Radiation therapy is one of the main treatments for head and neck tumors,and radiationinduced oral mucositis(RIOM)is a common serious adverse effect of radiation therapy.We summarized the pathogenesis,prevention and t...Radiation therapy is one of the main treatments for head and neck tumors,and radiationinduced oral mucositis(RIOM)is a common serious adverse effect of radiation therapy.We summarized the pathogenesis,prevention and treatment methods of RIOM related to traditional Chinese and Western medicine in recent years.The treatment of RIOM in traditional Chinese medicine should be based on clearing heat and detoxifying,nourishing Yin and promoting fluid,tonifying spleen and stomach,cooling blood and removing blood stasis.Osteopontin,immunoglobulin A and saliva flow tests may be effective clinical indicators in the future.Through analysis,the author believes that the use of integrated intervention of traditional Chinese and western medicine can better benefit patients,and the prevention and predictive diagnostic tools of RIOM should become the future focus of attention.展开更多
Cancer-related fatigue(CRF)is associated with cancer-related anemia(CRA).As the common comorbidities of cancer,both of them can seriously affect the quality of patient life.Yishen Qutong Granules(益肾祛痛颗粒,YSQTG)ha...Cancer-related fatigue(CRF)is associated with cancer-related anemia(CRA).As the common comorbidities of cancer,both of them can seriously affect the quality of patient life.Yishen Qutong Granules(益肾祛痛颗粒,YSQTG)have achieved good curative effects in the treatment of CRA.However,the mechanism of whether it can alleviate CRF needs further confirmation.We used network pharmacology and molecular docking to investigate the molecular mechanism and the effective compounds of the prescription.Through the analysis and research in this paper,we obtained 76 effective compounds and 76 drug-disease intersection targets to construct a network,indicating that quercetin,luteolin,baicalein,β-sitosterol and stigmasterol were possibly the most important compounds in YSQTG.The key targets of YSQTG for CRF were mainly enriched in IL-17 and TNF pathways.816 GO entries and 113 pathways were obtained by GO and KEGG enrichment,respectively,which proved that YSQTG might have a comprehensive therapeutic effect on CRF mainly through regulating IL-17,TNF,MAPK,NF-κB and chemokines,as well as cholinergic synapse and 5-HT synapse pathways.The results of molecular docking showed thatβ-sitosterol and stigmasterol could form PI-Alkyl or Alkyl hydrophobic interactions with CXCL8 and ESR1 at residues LEU25,ARG26,PHE65,ALA69 and LEU346,ALA350,LEU391,PHE404,LEU525,VAL533,respectively.In conclusion,the therapeutic effect of YSQTG on CRF is based on the comprehensive pharmacological effect of multicomponent,multitarget,and multichannel pathways.This study provides a theoretical basis for further experimental research.展开更多
Coronavirus Disease 2019(COVID-19)has caused a global outbreak and become a major public health issue.On January 20,2020,the announcement of National Health Commission(No.1 of 2020)included COVID-19 as a category B in...Coronavirus Disease 2019(COVID-19)has caused a global outbreak and become a major public health issue.On January 20,2020,the announcement of National Health Commission(No.1 of 2020)included COVID-19 as a category B infectious disease in Law of the People's Republic of China on prevention and control of Infectious Diseases,and took preventing and controlling measures like those of category A infectious diseases^([1]).Tumor patients are more susceptible to infection because of their vulnerable nutritional state and systemic immunosuppressive state caused by antitumor treatments,such as radiotherapy,chemotherapy and surgery^([2]).Cancer patients had an estimated 2-fold increased risk of COVID-19 than the general population according to the Report of the WHO-China Joint Mission on COVID-19^([3]);The incidence rate of COVID-19 in cancer patients in Wuhan is 0.79%,while the general population is 0.37%in the same period^([4]).And the COVID-19 cancer patients were with higher risk to become severe condition and worse prognosis,especially in those patients who received chemotherapy or surgery recently,than those without cancer^([5-6]).In addition,the inconvenience for patients going out to see doctors also leads to the delay of diagnosis and treatment.As a result,under the current severe situation,scientific and effective management measures and reasonable responsive strategies are urgently needed to minimize the impact of the epidemic on tumor patients^([7-9]).Especially recently,the outbreak continues to spread in many countries around the world.World Health Organization(WHO)believes the COVID-19 epidemic has the characteristics of a pandemic,calling on all countries to take urgent and active action.Under such circumstances,experts organized by Classical Traditional Chinese Medicine Prescription for Cancer Treatment and Research Committee of World Federation of Chinese Medicine Societies,discussed and formed"Expert Consensus on Integrated Traditional and Western Medicine Prevention and Rehabilitation During the Epidemics of Coronavirus Disease 2019",according to national prevention and treatment experience of COVID-19,especially in Wuhan.This consensus aims to provide a model for TCM experts around the world to guide tumor patients to respond reasonably and safely through COVID-19.Thoroughly taking advantages of integrated Chinese and Western medicine in diagnosis and treatment can minimize the adverse effects of the epidemic on patients with malignant tumors.展开更多
基金National Natural Science Foundation of China Youth Science Fund Project:Research on the Target and Molecular Mechanism of Wen Tong San Jie Traditional Chinese Medicine in Inhibiting Central Sensitization Therapy for Cancer Pain (project number:82104958)"Beijing Hope Marathon"Special Fund of China Cancer Foundation Key Project:Clinical Study on (Jianhua Guchang Decoction)to Prevent Radioactive Enteritis in Patients with Cervical Cancer (project number:LC2020A21)。
文摘Radiation therapy is one of the main treatments for head and neck tumors,and radiationinduced oral mucositis(RIOM)is a common serious adverse effect of radiation therapy.We summarized the pathogenesis,prevention and treatment methods of RIOM related to traditional Chinese and Western medicine in recent years.The treatment of RIOM in traditional Chinese medicine should be based on clearing heat and detoxifying,nourishing Yin and promoting fluid,tonifying spleen and stomach,cooling blood and removing blood stasis.Osteopontin,immunoglobulin A and saliva flow tests may be effective clinical indicators in the future.Through analysis,the author believes that the use of integrated intervention of traditional Chinese and western medicine can better benefit patients,and the prevention and predictive diagnostic tools of RIOM should become the future focus of attention.
