揭示其相关机制。方法 通过四氯化碳诱导6~8周龄雄性昆明种小鼠LF模型并随机分为5组,给予6周不同剂量DBWP进行体内实验验证。检测肝功能指标、肝脏病理形态和纤维化沉积;Western-blot检测胶原纤维因子及细胞外基质(extracellular matrixs,ECMs)降解酶表达,反转录聚合酶链反应(reverse transcription-polymerase chain reaction,PT-PCR)检测炎症相关因子表达。结果 与模型组相比较,DBWP可明显改善肝功能,降低小鼠血清谷丙转氨酶(alanine amino transferase,ALT)和谷草转氨酶(aspartate amino transferase,AST)水平。HE染色和Masson染色表明,DBWP可改善小鼠肝脏病理形态和纤维化沉积,同时,肝脏中Collagen 1和Collagen 3表达明显降低,纤维化明显改善。基质金属蛋白酶(matrix metalloproteinases,MMPs)/金属蛋白酶抑制因子1(metalloproteinase 1,TIMP1)比值明显升高,肝脏对细胞外基质降解能力进一步加强。炎症相关因子白细胞介素-1β(interleukin-1β,IL-1β)和白细胞介素-6(interleukin-6,IL-6)的表达明显降低。结论 DBWP通过抗炎、促进细胞外基质降解改善肝纤维化。 展开更多
关键词 百合 乌药 蒲公英 肝纤维化 炎症 细胞外基质
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Experimental Investigation on the Hydrodynamic Performance of A Wave Energy Converter 被引量:5
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作者 ZHENG Xiong-bo MA Yong +2 位作者 ZHANG Liang JIANG Jin liu heng-xu 《China Ocean Engineering》 SCIE EI CSCD 2017年第3期370-377,共8页
Wave energy is an important type of marine renewable energy. A wave energy converter (WEC) moored with two floating bodies was developed in the present study. To analyze the dynamic performance of the WEC, an experi... Wave energy is an important type of marine renewable energy. A wave energy converter (WEC) moored with two floating bodies was developed in the present study. To analyze the dynamic performance of the WEC, an experimental device was designed and tested in a tank. The experiment focused on the factors which impact the motion and energy conversion performance of the WEC. Dynamic performance was evaluated by the relative displacements and velocities of the oscillator and carrier which served as the floating bodies of WEC. Four factors were tested, i.e. wave height, wave period, power take-off (PTO) damping, and mass ratio (RM) of the oscillator and carrier. Experimental results show that these factors greatly affect the energy conversion performance, especially when the wave period matches RM and PTO damping. According to the results, we conclude that: (a) the maximization of the relative displacements and velocities leads to the maximization of the energy conversion efficiency; (b) the larger the wave height, the higher the energy conversion efficiency will be; (c) the relationships of energy conversion efficiency with wave period, PTO damping, and RM are nonlinear, but the maximum efficiency is obtained when these three factors are optimally matched. Experimental results demonstrated that the energy conversion efficiency reached the peak at 28.62% when the wave height was 120 mm, wave period was 1.0 s, RM was 0.21, and the PTO damping was corresponding to the resistance of 100 Ω. 展开更多
关键词 wave energy energy conversion experiment HYDRODYNAMIC floating body
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Quadratic Dissipation Effect on the Moonpool Resonance 被引量:2
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作者 liu heng-xu CHEN Hai-long +2 位作者 ZHANG Liang ZHANG Wan-chao liu Ming 《China Ocean Engineering》 SCIE EI CSCD 2017年第6期665-673,共9页
This paper adopted a semi-analytical method based on eigenfunction matching to solve the problem of sharp resonance of cylindrical structures with a moonpool that has a restricted entrance. To eliminate the sharp reso... This paper adopted a semi-analytical method based on eigenfunction matching to solve the problem of sharp resonance of cylindrical structures with a moonpool that has a restricted entrance. To eliminate the sharp resonance and to measure the viscous effect, a quadratic dissipation is introduced by assuming an additional dissipative disk at the moonpool entrance. The fluid domain is divided into five cylindrical subdomains, and the velocity potential in each subdomain is obtained by meeting the Laplace equation as well as the boundary conditions. The free-surface elevation at the center of the moonpool, along with the pressure and velocity at the restricted entrance for first-order wave are evaluated. By choosing appropriate dissipation coefficients, the free-surface elevation calculated at the center of the moonpool is in coincidence with the measurements in model tests both at the peak period and amplitude at resonance. It is shown that the sharp resonance in the potential flow theory can be eliminated and the viscous effect can be estimated with a simple method in some provided hydrodynamic models. 展开更多
关键词 in-fluid quadratic dissipation viscous effect moonpool sharp resonance
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百合乌药蒲公英汤对Ⅰ型糖尿病肝病改善和保健作用机制研究 被引量:2
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作者 高明明 李一达 +5 位作者 付子杰 杨冰 刘恒旭 刘丹丹 李继安 齐亚娟 《食品安全质量检测学报》 CAS 北大核心 2022年第3期737-745,共9页
