目的:探讨心搏骤停(Cardiac Arrest,CA)患者心肺复苏(Cardiopulmonary Resuscitation,CPR)后血流动力学及脑功能对预后的影响。方法:选取我院2021年1月至2022年8月期间收治的心搏骤停患者心肺复苏后亚低温治疗的66例患者为研究对象,根...目的:探讨心搏骤停(Cardiac Arrest,CA)患者心肺复苏(Cardiopulmonary Resuscitation,CPR)后血流动力学及脑功能对预后的影响。方法:选取我院2021年1月至2022年8月期间收治的心搏骤停患者心肺复苏后亚低温治疗的66例患者为研究对象,根据预后情况分为预后良好组(n=28)和预后不良组(n=38),比较患者血流动力学及脑功能变化。多因素Logistic分析患者预后不良的影响因素;绘制受试者工作特征(Receiver Operating Characteristic,ROC)曲线。结果:预后良好组血流动力学和脑功能指标与预后不良组比较,差异具有统计学意义(P<0.05)。多因素Logistic分析,血流动力学和脑功能指标是CPR后患者预后不良的影响因素。血流动力学联合脑功能曲线下面积(Area Under the Curve,AUC)为0.889。结论:血流动力学及脑功能可作为CA患者CPR后的预后指标。展开更多
Tourism can have both positive and negative outcomes for residents in tourism destinations. It is a good method to analyze the status of tourism impact by means of investigating residents’ perceptions of it. Various ...Tourism can have both positive and negative outcomes for residents in tourism destinations. It is a good method to analyze the status of tourism impact by means of investigating residents’ perceptions of it. Various methods have been used in previous authoritative studies. However, owing to inherent imprecision, difficulties always exist in some conventional methodologies when describing the interpretation of linguistic or measured uncertainties for real-world random phenomena. The purpose of this research is to present the fuzzy synthetic evaluation method to investigate residents’ perceptions of tourism impacts. At first, basic attributes and a hierarchical framework of tourism impacts are defined and formed. Secondly, the weighted vectors are determined according to the knowledge and experience of experts. Thirdly, the weighted evaluation matrices are aggregated to get the fuzzy sets of tourism impacts. In the last stage, the final fuzzy sets are defuzzified to get the rank of the residents’ perceptions of tourism impacts. A case study in Jiuzhaigou National Park of China is provided to demonstrate the application of this method.展开更多
A practical synthesis of （S）-N-（2-ethyl-6-methylphenyl）alanine, a key intermediate for （S）-metolachlor, was completed by means of lipase-catalyzed hydrolytic kinetic resolution and chemical racemization of the r...A practical synthesis of （S）-N-（2-ethyl-6-methylphenyl）alanine, a key intermediate for （S）-metolachlor, was completed by means of lipase-catalyzed hydrolytic kinetic resolution and chemical racemization of the remaining ester. The effects of operating temperature and enzyme concentration on the activity and enantioselectivity of enzyme were initially studied, and it was found that the enantioselectivity of CAL-B towards the resolution was not high enough to obtain enantiomerically pure compound（E=12.1）. When diethyl ether（15%, volume fraction） was added in the reaction medium, the lipase gave an excellent enantioselectivity（E=117.8）, which is about 9.7-fold that in pure buffered aqueous solution. For overcoming the limitation of a maximum theoretical yield of 50%, the acid product was separated from the remaining ester by a simple extraction procedure and the remaining ester was racemized with aldehyde and acetic acid under microwave irradiation or conventional heating condition, The results show the microwave irradiation was more effective than the conventional heating method and gave the desired （R,S）-N-（2- ethyl-6-methylphenyl）alanine methyl ester a high yield（92%） with R/S=50/50 in 1 h.展开更多
目的了解福建省MSM人群HIV新近感染状况,探讨其分子流行特征和相关影响因素,为制定艾滋病防治策略提供科学依据。方法对福建省2019年MSM哨点监测人群HIV抗体阳性样本采用HIV-1限制性抗原亲和力酶联免疫法(简称LAg-Avidity EIA)进行新近...目的了解福建省MSM人群HIV新近感染状况,探讨其分子流行特征和相关影响因素,为制定艾滋病防治策略提供科学依据。方法对福建省2019年MSM哨点监测人群HIV抗体阳性样本采用HIV-1限制性抗原亲和力酶联免疫法(简称LAg-Avidity EIA)进行新近感染检测,用多因素Logistic回归分析其影响因素,通过RT-PCR扩增pol和gag区,利用系统进化树和HIV db Program软件对序列进行基因亚型和耐药突变分析。结果福建省2019年哨点监测MSM人群863人,其中总的HIV抗体阳性率为12.17%(105/863),HIV新近感染率为11.97%;Logistic回归分析显示,样本来源和最近6个月内同性肛交安全套使用频率是新近感染的影响因素;基因亚型以CRF07_BC(47.61%)和CRF01_AE(38.10%)为主,其次为CRF55-01B(9.52%)、B亚型(4.76%);HIV-1耐药率为6.67%(1/15),其中15例对蛋白酶类抑制剂、核苷类逆转录抑制剂均敏感;1例对非核苷类逆转录酶抑制剂efavirenz(EFV)和nevirapine(NVP)产生高度耐药,1例为潜在耐药。结论福建省2019年哨点监测MSM人群HIV新近感染率处于较高水平,多种亚型并存,发现原发耐药株传播,应加强对HIV新近感染者的分子流行特征变化趋势以及原发耐药传播的动态监测,及时调整防控策略,有效控制福建省艾滋病感染与传播。展开更多
