Highly selective,sensitive,and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases.Electrochemical aptamer-based(E-AB)sensor is an appealing platform for...Highly selective,sensitive,and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases.Electrochemical aptamer-based(E-AB)sensor is an appealing platform for measurement in biological system,attributing to the combined advantages of high selectivity of the aptamer and high sensitivity of electrochemical analysis.This review summarizes the latest development of E-AB sensors,focuses on the modification strategies used in the fabrication of sensors and the sensing strategies for analytes of different sizes in biological system,and then looks forward to the challenges and prospects of the future development of electrochemical aptamerbased sensors.展开更多
基金supported by the National Natural Science Foundation of China(No.22104006)the Beijing Nova Program of Science and Technology,China(No.Z191100001119108)the Fund of Beijing National Laboratory for Molecular Sciences,China(No.BNLMS202009).
文摘Highly selective,sensitive,and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases.Electrochemical aptamer-based(E-AB)sensor is an appealing platform for measurement in biological system,attributing to the combined advantages of high selectivity of the aptamer and high sensitivity of electrochemical analysis.This review summarizes the latest development of E-AB sensors,focuses on the modification strategies used in the fabrication of sensors and the sensing strategies for analytes of different sizes in biological system,and then looks forward to the challenges and prospects of the future development of electrochemical aptamerbased sensors.