目的系统评价坤宝丸治疗更年期综合征的有效性和安全性。方法采用计算机检索PubMed,EMbase,The Cochrane Library,Web of Science及中国知网(CNKI)、万方(WanFang)、维普(VIP)数据库自建库起至2022年12月的相关文献。由2位评价员独立筛...目的系统评价坤宝丸治疗更年期综合征的有效性和安全性。方法采用计算机检索PubMed,EMbase,The Cochrane Library,Web of Science及中国知网(CNKI)、万方(WanFang)、维普(VIP)数据库自建库起至2022年12月的相关文献。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险,采用RevMan 5.3软件对纳入研究进行Meta分析。结果共纳入13项研究,涉及1590例更年期综合征患者,其中观察组803例,对照组787例。按对照组的用药种类进行亚组分析,坤宝丸单用组的临床疗效显著高于氟桂利嗪+谷维素+维生素B1组[RR=1.75,95%CI(1.38,2.22),P<0.00001],坤宝丸联用组临床疗效显著高于戊酸雌二醇+甲羟孕酮组[RR=1.18,95%CI(1.03,1.34),P=0.01]和刺五加组[RR=1.20,95%CI(1.08,1.33),P=0.0007];坤宝丸单用组对更年期临床症状调查表(Kupperman)评分显著低于替勃龙组[MD=-6.00,95%CI(-7.72,-4.28),P<0.00001];坤宝丸联用组卵泡刺激素(FSH)显著低于刺五加组[MD=-25.70,95%CI(-33.22,-18.18),P<0.00001];坤宝丸联用组促黄体素(LH)显著低于刺五加组[MD=-11.20,95%CI(-12.05,-10.35),P<0.00001];坤宝丸单用组雌二醇(E2)显著高于替勃龙组[MD=-7.00,95%CI(-11.44,-2.56),P=0.002]。药品不良反应主要为腹胀、便秘、头晕、阴道出血、体质量增加等,患者均能耐受。结论坤宝丸对更年期综合征患者的临床疗效、Kupperman评分、激素指标等的改善效果与激素类药物相当,甚至更优。但由于纳入研究的质量不高,尚需更严格、高质量的临床研究进一步证实。展开更多
It is shown in this paper that there is a difficulty in conventional black hole thermodynamics.To overcome the difficulty we introduce a“surface”near the event horizon as an additional thermodynamical object.The mas...It is shown in this paper that there is a difficulty in conventional black hole thermodynamics.To overcome the difficulty we introduce a“surface”near the event horizon as an additional thermodynamical object.The mass and entropy of the additional“surface”are the same as the correction of mass of Schwarzschild black hole obtained in the back-reaction program up to a constant factor.This implies that some effects of back reaction an automatically considered in our thermodynamic phenomenological treatment.展开更多
The authors show that the bubbles S^(2) × S^(2) can be created from vacuum fluctuation in the background de Sitter universes of k=0,1,so the space-time foam-like structure might really be constructed from bubbles...The authors show that the bubbles S^(2) × S^(2) can be created from vacuum fluctuation in the background de Sitter universes of k=0,1,so the space-time foam-like structure might really be constructed from bubbles of S2 x S2 in the very early inflating phase of our universe.Still,whether such foam-like structure persisted during the later evolution of the universe is a problem unsolved at present.展开更多
A new set of exact solutions in vacuum Brans-Dicke theory is obtained,which is a two-way traversable wormhole for the coupling parameterω(ω<-2).This new set of exact solutions satisfies not only the general const...A new set of exact solutions in vacuum Brans-Dicke theory is obtained,which is a two-way traversable wormhole for the coupling parameterω(ω<-2).This new set of exact solutions satisfies not only the general constraints on the shape function b(R)and the redshift functionφ(R)given by Morris and Thorne[Am.J.Phys.56(1988)395],but also the constraints on them from a trip through wormhole.It also follows that the scalar field φ plays a role of exotic mat ter violating the weak energy condition.展开更多
As is known,the two-dimensional(2D)gravitational theory is a very good toy model for studying the four-dimensional gravitational theory.Now in this paper,it is shown that the vacuum fluctuation in 2D gravity can creat...As is known,the two-dimensional(2D)gravitational theory is a very good toy model for studying the four-dimensional gravitational theory.Now in this paper,it is shown that the vacuum fluctuation in 2D gravity can create a foam-like structure of space-time,which is constructed from wormhole.展开更多
We generalize Visser’s method to construct traversable Lorentzian wormholes from surgically modified Friedman-Robertson-Walker spacetimes in both Brans-Dicke’s theory and induced theory of Gravity.Our result shows,i...We generalize Visser’s method to construct traversable Lorentzian wormholes from surgically modified Friedman-Robertson-Walker spacetimes in both Brans-Dicke’s theory and induced theory of Gravity.Our result shows,in both cases,the exotic matter is unavoidable to occur at the throats of the wormholes.展开更多
This article discusses the gravitational stability of anti-de Sitter universe.It turns out that anti-de Sitter universe with closed timelike curves is unstable to gravitational perturbations.
