目的:总结肝孤立性坏死结节(sol i tar y necrotic nodule,SNN)的超声造影表现,分析误诊原因,提高超声造影对该病的认识。方法:回顾性分析以超声造影或病理诊断为SNN的68名患者的超声造影表现及临床资料,评估超声造影对SNN的诊断效能,...目的:总结肝孤立性坏死结节(sol i tar y necrotic nodule,SNN)的超声造影表现,分析误诊原因,提高超声造影对该病的认识。方法:回顾性分析以超声造影或病理诊断为SNN的68名患者的超声造影表现及临床资料,评估超声造影对SNN的诊断效能,对误诊原因进行分析。结果:在68例患者中,66例经病理或随访证实为SNN,2例病理证实为肝癌;超声造影正确诊断SNN 65例,误诊为SNN 2例,误诊为转移癌1例,超声造影诊断符合率为95.59%(65/68)。SNN的典型超声造影表现为病灶整体三相无增强,伴或不伴有周边薄环状、内部纤细分隔样增强,门脉相及延迟相增强部分无消退。结论:SNN的超声造影有典型表现,具有较高的诊断效能,值得推广使用。展开更多
The Yalong River is an important river that runs across the abruptly changing terrain of the SE Tibetan Plateau. The terraces and Quaternary sediments in its valleys preserve the information of tectonic uplift, climat...The Yalong River is an important river that runs across the abruptly changing terrain of the SE Tibetan Plateau. The terraces and Quaternary sediments in its valleys preserve the information of tectonic uplift, climate changes, and landform evolution since the Middle Pleistocene. Based on geomorphological, sedimentological, and chronological investigations, 6-8 terraces are identified in the lower reaches of Yalong catchment and its tributary--the Anning River. The electron spin resonance （ESR） or optically stimulated luminescence （OSL） data on the alluvial sediments in the upper portion of terraces indicate that they formed in 1.10, 0.90, 0.72, 0.06-0.04, 0.03-0.02, and 0.01 Ma. Tectonic uplift and the climatic cycle controlled the formation of the Yalong River terraces. The former dominated the dissection depths and incision rates, whereas the latter controlled the transformation between accumulation, which developed during the glacial period, and incision, which developed during the glacial-interglacial transition. The Yalong downstream incised rapidly from 1.10 to 0.72 Ma and rapidly from 0.06 Ma until the present; the terraces developed during these two periods. The incision rates in space during the two periods indicate the uplifting extent of the Jinpingshan area, which decreases toward the east and the south. The results reveal two rapidly uplifting stages in the SE Tibetan Plateau, including an accelerated uplifting since 0.06 Ma. Since the Middle Pleistocene, the tectonic uplift of the SE and NE parts of the Tibetan Plateau is synchronous, according to the same development stages of the river terraces of the Yalong downstream and the Yellow River in the Lanzhou area of the NE Tibetan Plateau. The difference in the horizontal displacement between the Xianshuihe Fault and the Anninghe Fault bend resulted in the rapid uplift of the Jinpingshan area. The incision rate for the spatial distribution of the Yalong downstream is the geomorphologicai response of crustal shortening and uplift differences in the SE margin block of the Tibetan Plateau. The southeastward diffusion process of the Tibetan Plateau was recorded.展开更多