目的评价百合乌药蒲公英汤(DecotionofBaiheWuyaoPugongying,DBWP)对I型糖尿病(type1diabetes,T1D)肝病的改善作用,并进行机制探讨。方法8周龄雄性昆明小鼠腹腔注射链脲佐菌素(streptozotocin,STZ)制备T1D模型,模型制备成功后随机将小... 目的评价百合乌药蒲公英汤(DecotionofBaiheWuyaoPugongying,DBWP)对I型糖尿病(type1diabetes,T1D)肝病的改善作用,并进行机制探讨。方法8周龄雄性昆明小鼠腹腔注射链脲佐菌素(streptozotocin,STZ)制备T1D模型,模型制备成功后随机将小鼠分为7组,随后用不同剂量DBWP连续灌胃6周进行效果评价。然后观察小鼠肝组织形态学变化和纤维化状况;检测肝功能、空腹血糖和血清胰岛素水平;检测血清中抗氧化因子含量;同时检测肝脏炎症因子、抗氧化因子和糖异生因子在mRNA水平的表达。结果DBWP给药后,与模型组相比,给药组小鼠体重有所上升,血糖值降低,血清胰岛素水平升高,以中剂量组效果最为明显;染色结果可见肝细胞排列整齐紧密,肝脏病理损伤有所恢复;血清生化相关酶含量明显降低,且以低1剂量最为明显;给药组抗氧化因子超氧化物歧化酶(superoxidedismutase,SOD)中、低1剂量组明显上升、丙二醛(malondialdehyde,MDA)含量以中、高剂量下降明显,自由基清除能力增强,整体药效以中剂量效果最为显著。通过对DBWP组中剂量组进行检测,结果发现,与模型组相比,给药组肝脏中炎症相关因子在mRNA水平表达减少,抗炎抗氧化水平增强,DBWP可降低肝脏中糖原合成因子的表达,糖异生抑制明显。结论DBWP通过减轻炎症、增加抗氧化能力来改善血糖,减轻T1D及其并发肝损伤。 展开更多
关键词 百合 乌药 蒲公英 Ⅰ型糖尿病 肝损伤
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Piezoelectric Energy Analysis on Diverse Buoy Coupling with Hydrodynamic Parameters 被引量:1
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作者 liu heng-xu liu Ming +3 位作者 CHAI Yuan-chao SHU Guo-yang JING Feng-mei WANG Li-quan 《China Ocean Engineering》 SCIE EI CSCD 2019年第3期279-287,共9页
This paper mainly describes the influence factors of the captured energy power by huge wave energy harvesters, in which the vertical motion of buoy can transform ocean’s potential energy into piezoelectric energy pow... This paper mainly describes the influence factors of the captured energy power by huge wave energy harvesters, in which the vertical motion of buoy can transform ocean’s potential energy into piezoelectric energy power by undulating waves. Firstly, related environmental coefficients are analyzed by means of the incident wave theory. Besides, the geometric structural parameters are also analyzed and compared under optimal environmental coefficients with semi-analytical solutions. Thirdly, the numerical results also show the impact trend of hydrodynamic parameters and geometric volume on motion, voltage and power with qualitative agreement. The numerical simulation confirms that the improved structure parameters could markedly deliver sufficient power under the same conditions with long-time stability. 展开更多
关键词 SEMI-ANALYTICAL method INCIDENT wave theory PIEZOELECTRIC CANTILEVER beam HYDRODYNAMIC characteristics lumped and structural parameters
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Numerical and Experimental Analysis of A Vertical-Axis Eccentric-disc Variable-Pitch Turbine(VEVT) 被引量:1
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作者 CHEN Hai-long JING Feng-mei +3 位作者 liu heng-xu DING Hua-qiu KONG Fan-kai SHI Jian 《China Ocean Engineering》 SCIE EI CSCD 2020年第3期411-420,共10页
A combined experimental and numerical investigation is carried out to study the performance of a vertical-axis eccentric-disc variable-pitch turbine(VEVT).A scheme of eccentric disc pitch control mechanism based on do... A combined experimental and numerical investigation is carried out to study the performance of a vertical-axis eccentric-disc variable-pitch turbine(VEVT).A scheme of eccentric disc pitch control mechanism based on doubleblock mechanism is proposed.The eccentric control mechanism and the deflection angle control mechanism in the pitch control structure are designed and optimized according to the functional requirements of the turbine,and the three-dimensional model of the turbine is established.Kinematics analysis of the eccentric disc pitch control mechanism is carried out.Kinematics parameters and kinematics equations which can characterize its motion characteristics are derived.Kinematics analysis and simulation are carried out,and the motion law of the corresponding mechanical system is obtained.By analyzing the force and motion of blade of VEVT,the expressions of the important parameters such as deflection angle,attack angle and energy utilization coefficient are obtained.The lateral induced velocity coefficient is acquired by momentum theorem,the hydrodynamic parameters such as energy utilization coefficient are derived,and the hydrodynamic characteristics of VEVT are also obtained.The experimental results show that the turbine has good energy capture capability at different inflow velocities of different sizes and directions,which verifies that VEVT has good self-startup performance and high energy capture efficiency. 展开更多
关键词 vertical axis variable pitch turbine eccentric disc pitch control mechanism kinematics analysis hydraulic analysis flume experiment
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基于大数据背景下的政府审计监督全覆盖问题研究 被引量:3
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作者 胡炎军 柳恒旭 聂海涛 《山西财政税务专科学校学报》 2018年第5期26-29,共4页
中央审计委员会的成立是政府审计发展过程中的里程碑,对大数据背景下的审计全覆盖具有重要的影响。本文分析了大数据背景下政府审计监督全覆盖的发展现状,并剖析了中央审计委员会的成立和审计署职能的优化给政府审计监督全覆盖带来的挑... 中央审计委员会的成立是政府审计发展过程中的里程碑,对大数据背景下的审计全覆盖具有重要的影响。本文分析了大数据背景下政府审计监督全覆盖的发展现状,并剖析了中央审计委员会的成立和审计署职能的优化给政府审计监督全覆盖带来的挑战,最后从完善统筹多方协调机制、提高数据安全性管理水平、深化审计成果应用、创新复合型人才培养模式、加强与国外大数据审计经验交流等方面提出建议,以期更好地推动大数据背景下政府审计全覆盖,提升政府审计服务于国家治理现代化的能力。 展开更多
关键词 大数据 政府审计 审计全覆盖
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