目的系统整合婴儿父亲围产期心理体验和需求的质性研究,为制订相关心理干预措施提供依据。方法检索中国生物医学文献数据库、中国知网、万方、PubMed,Web of Science,Embase,Cochrane Library等数据库中有关婴儿父亲围产期心理体验和需...目的系统整合婴儿父亲围产期心理体验和需求的质性研究,为制订相关心理干预措施提供依据。方法检索中国生物医学文献数据库、中国知网、万方、PubMed,Web of Science,Embase,Cochrane Library等数据库中有关婴儿父亲围产期心理体验和需求的质性研究,检索时限为2012年4月至2022年4月。使用JBI质性研究质量评价工具进行评价,采用汇集性整合方法进行结果整合分析。结果共纳入13篇文献,提炼出36个研究结果,归纳成9个类别,综合形成4个整合结果:围产期婴儿父亲面临多重情感体验、对生活的挑战及影响、心理健康相关的需求和支持、采取不同类型的应对策略。结论婴儿父亲在围产期经历了复杂的心理体验,存在多元化需求,医护人员应结合我国文化背景,更多地关注围产期婴儿父亲相关的心理体验及需求,制定有效的干预策略。展开更多
A new method was presented to discuss the respective roles of short- and long-range interactions in protein folding. It's based on an off-lattice model, which is also being called as toy model. Simulated annealing...A new method was presented to discuss the respective roles of short- and long-range interactions in protein folding. It's based on an off-lattice model, which is also being called as toy model. Simulated annealing algorithm was used to search its native conformation. When it is applied to analysis proteins 1agt and 1aho, we find that helical segment cannot fold into native conformation without the influence of long-range interactions. That's to say that long-range interactions are the main determinants in protein folding. Key words toy model - protein folding - simulated annealing algorithm - short and long range interactions CLC number O 242.28 - Q71 Foundation item: Supported by the National Natural Science Foundation of China((60301009)Biography: WANG Long-hui (1976-), female, Ph. D candidate, research direction: machine learning, bioinformatics.展开更多
文摘目的系统整合婴儿父亲围产期心理体验和需求的质性研究,为制订相关心理干预措施提供依据。方法检索中国生物医学文献数据库、中国知网、万方、PubMed,Web of Science,Embase,Cochrane Library等数据库中有关婴儿父亲围产期心理体验和需求的质性研究,检索时限为2012年4月至2022年4月。使用JBI质性研究质量评价工具进行评价,采用汇集性整合方法进行结果整合分析。结果共纳入13篇文献,提炼出36个研究结果,归纳成9个类别,综合形成4个整合结果:围产期婴儿父亲面临多重情感体验、对生活的挑战及影响、心理健康相关的需求和支持、采取不同类型的应对策略。结论婴儿父亲在围产期经历了复杂的心理体验,存在多元化需求,医护人员应结合我国文化背景,更多地关注围产期婴儿父亲相关的心理体验及需求,制定有效的干预策略。
文摘A new method was presented to discuss the respective roles of short- and long-range interactions in protein folding. It's based on an off-lattice model, which is also being called as toy model. Simulated annealing algorithm was used to search its native conformation. When it is applied to analysis proteins 1agt and 1aho, we find that helical segment cannot fold into native conformation without the influence of long-range interactions. That's to say that long-range interactions are the main determinants in protein folding. Key words toy model - protein folding - simulated annealing algorithm - short and long range interactions CLC number O 242.28 - Q71 Foundation item: Supported by the National Natural Science Foundation of China((60301009)Biography: WANG Long-hui (1976-), female, Ph. D candidate, research direction: machine learning, bioinformatics.
文摘目的:探讨肠道菌群移植(fecal microbiota transplantation,FMT)对便秘合并帕金森病(parkinson disease,PD)患者肠道便秘症状及左旋多巴疗效的影响,为临床治疗提供参考。方法:纳入2020年10月—2021年12月招募诊断的51例PD患者为研究对象,随机分为FMT组(n=25)与对照组(n=26),两组均予左旋多巴常规治疗,FMT组在此基础上加用粪菌胶囊调整肠道菌群,对照组给予空白胶囊,采用便秘患者生活质量量表(patient-assessment of constipation quality of life,PAC-QOL)等评估患者便秘症状及满意度,采用统一PD评定量表(UPDRS-Ⅲ)等评估两组患者治疗前后的运动症状及心理状态。结果:①与治疗前及对照组比较,FMT组的PAC-QOL、Bristol粪便性状量表评分改善显著,差异有统计学意义(P<0.05);②与治疗前比较,两组患者的UPDRS-Ⅲ评分均有改善,FMT组差异有统计学意义(P<0.05);③与对照组比较,治疗后FMT组的匹兹堡睡眠质量指数评分下降,差异有统计学意义(P<0.05)。结论:FMT干预能有效改善PD患者的便秘症状及睡眠质量,可能有增强左旋多巴对运动症状的疗效,但远期影响仍有待研究。