On the Identification of N-rich Metal-poor Field Stars with Future Chinese Space Station Telescope

During the long term evolution of globular clusters(GCs), some member stars are lost to the field. The recently found nitrogen-rich(N-rich) metal-poor field stars are promising candidates of these GC escapees, since N enhancement is the fingerprint of chemically enhanced populations in GCs. In this work, we discuss the possibility of identifying N-rich metal-poor field stars with the upcoming Chinese Space Station Telescope(CSST). We focus on the main survey camera with NUV, u, g, r, i, z, y filters and slitless spectrograph with a resolution about 200.The combination of UV sensitive equipment and prominent N-related molecular lines in the UV band bodes well for the identification: the color–color diagram of(u-g) versus(g-r) is capable of separating N-rich field stars from normal halo stars, if metallicity can be estimated without using the information on u-band photometry.Besides, the synthetic spectra show that a signal-to-noise ratio of 10 is sufficient to identify N-rich field stars. In the near future, a large sample of N-rich field stars found by CSST, combined with state-of-the-art N-body simulations will be crucial to deciphering GC-Galaxy co-evolution.

IQGAP3 promotes the progression of glioma as an immune and prognostic marker

Background:IQGAP3 plays a crucial role in regulating cell proliferation,division,and cytoskeletal organization.Abnormal expression of IQGAP3 has been linked to various tumors,but its function in glioma is not well understood.Methods:Various methods,including genetic differential analysis,single-cell analysis,ROC curve analysis,Cox regression,Kaplan-Meier analysis,and enrichment analysis,were employed to analyze the expression patterns,diagnostic potential,prognostic implications,and biological processes involving IQGAP3 in normal and tumor tissues.The impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using immunofluorescence.Additionally,the cBioPortal database was used to analyze copy number variations and mutation sites of IQGAP3.Experimental validation was also performed to assess the effects of IQGAP3 on glioma cells and explore underlying mechanisms.Results:High IQGAP3 expression in gliomas is associated with an unfavorable prognosis,particularly in wild-type IDH and 1p/19q non-codeleted gliomas.Enrichment analysis revealed that IQGAP3 is involved in regulating the cell cycle,PI3K/AKT signaling,p53 signaling,and PLK1-related pathways.Furthermore,IQGAP3 expression may be closely related to the immunosuppressive microenvironment of glioblastoma.BRD-K88742110 and LY-303511 are potential drugs for targeting IQGAP3 in anti-glioma therapy.In vitro experiments showed that downregulation of IQGAP3 inhibits the proliferation and migration of glioma cells,with the PLK1/PI3K/AKT pathway potentially playing a crucial role in IQGAP3-mediated glioma progression.Conclusion:IQGAP3 shows promise as a valuable biomarker for diagnosis,prognosis,and immunotherapeutic strategies in gliomas.

Research on the Strategy of Integrating Red Culture into Patriotic Education Activities of Young People

Young people are the flowers of the motherland, is the future of the motherland, youth teachers have great responsibilities. Integrate red culture into daily teaching activities, inherit and carry forward, enhance children’s values, cultivate children’s excellent qualities such as patriotism and selfless dedication, improve children’s comprehensive quality, and let children grow up healthily. Taking red culture as the starting point, this paper discusses the strategy of integrating red cultural resources into patriotic education activities of teenagers, points out the existing problems in the current integration of red culture into patriotic education activities of teenagers and finds out the reasons;clarify the relevant concepts of red culture and patriotic education activities for young people;from the three aspects of integrating curriculum resources to enhance the significance of red culture education, creating a red environment to create a red education atmosphere, and digging deep into red cultural resources, this paper discusses the strategy of integrating red culture into patriotic education activities for young people, aiming to promote the organic combination of patriotic education activities and red culture for young people, and increase national and cultural self-confidence.

