The effects of acrylamide on calmodulin (CaM), cAMP, cGMP, Ca2+, Mg2+-ATPase and 45Ca2+ uptake in nervous system were determined in Wistar rats (ip, 10 or 50 mg-kg-1 for 12 d). The results indicate that acrylamide cau...The effects of acrylamide on calmodulin (CaM), cAMP, cGMP, Ca2+, Mg2+-ATPase and 45Ca2+ uptake in nervous system were determined in Wistar rats (ip, 10 or 50 mg-kg-1 for 12 d). The results indicate that acrylamide caused an alteration in calcium homeostasis in rat brain by decreasing the Ca2+-sequestering capacity of microsomes, and this may occur due to an efflux of calcium secondary to a microsomal structure damage. The changes of CaM in nervous system coupled with potential alteration in the intracellular Ca2+ concentration could affect many CaM-dependent enzymes (i.e. Ca2+, Mg2+-ATPase) and cyclic AMP system, and CaM or cAMP is known to be 'lexicological second messenger' that could initiate neurotoxicity, though more work is needed to elucidate the details of the mechanism.展开更多
Tungsten dioxo complex WO 2(C 9H 6NO) 2 was obtained via the low temperature solid-state reaction of(NH 4) 2WS 4, 8-hydroxyquinoline(8-hq) and(CH 3) 4NI, and it was characterized by means of elemental analyse...Tungsten dioxo complex WO 2(C 9H 6NO) 2 was obtained via the low temperature solid-state reaction of(NH 4) 2WS 4, 8-hydroxyquinoline(8-hq) and(CH 3) 4NI, and it was characterized by means of elemental analyses, IR spectroscopy and X-ray diffraction analysis. The crystal of the title compound belongs to monoclinic, space group C2/c, with the crystal cell parameters: a=1.3316(3) nm, b=0.94444(19) nm, c=1.3485(3) nm, β=109.66(3)°, V=1.5970(6) nm 3, Z=6. The title compound possesses a supramolecular structure formed through hydrogen bonds and π-π stacking interactions. The third-order non-linear optical(NLO) properties of the title compound were also investigated. The third-order non-linear absorption coefficient α 2 and refractive index n 2 are 0.85×10 -11 m/W -1 and -1.5×10 -19 m 2/W, respectively. The third-order non-linear susceptibility χ (3) is 3.03×10 -13 esu for 3.8×10 -5 mol/L sample concentration.展开更多
Wall pressure fluctuation is one of the source terms which result in thevibration of hydraulic structures. To consider both the space and time correlation of the pressurefield. the method of proper orthogonal decompos...Wall pressure fluctuation is one of the source terms which result in thevibration of hydraulic structures. To consider both the space and time correlation of the pressurefield. the method of proper orthogonal decomposition and low-dimensional approximation were usedhere to describe the pressure signals of the turbulent boundary layer, the apron of the stillingpond and the vertically impinging jet.展开更多
基金This work was supported by the Key Projects of the 7th Five-Year Plan from the State Commission of Science and Technology (No.75-62-03-30).
文摘The effects of acrylamide on calmodulin (CaM), cAMP, cGMP, Ca2+, Mg2+-ATPase and 45Ca2+ uptake in nervous system were determined in Wistar rats (ip, 10 or 50 mg-kg-1 for 12 d). The results indicate that acrylamide caused an alteration in calcium homeostasis in rat brain by decreasing the Ca2+-sequestering capacity of microsomes, and this may occur due to an efflux of calcium secondary to a microsomal structure damage. The changes of CaM in nervous system coupled with potential alteration in the intracellular Ca2+ concentration could affect many CaM-dependent enzymes (i.e. Ca2+, Mg2+-ATPase) and cyclic AMP system, and CaM or cAMP is known to be 'lexicological second messenger' that could initiate neurotoxicity, though more work is needed to elucidate the details of the mechanism.
基金the National Natural Science Foundation of China(No.2 0 2 710 2 1)
文摘Tungsten dioxo complex WO 2(C 9H 6NO) 2 was obtained via the low temperature solid-state reaction of(NH 4) 2WS 4, 8-hydroxyquinoline(8-hq) and(CH 3) 4NI, and it was characterized by means of elemental analyses, IR spectroscopy and X-ray diffraction analysis. The crystal of the title compound belongs to monoclinic, space group C2/c, with the crystal cell parameters: a=1.3316(3) nm, b=0.94444(19) nm, c=1.3485(3) nm, β=109.66(3)°, V=1.5970(6) nm 3, Z=6. The title compound possesses a supramolecular structure formed through hydrogen bonds and π-π stacking interactions. The third-order non-linear optical(NLO) properties of the title compound were also investigated. The third-order non-linear absorption coefficient α 2 and refractive index n 2 are 0.85×10 -11 m/W -1 and -1.5×10 -19 m 2/W, respectively. The third-order non-linear susceptibility χ (3) is 3.03×10 -13 esu for 3.8×10 -5 mol/L sample concentration.
文摘Wall pressure fluctuation is one of the source terms which result in thevibration of hydraulic structures. To consider both the space and time correlation of the pressurefield. the method of proper orthogonal decomposition and low-dimensional approximation were usedhere to describe the pressure signals of the turbulent boundary layer, the apron of the stillingpond and the vertically impinging jet.
