受风电、光伏等新能源出力的不确定性因素影响,需重新对有接入新能源的新型电力系统进行概率潮流计算与静态安全稳定性分析,目前所采用的Monte-Carlo法存在计算耗时长的问题,难以运用于实际工程。为此,基于光照强度和风速概率分布特性,...受风电、光伏等新能源出力的不确定性因素影响,需重新对有接入新能源的新型电力系统进行概率潮流计算与静态安全稳定性分析,目前所采用的Monte-Carlo法存在计算耗时长的问题,难以运用于实际工程。为此,基于光照强度和风速概率分布特性,分别构建光伏阵列和风力发电机组的出力概率密度函数模型,采用基于Gram-Charlier级数展开的半不变量法进行概率潮流计算,实现了对含风电、光伏接入的新型电力系统的潮流计算和静态稳定分析。以IEEE(Institute of Electrical and Electronics Engineers)30标准测试模型为算例对所提算法进行验证,结果表明,所提算法在保持Monte-Carlo法高精度优点的同时还具有较高的计算速度;研究了风电和光伏渗透率对电力系统潮流和静态安全稳定性的影响,结果表明,随着渗透率的增加,潮流分布值域扩大且部分支路可能出现负值,存在功率反向传输问题,导致系统运行风险增大;探索了线路增容对降低有功功率和节点电压越限风险以及提高静态安全稳定性的效果。展开更多
OBJECTIVE:To identify the main active components and targets of Huashi Xingyu Qingre recipe(化湿行淤清热方,HXQR)and to investigate its mechanism in the treatment of oral lichen planus(OLP).METHODS:The Traditional Chin...OBJECTIVE:To identify the main active components and targets of Huashi Xingyu Qingre recipe(化湿行淤清热方,HXQR)and to investigate its mechanism in the treatment of oral lichen planus(OLP).METHODS:The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was searched to identify the active ingredients and corresponding targets of HXQR.Disease genes were obtained from the Gene Cards database,and a“drugdisease regulatory network”was constructed using Cytoscape software and PERL programming language.The STRING database was used to build a protein-protein interaction network.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)terms were analyzed using R software with a Bioconducter plugin.Finally,the results and the efficacy of HXQR in treating OLP were validated in a clinical trial that included enzyme-linked immunosorbent assay(ELISA)testing and observations of the post-treatment changes in clinical symptoms.RESULTS:HXQR contained 167 active components and 261 targets,with 391 disease targets.The intersection of these two categories in a Venn diagram revealed 57 drugdisease common targets.A compound-target network was constructed and revealed that the six key pharmaceutical ingredients of HXQR were quercetin,luteolin,wogonin,kaempferol,beta-carotene,and baicalein.The protein-protein interaction network mainly involved core proteins such as ALB,interleukin-6,and AKT1.Drug-disease common targets were enriched in 1628 GO terms and 117 KEGG terms,mainly involving inflammatory responses,viral infections,and tumorrelated pathways.ELISA testing indicated that HXQR inhibited the tumor necrosis factor(TNF)signaling pathway by reducing the expression of interleukin-6,matrix metalloproteinase-9,and intercellular adhesion molecule-1.The clinical symptoms of the patients with OLP were significantly improved after 8 weeks of treatment with HXQR.CONCLUSION:HXQR treats OLP by regulating the TNF signaling pathway,resulting in a marked treatment effect with few adverse effects.展开更多
文摘受风电、光伏等新能源出力的不确定性因素影响,需重新对有接入新能源的新型电力系统进行概率潮流计算与静态安全稳定性分析,目前所采用的Monte-Carlo法存在计算耗时长的问题,难以运用于实际工程。为此,基于光照强度和风速概率分布特性,分别构建光伏阵列和风力发电机组的出力概率密度函数模型,采用基于Gram-Charlier级数展开的半不变量法进行概率潮流计算,实现了对含风电、光伏接入的新型电力系统的潮流计算和静态稳定分析。以IEEE(Institute of Electrical and Electronics Engineers)30标准测试模型为算例对所提算法进行验证,结果表明,所提算法在保持Monte-Carlo法高精度优点的同时还具有较高的计算速度;研究了风电和光伏渗透率对电力系统潮流和静态安全稳定性的影响,结果表明,随着渗透率的增加,潮流分布值域扩大且部分支路可能出现负值,存在功率反向传输问题,导致系统运行风险增大;探索了线路增容对降低有功功率和节点电压越限风险以及提高静态安全稳定性的效果。
基金Supported by Proteomics Study on Differential Protein of Oral Lichen Planus and Chinese Medicine Intervention of Huashi Xingyu Qingre recipe(No.81273813)Effect of Huashi Xingyu Qingre recipe on Differential Protein Expression Of Oral Lichen Planus(No.2011013)+3 种基金the Project of National Cancer Center Climbing Fund(No.NCC201803B006)the Project of Health Department Research Fund of Hebei Province(No.20170691)Scientific Research Project of TCM administration in Hebei Province(No.2018138)Governmentfunded Outstanding Talents Project in 2020(No.2704016)。
文摘OBJECTIVE:To identify the main active components and targets of Huashi Xingyu Qingre recipe(化湿行淤清热方,HXQR)and to investigate its mechanism in the treatment of oral lichen planus(OLP).METHODS:The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was searched to identify the active ingredients and corresponding targets of HXQR.Disease genes were obtained from the Gene Cards database,and a“drugdisease regulatory network”was constructed using Cytoscape software and PERL programming language.The STRING database was used to build a protein-protein interaction network.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)terms were analyzed using R software with a Bioconducter plugin.Finally,the results and the efficacy of HXQR in treating OLP were validated in a clinical trial that included enzyme-linked immunosorbent assay(ELISA)testing and observations of the post-treatment changes in clinical symptoms.RESULTS:HXQR contained 167 active components and 261 targets,with 391 disease targets.The intersection of these two categories in a Venn diagram revealed 57 drugdisease common targets.A compound-target network was constructed and revealed that the six key pharmaceutical ingredients of HXQR were quercetin,luteolin,wogonin,kaempferol,beta-carotene,and baicalein.The protein-protein interaction network mainly involved core proteins such as ALB,interleukin-6,and AKT1.Drug-disease common targets were enriched in 1628 GO terms and 117 KEGG terms,mainly involving inflammatory responses,viral infections,and tumorrelated pathways.ELISA testing indicated that HXQR inhibited the tumor necrosis factor(TNF)signaling pathway by reducing the expression of interleukin-6,matrix metalloproteinase-9,and intercellular adhesion molecule-1.The clinical symptoms of the patients with OLP were significantly improved after 8 weeks of treatment with HXQR.CONCLUSION:HXQR treats OLP by regulating the TNF signaling pathway,resulting in a marked treatment effect with few adverse effects.