基金the Capital Health Development Scientific Research Project(2020-2-4026)Clinical and Translational Medicine Research Fund Projects of Cancer Hospital of Chinese Academy of Medical Science(2019XK320072)
文摘Cancer-related fatigue(CRF)is associated with cancer-related anemia(CRA).As the common comorbidities of cancer,both of them can seriously affect the quality of patient life.Yishen Qutong Granules(益肾祛痛颗粒,YSQTG)have achieved good curative effects in the treatment of CRA.However,the mechanism of whether it can alleviate CRF needs further confirmation.We used network pharmacology and molecular docking to investigate the molecular mechanism and the effective compounds of the prescription.Through the analysis and research in this paper,we obtained 76 effective compounds and 76 drug-disease intersection targets to construct a network,indicating that quercetin,luteolin,baicalein,β-sitosterol and stigmasterol were possibly the most important compounds in YSQTG.The key targets of YSQTG for CRF were mainly enriched in IL-17 and TNF pathways.816 GO entries and 113 pathways were obtained by GO and KEGG enrichment,respectively,which proved that YSQTG might have a comprehensive therapeutic effect on CRF mainly through regulating IL-17,TNF,MAPK,NF-κB and chemokines,as well as cholinergic synapse and 5-HT synapse pathways.The results of molecular docking showed thatβ-sitosterol and stigmasterol could form PI-Alkyl or Alkyl hydrophobic interactions with CXCL8 and ESR1 at residues LEU25,ARG26,PHE65,ALA69 and LEU346,ALA350,LEU391,PHE404,LEU525,VAL533,respectively.In conclusion,the therapeutic effect of YSQTG on CRF is based on the comprehensive pharmacological effect of multicomponent,multitarget,and multichannel pathways.This study provides a theoretical basis for further experimental research.
基金The Disciplinary Construction Project of Peking Union Medical College Cancer Disciplinary Construction of Integration of Traditional Chinese and Western Medicine grant number 201920100302。
文摘Coronavirus Disease 2019(COVID-19)has caused a global outbreak and become a major public health issue.On January 20,2020,the announcement of National Health Commission(No.1 of 2020)included COVID-19 as a category B infectious disease in Law of the People's Republic of China on prevention and control of Infectious Diseases,and took preventing and controlling measures like those of category A infectious diseases^([1]).Tumor patients are more susceptible to infection because of their vulnerable nutritional state and systemic immunosuppressive state caused by antitumor treatments,such as radiotherapy,chemotherapy and surgery^([2]).Cancer patients had an estimated 2-fold increased risk of COVID-19 than the general population according to the Report of the WHO-China Joint Mission on COVID-19^([3]);The incidence rate of COVID-19 in cancer patients in Wuhan is 0.79%,while the general population is 0.37%in the same period^([4]).And the COVID-19 cancer patients were with higher risk to become severe condition and worse prognosis,especially in those patients who received chemotherapy or surgery recently,than those without cancer^([5-6]).In addition,the inconvenience for patients going out to see doctors also leads to the delay of diagnosis and treatment.As a result,under the current severe situation,scientific and effective management measures and reasonable responsive strategies are urgently needed to minimize the impact of the epidemic on tumor patients^([7-9]).Especially recently,the outbreak continues to spread in many countries around the world.World Health Organization(WHO)believes the COVID-19 epidemic has the characteristics of a pandemic,calling on all countries to take urgent and active action.Under such circumstances,experts organized by Classical Traditional Chinese Medicine Prescription for Cancer Treatment and Research Committee of World Federation of Chinese Medicine Societies,discussed and formed"Expert Consensus on Integrated Traditional and Western Medicine Prevention and Rehabilitation During the Epidemics of Coronavirus Disease 2019",according to national prevention and treatment experience of COVID-19,especially in Wuhan.This consensus aims to provide a model for TCM experts around the world to guide tumor patients to respond reasonably and safely through COVID-19.Thoroughly taking advantages of integrated Chinese and Western medicine in diagnosis and treatment can minimize the adverse effects of the epidemic on patients with malignant tumors.