超声空化作用下高温合金废料中战略金属的浸出机理

为提高高温合金废料中战略金属的回收效率,提出一种超声辅助浸出工艺。在超声辅助浸出过程中,浸出时间为60 min时,高温合金废料中Re、Ni、Co、Al、Cr和W的浸出率分别为92.3%、95.2%、98.5%、98.7%、97.5%和27.2%,明显优于常规浸出工艺中浸出时间为120 min时的浸出效率。高温合金废料中战略金属浸出效率的提高可归因于超声空化作用下产生的物理和化学协同作用。超声空化的物理作用可以阻止高温合金废料表面溶解层的形成,促进浸出液与高温合金废料接触,从而提高高温合金废料中战略金属的浸出率;而超声空化的化学作用可以促进HCl-H_(2)O_(2)体系中羟基自由基的产生,从而增强浸出体系的电位,促进体系中Re向ReO_(4)^(-)的氧化反应过程。

Synergistic Effect and Electrochromic Mechanism of Nanoflake Li-doped NiO in LiOH Electrolyte

Inorganic metal oxide electrochromic materials have good application prospects for energy-saving windows in buildings and smart display applications.Therefore,the development of electrochromic films with good cycling stabilities,fast color-change response times,and high coloring efficiencies has attracted considerable attention.In this study,nanoflake Li-doped NiO electrochromic films were prepared using a hydrothermal method,and the films exhibited superior electrochromic performances in the LiOH electrolyte.Li^(+)ions doping increased the ion transmission rates of the NiO films,and effectively promoted the transportation of ions from the electrolyte into NiO films.Meanwhile,the nanoflake microstructure caused the NiO films to have larger specific surface areas,providing more active sites for electrochemical reactions.It was determined that the NiO-Li20%film exhibited an ultra-fast response in the LiOH electrolyte(coloring and bleaching times reached 3 and 1.5 s,respectively).Additionally,the coloration efficiency was 62.1 cm^(2)C^(−1),and good cycling stability was maintained beyond 1500 cycles.Finally,the simulation calculation results showed that Li doping weakened the adsorption strengths of the NiO films to OH^(−),which reduced the generation and decomposition of NiOOH and helped to improve the cycling stabilities of the films.Therefore,the research presented in this article provides a strategy for designing electrochromic materials in the future.

王诚喜基于“扶阳”理论治疗胃食管反流性咳嗽

胃食管反流性咳嗽在中医多以“胃咳”命名,为咳嗽病的常见类型,中医采用辨证论治,临床疗效显著且不易复发。王诚喜教授在翻阅古籍及对胃食管反流性咳嗽的临证中发现,此病常见于贪食寒凉之物伤及脾胃或素体脾胃阳虚患者,中焦枢纽运行失常,浊气随经络上冲于肺而引发咳嗽,多从寒论治,基于“扶阳”理论采用吴萸干姜汤治疗,效如桴鼓。

Spatial Distribution of Different Types of Villages for Rural Revitalization Strategy and Their Influencing Factors:A Case of Jilin Province,China

Village classification is the first step to implementing China’s rural revitalization(RR)strategy,and understanding the geographic differences in the distribution of village types helps to grasp the pathway of their unique development.This study spatialized9250 villages in Jilin Province(divided into six types)of China,and their distribution characteristics and influencing factors were examined using methods such as kernel density estimation,Ripley’s K function,the co-location quotient,and Geodetector.The results indicate that the spatial distribution balance and density of village types are different.All types of villages show an agglomeration distribution pattern,but the scale and intensity vary.There is a strong spatial association between agglomerative promotion(AP)and stable improvement(SIm)villages,as well as between characteristic protection(CP)and prospering frontier and enriching people(PE)villages.The factors affecting their distribution include terrain undulation,the percentage of arable land,the distance to the county town,road network density,population density,gross domestic product(GDP),and industrial enterprise density.The influencing factors for the distribution of village types are closely related to the function of each village.Based on the differences in the spatial distribution and influencing factors of different village types,policy suggestions are given for classified development.