本试验旨在探究丹参多糖缓解氟苯尼考致肉鸡肝脏损伤的转录组学靶点与通路。将30只1日龄肉鸡随机平均分成3组:空白对照组(LA组)饲喂自来水、氟苯尼考造模组(LB组)给予含0.15 g/L氟苯尼考的自来水、丹参多糖治疗组(LC组)给予含0.15 g/L...本试验旨在探究丹参多糖缓解氟苯尼考致肉鸡肝脏损伤的转录组学靶点与通路。将30只1日龄肉鸡随机平均分成3组:空白对照组(LA组)饲喂自来水、氟苯尼考造模组(LB组)给予含0.15 g/L氟苯尼考的自来水、丹参多糖治疗组(LC组)给予含0.15 g/L氟苯尼考和5 g/L丹参多糖的自来水。从1日龄开始,连续给药5 d。于第6天各组分别随机取3只鸡,处死,无菌摘取其肝脏组织。肝脏组织经过RNA抽提、纯化和建库后,采用IlluminaHiSeq测序平台,对这些文库进行双末端测序。然后对原始下机数据进行过滤,将过滤后得到的高质量序列比对到该物种的参考基因组上。根据比对结果,计算每个基因的表达量。分别构建3组肉鸡肝脏的数字化基因表达谱(DGE)文库,比较DGE文库的差异表达基因,寻找基因表达差异最显著的关键基因,并进行GO功能注释、KEGG通路分析。结果显示:LA vs LB、LA vs LC及LB vs LC比较组分别筛选出1989(上调基因495个,下调基因1494个)、1278(上调基因344个,下调基因934个)、380个(上调基因165个,下调基因215个)表达差异显著的基因。LA vs LB、LA vs LC及LB vs LC比较组差异表达基因的GO功能注释主要归类为生物过程和细胞组成两个分支。KEGG通路分析结果表明,LA vs LB的差异表达的基因主要富集到药物代谢-细胞色素P450,细胞外基质(ECM)受体相互作用、细胞因子与细胞因子受体的相互作用、细胞色素P450对异生物的代谢,谷胱甘肽代谢,过氧化物酶体增殖物激活受体(PPAR)信号通路,甘氨酸、丝氨酸和苏氨酸代谢,丙氨酸、天冬氨酸和谷氨酸代谢等通路。LB vs LC差异表达的基因主要富集到药物代谢-细胞色素P450和甘氨酸、丝氨酸和苏氨酸代谢及PPAR信号通路等。丹参多糖可通过调节与细胞色素P450代谢通路有关的细胞色素P4503A4酶(CYP3A4)、细胞色素P4502C23b酶(CYP2C23b)、谷胱甘肽S-转移酶(GSTA3)、类谷胱甘肽S-转移酶α2(GSTAL2)等mRNA的表达以及与PPAR信号通路有关的脂肪酸结合蛋白1(FABP1)和长链脂肪酸辅酶A连接酶(ACSBG2)等mRNA的表达,从而抑制氟苯尼考产生的有害代谢产物,促进肝脏脂质的正常代谢,进而缓解氟苯尼考引起的肝脏损伤。展开更多
文摘目的:总结肝孤立性坏死结节(sol i tar y necrotic nodule,SNN)的超声造影表现,分析误诊原因,提高超声造影对该病的认识。方法:回顾性分析以超声造影或病理诊断为SNN的68名患者的超声造影表现及临床资料,评估超声造影对SNN的诊断效能,对误诊原因进行分析。结果:在68例患者中,66例经病理或随访证实为SNN,2例病理证实为肝癌;超声造影正确诊断SNN 65例,误诊为SNN 2例,误诊为转移癌1例,超声造影诊断符合率为95.59%(65/68)。SNN的典型超声造影表现为病灶整体三相无增强,伴或不伴有周边薄环状、内部纤细分隔样增强,门脉相及延迟相增强部分无消退。结论:SNN的超声造影有典型表现,具有较高的诊断效能,值得推广使用。
基金supported by the Project of China Geological Survey (grant nos.1212011120071,201211077-3 and 1212011120182)
文摘The Yalong River is an important river that runs across the abruptly changing terrain of the SE Tibetan Plateau. The terraces and Quaternary sediments in its valleys preserve the information of tectonic uplift, climate changes, and landform evolution since the Middle Pleistocene. Based on geomorphological, sedimentological, and chronological investigations, 6-8 terraces are identified in the lower reaches of Yalong catchment and its tributary--the Anning River. The electron spin resonance （ESR） or optically stimulated luminescence （OSL） data on the alluvial sediments in the upper portion of terraces indicate that they formed