Chitosan-graft-poly（L-glutamic acid）（CS-g-PGA） copolymer was successfully synthesized by grafting polymerization of γ-benzyl-L-glutamate N-carboxyanhydride onto the modified chitosan chains. The self-assembly beh...Chitosan-graft-poly（L-glutamic acid）（CS-g-PGA） copolymer was successfully synthesized by grafting polymerization of γ-benzyl-L-glutamate N-carboxyanhydride onto the modified chitosan chains. The self-assembly behavior of such a CS-g-PGA amphiphilic copolymer was studied. The results show that spherical nanoparticles have been formed. The size of CS-g-PGA nanoparticles is found to be controlled by the grafting ratio of PGA. These bio-based polysaccharide/polypeptide hybrid nanoparticles with controllable size may have great potential application in biomedical fields, such as drug delivery systems.展开更多
基金Supported by the National Natural Science Foundation of China(Nos.21034003, 20974025, 10979022)
文摘Chitosan-graft-poly（L-glutamic acid）（CS-g-PGA） copolymer was successfully synthesized by grafting polymerization of γ-benzyl-L-glutamate N-carboxyanhydride onto the modified chitosan chains. The self-assembly behavior of such a CS-g-PGA amphiphilic copolymer was studied. The results show that spherical nanoparticles have been formed. The size of CS-g-PGA nanoparticles is found to be controlled by the grafting ratio of PGA. These bio-based polysaccharide/polypeptide hybrid nanoparticles with controllable size may have great potential application in biomedical fields, such as drug delivery systems.