Prediction of Cuttings-Induced Annular-Pressure Loss in Extended-Reach Wells

Drill cuttings are broken bits of solid material removed from a borehole drilled by rotary,percussion,or auger methods and brought to the surface in the drilling mud.When these cuttings enter the annulus,they have an effect on the drillingfluid rheology and density,which is,in general,quite difficult to evaluate.By introducing an empirical correlation for the rheological properties of cuttings-laden drillingfluids,this study proposes a pres-sure-loss prediction method for an extended-reach well(ERW).After verifying the accuracy of this method,a case study is considered and a sensitivity analysis is conducted assuming a yield-power lawfluid.The results show that an increased concentration of cuttings in the annulus contributes to an increased annular pressure loss.Com-pared to their effect on the drillingfluid density,cuttings have a greater impact on the drillingfluid rheology.A larger rate of penetration contributes to an increased annular pressure loss.For higher drillingfluidflow rates,the annular pressure lossfirst decreases and then it increases.In addition,the annular pressure loss becomes high-er as the cuttings’particle size decreases and the cuttings’concentration grows.

An internally damped inertial platform for marine gravimetry and a test case in the South China Sea

To dampen periodic off-levelling motions within an inertial platform while undergoing horizontal accelerations of the same period and to achieve a levelling accuracy of a few tens of arcseconds with that system,an internally damped inertial platform for a marine scalar gravity system was the developed.Methods for attenuating horizontal acceleration and reducing off-levelling error by a satisfactory gyro-levelling loop,which are fundamental to the internally damped inertial platform,were designed and implemented.In addition,phase delays are introduced by the levelling loop.The resulting off-levelling gravity errors were analyzed and modeled.A series of tests on a motion simulator were performed in laboratory for a variety of simulated sea conditions.We found that the motion of the platform is a function of the amplitude and period of the simulated ship motions and ranges between 10 and 40 arcseconds.In addition,the phase lag between platform motion and ship motion is not constant but ranges 180°-270°,depending on the period and amplitude of the motion.Then,the platform,on which a gravimeter was mounted,was installed on the R/V Shiyan 2 to conduct a gravity survey in the South China Sea.Despite rough sea conditions,it was shown that in short periods of 2-30 s,the off-levelling angle was less than 30 arcseconds,and the phase lagged the horizontal acceleration by 230°-260°.From a repeated survey line and intersecting survey points,the estimated errors of gravity measurements were between 1.3 and 1.7 mGal.The marine measurements results were compared with those of satellite altimetry data and show a mean value of 0.5 mGal in a standard deviation of 1.5 mGal.

A marine gravimeter based on electromagnetic damping and its tests in the South China Sea

A new gravity sensor based on electromagnetic damping for the JMGrav marine gravimeter is presented.The new gravity sensor considered the advanced construction methods of the electromagnetic damping system of the gravimeter.The design features of the new system are discussed and the research survey data in the South China Sea are shown.Numerical simulations are applied to model the magnetic and mechanical characteristics of the system using finite element analysis and to evaluate the force distribution and the resulting damping effects.The performance characteristics of the system were tested on a motion simulator in laboratory,and the gravimeter was subjected to vertical accelerations of up to 100 Gal in 1-1000 s.It was found that the amplitude reduction of vertical accelerations in 3-15 s is 30-45 dB,with a time lag of 2-5 s,while the effect on gravity in period greater than 600 s is less than 0.5 dB,with a time lag of less than 100 s.The accelerations cause discrepancies of approximately only 1 mGal between the static value and the mean dynamic value.The sea tests were conducted in September 2020.Gravity measurements were taken with a JMGrav marine gravimeter onboard the R/V Dongfanghong 3,and the effective survey line exceeded 2000 km.Completely irregular accelerations with peaks up to 100 Gal yielded a reduction of approximately 40 dB in amplitude.The survey data were evaluated using ocean gravity field models and grid line tests.The results show that the accuracy of the gravity measurements is better than 2 mGal.

