Objective:To investigate the impact factors of the COVID-19 epidemic on the mental health of patients with depression.Methods:The relevant data of 242 residents aged 18-50 years in a certain area were collected,118 pa...Objective:To investigate the impact factors of the COVID-19 epidemic on the mental health of patients with depression.Methods:The relevant data of 242 residents aged 18-50 years in a certain area were collected,118 patients and 124 healthy people were analyzed by general information questionnaire,the PsychoSocial Index(PSI)questionnaire,Social Support Rating Scale(SSRS)and Symptom Checklist 90(SCL-90).Compare the differences in social and psychological factors between the two groups.Then use logistic regression to evaluate the social and psychological influencing factors of depression patients during the epidemic.Results:Two results of logistic regression analysis showed that marital status,occupational status,abnormal pathological behavior,and utilization of support were still significantly associated with depression.Compared to working,unemployed/unemployed/retired,students are closely related to depression,followed by abnormal pathological behavior and utilization of support.Conclusion:Under the epidemic,depression groups lacking social relationships should actively pay attention to their mental health status and comprehensively enhance their social and psychological support.To avoid the exacerbation of psychological and psychological symptoms caused by the epidemic.展开更多
目的:利用分子对接和中药网络药理学技术预测银翘解毒合剂防治新型冠状病毒肺炎(COVID-19)的可行性。方法:借助TCMSP、Pubchem等数据库检索银翘解毒合剂中金银花、连翘、桔梗、荆芥、薄荷、牛蒡子、淡豆豉、淡竹叶和甘草的化学成分。以...目的:利用分子对接和中药网络药理学技术预测银翘解毒合剂防治新型冠状病毒肺炎(COVID-19)的可行性。方法:借助TCMSP、Pubchem等数据库检索银翘解毒合剂中金银花、连翘、桔梗、荆芥、薄荷、牛蒡子、淡豆豉、淡竹叶和甘草的化学成分。以银翘解毒合剂中成分为配体,利用分子对接技术探讨可能作用于人血管紧张素转化酶Ⅱ(ACE2)的活性成分,进而运用Cytoscape软件构建活性成分-靶点(基因)网络,通过DAVID数据库对活性成分靶点进行基因本体(GO)和京都基因与基因组百科全书(KEGG,Kyoto Encyclopedia of Genes and Genomes)通路富集分析。结果:获得银翘解毒合剂中化合物1060个,分子对接结果显示有301个化合物与ACE2具有较好的亲和作用(其中18个化合物优于参照药物洛匹那韦和瑞德西韦),进一步通过吸收、分布、代谢、排泄(ADME)参数从中优选出关键活性成分55个。关键成分靶点生物功能富集分析得到GO条目2080个(P<0.05),其中生物过程(BP)条目1862个,细胞组成(CC)条目88个,分子功能(MF)条目130个;KEGG通路富集分析得到152条信号通路(P<0.05),主要涉及与COVID-19感染源类似(病毒感染)的疾病,以及与肺炎和免疫、炎症反应相关的信号通路。结论:银翘解毒合剂中具有潜在作用于ACE2蛋白的活性物质,其有可能通过多靶点、多通路发挥防治COVID-19的作用。展开更多
目的:利用中药网络药理学和分子对接技术探讨维血宁合剂防治新型冠状病毒肺炎(COVID⁃19)的潜在活性成分及其作用机制。方法:借助TCMSP数据库检索维血宁合剂中所含的主要化学成分及其作用靶点,并与冠状病毒感染相关的靶点进行叠加分析,...目的:利用中药网络药理学和分子对接技术探讨维血宁合剂防治新型冠状病毒肺炎(COVID⁃19)的潜在活性成分及其作用机制。方法:借助TCMSP数据库检索维血宁合剂中所含的主要化学成分及其作用靶点,并与冠状病毒感染相关的靶点进行叠加分析,筛选维血宁合剂潜防治COVID⁃19的靶点;通过Cytoscape软件构建药材⁃活性成分⁃靶点网络;通过DAVID数据库对活性成分靶点进行基因本体(GO)和KEGG(Kyoto Encyclopedia of Genes and Genomes)通路富集分析;最后运用分子对接技术虚拟筛选维血宁合剂中活性成分与2019⁃nCoV S蛋白、人ACE2蛋白及2019⁃nCoV 3CL水解酶(3CLpro)的作用,预测维血宁合剂潜在的抗2019⁃nCoV成分。结果:从维血宁合剂中共梳理得到326个成分及555个相关靶点,其中101个成分对应的35个靶点与COVID⁃19密切相关;靶点通路富集分析表明,维血宁合剂主要作用于感染性疾病、炎症反应及免疫调节等过程。分子对接结果显示16个成分与S蛋白、ACE2及3CLpro均显示了较好的结合作用,成分类型主要为甾体、脂肪酸和酚类。结论:维血宁合剂可能主要通过调节机体免疫和炎症反应等,从而对COVID⁃19发挥潜在的防治作用。展开更多
