中国动画故事与人物百年嬗变的实证分析

在中国动画历经百年发展之际,为填补中国动画系统化实证性研究的相对短缺,文章选取故事与人物两大动画核心要素,采用内容分析方法,对1927—2020年中国动画故事题材、故事来源、角色形象、技术类型四个方面的分布特征与变化机制进行了分片种的量化考察与逐代梳理。文章自主构建了中国动画故事题材与角色形象的全新分析框架,并基于数据表现提出中国动画的三点变迁规律,以期为后续理论开拓与产业发展提供实用性参考。

基于网络药理学分析丹参在骨关节炎中的作用机制

目的:运用网络药理学方法,探讨丹参有效成分对OA靶基因及信号通路的影响,揭示其可能的作用机制。方法:先通过TCMSP数据库筛选丹参有效成分及靶点,再采用GeneCards、OMIM数据库筛选与OA相关的基因并与靶点交集获得靶基因,然后利用Cytoscape3.6.1软件作出丹参有效成分与靶基因关系网络图,并对靶基因进行GO、KEGG富集分析。结果:丹参中筛选出木犀草素、丹参酮ⅡA和隐丹参酮等57种有效成分和作用于OA的IL-6、AKT1、VEGFA、EGFR、STAT3等65个靶基因。富集分析显示靶基因主要富含在细胞因子受体结合、DNA结合转录激活因子活性和RNA聚合酶Ⅱ特异性等生物过程,涉及PI3K-Akt、IL-17、JAK-STAT、MAPK及NF-kappa B等信号通路。结论:从网络药理学角度筛选丹参治疗OA潜在的有效成分及作用靶基因和信号通路,为开发丹参的相关新药治疗OA提供理论依据。

关于预嘱尊严死的认知和接受度调查——以ICU终末期患者家属为例

[目的]了解重症监护室(Intensive Care Unit,ICU)终末期患者家属对预嘱尊严死的认知与接受度,为生前预嘱推广提供理论参考。[方法]对100例广州中医药大学第三附属医院和广东省第二中医院的ICU终末期患者家属进行调研,探讨他们对生前预嘱的认知接受度及其影响因素,采用描述性统计分析、χ2检验等方法分析数据。[结果] 48例填写问卷之前"从未听说过生前预嘱";对不了解生前预嘱的患者家属给予解释后,53例家属表示理解并愿意填写帮助安排临终时是否使用生命支持系统的文件。家庭年收入、认为临终时使用生命支持系统对延长存活时间有无意义是家属对预嘱尊严死的接受度(P<0. 05)的影响因素,性别、受教育程度、职业、是否目睹过患者临终前的情况对预嘱尊严死的认知和接受度影响不显著(P>0. 05)。[结论] ICU终末期患者家属对预嘱尊严死的认知和接受度处于较低的水平,推广生前预嘱仍需更多努力。

金昌市不同季节大气颗粒物的传输路径和潜在源分析

选取金昌市2019年3月—2020年2月PM_(2.5)和PM_(10)逐小时观测数据,分析该市颗粒物污染水平的季节差异,并利用HYSPLIT后向轨迹模式和GDAS气象数据,分析不同气流轨迹对金昌市颗粒物浓度的影响及不同季节颗粒物的潜在污染来源。结果表明,2019年金昌市冬季PM_(2.5)污染最严重,春季PM_(10)污染严重;春、秋季PM_(10)污染程度最高的气流轨迹主要来自西北的长距离输送,而夏、秋、冬季来自周边的短距离气流PM_(2.5)污染程度较高;春季PM_(2.5)贡献源区主要位于新疆东部和俄罗斯南部,秋季主要位于甘肃东南部和阿拉善盟,夏、冬季主要位于青海中西部、西藏北部和新疆西部。

Steady-State Screening-Photovoltaic Spatial Solitons in the Biased Photorefractive-Photovoltaic Crystals

The theory of the screening-photovoltaic solitons is improved in biased photorefractive-photovoltaic crystals.When the photovoltaic effect is negligible,the screening-photovoltaic solitons are the screening ones,and their space-charge field is the space-charge field of the screening solitons.If the external field is absent,the screening-photovoltaic solitons are the photovoltaic ones on the open-and closed-circuit conditions,and their space-charge field is of the photovoltaic solitons.We also show theoretically that the screening and the photovoltaic solitons on the open-and closed-circuit conditions may be studies together as the screening-photovoltaic solitons.