A survey of real-time rendering on Web3D application

Background In recent years, with the rapid development of mobile Internet and Web3D technologies, a large number of web-based online 3D visualization applications have emerged. Web3D applications, including Web3D online tourism, Web3D online architecture, Web3D online education environment, Web3D online medical care, and Web3D online shopping are examples of these applications that leverage 3D rendering on the web. These applications have pushed the boundaries of traditional web applications that use text, sound, image, video, and 2D animation as their main communication media, and resorted to 3D virtual scenes as the main interaction object, enabling a user experience that delivers a strong sense of immersion. This paper approached the emerging Web3D applications that generate stronger impacts on people's lives through “real-time rendering technology”, which is the core technology of Web3D. This paper discusses all the major 3D graphics APIs of Web3D and the well-known Web3D engines at home and abroad and classify the real-time rendering frameworks of Web3D applications into different categories. Results Finally, this study analyzed the specific demand posed by different fields to Web3D applications by referring to the representative Web3D applications in each particular field. Conclusions Our survey results show that Web3D applications based on real-time rendering have in-depth sectors of society and even family, which is a trend that has influence on every line of industry.

Evolutionary games and spatial periodicity

Spatial interactions are considered an important factor influencing a variety of evolutionary processes that take place in structured populations.It still remains an open problem to fully understand evolutionary game dynamics on networks except for certain limiting scenarios such as weak selection.Here we study the evolutionary dynamics of spatial games under strong selection where strategy evolution of individuals becomes deterministic in a fashion of winners taking all.We show that the long term behavior of the evolutionary process eventually converges to a particular basin of attraction,which is either a periodic cycle or a single fixed state depending on specific initial conditions and model parameters.In particular,we find that symmetric starting configurations can induce an exceedingly long transient phase encompassing a large number of aesthetic spatial patterns including the prominent kaleidoscopic cooperation.Our finding holds for any population structure and a broad class of finite games beyond the Prisoner’s Dilemma.Our work offers insights into understanding evolutionary dynamics of spatially extended systems ubiquitous in biology and ecology.

个体化诊疗模式在胃肠道恶性肿瘤中预防中度致吐性化疗方案的临床观察

目的:分析真实世界中化疗引起的恶心和呕吐(chemotherapy-induced nausea and vomiting,CINV)的个体化诊疗模式对胃肠道恶性肿瘤患者的CINV控制效果及对生存质量的影响。方法:选取2018年10月至2020年10月就诊于河北医科大学第四医院接受中度致吐风险化疗方案的289例胃肠道恶性肿瘤患者,按照CINV评估治疗方法分为CINV个体化诊疗组(A组)和医师选择诊疗组(B组),分析比较两组CINV控制效果及对生存质量的影响。结果:289例患者中A组146例,B组143例。A组全程恶心(74.66%vs.34.27%,P<0.001)、呕吐(87.67%vs.55.94%,P<0.001)完全控制率均明显优于B组,A组急性期及延迟期恶心、呕吐完全控制率优于B组。同时,A组患者在生存质量的功能领域(躯体功能、角色功能、社会功能),症状领域(恶心呕吐、疲倦、失眠、厌食),以及总体健康状况方面均表现出显著的优势。结论:个体化CINV诊疗模式可显著改善真实世界中胃肠道恶性肿瘤患者的CINV控制率和生存质量。

胃癌骨转移患者临床病理特征及预后影响因素分析

目的对胃癌骨转移患者临床病理特征及预后进行回顾性分析。方法收集2005~2015年收治的胃癌骨转移患者139例,分析患者临床病理特征和治疗对患者生存时间的影响。结果胃癌患者常见的骨转移部位依次为脊柱、骨盆及肋骨。胃癌骨转移患者中位生存时间15.1个月,确诊骨转移后患者中位生存时间为5.7个月。TNM分期、同时或异时性骨转移、是否化疗及是否双膦酸盐治疗是影响胃癌骨转移患者总生存期的独立预后因素(P<0.05)。而骨转移后是否接受化疗是影响患者骨转移后生存期的独立预后因素(P<0.05)。结论骨转移多发生于胃癌病程晚期,患者一旦发生骨转移则提示预后差,化疗可延长患者骨转移后的生存时间。临床医生应注意筛查并采取积极的治疗措施延长患者生存期。

