GaN nanowires are grown by hydride vapor phase epitaxy using nickel as a catalyst.The properties of the obtained GaN nanowires are characterized by scanning and transmission electron microscopy,electron diffraction,ro...GaN nanowires are grown by hydride vapor phase epitaxy using nickel as a catalyst.The properties of the obtained GaN nanowires are characterized by scanning and transmission electron microscopy,electron diffraction,roomtemperature photoluminescence and energy dispersive spectroscopy.The results show that the nanowires are wurtzite single crystals growing along the[0001]direction and a redshift in the photoluminescence is observed due to a superposition of several effects.The Raman spectra are close to those of the bulk GaN and the significantly broadening of those modes indicates the phonon confinement effects associated with the nanoscale dimensions of the system.展开更多
目的:探讨阿托伐他汀对大鼠蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的缓解效果及对线粒体融合蛋白2(Mitofusin-2)、脑源性神经营养因子(BDNF)表达的影响,为SAH后CVS的防治提供实验依据和新方法。方法:选取雄性SD大鼠30只,随机数字表法随...目的:探讨阿托伐他汀对大鼠蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的缓解效果及对线粒体融合蛋白2(Mitofusin-2)、脑源性神经营养因子(BDNF)表达的影响,为SAH后CVS的防治提供实验依据和新方法。方法:选取雄性SD大鼠30只,随机数字表法随机分为假手术组、模型组和治疗组,每组10只。模型组和治疗组使用枕大池二次注血法制作蛛网膜下腔出血模型,假手术组同样操作方式注入生理盐水。治疗组予阿托伐他汀20 mg/kg溶于2 mL蒸馏水灌胃。假手术组与模型组给与蒸馏水2 mL灌胃。观察干预5 d后各组大鼠的体重、死亡率、神经功能缺失情况、基底动脉血管内径、管壁厚度以及平滑肌细胞凋亡情况,观察各组Mitofusin-2、BDNF表达水平。结果: 3组大鼠的体重由低到高分别为假手术组、治疗组、模型组,差异具有统计学意义( P <0.05),假手术组和治疗组各有1只大鼠死亡,模型组有2只大鼠死亡,3组死亡率无显著差异( P >0.05)。3组神经功能评分由低到高分别为模型组、治疗组和假手术组,差异具有统计学意义( P <0.05)。3组血管内径由小到大分别为模型组、治疗组、假手术组,差异具有统计学意义( P <0.05),而血管壁的厚度由小到大分别为假手术组、治疗组、模型组,差异具有统计学意义( P <0.05)。3组血管内皮细胞凋亡率由低到高分别为模型组、治疗组和假手术组,差异具有统计学意义( P <0.05)。Mitofusin-2的表达水平由低到高分别为假手术组、模型组和治疗组,差异具有统计学意义( P <0.05),BDNF的表达水平由低到高分别为假手术组、治疗组和模型组,差异具有统计学意义( P <0.05)。结论:阿托伐他汀能够减轻SAH后CVS的发生,减轻脑组织的损伤,且其机制可能通过上调Mitofusin-2的表达相关。展开更多
基金Supported by the National Basic Research Program of China(2011CB301900)the National Nature Science Foundation of China(60990311,60820106003,60906025,60936004)+1 种基金the Nature Science Foundation of Jiangsu Province(BK2008019,BK2010385,BK2009255,BK2010178)the Research Funds from NJU-Yangzhou Institute of Opto-electronics.
文摘GaN nanowires are grown by hydride vapor phase epitaxy using nickel as a catalyst.The properties of the obtained GaN nanowires are characterized by scanning and transmission electron microscopy,electron diffraction,roomtemperature photoluminescence and energy dispersive spectroscopy.The results show that the nanowires are wurtzite single crystals growing along the[0001]direction and a redshift in the photoluminescence is observed due to a superposition of several effects.The Raman spectra are close to those of the bulk GaN and the significantly broadening of those modes indicates the phonon confinement effects associated with the nanoscale dimensions of the system.
文摘目的:探讨阿托伐他汀对大鼠蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的缓解效果及对线粒体融合蛋白2(Mitofusin-2)、脑源性神经营养因子(BDNF)表达的影响,为SAH后CVS的防治提供实验依据和新方法。方法:选取雄性SD大鼠30只,随机数字表法随机分为假手术组、模型组和治疗组,每组10只。模型组和治疗组使用枕大池二次注血法制作蛛网膜下腔出血模型,假手术组同样操作方式注入生理盐水。治疗组予阿托伐他汀20 mg/kg溶于2 mL蒸馏水灌胃。假手术组与模型组给与蒸馏水2 mL灌胃。观察干预5 d后各组大鼠的体重、死亡率、神经功能缺失情况、基底动脉血管内径、管壁厚度以及平滑肌细胞凋亡情况,观察各组Mitofusin-2、BDNF表达水平。结果: 3组大鼠的体重由低到高分别为假手术组、治疗组、模型组,差异具有统计学意义( P <0.05),假手术组和治疗组各有1只大鼠死亡,模型组有2只大鼠死亡,3组死亡率无显著差异( P >0.05)。3组神经功能评分由低到高分别为模型组、治疗组和假手术组,差异具有统计学意义( P <0.05)。3组血管内径由小到大分别为模型组、治疗组、假手术组,差异具有统计学意义( P <0.05),而血管壁的厚度由小到大分别为假手术组、治疗组、模型组,差异具有统计学意义( P <0.05)。3组血管内皮细胞凋亡率由低到高分别为模型组、治疗组和假手术组,差异具有统计学意义( P <0.05)。Mitofusin-2的表达水平由低到高分别为假手术组、模型组和治疗组,差异具有统计学意义( P <0.05),BDNF的表达水平由低到高分别为假手术组、治疗组和模型组,差异具有统计学意义( P <0.05)。结论:阿托伐他汀能够减轻SAH后CVS的发生,减轻脑组织的损伤,且其机制可能通过上调Mitofusin-2的表达相关。
