Pregnancy toxemia is a metabolic disorder of lipid and glucose. Recent investigations have found that angiopoietin-like protein 3 （ANGPTL3） can contribute to disorder of carbohydrate and lipid metabolism. The presen...Pregnancy toxemia is a metabolic disorder of lipid and glucose. Recent investigations have found that angiopoietin-like protein 3 （ANGPTL3） can contribute to disorder of carbohydrate and lipid metabolism. The present study was conducted to investigate the change of ANGPTL3 expression during pregnancy toxemia, We firstly cloned the full-length cDNA of ANGPTL3 in Liuyang Black goats, revealing that goat ANGPTL3 had the typical structure of the angiopoietin-like family, and its mRNA was exclusively expressed in liver. Pregnancy toxemia of pregnant goat does with twins during late gestation was induced by being fasted for 72 h, and then they were recovered after 5 d ofrefeeding. Hepatic ANGPTL3 gene expression was significantly down-regulated concomitantly with decreased serum glucose concentration, elevated serum β-hydroxybutyrate and free fatty acid levels in pregnant toxemic goats, and these changes were reversed after refeeding. These results suggest ANGPTL3 may play a certain role in the development of pregnancy toxemia in goats.展开更多
Spiral plate heat exchanger is a traditional compact heat exchanger,and widely used in the occasion of the high heat transfer capacity requirements,such as waste heat recovery. In the situation of energy shortage and ...Spiral plate heat exchanger is a traditional compact heat exchanger,and widely used in the occasion of the high heat transfer capacity requirements,such as waste heat recovery. In the situation of energy shortage and rapid development of heat transfer technology^([1-3]),cylindrical,elliptical and rhombic spiral pile-honeycomb heat transfer models are established^([4-5]). The internal flow and heat transfer are simulated by using CFD software FLUENT15. 0 and RNG k-ε turbulent model,and then the three models are analyzed. The results show that the secondary flow and vortex are induced again in the secondary honeycomb,which further increases the turbulence intensity of the fluid. The thickness of the boundary layer is reduced twice,and the heat transfer effect is better than that of the honeycomb spiral structure. The spiral pile-honeycomb model for the rhombus is better than the models of cylinder and ellipse in heat transfer performance.展开更多
基金the National Natural Science Foundation of China (31072167)the Key Project of Hunan Provincial Science & Technology Department, China(2009FJ1005)Innovation Project of Hunan Provincial Education Department (CX2009B153), China
文摘Pregnancy toxemia is a metabolic disorder of lipid and glucose. Recent investigations have found that angiopoietin-like protein 3 （ANGPTL3） can contribute to disorder of carbohydrate and lipid metabolism. The present study was conducted to investigate the change of ANGPTL3 expression during pregnancy toxemia, We firstly cloned the full-length cDNA of ANGPTL3 in Liuyang Black goats, revealing that goat ANGPTL3 had the typical structure of the angiopoietin-like family, and its mRNA was exclusively expressed in liver. Pregnancy toxemia of pregnant goat does with twins during late gestation was induced by being fasted for 72 h, and then they were recovered after 5 d ofrefeeding. Hepatic ANGPTL3 gene expression was significantly down-regulated concomitantly with decreased serum glucose concentration, elevated serum β-hydroxybutyrate and free fatty acid levels in pregnant toxemic goats, and these changes were reversed after refeeding. These results suggest ANGPTL3 may play a certain role in the development of pregnancy toxemia in goats.
文摘Spiral plate heat exchanger is a traditional compact heat exchanger,and widely used in the occasion of the high heat transfer capacity requirements,such as waste heat recovery. In the situation of energy shortage and rapid development of heat transfer technology^([1-3]),cylindrical,elliptical and rhombic spiral pile-honeycomb heat transfer models are established^([4-5]). The internal flow and heat transfer are simulated by using CFD software FLUENT15. 0 and RNG k-ε turbulent model,and then the three models are analyzed. The results show that the secondary flow and vortex are induced again in the secondary honeycomb,which further increases the turbulence intensity of the fluid. The thickness of the boundary layer is reduced twice,and the heat transfer effect is better than that of the honeycomb spiral structure. The spiral pile-honeycomb model for the rhombus is better than the models of cylinder and ellipse in heat transfer performance.
