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多肿瘤淋巴管癌栓自动检测模型效果评价研究
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作者 王春宝 丁彩霞 +5 位作者 罗阿丽 李涵生 杨喆 廉洁 崔磊 张冠军 《现代肿瘤医学》 CAS 北大核心 2023年第19期3572-3577,共6页
目的:测试并分析全局库(GLB)的淋巴管癌栓(lymphovascular infiltration,LVI)目标检测模型的检测效果及泛化能力。方法:随机选取西安交通大学第一附属医院病理科多癌种的淋巴管癌栓阳性及阴性病例共131例,所有切片均采用HE以及D2-40免... 目的:测试并分析全局库(GLB)的淋巴管癌栓(lymphovascular infiltration,LVI)目标检测模型的检测效果及泛化能力。方法:随机选取西安交通大学第一附属医院病理科多癌种的淋巴管癌栓阳性及阴性病例共131例,所有切片均采用HE以及D2-40免疫组化染色。实验分组包括病理医师人工阅片组、算法组以及算法辅助病理医师三组。分别统计三组检测LVI结果以及检测时间。结果:比较病理医师、纯算法和算法辅助病理医师的一致性显示:131例病例中显示三种模式下一致性Kappa值分别为较好(0.709、0.786、0.796)、轻微(0.208)和中等一致(0.412)。病理医师出错的最常见的原因是漏诊(n=8),第二是由于IHC染色问题(包括6例染色不足,而3例未着色)。其余包括2例组织裂隙,1例小静脉(D2-40未着色),3例原因不明。纯算法判断错误的原因,一方面是由于病理切片或染色技术引起的,例如游离小组织(15/63),非特异性或染色不足(14/63),气泡(8/63)等。另一方面是由于某些LVI的组织形态和检测目标的相似性而导致算法误判,例如腺体(14/63),血管(13/63)和周围小神经(5/63)等。三种模式下所花费时间分别为59.28 s、82.40 s和10.43 s。结论:我们的结果虽然证实了算法辅助病理诊断提高诊断效率的能力,然而,考虑到算法辅助诊断的落地,病理切片的质量控制问题不容忽视,此外应考虑是否按照不同系统或疾病开展多层次算法设计,并且尽可能通过大数据的积累以覆盖多种检测目标类似物的必要性。 展开更多
关键词 病理学 癌症 淋巴管浸润 算法 人工智能
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LAMOST天体光谱数据开放共享的回顾与展望 被引量:1
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作者 李珊珊 樊东卫 +17 位作者 崔辰州 何勃亮 陶一寒 霍志英 米琳莹 罗阿理 陈建军 侯文 孔啸 李荫碧 郭炎鑫 李双 李长华 许允飞 韩军 杨丝丝 杨涵溪 赵永恒 《中国科技资源导刊》 2022年第1期47-55,82,共10页
大天区面积多目标光纤光谱天文望远镜(LAMOST,也称郭守敬望远镜)是国家重大科技基础设施。其每天观测获取的原始数据及经过处理产生的次生数据,可以通过LAMOST数据发布平台实现开放共享。本文回顾近10年来LAMOST数据开放共享历程。对LAM... 大天区面积多目标光纤光谱天文望远镜(LAMOST,也称郭守敬望远镜)是国家重大科技基础设施。其每天观测获取的原始数据及经过处理产生的次生数据,可以通过LAMOST数据发布平台实现开放共享。本文回顾近10年来LAMOST数据开放共享历程。对LAMOST数据发布批次、数据概况、发布系统架构及功能等进行概述,并总结相关科学成果,展望未来发展。LAMOST数据开放共享促进了中国虚拟天文台技术的进步,符合未来科学数据管理的发展方向,推动了科研模式的变革。 展开更多
关键词 天文数据 开放共享 虚拟天文台 郭守敬望远镜 科学平台
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环境烟草烟雾对小鼠泪膜功能和角膜上皮组织结构的影响 被引量:2
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作者 李娟 郝江东 +6 位作者 乔妮妮 罗阿丽 张光伟 李勇 周颖 陈旭洋 年申 《眼科新进展》 CAS 北大核心 2020年第6期516-519,共4页
目的探讨环境烟草烟雾(enviromental tobacco smoke,ETS)对小鼠泪膜功能和角膜上皮组织结构的影响。方法选取SPF级c57BL雄性小鼠12只,随机分为对照组和ETS干预组,每组6只。对照组不进行ETS干预,ETS干预组进行ETS干预,每天2次,一次30 min... 目的探讨环境烟草烟雾(enviromental tobacco smoke,ETS)对小鼠泪膜功能和角膜上皮组织结构的影响。方法选取SPF级c57BL雄性小鼠12只,随机分为对照组和ETS干预组,每组6只。对照组不进行ETS干预,ETS干预组进行ETS干预,每天2次,一次30 min,干预12周。在干预前及干预后对各组小鼠进行泪膜功能检测,包括泪膜破裂时间、荧光素染色(FL)评分;干预后摘取小鼠角膜组织,行HE染色,在光学显微镜下观察小鼠角膜上皮结构变化情况。结果干预12周后,对照组泪膜破裂时间和FL评分与干预前相比,差异均无统计学意义(均为P>0.05);而ETS干预组泪膜破裂时间较干预前明显缩短,FL评分较干预前明显增加,差异均有统计学意义(均为P<0.05)。ETS干预组干预12周后泪膜破裂时间较对照组明显缩短,FL评分较对照组明显增加,差异均有统计学意义(均为P<0.05);两组干预前泪膜破裂时间和FL评分差异均不明显(均为P>0.05)。FL染色结果显示干预12周后,对照组小鼠角膜上皮完整,角膜染色呈阴性;ETS干预组整个角膜上皮荧光素着染区域明显增加,呈点片状。HE染色结果显示干预12周后,对照组未见角膜上皮层数的改变,厚度也基本未变,基底细胞仍为单层柱状上皮细胞,表层上皮较完整;ETS干预组可见角膜上皮细胞层数增多,厚度增加,细胞排列紊乱,表层上皮细胞有损失及脱落,角膜表面不光滑。干预前对照组小鼠上皮细胞为(5±1)层,干预后基本不变;ETS干预组干预后为(7±1)层;干预后两组上皮细胞层数比较差异有统计学意义(P<0.05)。结论ETS会影响小鼠泪膜功能,损伤小鼠角膜上皮的组织结构。 展开更多
关键词 环境烟草烟雾 泪膜功能 角膜上皮
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一种星系形态分类的新方法 被引量:2
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作者 王林倩 邱波 +3 位作者 罗阿理 孔啸 逯亚坤 郭小雨 《天文研究与技术》 CSCD 2022年第4期359-370,共12页
