[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0....[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0.25, 0.5 and 1.0 g/（kg d）, a total of 5 groups. Using the subacute D-galactose induced aging models, the mice were killed after 6 weeks of experiment and the activity of Superoxide dismutase （SOD）, Glutathione peroxidase （GSH-Px） and Malondialdehyde （MDA） content in plasma, brain and liver tissue were determined. [ Result.] The activity of SOD and GSH-Px in plasma, brain and liver tissue were significantly increased after treated with LC, while the content of MDA were decreased with a dose-dependent manner. [ Conclusion] LC had anti-aging effects in mice, and the mechanism may be correlated with the antioxidation.展开更多
[Objective] To study the effects of L-carnitine （LC） on lowering the high blood lipid and antioxidation in hyperlipidemia rats. [Method] 50 healthy SD rats were randomly divided into 5 groups. They were fed with sta...[Objective] To study the effects of L-carnitine （LC） on lowering the high blood lipid and antioxidation in hyperlipidemia rats. [Method] 50 healthy SD rats were randomly divided into 5 groups. They were fed with standard diet, high-cholesterol diet and high-cholesterol diet with 0.25, 0.5, 1.0 g/（ kg · d） LC. After the LC groups were consecutively orally administered LC for 28 days, rat serum total cholesterol （ TC）, triglyceride （TG）, high density lipoprotein （ HDL-C）, low density lipoprotein （LDL-C） content, as well as super oxide dismutase （SOD） activity and malondial- dehyde （MDA） content in serum and liver were determined. [ Reset~ Compared with the high-fat model group, LC could significantly reduce the se- rum TC, TG, LDL-C levels, increase HDL-C level, and enhance SOD activity in serum and liver, decrease the content of MDA （ P 〈0.05）. [ Con- Clusion] LC might have a significant role in lowering the high blood lipid and improving internal antioxidant capacity in hyperlipidemia rats.展开更多
基金Yantai Science and Technology Development Plan (2011074)
文摘[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0.25, 0.5 and 1.0 g/（kg d）, a total of 5 groups. Using the subacute D-galactose induced aging models, the mice were killed after 6 weeks of experiment and the activity of Superoxide dismutase （SOD）, Glutathione peroxidase （GSH-Px） and Malondialdehyde （MDA） content in plasma, brain and liver tissue were determined. [ Result.] The activity of SOD and GSH-Px in plasma, brain and liver tissue were significantly increased after treated with LC, while the content of MDA were decreased with a dose-dependent manner. [ Conclusion] LC had anti-aging effects in mice, and the mechanism may be correlated with the antioxidation.
基金Yantai Science and Technology Development Plan( 2011074)
文摘[Objective] To study the effects of L-carnitine （LC） on lowering the high blood lipid and antioxidation in hyperlipidemia rats. [Method] 50 healthy SD rats were randomly divided into 5 groups. They were fed with standard diet, high-cholesterol diet and high-cholesterol diet with 0.25, 0.5, 1.0 g/（ kg · d） LC. After the LC groups were consecutively orally administered LC for 28 days, rat serum total cholesterol （ TC）, triglyceride （TG）, high density lipoprotein （ HDL-C）, low density lipoprotein （LDL-C） content, as well as super oxide dismutase （SOD） activity and malondial- dehyde （MDA） content in serum and liver were determined. [ Reset~ Compared with the high-fat model group, LC could significantly reduce the se- rum TC, TG, LDL-C levels, increase HDL-C level, and enhance SOD activity in serum and liver, decrease the content of MDA （ P 〈0.05）. [ Con- Clusion] LC might have a significant role in lowering the high blood lipid and improving internal antioxidant capacity in hyperlipidemia rats.