in 1.10, 0.90, 0.72, 0.06-0.04, 0.03-0.02, and 0.01 Ma. Tectonic uplift and the climatic cycle controlled the formation of the Yalong River terraces. The former dominated the dissection depths and incision rates, whereas the latter controlled the transformation between accumulation, which developed during the glacial period, and incision, which developed during the glacial-interglacial transition. The Yalong downstream incised rapidly from 1.10 to 0.72 Ma and rapidly from 0.06 Ma until the present; the terraces developed during these two periods. The incision rates in space during the two periods indicate the uplifting extent of the Jinpingshan area, which decreases toward the east and the south. The results reveal two rapidly uplifting stages in the SE Tibetan Plateau, including an accelerated uplifting since 0.06 Ma. Since the Middle Pleistocene, the tectonic uplift of the SE and NE parts of the Tibetan Plateau is synchronous, according to the same development stages of the river terraces of the Yalong downstream and the Yellow River in the Lanzhou area of the NE Tibetan Plateau. The difference in the horizontal displacement between the Xianshuihe Fault and the Anninghe Fault bend resulted in the rapid uplift of the Jinpingshan area. The incision rate for the spatial distribution of the Yalong downstream is the geomorphologicai response of crustal shortening and uplift differences in the SE margin block of the Tibetan Plateau. The southeastward diffusion process of the Tibetan Plateau was recorded.
文摘本试验旨在探究丹参多糖缓解氟苯尼考致肉鸡肝脏损伤的转录组学靶点与通路。将30只1日龄肉鸡随机平均分成3组:空白对照组(LA组)饲喂自来水、氟苯尼考造模组(LB组)给予含0.15 g/L氟苯尼考的自来水、丹参多糖治疗组(LC组)给予含0.15 g/L氟苯尼考和5 g/L丹参多糖的自来水。从1日龄开始,连续给药5 d。于第6天各组分别随机取3只鸡,处死,无菌摘取其肝脏组织。肝脏组织经过RNA抽提、纯化和建库后,采用IlluminaHiSeq测序平台,对这些文库进行双末端测序。然后对原始下机数据进行过滤,将过滤后得到的高质量序列比对到该物种的参考基因组上。根据比对结果,计算每个基因的表达量。分别构建3组肉鸡肝脏的数字化基因表达谱(DGE)文库,比较DGE文库的差异表达基因,寻找基因表达差异最显著的关键基因,并进行GO功能注释、KEGG通路分析。结果显示:LA vs LB、LA vs LC及LB vs LC比较组分别筛选出1989(上调基因495个,下调基因1494个)、1278(上调基因344个,下调基因934个)、380个(上调基因165个,下调基因215个)表达差异显著的基因。LA vs LB、LA vs LC及LB vs LC比较组差异表达基因的GO功能注释主要归类为生物过程和细胞组成两个分支。KEGG通路分析结果表明,LA vs LB的差异表达的基因主要富集到药物代谢-细胞色素P450,细胞外基质(ECM)受体相互作用、细胞因子与细胞因子受体的相互作用、细胞色素P450对异生物的代谢,谷胱甘肽代谢,过氧化物酶体增殖物激活受体(PPAR)信号通路,甘氨酸、丝氨酸和苏氨酸代谢,丙氨酸、天冬氨酸和谷氨酸代谢等通路。LB vs LC差异表达的基因主要富集到药物代谢-细胞色素P450和甘氨酸、丝氨酸和苏氨酸代谢及PPAR信号通路等。丹参多糖可通过调节与细胞色素P450代谢通路有关的细胞色素P4503A4酶(CYP3A4)、细胞色素P4502C23b酶(CYP2C23b)、谷胱甘肽S-转移酶(GSTA3)、类谷胱甘肽S-转移酶α2(GSTAL2)等mRNA的表达以及与PPAR信号通路有关的脂肪酸结合蛋白1(FABP1)和长链脂肪酸辅酶A连接酶(ACSBG2)等mRNA的表达,从而抑制氟苯尼考产生的有害代谢产物,促进肝脏脂质的正常代谢,进而缓解氟苯尼考引起的肝脏损伤。