硫化铋微球的制备及其可见光下高效光催化性能（英文）

通过一步尿素辅助水热法合成新颖的硫化铋微球,对作合成的硫化铋微球采用X射线衍射(XRD)、扫描电镜(SEM)、红外光谱(FT-IR)和差示扫描量热法和热重分析法(DTA-TG)进行表征。随后,在可见光照射条件下,通过光降解甲基橙模拟溶液对硫化铋微球的光催化活性进行评估。实验结果表明,在180 min内,硫化铋微球光降解效率可达91.07%,且其可作为一种潜在高效的催化剂用于溶液中甲基橙的去除。同时,依据催化剂价带位置提出了可能性的光降解机理途径。因此,本实验设计了一种可见光响应的光催化剂,并可作为一种有效的光催化剂用于太阳能转换和环境污染物处理领域。

Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model

Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocardial infarction(MI). Increasing evidence indicates that neuregulin-1(NRG-1) improves cardiac function following heart failure. Since its impact on cardiac function and neural remodeling post-MI is poorly understood, we aimed to investigate the role of NRG-1 in autonomic nervous system remodeling post-MI. Forty-five Sprague-Dawley rats were equally randomized into three groups: sham(with the left anterior descending coronary artery exposed but without ligation), MI(left anterior descending coronary artery ligation), and MI plus NRG-1(left anterior descending coronary artery ligation followed by intraperitoneal injection of NRG-1(10 μg/kg, once daily for 7 days)). At 4 weeks after MI, echocardiography was used to detect the rat cardiac function by measuring the left ventricular end-systolic inner diameter, left ventricular diastolic diameter, left ventricular end-systolic volume, left ventricular end-diastolic volume, left ventricular ejection fraction, and left ventricular fractional shortening. m RNA and protein expression levels of tyrosine hydroxylase, growth associated protein-43(neuronal specific protein), nerve growth factor, choline acetyltransferase(vagus nerve marker), and vesicular acetylcholine transporter(cardiac vagal nerve fiber marker) in ischemic myocardia were detected by real-time PCR and western blot assay to assess autonomous nervous remodeling. After MI, the rat cardiac function deteriorated significantly, and it was significantly improved after NRG-1 injection. Compared with the MI group, m RNA and protein levels of tyrosine hydroxylase and growth associated protein-43, as well as choline acetyltransferase m RNA level significantly decreased in the MI plus NRG-1 group, while m RNA and protein levels of nerve growth factor and vesicular acetylcholine transporters, as well as choline acetyltransferase protein level slightly decreased. Our results indicate that NRG-1 can improve cardiac function and regulate sympathetic and vagus nerve remodeling post-MI, thus reaching a new balance of the autonomic nervous system to protect the heart from injury.

A novel noise reduction technique for underwater acoustic signals based on complete ensemble empirical mode decomposition with adaptive noise,minimum mean square variance criterion and least mean square adaptive filter

Underwater acoustic signal processing is one of the research hotspots in underwater acoustics.Noise reduction of underwater acoustic signals is the key to underwater acoustic signal processing.Owing to the complexity of marine environment and the particularity of underwater acoustic channel,noise reduction of underwater acoustic signals has always been a difficult challenge in the field of underwater acoustic signal processing.In order to solve the dilemma,we proposed a novel noise reduction technique for underwater acoustic signals based on complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN),minimum mean square variance criterion(MMSVC) and least mean square adaptive filter(LMSAF).This noise reduction technique,named CEEMDAN-MMSVC-LMSAF,has three main advantages:(i) as an improved algorithm of empirical mode decomposition(EMD) and ensemble EMD(EEMD),CEEMDAN can better suppress mode mixing,and can avoid selecting the number of decomposition in variational mode decomposition(VMD);(ii) MMSVC can identify noisy intrinsic mode function(IMF),and can avoid selecting thresholds of different permutation entropies;(iii) for noise reduction of noisy IMFs,LMSAF overcomes the selection of deco mposition number and basis function for wavelet noise reduction.Firstly,CEEMDAN decomposes the original signal into IMFs,which can be divided into noisy IMFs and real IMFs.Then,MMSVC and LMSAF are used to detect identify noisy IMFs and remove noise components from noisy IMFs.Finally,both denoised noisy IMFs and real IMFs are reconstructed and the final denoised signal is obtained.Compared with other noise reduction techniques,the validity of CEEMDAN-MMSVC-LMSAF can be proved by the analysis of simulation signals and real underwater acoustic signals,which has the better noise reduction effect and has practical application value.CEEMDAN-MMSVC-LMSAF also provides a reliable basis for the detection,feature extraction,classification and recognition of underwater acoustic signals.