文摘目的:探讨心搏骤停(Cardiac Arrest,CA)患者心肺复苏(Cardiopulmonary Resuscitation,CPR)后血流动力学及脑功能对预后的影响。方法:选取我院2021年1月至2022年8月期间收治的心搏骤停患者心肺复苏后亚低温治疗的66例患者为研究对象,根据预后情况分为预后良好组(n=28)和预后不良组(n=38),比较患者血流动力学及脑功能变化。多因素Logistic分析患者预后不良的影响因素;绘制受试者工作特征(Receiver Operating Characteristic,ROC)曲线。结果:预后良好组血流动力学和脑功能指标与预后不良组比较,差异具有统计学意义(P<0.05)。多因素Logistic分析,血流动力学和脑功能指标是CPR后患者预后不良的影响因素。血流动力学联合脑功能曲线下面积(Area Under the Curve,AUC)为0.889。结论:血流动力学及脑功能可作为CA患者CPR后的预后指标。
基金Under the auspices of Canadian International Development Agency Project (No. S-61562) Ecotourism Planning and Management in Dalian City of Dalian Science&Technology Bureau(No.2004B3SF171)
文摘Tourism can have both positive and negative outcomes for residents in tourism destinations. It is a good method to analyze the status of tourism impact by means of investigating residents’ perceptions of it. Various methods have been used in previous authoritative studies. However, owing to inherent imprecision, difficulties always exist in some conventional methodologies when describing the interpretation of linguistic or measured uncertainties for real-world random phenomena. The purpose of this research is to present the fuzzy synthetic evaluation method to investigate residents’ perceptions of tourism impacts. At first, basic attributes and a hierarchical framework of tourism impacts are defined and formed. Secondly, the weighted vectors are determined according to the knowledge and experience of experts. Thirdly, the weighted evaluation matrices are aggregated to get the fuzzy sets of tourism impacts. In the last stage, the final fuzzy sets are defuzzified to get the rank of the residents’ perceptions of tourism impacts. A case study in Jiuzhaigou National Park of China is provided to demonstrate the application of this method.
基金Supported by the National Natural Science Foundation of China(No.20802025)the Hi-Tech Research and Development Program of China(No.2007AA021306)Jilin Provincial Science & Technology Sustentation Program,China(No.20070553)
文摘A practical synthesis of （S）-N-（2-ethyl-6-methylphenyl）alanine, a key intermediate for （S）-metolachlor, was completed by means of lipase-catalyzed hydrolytic kinetic resolution and chemical racemization of the remaining ester. The effects of operating temperature and enzyme concentration on the activity and enantioselectivity of enzyme were initially studied, and it was found that the enantioselectivity of CAL-B towards the resolution was not high enough to obtain enantiomerically pure compound（E=12.1）. When diethyl ether（15%, volume fraction） was added in the reaction medium, the lipase gave an excellent enantioselectivity（E=117.8）, which is about 9.7-fold that in pure buffered aqueous solution. For overcoming the limitation of a maximum theoretical yield of 50%, the acid product was separated from the remaining ester by a simple extraction procedure and the remaining ester was racemized with aldehyde and acetic acid under microwave irradiation or conventional heating condition, The results show the microwave irradiation was more effective than the conventional heating method and gave the desired （R,S）-N-（2- ethyl-6-methylphenyl）alanine methyl ester a high yield（92%） with R/S=50/50 in 1 h.
文摘目的了解福建省MSM人群HIV新近感染状况,探讨其分子流行特征和相关影响因素,为制定艾滋病防治策略提供科学依据。方法对福建省2019年MSM哨点监测人群HIV抗体阳性样本采用HIV-1限制性抗原亲和力酶联免疫法(简称LAg-Avidity EIA)进行新近感染检测,用多因素Logistic回归分析其影响因素,通过RT-PCR扩增pol和gag区,利用系统进化树和HIV db Program软件对序列进行基因亚型和耐药突变分析。结果福建省2019年哨点监测MSM人群863人,其中总的HIV抗体阳性率为12.17%(105/863),HIV新近感染率为11.97%;Logistic回归分析显示,样本来源和最近6个月内同性肛交安全套使用频率是新近感染的影响因素;基因亚型以CRF07_BC(47.61%)和CRF01_AE(38.10%)为主,其次为CRF55-01B(9.52%)、B亚型(4.76%);HIV-1耐药率为6.67%(1/15),其中15例对蛋白酶类抑制剂、核苷类逆转录抑制剂均敏感;1例对非核苷类逆转录酶抑制剂efavirenz(EFV)和nevirapine(NVP)产生高度耐药,1例为潜在耐药。结论福建省2019年哨点监测MSM人群HIV新近感染率处于较高水平,多种亚型并存,发现原发耐药株传播,应加强对HIV新近感染者的分子流行特征变化趋势以及原发耐药传播的动态监测,及时调整防控策略,有效控制福建省艾滋病感染与传播。