Effect of Boundary Condition on Impact Response and Damage Meso-mechanism for Scarf Bonded Repair of Load-bearing Composite Structures

Composite scarf repair is applied in airplane load-bearing structures. But the repairs would have different boundary supports in real situation, such as simply support, clamped support and flexible support. With different boundary supports, the bonded scarf repair of composite structures could have diverse damage mechanisms and responses. This work intends to study the impact performance of different boundaries. For this purpose, experimental tests were carried out on the specimens with two sides support and four sides support. The impact load and deflection was monitored during the tests. After impact being finished, the meso-mechanism was studied by means of micro-cracks of the side section for two sides support condition and cross section for the four sides support condition. It was possible to conclude that the four sides boundary possess higher impact resistance maximum loads, lower displacements and lower extent load dropping. In terms of damage modes, as the impact energy relative low 12 J and 16 J, the central position of scarf bonding zone for two sides support appears adhesive cohesive failure and adhesive-composite interface failure. When the energy increases to 20 J, the dominated damage of two sides support moves down to the feathered tip. For four sides support, the critical energy level is 25 J, under which the scarf adhesive begins to be damaged.

Effects of Environment and Open Hole on the Mechanical Performance for Composite Laminate Plates

As composites are increasingly used in aircraft,composites-based the primary-load bearing structures were gradually considered for wide application. However,to determine worst case of the primary-load bearing structures of composites is quite necessary. In this paper,to reveal the effects on the mechanical performance of composite laminate plates were made,respectively by open holes and different environments. Firstly,we obtained the benchmark of composite plates by conducting tension and compression of room temperature and dry air( RTD),tension of cold temperature and dry air( CTD),and compression of elevated temperature and wet( ETW). Then opened circle holes were introduced into composite plates to know the influence of holes. Finally,CTD and ETW environment were respectively investigated to composite plate with holes being under tension and compression loads. As shown by experimental results,open-holes decreased tension and compression mechanical performance 42% and 46% respectively,and ETW environment have 17% and 23% decreasing influence on the compression mechanical performance of composite plate and plate with holes. Furthermore,the compression damage mechanism of composite plates and plates with holes are fiber compressing-shearing fracture after fiber buckling.

肾移植术后并发导尿管相关尿路感染病原菌分布与外周血NK细胞水平及临床意义

目的 探究肾移植术后并发导尿管相关尿路感染(CAUTI)病原菌分布、危险因素及外周血免疫细胞水平。方法 选取2018年6月-2021年6月于郑州市第七人民医院接受肾移植的受者74例,根据术后CAUTI发生情况将患者分为CAUTI组17例和非CAUTI组57例,分析CAUTI病原菌分布,多因素Logistic回归分析肾移植术后发生CAUTI的危险因素,受试者工作特征(ROC)曲线评估自然杀伤(NK)细胞、T淋巴细胞亚群诊断肾移植术后CAUTI的临床价值。结果 74例肾移植受者术后17例发生CAUTI,感染率为22.97%,共检出31株感染病原菌,其中革兰阴性菌23株占74.19%;多因素Logistic回归分析结果显示,双J管留置时间是肾移植受者术后并发CAUTI的独立危险因素(P<0.05);CAUTI组NK细胞、CD_(4)^(+)/CD8^(+)T淋巴细胞水平均较非CAUTI组下降(P<0.05);ROC曲线结果显示,NK细胞、CD_(4)^(+)/CD8^(+)T淋巴细胞诊断肾移植术后并发CAUTI的曲线下面积(AUC)为0.843、0.810。结论 肾移植术后CAUTI的发生率较高,感染病原菌以革兰阴性菌为主;双J管留置时间过长会增加肾移植受者术后并发CAUTI风险,临床或可通过检测外周血NK细胞、CD_(4)^(+)/CD8^(+)T淋巴细胞水平对肾移植受者并发CAUTI进行诊断。

探讨肠道菌群对膝骨关节炎治疗的影响

膝骨关节炎是一种中老年人常见的慢性疾病,因其发病率及致残率高,严重影响患者的生存质量。膝骨关节炎不仅增加了患者及其家庭乃至社会的经济压力,而且还加重了心理负担。治疗方案虽然多,但目前尚无根治方法,而且疗效也参差不齐。肠道菌群作为人体巨大的微生物宝库,拥有着很大的潜力,这使之成为了科研领域一个新的研究热点,其对膝骨关节炎的影响也成为了人们关注的焦点。本文通过查阅相关文献,从慢性炎症、代谢性疾病、成骨细胞以及破骨细胞这四个方面来阐述和总结肠道菌群与膝骨关节炎的关系,以期为临床上治疗膝骨关节炎提供新的方法与思路。