Nano-cerium-element-doped titanium dioxide induces apoptosis of Bel 7402 human hepatoma cells in the presence of visible light

AIM: To investigate the apoptotic effect of photoexcited titanium dioxide (TiO2) nanoparticles in the presence of visible light on human hepatoma cell line (Bel 7402) and to study the underlying mechanism. METHODS: Cerium-element-doped titanium dioxide nanoparticles were prepared by impregnation method. Bel 7402 human hepatoma cells were cultured in RPMI 1640 medium in a humidified incubator with 50 mL/L CO2 at 37℃. A 15 W fluorescent lamp with continuous wavelength light was used as light source in the photocatalytic test. Fluorescence morphology and agarose gel eletrophoresis pattern were performed to analyze apoptotic cells. RESULTS: The Ce (Ⅳ)-doped TiO2 nanoparticles displayed their superiority. The adsorption edge shifted to the 400-450 nm region. With visible light illuminated for 10 min, 10 μg/cm3 Ce (Ⅳ)-doped TiO2 induced micronuclei and significant apoptosis in 4 and 24 h, respectively. Hochest 33 258 staining of the fixed cells revealed typical apoptotic structures (apoptotic bodies), agarose gel electrophoresis showed typical DNA ladder pattern in treated cells but not in untreated ones. CONCLUSION: Ce (Ⅳ) doped TiO2 nanoparticles can induce apoptosis of Bel 7402 human hepatoma cells in the presence of visible light.

Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray

AIM: To study the differential gene expression profiles of target cells in primary gastric cancer and its metastatic lymph nodes using laser microdissection (LMD) in combi- nation with cDNA microarray. METHODS: Normal gastric tissue samples from 30 healthy individuals, 36 cancer tissue samples from pri- mary gastric carcinoma and lymph node metastasis tissue samples from 58 patients during gastric cancer resection were obtained using LMD in combination with cDNA microarray independently. After P27-based am- plification, aRNA from 36 of 58 patients (group 1) with lymph node metastasis and metastatic tissue specimens from the remaining 22 patients (group 2) were applied to cDNA microarray. Semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) and immunohisto- chemical assay verified the results of microarray in group 2 and further identified genes differentially expressed in the progression of gastric cancer. RESULTS: The expression of 10 genes was up-regulated while the expression of 15 genes was down-regulated in 22 gastric carcinoma samples compared with that of genes in the normal controls. The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer. The expression pattern of 3 genes (OPCML, RNASE1 and YES1) was similar to tumor suppressor genes. For example, the expression level of these genes was the highest in normal gastric epithelium, which was decreased in primary carcinoma, and further decreased in metastatic lymph nodes. On the contrary, the expres-sion pattern of gene ACK1 was similar to that of onco- gene. Four genes were further identified as differentially expressed genes in the majority of the cases in the pro- gression of gastric cancer. CONCLUSION: LMD in combination with cDNA microar- ray provides a unique support foe the identification of early expression profiles of differential genes and the ex- pression pattern of 3 genes (OPCML, RNASE1 and YES1) associated with the progression of gastric cancer. Further study is needed to reveal the molecular mechanism of lymph node metastasis in patients with gastric cancer.