OBJECTIVE To make full of resource,the bioactivity and active constituent analysis were firstly system⁃atically investigated on damask rose flower residue(DRFR).METHODS DPPH and ABTS experiments were applied to assess...OBJECTIVE To make full of resource,the bioactivity and active constituent analysis were firstly system⁃atically investigated on damask rose flower residue(DRFR).METHODS DPPH and ABTS experiments were applied to assess the antioxidant activity of DRFR.Then,column chromatography was used to purify compounds from DRFR-A,and the chemical structure was identified using nuclear magnetic resonance(NMR).The total phenolic acid content was measured by folin-ciocalteu colorimetric method and the content of gallic acid the indicator ingredient,was detected by high performance liquid chromatography(HPLC).RESULTS By DPPH and ABTS experiments,an antioxidation extract(DRFR-A)was found and displayed a high activity both on DPPH(IC50:2.760 mg·L^-1)and ABTS(IC50:2.258 mg·L^-1)compared to positive control VC.Ten compounds were isolated and identified from DRFR-A,and the most are phenolic acids.Among them,pyrogallic acid,2-phenylethyl-3,4,5-trihydroxybenzoate,p-hydroxybenzoic acid and p-hydroxy⁃phenethyl alcohol were obtained from the plant for the first time.The content of total phenolic acids and main ingredient,gallic acid,in DRFR-A was determined as 63.73%and 5.12%,respectively.CONCLUSION This study provides reliable science data and lays the foundation for the development and utilization of rose residue,and hence for the full utilization of rose resources.展开更多
Background The computed tomography （CT） findings of invasive pulmonary aspergillosis （IPA） are unclear in non- hematological patients. The present study was a retrospective evaluation of CT images in non-hematolog...Background The computed tomography （CT） findings of invasive pulmonary aspergillosis （IPA） are unclear in non- hematological patients. The present study was a retrospective evaluation of CT images in non-hematological patients with IPA. Methods All adult patients who met the 2008 European Organization for Research and Treatment of Cancer/Mycoses Study Group （EORTC/MSG） criteria for proven or probable IPA were included during a 5-year study at our institutions. Initial CT findings in our cohort were retrospectively reviewed by two independent thoracic radiologists blinded to patient demographics and clinical outcomes. The presence, pattern, and distribution of abnormalities were recorded. Results Twenty-three non-hematological patients with pathologically confirmed IPA were included in our study. Areas of ground-glass opacities were present in 14 patients （61%）, which were bilateral in 10 patients and unilateral in four. This pattern mainly involved the middle and upper lung zones. Air-space consolidation was identified in 12 patients （52%）, and the areas were distributed along the bronchus or subpleura in most cases. Other findings, including five small nodules （22%）, three macronodules （13%）, and one halo sign （4%）, were less common. Conclusions CT findings of IPA in non-hematological patients frequently manifested as acute bronchopneumonia, and ground-glass opacities and air-space consolidations were the most common CT findings of IPA in these patients.展开更多
Background Although the computer tomography （CT） or magnetic resonance ）mag）ng （MRI） findings of alveolar echinococcosis （AE） have been well documented, the consecutive imaging changes of this disease in each ...Background Although the computer tomography （CT） or magnetic resonance ）mag）ng （MRI） findings of alveolar echinococcosis （AE） have been well documented, the consecutive imaging changes of this disease in each PNM stage （parasite lesion, neighboring organ invasion, metastases） were not described accurately. The aim of this study was to analyze the correlation between imaging type and PNM stage and diameter of AE lesions, and to explore the development features of this disease. Methods A total of 87 patients with AE were examined using CT and MRI before medical management. Imaging features including the maximum diameter, calcification pattern, and imaging type of lesion were retrospectively assessed. The correlation of imaging type with PNM stage, diameter and calcification pattern was analyzed. Results Lesions （n=111） in 87 patients were divided into three types based on imaging characteristics; solid type （33.3%, 37/111, a solid lesion without liquid necrosis or only small patches of necrosis）, mixed type （41.4%, 46/111, solid component surrounding large and/or irregular liquid necrosis area）, and pseudo-cystic type （25.2%, 28/111, large cyst without visible solid component）. Lesion calcification in the alveolar echinococcosis was categorized into three patterns; mild calcification （45.1%, 50/111, i.e. inconspicuous calcification or punctuate scattered calcification）, moderate calcification （46.8%, 52/111, coastline calcification located at the periphery of the lesion, with or without the central dot-calcification） and abundant calcification （8.1%, 9/111, large calcified deposits）. Significant differences were found between pseudo-cystic type and other two types in PNM stage, maximum diameter and calcification （P 〈0.05）, but there was no significant difference between solid type and mixed type in those mentioned aspects （P 〉0.05）. No correlation was observed between calcification patterns and maximum diameter （P 〉0.05）. Conclusions Solid and mixed type lesions showed some similarities during the course of the disease and accounted for the major form of advanced AE. Pseudo-cystic type represented neither earlier nor advanced stage of AE, but a special presentation during AE development.展开更多
