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Radio-Frequency Power Test of a Four-Rod RFQ Accelerator for PKUNIFTY
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作者 ZENG Hong-Jin LIU Ge +9 位作者 lu yuan-rong CHEN Wei ZHOU Quan-Feng ZHU Kun XIA Wen-Long SHI Ben-Liang GAO Shu-Li YAN Xue-Qing GUO Zhi-Yu CHEN Jia-Er 《Chinese Physics Letters》 SCIE CAS CSCD 2012年第6期106-109,共4页
A four-rod radio frequency quadruple (RFQ) accelerator is designed,manufactured,installed and commissioned for the Peking University Neutron Imaging Facility (PKUNIFTY).This 2699.6-mm-long RFQ accelerator with the mea... A four-rod radio frequency quadruple (RFQ) accelerator is designed,manufactured,installed and commissioned for the Peking University Neutron Imaging Facility (PKUNIFTY).This 2699.6-mm-long RFQ accelerator with the mean aperture radius of 3.88mm is operating at 201.5MHz in pulse mode.An inter-electrode voltage of 70kV is needed to accelerate the injected 50keV 40mA D+ ions up to 2MeV.We present the rf system,high rf power feeder design,lowver rf measurements and higher rf power test.Especially,the rf commissioning was carried out with rf power up to ~280 k W and duty factor of 4%.The measured x-ray spectrum shows that the rf inter-electrode voltage reaches 70.7 kV.It is found that the specific shunt impedance of the RFQ cavity reaches 52.7kΩ.m. 展开更多
关键词 RFQ RADIUS CAVITY
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Preliminary Study on Neutron Radiography with Several Hundred keV Fast Neutrons
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作者 LI Hang ZOU Yu-Bin +2 位作者 lu yuan-rong GUO Zhi-Yu TANG Guo-You 《Chinese Physics Letters》 SCIE CAS CSCD 2012年第11期227-230,共4页
Several hundred keV fast neutron radiography(HKFNR)can be a complementary technique to common thermal neutron radiography(TNR)and several MeV fast neutron radiography(MFNR).We tested HKFNR on a 4.5 MV Van de Graaff ac... Several hundred keV fast neutron radiography(HKFNR)can be a complementary technique to common thermal neutron radiography(TNR)and several MeV fast neutron radiography(MFNR).We tested HKFNR on a 4.5 MV Van de Graaff accelerator,and the experimental results show that the spatial resolution of this technique is better than MFNR and close to TNR.Several hundred keV fast neutrons can penetrate some thermal neutron absorbers such as Cd,and it is feasible to investigate its use on some materials which are transparent to cold/thermal neutrons,such as aluminum,using this technique. 展开更多
关键词 TECHNIQUE KEV ABSORBER
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Power Test of the Ladder IH-RFQ Accelerator at Peking University
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作者 lu yuan-rong CHEN Wei +5 位作者 NIE Yuan-Cun LIU Ge GAO Shu-Li ZENG Hong-Jin YAN Xue-Qing CHEN Jia-Er 《Chinese Physics Letters》 SCIE CAS CSCD 2011年第7期89-92,共4页