在天文学研究领域,星系的分类一直是一个热点和难点问题。近年来有学者将机器学习应用于星系形态的简单分类,但在分类过程中出现特征选择困难、特征遗漏、分类器选择困难等一系列问题。星系在视觉形态上可以分为椭圆星系、旋涡星系、透... 在天文学研究领域,星系的分类一直是一个热点和难点问题。近年来有学者将机器学习应用于星系形态的简单分类,但在分类过程中出现特征选择困难、特征遗漏、分类器选择困难等一系列问题。星系在视觉形态上可以分为椭圆星系、旋涡星系、透镜星系以及不规则星系。针对SDSS DR16,Galaxy Zoo2和EFIGI目录中星系的测光图像,提出了一种分类精度更高的星系形态分类(Galaxy Morphological Classification,GMC)方法。首先对图像进行剪裁、去噪,然后采用旋转、平移、缩放等方法进行数据增强,最后搭建了星系形态分类网络GMC-net对图像进行分类。从实验结果来看,旋涡星系、椭圆星系、透镜星系以及不规则星系分类精确率分别为98.29%,98.49%,99.18%和99.91%,召回率分别为98.44%,99.03%,98.89%和99.34%;对单独来自EFIGI目录中4种形态星系的分类准确率也达到了99.34%。实验结果表明,星系形态分类相较于其他分类方法表现更好,可以有效地用于星系的形态分类。 展开更多
关键词 星系形态分类 数据增强 卷积神经网络
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香烟烟雾对小鼠视网膜组织病理学结构的影响
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作者 罗阿丽 李娟 年申 《眼科新进展》 CAS 北大核心 2020年第1期6-10,共5页
目的探讨香烟烟雾对小鼠视网膜组织病理学结构的影响。方法选取12只C57BL雄性小鼠,随机分为对照组(6只)及实验组(6只)。对照组不做特殊处理,实验组小鼠暴露于香烟烟雾中,每天2次,每次30 min,持续暴露12周后处死。取两组小鼠左眼分别行H... 目的探讨香烟烟雾对小鼠视网膜组织病理学结构的影响。方法选取12只C57BL雄性小鼠,随机分为对照组(6只)及实验组(6只)。对照组不做特殊处理,实验组小鼠暴露于香烟烟雾中,每天2次,每次30 min,持续暴露12周后处死。取两组小鼠左眼分别行HE染色、免疫荧光染色及TUNEL染色观察视网膜各层结构的变化、三级β-微管蛋白(class IIIβ-tubulin,Tuj1)的表达及视网膜内细胞凋亡情况;两组小鼠右眼在透射电子显微镜下观察视网膜色素上皮(retinal pigment epithelium,RPE)细胞超微结构的改变。结果对照组及实验组小鼠视网膜全层厚度分别为(216.53±7.43)μm和(182.27±4.98)μm,视网膜神经纤维层厚度分别为(11.49±0.56)μm和(4.62±1.07)μm,内网状层厚度分别为(52.08±3.17)μm和(37.28±2.86)μm,两组相比差异均有统计学意义(均为P<0.05)。对照组和实验组视网膜神经节细胞层内细胞数分别为(389.72±4.56)个和(378.71±2.16)个,差异无统计学意义(P>0.05)。与对照组比较,实验组神经节细胞的细胞核部分形状不规则,排列疏密不均,局部可见细胞核缺失,Tuj1免疫荧光染色的荧光强度实验组较对照组减弱。TUNEL染色结果显示,两组视网膜各层均未见明确阳性染色。透射电子显微镜下观察,实验组RPE细胞内细胞基底部褶皱数量明显减少、局部有缺失。结论香烟烟雾对小鼠视网膜神经层的组织病理学结构及RPE细胞的超微结构均有一定影响。 展开更多
关键词 香烟烟雾 视网膜色素上皮细胞 视网膜神经纤维层 三级β-微管蛋白
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探秘超高速星
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作者 李荫碧 罗阿理 《大学科普》 2021年第2期62-64,共3页
一、引子这夏日的夜,静得出奇,耳边只有草丛中蟋蟀的叫声,倏忽间将我拽回儿时同样的夜晚,想起曾仰望星空的小小的自己。一直觉得,探索宇宙的种子可能是在那个夜晚悄悄走进了我心里。今夜,仰望苍穹,感慨万千。从事天文研究已十余年,研究... 一、引子这夏日的夜,静得出奇,耳边只有草丛中蟋蟀的叫声,倏忽间将我拽回儿时同样的夜晚,想起曾仰望星空的小小的自己。一直觉得,探索宇宙的种子可能是在那个夜晚悄悄走进了我心里。今夜,仰望苍穹,感慨万千。从事天文研究已十余年,研究高速星也即将十年。多年耕耘,虽然还有很多问题等待我们去解开,也请允许我带您走进超高速星的世界,探寻这种神秘恒星的前世今生。 展开更多
关键词 天文研究 仰望苍穹 仰望星空 前世今生 夜晚
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The effects of spectrograph slit modes on the accuracy of stellar radial velocity measurement and atmospheric parameter estimation 被引量:2
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作者 WANG FengFei ZHANG HaoTong +3 位作者 luo ali BAI ZhongRui DU Bing ZHAO YongHeng 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2013年第10期1833-1839,共7页
Spectrograph slit is conventionally used to enhance the spectral resolution and manage how much light can be allowed to enter spectrograph.The narrow slit provides a higher resolution but sacrifices efficiency of spec... Spectrograph slit is conventionally used to enhance the spectral resolution and manage how much light can be allowed to enter spectrograph.The narrow slit provides a higher resolution but sacrifices efficiency of spectrograph and results in a low signal to noise ratio(S/N) spectra product.We take GuoShouJing telescope as an example and carry out a series of experiments to study how its 2/3 slit mode