目的系统梳理并分析10年来股骨头坏死(osteonecrosis of the femoral head,ONFH)的中日友好医院(China-Japan Friendship Hospital,CJFH)分型相关生物力学及循证临床研究。方法计算机检索CNKI、WanFang Data、VIP、SinoMed、MEDLINE、Sc...目的系统梳理并分析10年来股骨头坏死(osteonecrosis of the femoral head,ONFH)的中日友好医院(China-Japan Friendship Hospital,CJFH)分型相关生物力学及循证临床研究。方法计算机检索CNKI、WanFang Data、VIP、SinoMed、MEDLINE、ScienceDirect、PubMed、Web of Science数据库,搜集国内外与股骨头坏死CJFH分型相关的研究,检索时限为2012年6月至2022年5月。根据纳入及排除标准筛选文献,从生物力学研究、股骨头塌陷进展预测的有效性、股骨头坏死不同保髋选择的疗效评价、股骨头坏死的保髋选择4方面,对文献进行分析。结果共纳入34篇文献。其中,生物力学研究从宏观及微观角度分别对CJFH分型进行了探索和验证,多项研究将CJFH分型作为研究对象的分类基础。随着分型的升高,患者临床成功率及股骨头生存率均明显下降,且结论适用于大多数保髋治疗方式。CJFH分型对股骨头坏死进展塌陷率及治疗预后预测具有准确性和可重复性,为分型的临床应用提供了证据支持。结论CJFH分型可以应用于ONFH塌陷预测、疗效分析并指导治疗,其可在层面选择方面与新技术结合,在保证临床适用的同时提高准确率。展开更多
In order to optimize the ultrasonic extraction technique for the total flavonoid of leaf yellows plus, the contents of 21 leaf yellows plus total flavonoid from four regions in Heilongjiang Province were comparatively...In order to optimize the ultrasonic extraction technique for the total flavonoid of leaf yellows plus, the contents of 21 leaf yellows plus total flavonoid from four regions in Heilongjiang Province were comparatively analyzed. The ultrasonic extraction technology was optimized by Box-Behnken response surface method, and the total flavonoid content of 21 kinds of Acanthopanax senticosus(Rupr. et Maxim.) Harms from different producing areas were analyzed by cluster analysis. The optimal process conditions were determined as ultrasonic time 30 min, solid-liquid ratio 1 : 12 and ultrasonic power 250 W, and the average yield of the total flavonoid was 1.453 mg·g^ (-1). By optimizing the ultrasonic-assisted extraction method, the total flavonoid content from different producing areas was compared in the experiment, which provided certain data support for the optimization of the extraction process in the future and laid a certain theoretical foundation for the quality analysis of Chinese medicinal materials.展开更多
The accurate assessment of the energy dissipation of internal tides(ITs)is of great importance because ITs contribute significantly to abyssal mixing.Thus,in this study,the IT-driven dissipation and diapycnal diffusio...The accurate assessment of the energy dissipation of internal tides(ITs)is of great importance because ITs contribute significantly to abyssal mixing.Thus,in this study,the IT-driven dissipation and diapycnal diffusion in the northern Pacific are esti-mated using parameterizations proposed by St.Laurent et al.(2002),Koch-Larrouy et al.(2007),and de Lavergne et al.(2020)(hereaf-ter referred to as LSJ02,KL07,and dL20,respectively).The performances of the three parameterizations are evaluated by comparing the calculated results with fine structure observations.In particular,the dissipation estimated by LSJ02 parameterization shows a bottom-intensified characteristic,with the patterns showing good agreement with the observations near seamounts.Moreover,43%of the results calculated using the LSJ02 parameterization have errors lower than one order of magnitude in the generation sites of ITs.Meanwhile,the strongest dissipation estimated by the KL07 parameterization shifts to the thermocline,with the results showing the highest level of consistency with observations in the generation sites.The proportion of results with errors lower than one order of magnitude is 80.7%.Furthermore,the results calculated by dL20 parameterization agree well with the observations in the upper and middle layers,with the parameterization showing an accurate estimation of the remote dissipation.The percentages of the errors lower than one order of magnitude between the dL20 parameterization and observations account for 77.1%and 88.7%in the genera-tion sites and far-field regions,respectively.展开更多
