Based on the dynamic analysis and research of pollution risk of groundwater sources, this paper creates the dynamic assessment method of pollution risk of groundwater source area under the theory of "source-pathw...Based on the dynamic analysis and research of pollution risk of groundwater sources, this paper creates the dynamic assessment method of pollution risk of groundwater source area under the theory of "source-pathway-receptor", and applies this method to one typical fissure karst groundwater source area in northern China. Following the 30-year petroleum pollutant migration simulation and pollution risk assessment of groundwater source area, this study finds that the very high risk zone is mainly located in Q Petrochemical Company and the surrounding area and the area adjacent to River Z. Within this period of thirty years, the pollution risk of groundwater source area has showed a dynamic trend that features an inverted "V" shape. The ratio of very high risk zone to the total area will be 18.1%, 17.47% and 16.62% during the tenth year, the twentieth year and the thirtieth year separately, and will reach the highest level of 19.45% during the fifteenth year. Meanwhile, the vertical migration distance of pollutant centre concentration changed from the surface soil at the outset to the deepest point of about 250 meters underground during the tenth year. The results of this risk assessment indicate the dynamic feature of pollution risk. The dilution, degradation and migration of petroleum pollutants in groundwater system contribute to an ultimate decline in pollution risk.展开更多
目的应用响应曲面分析舒芬太尼与丙泊酚在行肠道肿瘤根治术的老年患者麻醉中的相互作用,并探究靶控输注舒芬太尼与丙泊酚的最佳配伍剂量。方法选取2020年1月至2023年1月西安交通大学医学院第一附属医院接受肠道肿瘤根治术并行静脉全身...目的应用响应曲面分析舒芬太尼与丙泊酚在行肠道肿瘤根治术的老年患者麻醉中的相互作用,并探究靶控输注舒芬太尼与丙泊酚的最佳配伍剂量。方法选取2020年1月至2023年1月西安交通大学医学院第一附属医院接受肠道肿瘤根治术并行静脉全身麻醉诱导的老年患者作为研究对象,选择舒芬太尼与丙泊酚靶控输注起始配伍浓度,观察患者麻醉后的警觉/镇静评分(OAA/S)≤1分的意识消失时间(T_(LOC)),依据手术过程中脑电双频指数(BIS)、平均动脉压(MAP)和心率(HR)调整舒芬太尼和丙泊酚的靶控输注浓度,维持BIS 40~60、MAP≥60 mm Hg(1 mm Hg=0.133 kPa)、HR>50次。记录舒芬太尼和丙泊酚输注后至OAA/S评分≥3分的意识恢复时间(T_(ROC))。应用响应曲面模型分析舒芬太尼与丙泊酚在肠道肿瘤根治术麻醉诱导中的药效学相互作用,并计算最佳配伍浓度范围。结果共纳入200例患者,每组10例,共20组。响应曲面模型显示,舒芬太尼与丙泊酚在行肠道肿瘤根治术老年患者麻醉诱导过程中的体动反应和循环反应具有显著协同作用,其最佳配伍浓度范围:靶控输注丙泊酚浓度为2.00μg/mL时,使用舒芬太尼0.40~0.70μg/kg;靶控输注丙泊酚浓度为3.00μg/mL时,使用舒芬太尼0.20~0.38μg/kg;靶控输注丙泊酚浓度为4.00μg/mL时,使用舒芬太尼0.19~0.22μg/kg;靶控输注丙泊酚浓度为4.70μg/mL时,使用舒芬太尼0.20μg/kg。结论舒芬太尼与丙泊酚镇静药效呈协同作用,通过不同的药效反应确定了舒芬太尼与丙泊酚最佳配伍剂量范围,在最佳配伍浓度范围内可以为患者提供良好的麻醉效果,并且具有较快的麻醉诱导和麻醉恢复速度。展开更多
基金Foundation project:the Specific Research on Public Service of Environmental Protection in China(201009009)
文摘Based on the dynamic analysis and research of pollution risk of groundwater sources, this paper creates the dynamic assessment method of pollution risk of groundwater source area under the theory of "source-pathway-receptor", and applies this method to one typical fissure karst groundwater source area in northern China. Following the 30-year petroleum pollutant migration simulation and pollution risk assessment of groundwater source area, this study finds that the very high risk zone is mainly located in Q Petrochemical Company and the surrounding area and the area adjacent to River Z. Within this period of thirty years, the pollution risk of groundwater source area has showed a dynamic trend that features an inverted "V" shape. The ratio of very high risk zone to the total area will be 18.1%, 17.47% and 16.62% during the tenth year, the twentieth year and the thirtieth year separately, and will reach the highest level of 19.45% during the fifteenth year. Meanwhile, the vertical migration distance of pollutant centre concentration changed from the surface soil at the outset to the deepest point of about 250 meters underground during the tenth year. The results of this risk assessment indicate the dynamic feature of pollution risk. The dilution, degradation and migration of petroleum pollutants in groundwater system contribute to an ultimate decline in pollution risk.
文摘目的应用响应曲面分析舒芬太尼与丙泊酚在行肠道肿瘤根治术的老年患者麻醉中的相互作用,并探究靶控输注舒芬太尼与丙泊酚的最佳配伍剂量。方法选取2020年1月至2023年1月西安交通大学医学院第一附属医院接受肠道肿瘤根治术并行静脉全身麻醉诱导的老年患者作为研究对象,选择舒芬太尼与丙泊酚靶控输注起始配伍浓度,观察患者麻醉后的警觉/镇静评分(OAA/S)≤1分的意识消失时间(T_(LOC)),依据手术过程中脑电双频指数(BIS)、平均动脉压(MAP)和心率(HR)调整舒芬太尼和丙泊酚的靶控输注浓度,维持BIS 40~60、MAP≥60 mm Hg(1 mm Hg=0.133 kPa)、HR>50次。记录舒芬太尼和丙泊酚输注后至OAA/S评分≥3分的意识恢复时间(T_(ROC))。应用响应曲面模型分析舒芬太尼与丙泊酚在肠道肿瘤根治术麻醉诱导中的药效学相互作用,并计算最佳配伍浓度范围。结果共纳入200例患者,每组10例,共20组。响应曲面模型显示,舒芬太尼与丙泊酚在行肠道肿瘤根治术老年患者麻醉诱导过程中的体动反应和循环反应具有显著协同作用,其最佳配伍浓度范围:靶控输注丙泊酚浓度为2.00μg/mL时,使用舒芬太尼0.40~0.70μg/kg;靶控输注丙泊酚浓度为3.00μg/mL时,使用舒芬太尼0.20~0.38μg/kg;靶控输注丙泊酚浓度为4.00μg/mL时,使用舒芬太尼0.19~0.22μg/kg;靶控输注丙泊酚浓度为4.70μg/mL时,使用舒芬太尼0.20μg/kg。结论舒芬太尼与丙泊酚镇静药效呈协同作用,通过不同的药效反应确定了舒芬太尼与丙泊酚最佳配伍剂量范围,在最佳配伍浓度范围内可以为患者提供良好的麻醉效果,并且具有较快的麻醉诱导和麻醉恢复速度。