affects the precision of stellar radial velocity measurement and atmosphere parameters estimate.By transforming the resolution and adding a Gaussian White Noise to the extremely high quality spectra from the Sloan Digital Sky Survey,we generate synthetic stellar spectra of various brightness with different S/Ns.Comparing the measurements on these noise added spectra with the original high quality ones,we summarize the influences of the 2/3 slit mode on the measurement accuracy of stellar radial velocity and atmospheric parameters. 展开更多
关键词 径向速度测量 大气参数 参数估计 狭缝 恒星 摄谱仪 光谱分辨率 信号噪声比
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A method of searching for supernova candidates from massive galaxy spectra 被引量:2
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作者 TU LiangPing luo ali +1 位作者 WU FuChao ZHAO YongHeng 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2010年第10期1928-1938,共11页
This paper presents a novel spectroscopic method for searching for supernova candidates from massive galaxy spectra,which is expected to be applied to the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAM... This paper presents a novel spectroscopic method for searching for supernova candidates from massive galaxy spectra,which is expected to be applied to the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST).This method includes mainly five steps.The first step is spectral preprocessing,including removing spectral noise using wavelet transform,spectral de-redshift,etc.The second step is decomposition of galactic spectra;we can get the galaxy component and supernova component and calculate the Supernova Statistical Characterization Vector (SNSCV) of each galaxy spectrum.The third step is to decrease samples in all the galaxy spectral datasets according to SNSCV of each spectrum,and to use the LOF (Local Outlier Factor)-based outlier detection algorithm to obtain the preliminary selected spectral data.The fourth step is template matching by cross-correlation,according to the matched results we get the secondary selected spectral data.Finally,we choose the final supernova candidates manually through checking the spectral features characteristic of a supernova.By the spectroscopic method proposed in this paper,thirty-six supernova candidates have been detected in a dataset including 294843 galaxy spectra from the Sloan Digital Sky Survey Data Release 7.Nine of these objects are detected first and the other twenty-seven have been reported in other publications (fifteen of which are detected and reported first by us).The twenty-four new super-nova candidates include twenty Ia type supernova candidates,three Ic type supernova candidates and one II type supernova candidate. 展开更多
关键词 SUPERNOVAE decomposition of galaxy spectrum sample decrease local outlier factor cross-correlation matching.
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Search for carbon stars and DZ white dwarfs in SDSS spectra survey through machine learning 被引量:1