In this paper we constructed the formula of the third quantization of a solvable model in quantum cosmology based on the Brans-Dicke theory and got an abnormal distribution.
The Wheeler-DeWitt equation for the Brans-Dicke's theory of gravitation is constructed in the minisuperspace approximation and solved for a simple model in which the matter field is absent and the cosmological“co...The Wheeler-DeWitt equation for the Brans-Dicke's theory of gravitation is constructed in the minisuperspace approximation and solved for a simple model in which the matter field is absent and the cosmological“constant”,Λ(),in the Brans-Dicke's theory is equal to zero.展开更多
A quantum gravity version is given to the Brans-Dicke theory.We find that the matter field quantum fluctuation induces the conformal quantum fluctuation of space-time,and that the latter backreacts to the classical sp...A quantum gravity version is given to the Brans-Dicke theory.We find that the matter field quantum fluctuation induces the conformal quantum fluctuation of space-time,and that the latter backreacts to the classical space-time and transforms it from Einstein space-time into the Brans-Dicke one.展开更多
By considering the non-uniform phase transition,a theoretical lower bound of the probability of finding the rt Hooft-Polyakov monopole in the so-called Inflationary universe is given.
文摘It is shown in this paper that there is a difficulty in conventional black hole thermodynamics.To overcome the difficulty we introduce a“surface”near the event horizon as an additional thermodynamical object.The mass and entropy of the additional“surface”are the same as the correction of mass of Schwarzschild black hole obtained in the back-reaction program up to a constant factor.This implies that some effects of back reaction an automatically considered in our thermodynamic phenomenological treatment.
基金Supported by the National Natural Science Foundation of China under Grant No.19473005the Education Commit tee of Hu’nan Province.
文摘The authors show that the bubbles S^(2) × S^(2) can be created from vacuum fluctuation in the background de Sitter universes of k=0,1,so the space-time foam-like structure might really be constructed from bubbles of S2 x S2 in the very early inflating phase of our universe.Still,whether such foam-like structure persisted during the later evolution of the universe is a problem unsolved at present.
基金Supported by the National Natural Science Foundation of China under Grant No.19473003.
文摘A new set of exact solutions in vacuum Brans-Dicke theory is obtained,which is a two-way traversable wormhole for the coupling parameterω(ω<-2).This new set of exact solutions satisfies not only the general constraints on the shape function b(R)and the redshift functionφ(R)given by Morris and Thorne[Am.J.Phys.56(1988)395],but also the constraints on them from a trip through wormhole.It also follows that the scalar field φ plays a role of exotic mat ter violating the weak energy condition.
基金Supported by the National Natural Science Foundation of China under Grant No.19473005。
文摘As is known,the two-dimensional(2D)gravitational theory is a very good toy model for studying the four-dimensional gravitational theory.Now in this paper,it is shown that the vacuum fluctuation in 2D gravity can create a foam-like structure of space-time,which is constructed from wormhole.
基金Supported by the National Natural Science Foundation of China.
文摘We generalize Visser’s method to construct traversable Lorentzian wormholes from surgically modified Friedman-Robertson-Walker spacetimes in both Brans-Dicke’s theory and induced theory of Gravity.Our result shows,in both cases,the exotic matter is unavoidable to occur at the throats of the wormholes.
文摘This article discusses the gravitational stability of anti-de Sitter universe.It turns out that anti-de Sitter universe with closed timelike curves is unstable to gravitational perturbations.
文摘In this paper we constructed the formula of the third quantization of a solvable model in quantum cosmology based on the Brans-Dicke theory and got an abnormal distribution.
文摘The Wheeler-DeWitt equation for the Brans-Dicke's theory of gravitation is constructed in the minisuperspace approximation and solved for a simple model in which the matter field is absent and the cosmological“constant”,Λ(),in the Brans-Dicke's theory is equal to zero.
文摘A quantum gravity version is given to the Brans-Dicke theory.We find that the matter field quantum fluctuation induces the conformal quantum fluctuation of space-time,and that the latter backreacts to the classical space-time and transforms it from Einstein space-time into the Brans-Dicke one.
文摘By considering the non-uniform phase transition,a theoretical lower bound of the probability of finding the rt Hooft-Polyakov monopole in the so-called Inflationary universe is given.
