^(223)Ra对去势抵抗性前列腺癌骨转移疗效的核医学评估研究进展

2020年氯化镭(^(223)Ra)注射液(多菲戈;)获中国国家食品药品监督管理总局(China Food and Drug Administration,CFDA)批准用于治疗伴症状性骨转移,且无已知内脏转移的去势抵抗性前列腺癌(Castration?resistant Prostate Cancer and bone metastases,mCRPC)患者,它是目前世界上第一个应用于mCRPC患者的α粒子靶向放射活性治疗药物。近年来,国外应用核医学技术评估^(223)Ra治疗mCRPC患者的疗效已经十分普遍,国内仅少数医院刚进入临床应用阶段。为使该药在国内得到规范使用,现将国内外^(223)Ra治疗mCRPC患者的临床核医学评估技术进行分析评述。

Chinese SPECT semi-quantitative analysis of striatum

To study and analyze reconstruction parameters in 99mTc-Trodat-l SPECT（Tomography EmissionComputed Single-Photon） brain semi-quantitative analysis,and the outlined methods of ROIs（regions of interests）. The 99mTc-trodat-l SPECT brain imaging was processed,and the ROIs were outlined four times from December 2009 to July 2011.The results for each method were analyzed and compared to improve our experience.There was no statistically significance between the outlined number of pixel in both sides of the cerebellum and the ratio of the radioactive counts.From LEHR and FAN beam collimator,the average ratio became better with increasing the outlining method,especially the fourth time.It could be estimated that striatum mean volume（±SD） was（39.51±9.54 ml,in the range of 19.97-51.98 mL） and mean weight（±SD） was（44.09±10.64 g in the range of 22.28-58.01 g）.The details of image processing and data analysis should not be ignored to outline appropriate methods,and withstand the repetitive inspection.The total striatum was outlined and its volume and weight was analyzed.

Comparable investigation in dopamine transporters with ^(99m)Tc-TRODAT-1 and ^(131)I-FP-CIT SPECT in Parkinson's disease patients

Dopamine transporter (DAT) mediates the regulation of dopaminergic function. Two agents of TRODAT-1 and FP-CIT were observed in evaluating DAT change of Parkinson's disease (PD). The relationship between them was also evaluated. The results suggested that 99mTc-TRODAT-1 SPECT and 131I-FP-CIT SPECT may serve as sensitive and objective in vivo markers to reflect the severity of PD. The 99mTc-TRODAT-1 image is more accurate and clearer compared with 131I-FP-CIT.

Feasibility of ^(99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas

In this paper,^(99m)Tc-TRODAT-1 Micro-SPECT (single-photon emission computed tomography) was used for imaging dopamine transporter (DAT) in retinas and to investigate the changes of DAT in retinas of guinea pigs with form deprivation myopia.Pigmented guinea pigs aged 3 weeks were derided into form deprivation myopia (FDM) group (n=6) and normal control group (n=6).The test group wore translucent goggles randomly for 4 weeks, and both groups underwent biometric measurement (refraction and axial length) before and after the experiment. Micro-SPECT retinas imaging was performed at the 4^(th) week after injection of ^(99m)Tc-TRODAT-1.The retinas were clearly resolved in the images.The ratio of ^(99m)Tc-TRODAT-1 uptake in the myopic retinas (11.55±2.80) was 3.64±1.40 lower than that in the control eye (15.20±1.98),and 2.35±1.05 lower than that in the fellow eyes (13.90±2.04).The results showed that ^(99m)Tc-TRODAT-1 Micro-SPECT eye imaging can be used to trace the distribution and changes of DAT in retina,and DAT in the myopic retinas were lower than that in the normal control eyes and fellow eyes.Micro-SPECT may provide a new approach for further studies on the role of dopamine system in the experimental myopia.

DXA骨密度测量的规范化诊断报告书写专家共识

规范化的双能X线吸收法(DXA)骨密度测量诊断报告在骨骼健康诊疗工作中具有重要的临床参考价值。在参考国际临床骨密度学会(ISCD)官方立场的基础上,结合中国的国情,中国健康促进基金会骨密度测量与骨质疏松症诊断专家委员会形成了DXA骨密度测量的诊断报告书写的共识,以期使DXA诊断报告能准确地反映DXA的重要临床价值,并更好地发挥其在临床诊疗中的作用。