A 104-MHz ladder interdigital-H radio frequency quadrupole accelerator(T-IH-RFQ)is developed for applying RFQs to heavy ion implantation and accelerator-based mass spectroscopy in recent years at the Institute of Heav... A 104-MHz ladder interdigital-H radio frequency quadrupole accelerator(T-IH-RFQ)is developed for applying RFQs to heavy ion implantation and accelerator-based mass spectroscopy in recent years at the Institute of Heavy Ion Physics,Peking University.It could accelerate ions with a mass-to-charge ratio of less than 14,from 2.9 keV/u to 35.7 keV/u within a length of 1.1 m.The T-IH-RFQ cavity operating at H21(0)mode was constructed successfully.Based on a well designed rf power feeding system,the cavity was cold measured and tested with high rf power.In the case of cold measurement,the rf properties were obtained using a vector network analyzer with the help of a perturbation capacitor.During a high power test,the inter−electrode voltage was derived from the energy spectrum of x-rays measured by a high purity Ge detector.The results show that the specific shunt impedance of the T-IH-RFQ cavity reaches 178 kΩm,which could meet the requirements of beam dynamics design. 展开更多
关键词 PURITY IMPLANTATION APPLYING
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电针对肌萎缩侧索硬化症小鼠脊髓PPIA/NF-κB信号通路的影响
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作者 刘隽阳 卢苑蓉 +5 位作者 郭婕 李华 王渊 赵颖倩 李杰 王强 《针刺研究》 CAS CSCD 北大核心 2023年第10期1009-1016,共8页
目的:观察电针对肌萎缩侧索硬化症(ALS)小鼠发病期运动功能、脊髓细胞外亲环素A(PPIA)及PPIA/核因子(NF)-κB信号通路相关蛋白表达的影响,探讨电针干预调节细胞外PPIA对ALS小鼠神经炎性的作用机制。方法:铜锌超氧化物歧化酶1(SOD1)^(G9... 目的:观察电针对肌萎缩侧索硬化症(ALS)小鼠发病期运动功能、脊髓细胞外亲环素A(PPIA)及PPIA/核因子(NF)-κB信号通路相关蛋白表达的影响,探讨电针干预调节细胞外PPIA对ALS小鼠神经炎性的作用机制。方法:铜锌超氧化物歧化酶1(SOD1)^(G93A)小鼠按随机数字表法分为模型组、电针组、利鲁唑组,同窝SOD1^(G93A)阴性小鼠作为空白组,每组10只。电针组电针双侧“阳陵泉”“足三里”,每次20 min,每日1次,每周治疗5 d,共治疗2周。利鲁唑组小鼠按照30 mg·kg^(-1)·d^(-1)的剂量予利鲁唑灌胃,治疗时间与电针组一致。采用转棒实验和旷场实验评价各组小鼠运动功能的变化;HE染色法观察各组小鼠脊髓前角运动神经元形态;Western blot法检测各组小鼠脊髓组织PPIA、43 kDa Tar DNA结合蛋白(TDP-43)、NF-κB蛋白相对表达量;免疫组织化学法检测各组小鼠脊髓组织TDP-43阳性表达水平;免疫荧光法检测各组小鼠脊髓组织PPIA阳性表达水平;ELISA法检测各组小鼠血清PPIA含量。结果:与空白组比较,模型组小鼠掉棒潜伏期及旷场运动总距离缩短(P<0.01),脊髓前角运动神经元数量减少,细胞形态不完整,胞体萎缩,TDP-43蛋白表达及阳性表达升高(P<0.01),PPIA、NF-κB蛋白相对表达量升高(P<0.01),血清PPIA含量及脊髓组织PPIA免疫荧光表达升高(P<0.01)。与模型组比较,电针组和利鲁唑组小鼠掉棒潜伏期、旷场运动总距离延长(P<0.05,P<0.01),脊髓前角运动神经元损伤减轻,脊髓组织TDP-43蛋白表达及阳性表达降低(P<0.05,P<0.01);电针组小鼠脊髓组织PPIA、NF-κB蛋白相对表达量降低(P<0.05,P<0.01),血清PPIA含量及脊髓组织PPIA免疫荧光表达降低(P<0.05,P<0.01);利鲁唑组小鼠脊髓组织NF-κB蛋白相对表达量及PPIA免疫荧光表达降低(P<0.05)。结论:电针干预可改善ALS小鼠运动功能,其机制可能与电针抑制PPIA/NF-κB信号通路进而缓解神经炎性反应有关。 展开更多
关键词 肌萎缩侧索硬化症 电针 细胞外亲环素A 核因子-ΚB
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电针对帕金森病痴呆小鼠海马突触可塑性和补体依赖性记忆障碍的影响 被引量:5
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作者 郭婕 赵颖倩 +4 位作者 李华 张改月 卢苑蓉 郭盼盼 王强 《针刺研究》 CAS CSCD 北大核心 2022年第12期1041-1047,共7页
目的:观察电针干预对帕金森病痴呆(PDD)模型小鼠海马CA1区突触素(SYN)、突触后密度蛋白95(PSD-95)、离子钙结合接头分子1(Iba-1)+CD68^(+)小胶质细胞数及补体(C)相关蛋白表达的影响,探讨“嗅三针”改善PDD记忆障碍的部分作用机制。方法... 目的:观察电针干预对帕金森病痴呆(PDD)模型小鼠海马CA1区突触素(SYN)、突触后密度蛋白95(PSD-95)、离子钙结合接头分子1(Iba-1)+CD68^(+)小胶质细胞数及补体(C)相关蛋白表达的影响,探讨“嗅三针”改善PDD记忆障碍的部分作用机制。方法:雄性C57BL/6小鼠随机分为空白组、假手术组、模型组和电针组,每组10只。采用单侧内侧前脑束注射6-羟多巴胺建立PDD小鼠模型。电针组予“嗅三针”电针干预,每日1次,每次20 min,连续14 d。采用Morris水迷宫及新物体识别实验评估各组小鼠学习记忆能力;Western blot法检测海马CA1区SYN、PSD-95蛋白的表达量;免疫荧光法标记海马CA1区Iba-1^(+)CD68^(+)小胶质细胞及C1q阳性细胞并计算阳性细胞率;ELISA法检测海马CA1区C3蛋白含量。结果:与空白组比较,假手术组各指标差异均无统计学意义(P>0.05)。与假手术组比较,模型组小鼠逃避潜伏期延长(P<0.01),穿越原平台次数、新物体识别认知指数(NORI)降低(P<0.01);与模型组比较,电针组小鼠逃避潜伏期缩短(P<0.01),穿越原平台次数、NORI升高(P<0.05)。与假手术组比较,模型组小鼠海马CA1区SYN、PSD-95蛋白表达量显著降低(P<0.01),Iba-1^(+)CD68^(+)小胶质细胞率、C1q阳性细胞率及C3蛋白含量显著升高(P<0.01);与模型组比较,电针组小鼠海马CA1区SYN、PSD-95蛋白表达量升高(P<0.01,P<0.05),Iba-1^(+)CD68^(+)小胶质细胞率、C1q阳性细胞率及C3蛋白含量显著降低(P<0.01)。结论:“嗅三针”可缓解PDD模型小鼠学习记忆障碍,改善海马CA1区突触可塑性,其机制可能与减少海马CA1区C1q、C3表达,降低小胶质细胞吞噬能力有关。 展开更多
关键词 帕金森病痴呆 电针 突触 小胶质细胞 补体C1Q 补体C3
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