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作者 SI JianMin luo ali +5 位作者 LI YinBi ZHANG JianNan WEI Peng WU YiHong WU FuChao ZHAO YongHeng 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2014年第1期176-186,共11页
Carbon stars and DZ white dwarfs are two types of rare objects in the Galaxy.In this paper,we have applied the label propagation algorithm to search for these two types of stars from Data Release Eight(DR8)of the Sloa... Carbon stars and DZ white dwarfs are two types of rare objects in the Galaxy.In this paper,we have applied the label propagation algorithm to search for these two types of stars from Data Release Eight(DR8)of the Sloan Digital Sky Survey(SDSS),which is verified to be efcient by calculating precision and recall.From nearly two million spectra including stars,galaxies and QSOs,we have found 260 new carbon stars in which 96 stars have been identified as dwarfs and 7 identified as giants,and 11 composition spectrum systems(each of them consists of a white dwarf and a carbon star).Similarly,using the label propagation method,we have obtained 29 new DZ white dwarfs from SDSS DR8.Compared with PCA reconstructed spectra,the 29 findings are typical DZ white dwarfs.We have also investigated their proper motions by comparing them with proper motion distribution of 9,374 white dwarfs,and found that they satisfy the current observed white dwarfs by SDSS generally have large proper motions.In addition,we have estimated their efective temperatures by fitting the polynomial relationship between efective temperature and g-r color of known DZ white dwarfs,and found 12 of the 29 new DZ white dwarfs are cool,in which nine are between 6,000 K and 6,600 K,and three are below 6,000 K. 展开更多
关键词 SDSS 白矮星 碳星 机器学习 光谱 搜索 有效温度 数字巡天
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New cross-matching algorithm in large-scale catalogs with ThreadPool technique 被引量:1
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作者 DU Peng REN JuanJuan +1 位作者 PAN JingChang luo ali 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2014年第3期577-583,共7页
We introduce an algorithm to solve the block-edge problem taking advantage of the two diferent sky splitting functions:HTM and HEALPix.We make the cross-match with the two functions,and then we obtain the union set of... We introduce an algorithm to solve the block-edge problem taking advantage of the two diferent sky splitting functions:HTM and HEALPix.We make the cross-match with the two functions,and then we obtain the union set of the two diferent sets.We use the ThreadPool technique to speed up the cross-match.In this way improved accuracy can be obtained on the cross-match.Our experiments show that this algorithm has a remarkable performance superiority compared with the previous ones and can be applied to the cross-match between large-scale catalogs.We give some ideas about solving the many-for-one situation occurred in the cross-match. 展开更多
关键词 匹配算法 线程池 技术 目录 性能优势 HTM 分割
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The spatial distribution of old neutron stars in the Galaxy 被引量:1
