目的利用孟德尔随机化(MR)研究分析哮喘对膝骨关节炎(KOA)的影响。方法以逆方差加权法(IVW)作为主要评估方法,同时采用MR-Egger回归、加权中位值(WM)、基于众数的简单估计和基于众数的加权估计4种方法检验结果的可靠性与稳定性。留一法...目的利用孟德尔随机化(MR)研究分析哮喘对膝骨关节炎(KOA)的影响。方法以逆方差加权法(IVW)作为主要评估方法,同时采用MR-Egger回归、加权中位值(WM)、基于众数的简单估计和基于众数的加权估计4种方法检验结果的可靠性与稳定性。留一法对研究结果进行敏感性分析。Cochran s Q检验计算截距和P值,分析IVW与MR-Egger各SNP的异质性。MR-pleiotropy函数对研究结果进行多效性分析。两样本MR评估哮喘(主数据集和次要数据集)与KOA的因果关系,反向MR研究KOA对哮喘的影响。结果哮喘主数据集与KOA的发生概率增加有关(OR=1.664,95%CI:1.1342.441,P=0.009)。哮喘次要数据集与KOA的发生概率增加有关(OR=6405.249,95%CI:1.85022176818.850,P=0.035)。留一法显示正向MR结果稳定。反向MR研究显示,KOA与哮喘的发生概率增加无关(P>0.05)。结论哮喘一定程度上能够促进KOA的发生和发展,是KOA的潜在不利因素。展开更多
Satellite remote sensing observations show that during winter, sea surface temperature （SST） presents the structure of double warm tongues in the Huanghai Sea trough： the western and the eastern warm tongues. Numer...Satellite remote sensing observations show that during winter, sea surface temperature （SST） presents the structure of double warm tongues in the Huanghai Sea trough： the western and the eastern warm tongues. Numerical experiments based on POM are carried out to study the forming mechanism of this thermal structure and its relation to the Huanghai Sea Warm Current （HSWC）. The control experiment reproduces this phenomenon quite well, and comparing experiments investigate the effect of wind and tide. It is found that the western warm tongue is mainly caused by the HSWC, which can be strengthened by wintertime southward wind. The eastern warm tongue develops under the influence of an anti-clockwise circulation which is induced by the temperature front of the Huanghai Sea Cold Water Mass （HSCWM） in summer and autumn. In the eastern portion of this circulation, the northward current carries warm water to the north, forming the eastern warm tongue, which remains till winter.展开更多
文摘目的利用孟德尔随机化(MR)研究分析哮喘对膝骨关节炎(KOA)的影响。方法以逆方差加权法(IVW)作为主要评估方法,同时采用MR-Egger回归、加权中位值(WM)、基于众数的简单估计和基于众数的加权估计4种方法检验结果的可靠性与稳定性。留一法对研究结果进行敏感性分析。Cochran s Q检验计算截距和P值,分析IVW与MR-Egger各SNP的异质性。MR-pleiotropy函数对研究结果进行多效性分析。两样本MR评估哮喘(主数据集和次要数据集)与KOA的因果关系,反向MR研究KOA对哮喘的影响。结果哮喘主数据集与KOA的发生概率增加有关(OR=1.664,95%CI:1.1342.441,P=0.009)。哮喘次要数据集与KOA的发生概率增加有关(OR=6405.249,95%CI:1.85022176818.850,P=0.035)。留一法显示正向MR结果稳定。反向MR研究显示,KOA与哮喘的发生概率增加无关(P>0.05)。结论哮喘一定程度上能够促进KOA的发生和发展,是KOA的潜在不利因素。
基金The National Key Basic Research Program of China under contract 2006CB403605the National Natural Science Foundation of China under contract Nos.40806016 and 40706016China 908–project under contract No. 908–02–01–03
文摘Satellite remote sensing observations show that during winter, sea surface temperature （SST） presents the structure of double warm tongues in the Huanghai Sea trough： the western and the eastern warm tongues. Numerical experiments based on POM are carried out to study the forming mechanism of this thermal structure and its relation to the Huanghai Sea Warm Current （HSWC）. The control experiment reproduces this phenomenon quite well, and comparing experiments investigate the effect of wind and tide. It is found that the western warm tongue is mainly caused by the HSWC, which can be strengthened by wintertime southward wind. The eastern warm tongue develops under the influence of an anti-clockwise circulation which is induced by the temperature front of the Huanghai Sea Cold Water Mass （HSCWM） in summer and autumn. In the eastern portion of this circulation, the northward current carries warm water to the north, forming the eastern warm tongue, which remains till winter.
