非溶剂体系温度对细化RDX影响的分子动力学模拟及实验研究

利用自行研制能定量控制的喷射重结晶装置,以二甲基亚砜为溶剂、水为非溶剂细化得到RDX,同时结合分子动力学方法探讨了喷射重结晶RDX过程中最佳非溶剂体系温度,以及不同温度对制备RDX晶体的影响;采用扫描电子显微镜(SEM)、X射线粉末衍射仪(P-XRD)、差式扫描量热法(DSC)对其进行性能表征和热分析;并测试了其撞击感度。结果表明,分子动力学模拟制备RDX的最佳非溶剂体系温度与实验结果一致,即最佳温度为30℃,在此条件下可获得中值粒径为836nm、粒径分布均匀、形貌趋于球形且表面光滑的RDX;与原料RDX相比,细化后的RDX表观活化能升高了46.85kJ/mol,具有较好的热安定性,指前因子(lg(A/min))提高了4.87,热爆炸临界温度增加1.14℃,撞击感度(H_(50))最大提高至40.07cm。

Analysis of Radial Peripapillary Capillary Density in Patients with Bietti Crystalline Dystrophy by Optical Coherence Tomography Angiography

Objective We wanted to investigate the radial peripapillary capillary(RPC)network in patients with Bietti crystalline dystrophy(BCD).Methods We compared RPC densities in the disk and different peripapillary regions,obtained using optical coherence tomography angiography in 22 patients with BCD(37 eyes)and 22 healthy subjects(37 eyes).The BCD group was then divided into Stage 2 and Stage 3 subgroups based on Yuzawa staging,comparing the RPC densities of the two.Results The disk area RPC density was 38.8%±6.3%in the BCD group and 49.2%±6.1%in the control group(P<0.001),and peripapillary region RPC density was significantly lower in the BCD group than in the control group(49.1%±4.7%and 54.1%±3.0%,respectively,P<0.001).There were no significant RPC density differences between the tempo quadrant and inside disk of Stages 2 and 3 subgroups;the other areas showed a significantly lower RPC density in Stage 3 than in Stage 2 BCD.Conclusion The BCD group RPC density was significantly lower than the control group.The reduction of RPC density in the tempo quadrant occurred mainly in the Stage 1 BCD.In contrast,the reduction of RPC density in superior,inferior,and nasal quadrants occurred mainly in Stage 2.

Studies on the Side Chain Liquid Crystalline Copolymer Containing Nonlinear Optical Groups

A new side chain liquid crystalline poly[4 (methacryloxy)hexanoloxy 4′ benzyloxy biphenyl] was synthesized. The phase behavior of the monomer and homopolymer was studied. The monomer shows a smectic B phase, while the homopolymer shows a nematic phase. The nonmesogenic nonlinear optical group was introduced to synthesize a series of side chain liquid crystalline copolymers which also show a nematic phase. Owing to the liquid crystallinity of the copolymer has been the orientational stability improved, down the relax of the orientation slowed and the nonlinear optical properties enhanced.

新疆维吾尔族心房颤动患者载脂蛋白E基因rs429358位点多态性及华法林剂量的差异性研究

目的研究新疆地区维吾尔族心房颤动(简称房颤)患者载脂蛋白E(ApoE)基因rs429358位点基因多态性及有效华法林剂量的差异。方法选取2014年7月至2016年7月在新疆医科大学第一附属医院就诊的维吾尔族房颤患者100例;同期体检中心体检的维吾尔族非房颤人群100例作为对照组,采用标准酚-氯仿法提取新疆地区维吾尔族人群200例受试者外周静脉血DNA,采用聚合酶链反应/限制性片段长度多态性(PCR-RFLP)技术检测ApoE基因rs429358位点的基因多态性,计算基因型及等位基因频率,比较ApoE基因rs429358位点不同基因型的房颤患者口服华法林剂量。结果 ApoE基因rs429358位点的基因型E2/E2、E2/E3、E2/E4、E3/E3、E3/E4和E4/E4的基因型频率比例分别为0.5%、8%、1.5%、73.5%、14%、2.5%;等位基因型E2、E3、E4比例为8.5%、75%、16.5%。维吾尔族房颤患者E2/E3、E3/E4与E3/E3三种基因型相比,有效华法林剂量具有统计学差异(P<0.05)。E2/E3基因型有效华法林剂量高于E3/E3,而E3/E4基因型低于E3/E3基因型,但无统计学差异。结论新疆地区维吾尔族房颤患者中,ApoE基因rs429358基因位点多态性可能是房颤患者华法林剂量的影响因素之一。