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作者 WEI YingChun ZHANG ChengMin +3 位作者 WU XinJi ZHAO YongHeng CHOU ChiKang luo ali 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2010年第10期1939-1946,共8页
The spatial distributions of old neutron stars (NSs) with ages 109 to 1010 yr in our Galaxy are investigated by Monte Carlo simulation under two different initial random velocity models.It is found that the scale heig... The spatial distributions of old neutron stars (NSs) with ages 109 to 1010 yr in our Galaxy are investigated by Monte Carlo simulation under two different initial random velocity models.It is found that the scale heights of the distribution increase with the Galactic radial distance.The location of the peak of the NS distribution is closer to the Galactic center than that of their progenitors.The results from our detailed numerical analysis reveal that there is resemblance between the simulated old NS distribution and the structure of the observed HI disk. 展开更多
关键词 neutron stars Galaxy structure Galaxy disk star evolution
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Unsupervised pseudoinverse hashing learning model for rare astronomical object retrieval
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作者 WANG Ke GUO Ping +1 位作者 luo ali XU MingLiang 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2022年第6期1338-1348,共11页
Searching for rare astronomical objects based on spectral data is similar to finding needles in a haystack owing to their rarity and the immense data volume gathered from large astronomical spectroscopic surveys.In th... Searching for rare astronomical objects based on spectral data is similar to finding needles in a haystack owing to their rarity and the immense data volume gathered from large astronomical spectroscopic surveys.In this paper,we propose a novel automated approximate nearest neighbor search method based on unsupervised hashing learning for rare spectra retrieval.The proposed method employs a multilayer neural network using autoencoders as the local compact feature extractors.Autoencoders are trained with a non-gradient learning algorithm with graph Laplace regularization.This algorithm also simplifies the tuning of network architecture hyperparameters and the learning control hyperparameters.Meanwhile,the graph Laplace regularization can enhance the robustness by reducing the sensibility to noise.The proposed model is data-driven;thus,it can be viewed as a general-purpose retrieval model.The proposed model is evaluated in experiments and real-world applications where rare Otype stars and their subclass are retrieved from the dataset obtained from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope(Guo Shoujing Telescope).The experimental and application results show that the proposed model outperformed the baseline methods,demonstrating the effectiveness of the proposed method in rare spectra retrieval tasks. 展开更多
关键词 compact features unsupervised hashing object retrieval pseudoinverse learning
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