目的探讨血清脑钠肽(BNP)、D-二聚体(D-D)水平及24 h室性期前收缩(PVC)负荷对心力衰竭患者心源性不良事件发生的预测价值。方法将该院2017年7月至2020年12月收治的82例心力衰竭患者作为观察组,同期50例入院排除心力衰竭的患者作为对照...目的探讨血清脑钠肽(BNP)、D-二聚体(D-D)水平及24 h室性期前收缩(PVC)负荷对心力衰竭患者心源性不良事件发生的预测价值。方法将该院2017年7月至2020年12月收治的82例心力衰竭患者作为观察组,同期50例入院排除心力衰竭的患者作为对照组。检测患者血清BNP和D-D水平,行24 h心电图检查,记录24 h PVC负荷。比较观察组与对照组、发生心源性不良事件与未发生心源性不良事件心力衰竭患者的BNP、D-D水平及24 h PVC负荷,分析血清BNP、D-D水平及24 h PVC负荷与心源性不良事件发生的关系及其预测心源性不良事件发生的价值。结果观察组血清BNP、D-D水平及24 h PVC负荷均明显高于对照组(P<0.05);发生心源性不良事件心力衰竭患者血清BNP、D-D水平及24 h PVC负荷均明显高于未发生心源性不良事件者(P<0.05);心力衰竭患者血清BNP、D-D水平及24 h PVC负荷与心源性不良事件发生均呈正相关(r=0.743、0.611、0.658,P<0.05);BNP、D-D及24 h PVC负荷联合检测预测心源性不良事件发生的灵敏度、特异度及曲线下面积均明显高于各项指标单独检测(P<0.05)。结论联合分析BNP、D-D水平及24 h PVC负荷变化可有效预测心力衰竭患者心源性不良事件的发生,具有较高的临床应用价值。展开更多
Lanthanide metal-organic frameworks(MOFs)have received special attention due to their unusual coordination characteristics and exceptional luminescence properties,while their development has extremely limited by the c...Lanthanide metal-organic frameworks(MOFs)have received special attention due to their unusual coordination characteristics and exceptional luminescence properties,while their development has extremely limited by the cost effective and powder form.Herein,a gentle and facile strategy was developed to create a granular lanthanide MOFs@activated carbon(AC)composite.The obtained granular Tb-BTC@AC composite displays high fluorescent selectivity and sensitivity towards Cr^(3+) cations in water with quenching efficiency up to 90.12%,and shows great sensitivity in the range of 10^(-5)—10^(-4) mol/L with the Stern-Volmer constant of 2.224×10^(3) L/mol.Benefited by the high surface area,the abundant self-assembly space was provided for the self-assembling of the Lanthanide MOFs,which leads to promising Cr^(3+) cation-recognition ability with low MOF quantity.Also,the large size(with an average diameter of 2 mm);shaped form of this new composite material reduced the threshold of MOF application.展开更多
文摘目的探讨血清脑钠肽(BNP)、D-二聚体(D-D)水平及24 h室性期前收缩(PVC)负荷对心力衰竭患者心源性不良事件发生的预测价值。方法将该院2017年7月至2020年12月收治的82例心力衰竭患者作为观察组,同期50例入院排除心力衰竭的患者作为对照组。检测患者血清BNP和D-D水平,行24 h心电图检查,记录24 h PVC负荷。比较观察组与对照组、发生心源性不良事件与未发生心源性不良事件心力衰竭患者的BNP、D-D水平及24 h PVC负荷,分析血清BNP、D-D水平及24 h PVC负荷与心源性不良事件发生的关系及其预测心源性不良事件发生的价值。结果观察组血清BNP、D-D水平及24 h PVC负荷均明显高于对照组(P<0.05);发生心源性不良事件心力衰竭患者血清BNP、D-D水平及24 h PVC负荷均明显高于未发生心源性不良事件者(P<0.05);心力衰竭患者血清BNP、D-D水平及24 h PVC负荷与心源性不良事件发生均呈正相关(r=0.743、0.611、0.658,P<0.05);BNP、D-D及24 h PVC负荷联合检测预测心源性不良事件发生的灵敏度、特异度及曲线下面积均明显高于各项指标单独检测(P<0.05)。结论联合分析BNP、D-D水平及24 h PVC负荷变化可有效预测心力衰竭患者心源性不良事件的发生,具有较高的临床应用价值。
基金supported by the National Natural Science Foundation of China(Nos.22071076,22090061)the Project of the Department of Science and Technology of Guangdong Province,China(No.2021A1515010204).
文摘Lanthanide metal-organic frameworks(MOFs)have received special attention due to their unusual coordination characteristics and exceptional luminescence properties,while their development has extremely limited by the cost effective and powder form.Herein,a gentle and facile strategy was developed to create a granular lanthanide MOFs@activated carbon(AC)composite.The obtained granular Tb-BTC@AC composite displays high fluorescent selectivity and sensitivity towards Cr^(3+) cations in water with quenching efficiency up to 90.12%,and shows great sensitivity in the range of 10^(-5)—10^(-4) mol/L with the Stern-Volmer constant of 2.224×10^(3) L/mol.Benefited by the high surface area,the abundant self-assembly space was provided for the self-assembling of the Lanthanide MOFs,which leads to promising Cr^(3+) cation-recognition ability with low MOF quantity.Also,the large size(with an average diameter of 2 mm);shaped form of this new composite material reduced the threshold of MOF application.