文摘目的系统梳理并分析10年来股骨头坏死(osteonecrosis of the femoral head,ONFH)的中日友好医院(China-Japan Friendship Hospital,CJFH)分型相关生物力学及循证临床研究。方法计算机检索CNKI、WanFang Data、VIP、SinoMed、MEDLINE、ScienceDirect、PubMed、Web of Science数据库,搜集国内外与股骨头坏死CJFH分型相关的研究,检索时限为2012年6月至2022年5月。根据纳入及排除标准筛选文献,从生物力学研究、股骨头塌陷进展预测的有效性、股骨头坏死不同保髋选择的疗效评价、股骨头坏死的保髋选择4方面,对文献进行分析。结果共纳入34篇文献。其中,生物力学研究从宏观及微观角度分别对CJFH分型进行了探索和验证,多项研究将CJFH分型作为研究对象的分类基础。随着分型的升高,患者临床成功率及股骨头生存率均明显下降,且结论适用于大多数保髋治疗方式。CJFH分型对股骨头坏死进展塌陷率及治疗预后预测具有准确性和可重复性,为分型的临床应用提供了证据支持。结论CJFH分型可以应用于ONFH塌陷预测、疗效分析并指导治疗,其可在层面选择方面与新技术结合,在保证临床适用的同时提高准确率。
基金Supported by the Breeding Techniques for New Varieties of Acanthopanax senticosus(CZKYF2022-1-B023)。
文摘In order to optimize the ultrasonic extraction technique for the total flavonoid of leaf yellows plus, the contents of 21 leaf yellows plus total flavonoid from four regions in Heilongjiang Province were comparatively analyzed. The ultrasonic extraction technology was optimized by Box-Behnken response surface method, and the total flavonoid content of 21 kinds of Acanthopanax senticosus(Rupr. et Maxim.) Harms from different producing areas were analyzed by cluster analysis. The optimal process conditions were determined as ultrasonic time 30 min, solid-liquid ratio 1 : 12 and ultrasonic power 250 W, and the average yield of the total flavonoid was 1.453 mg·g^ (-1). By optimizing the ultrasonic-assisted extraction method, the total flavonoid content from different producing areas was compared in the experiment, which provided certain data support for the optimization of the extraction process in the future and laid a certain theoretical foundation for the quality analysis of Chinese medicinal materials.
基金supported by the National Key Research and Development Program of China(No.2017YFA0604103)the National Natural Science Foundation of China(No.41876015)+1 种基金the Fundamental Research Funds for the Central Universities(No.202061001)the Open Innovative Fund of Marine Environment Guarantee(No.HHB 003)。
文摘The accurate assessment of the energy dissipation of internal tides(ITs)is of great importance because ITs contribute significantly to abyssal mixing.Thus,in this study,the IT-driven dissipation and diapycnal diffusion in the northern Pacific are esti-mated using parameterizations proposed by St.Laurent et al.(2002),Koch-Larrouy et al.(2007),and de Lavergne et al.(2020)(hereaf-ter referred to as LSJ02,KL07,and dL20,respectively).The performances of the three parameterizations are evaluated by comparing the calculated results with fine structure observations.In particular,the dissipation estimated by LSJ02 parameterization shows a bottom-intensified characteristic,with the patterns showing good agreement with the observations near seamounts.Moreover,43%of the results calculated using the LSJ02 parameterization have errors lower than one order of magnitude in the generation sites of ITs.Meanwhile,the strongest dissipation estimated by the KL07 parameterization shifts to the thermocline,with the results showing the highest level of consistency with observations in the generation sites.The proportion of results with errors lower than one order of magnitude is 80.7%.Furthermore,the results calculated by dL20 parameterization agree well with the observations in the upper and middle layers,with the parameterization showing an accurate estimation of the remote dissipation.The percentages of the errors lower than one order of magnitude between the dL20 parameterization and observations account for 77.1%and 88.7%in the genera-tion sites and far-field regions,respectively.