基金Capital’s Funds for Health Improvement and Research (No.CFH2022-2-2133)。
文摘Objective:To investigate the impact factors of the COVID-19 epidemic on the mental health of patients with depression.Methods:The relevant data of 242 residents aged 18-50 years in a certain area were collected,118 patients and 124 healthy people were analyzed by general information questionnaire,the PsychoSocial Index(PSI)questionnaire,Social Support Rating Scale(SSRS)and Symptom Checklist 90(SCL-90).Compare the differences in social and psychological factors between the two groups.Then use logistic regression to evaluate the social and psychological influencing factors of depression patients during the epidemic.Results:Two results of logistic regression analysis showed that marital status,occupational status,abnormal pathological behavior,and utilization of support were still significantly associated with depression.Compared to working,unemployed/unemployed/retired,students are closely related to depression,followed by abnormal pathological behavior and utilization of support.Conclusion:Under the epidemic,depression groups lacking social relationships should actively pay attention to their mental health status and comprehensively enhance their social and psychological support.To avoid the exacerbation of psychological and psychological symptoms caused by the epidemic.
文摘目的:利用分子对接和中药网络药理学技术预测银翘解毒合剂防治新型冠状病毒肺炎(COVID-19)的可行性。方法:借助TCMSP、Pubchem等数据库检索银翘解毒合剂中金银花、连翘、桔梗、荆芥、薄荷、牛蒡子、淡豆豉、淡竹叶和甘草的化学成分。以银翘解毒合剂中成分为配体,利用分子对接技术探讨可能作用于人血管紧张素转化酶Ⅱ(ACE2)的活性成分,进而运用Cytoscape软件构建活性成分-靶点(基因)网络,通过DAVID数据库对活性成分靶点进行基因本体(GO)和京都基因与基因组百科全书(KEGG,Kyoto Encyclopedia of Genes and Genomes)通路富集分析。结果:获得银翘解毒合剂中化合物1060个,分子对接结果显示有301个化合物与ACE2具有较好的亲和作用(其中18个化合物优于参照药物洛匹那韦和瑞德西韦),进一步通过吸收、分布、代谢、排泄(ADME)参数从中优选出关键活性成分55个。关键成分靶点生物功能富集分析得到GO条目2080个(P<0.05),其中生物过程(BP)条目1862个,细胞组成(CC)条目88个,分子功能(MF)条目130个;KEGG通路富集分析得到152条信号通路(P<0.05),主要涉及与COVID-19感染源类似(病毒感染)的疾病,以及与肺炎和免疫、炎症反应相关的信号通路。结论:银翘解毒合剂中具有潜在作用于ACE2蛋白的活性物质,其有可能通过多靶点、多通路发挥防治COVID-19的作用。
文摘目的:利用中药网络药理学和分子对接技术探讨维血宁合剂防治新型冠状病毒肺炎(COVID⁃19)的潜在活性成分及其作用机制。方法:借助TCMSP数据库检索维血宁合剂中所含的主要化学成分及其作用靶点,并与冠状病毒感染相关的靶点进行叠加分析,筛选维血宁合剂潜防治COVID⁃19的靶点;通过Cytoscape软件构建药材⁃活性成分⁃靶点网络;通过DAVID数据库对活性成分靶点进行基因本体(GO)和KEGG(Kyoto Encyclopedia of Genes and Genomes)通路富集分析;最后运用分子对接技术虚拟筛选维血宁合剂中活性成分与2019⁃nCoV S蛋白、人ACE2蛋白及2019⁃nCoV 3CL水解酶(3CLpro)的作用,预测维血宁合剂潜在的抗2019⁃nCoV成分。结果:从维血宁合剂中共梳理得到326个成分及555个相关靶点,其中101个成分对应的35个靶点与COVID⁃19密切相关;靶点通路富集分析表明,维血宁合剂主要作用于感染性疾病、炎症反应及免疫调节等过程。分子对接结果显示16个成分与S蛋白、ACE2及3CLpro均显示了较好的结合作用,成分类型主要为甾体、脂肪酸和酚类。结论:维血宁合剂可能主要通过调节机体免疫和炎症反应等,从而对COVID⁃19发挥潜在的防治作用。