基金National Natural Science Foundation of China(331/313400531021)
文摘OBJECTIVE To make full of resource,the bioactivity and active constituent analysis were firstly system⁃atically investigated on damask rose flower residue(DRFR).METHODS DPPH and ABTS experiments were applied to assess the antioxidant activity of DRFR.Then,column chromatography was used to purify compounds from DRFR-A,and the chemical structure was identified using nuclear magnetic resonance(NMR).The total phenolic acid content was measured by folin-ciocalteu colorimetric method and the content of gallic acid the indicator ingredient,was detected by high performance liquid chromatography(HPLC).RESULTS By DPPH and ABTS experiments,an antioxidation extract(DRFR-A)was found and displayed a high activity both on DPPH(IC50:2.760 mg·L^-1)and ABTS(IC50:2.258 mg·L^-1)compared to positive control VC.Ten compounds were isolated and identified from DRFR-A,and the most are phenolic acids.Among them,pyrogallic acid,2-phenylethyl-3,4,5-trihydroxybenzoate,p-hydroxybenzoic acid and p-hydroxy⁃phenethyl alcohol were obtained from the plant for the first time.The content of total phenolic acids and main ingredient,gallic acid,in DRFR-A was determined as 63.73%and 5.12%,respectively.CONCLUSION This study provides reliable science data and lays the foundation for the development and utilization of rose residue,and hence for the full utilization of rose resources.
文摘Background The computed tomography （CT） findings of invasive pulmonary aspergillosis （IPA） are unclear in non- hematological patients. The present study was a retrospective evaluation of CT images in non-hematological patients with IPA. Methods All adult patients who met the 2008 European Organization for Research and Treatment of Cancer/Mycoses Study Group （EORTC/MSG） criteria for proven or probable IPA were included during a 5-year study at our institutions. Initial CT findings in our cohort were retrospectively reviewed by two independent thoracic radiologists blinded to patient demographics and clinical outcomes. The presence, pattern, and distribution of abnormalities were recorded. Results Twenty-three non-hematological patients with pathologically confirmed IPA were included in our study. Areas of ground-glass opacities were present in 14 patients （61%）, which were bilateral in 10 patients and unilateral in four. This pattern mainly involved the middle and upper lung zones. Air-space consolidation was identified in 12 patients （52%）, and the areas were distributed along the bronchus or subpleura in most cases. Other findings, including five small nodules （22%）, three macronodules （13%）, and one halo sign （4%）, were less common. Conclusions CT findings of IPA in non-hematological patients frequently manifested as acute bronchopneumonia, and ground-glass opacities and air-space consolidations were the most common CT findings of IPA in these patients.
基金This work was supported by a grant from the National Natural Science Foundation of China （No. 30960100）.
文摘Background Although the computer tomography （CT） or magnetic resonance ）mag）ng （MRI） findings of alveolar echinococcosis （AE） have been well documented, the consecutive imaging changes of this disease in each PNM stage （parasite lesion, neighboring organ invasion, metastases） were not described accurately. The aim of this study was to analyze the correlation between imaging type and PNM stage and diameter of AE lesions, and to explore the development features of this disease. Methods A total of 87 patients with AE were examined using CT and MRI before medical management. Imaging features including the maximum diameter, calcification pattern, and imaging type of lesion were retrospectively assessed. The correlation of imaging type with PNM stage, diameter and calcification pattern was analyzed. Results Lesions （n=111） in 87 patients were divided into three types based on imaging characteristics; solid type （33.3%, 37/111, a solid lesion without liquid necrosis or only small patches of necrosis）, mixed type （41.4%, 46/111, solid component surrounding large and/or irregular liquid necrosis area）, and pseudo-cystic type （25.2%, 28/111, large cyst without visible solid component）. Lesion calcification in the alveolar echinococcosis was categorized into three patterns; mild calcification （45.1%, 50/111, i.e. inconspicuous calcification or punctuate scattered calcification）, moderate calcification （46.8%, 52/111, coastline calcification located at the periphery of the lesion, with or without the central dot-calcification） and abundant calcification （8.1%, 9/111, large calcified deposits）. Significant differences were found between pseudo-cystic type and other two types in PNM stage, maximum diameter and calcification （P 〈0.05）, but there was no significant difference between solid type and mixed type in those mentioned aspects （P 〉0.05）. No correlation was observed between calcification patterns and maximum diameter （P 〉0.05）. Conclusions Solid and mixed type lesions showed some similarities during the course of the disease and accounted for the major form of advanced AE. Pseudo-cystic type represented neither earlier nor advanced stage of AE, but a special presentation during AE development.
