“炎-癌转化”是宫颈由高危型人乳头瘤病毒(high-risk human papillomavirus,HR-HPV)感染发展至宫颈癌的重要机制之一。持续性宫颈HR-HPV感染作为宫颈癌的重要诱因,其引起的局部非可控性炎症微环境是宫颈癌发生的内在机制。“炎-癌转化...“炎-癌转化”是宫颈由高危型人乳头瘤病毒(high-risk human papillomavirus,HR-HPV)感染发展至宫颈癌的重要机制之一。持续性宫颈HR-HPV感染作为宫颈癌的重要诱因,其引起的局部非可控性炎症微环境是宫颈癌发生的内在机制。“炎-癌转化”的宏观及微观病理过程均与中医“湿热蕴毒”的病机演变相契合,湿热聚结为“炎-癌转化”的驱动因素;湿热久蕴致脾虚肝郁为其病机演变特征;湿热久稽,肝脾失调,瘀滞蕴结胞门,终成“癌毒”。持续性宫颈HR-HPV感染所致的“炎-癌转化”进程主要责之于中医的湿、热、虚、毒病理因素。调控持续性宫颈HR-HPV感染炎性微环境为宫颈癌防治的重要途径。临证时以清热燥湿、健脾疏肝为核心治法,攻伐有道、内外同调,以截断“炎-癌转化”的进程。基于“湿热蕴毒”探讨持续性宫颈HR-HPV感染“炎-癌转化”进程,可为中医防治宫颈癌及中医药干预“炎-癌转化”提供思路。展开更多
Soil microbial communities and enzyme activities play key roles in soil ecosystems.Both are sensitive to changes in environmental factors,including seasonal temperature,precipitation variations and soil properties.To ...Soil microbial communities and enzyme activities play key roles in soil ecosystems.Both are sensitive to changes in environmental factors,including seasonal temperature,precipitation variations and soil properties.To understand the interactive mechanisms of seasonal changes that affect soil microbial communities and enzyme activities in a subtropical masson pine(Pinus massoniana)forest,we investigated the soil microbial community structure and enzyme activities to identify the effect of seasonal changes on the soil microbial community for two years in Jinyun Mountain National Nature Reserve,Chongqing,China.The soil microbial community structure was investigated using phospholipid fatty acids(PLFAs).The results indicated that a total of 36 different PLFAs were identified,and 16:0 was found in the highest proportions in the four seasons,moreover,the total PLFAs abundance were highest in spring and lowest in winter.Bacteria and actinomycetes were the dominant types in the study area.Seasonal changes also had a significant(P<0.05)influence on the soil enzyme activity.The maximum and minimum values of the invertase and catalase activities were observed in autumn and winter,respectively.However,the maximum and minimum values of the urease and phosphatase acid enzymatic activities were found in spring and winter,respectively.Canonical correspondence analysis(CCA)analysis revealed that the seasonal shifts in soil community composition and enzyme activities were relatively more sensitive to soil moisture and temperature,but the microbial community structure and enzyme activity were not correlated with soil pH in the study region.This study highlights how the seasonal variations affect the microbial community and function(enzyme activity)to better understand and predict microbial responses to future climate regimes in subtropical area.展开更多
文摘“炎-癌转化”是宫颈由高危型人乳头瘤病毒(high-risk human papillomavirus,HR-HPV)感染发展至宫颈癌的重要机制之一。持续性宫颈HR-HPV感染作为宫颈癌的重要诱因,其引起的局部非可控性炎症微环境是宫颈癌发生的内在机制。“炎-癌转化”的宏观及微观病理过程均与中医“湿热蕴毒”的病机演变相契合,湿热聚结为“炎-癌转化”的驱动因素;湿热久蕴致脾虚肝郁为其病机演变特征;湿热久稽,肝脾失调,瘀滞蕴结胞门,终成“癌毒”。持续性宫颈HR-HPV感染所致的“炎-癌转化”进程主要责之于中医的湿、热、虚、毒病理因素。调控持续性宫颈HR-HPV感染炎性微环境为宫颈癌防治的重要途径。临证时以清热燥湿、健脾疏肝为核心治法,攻伐有道、内外同调,以截断“炎-癌转化”的进程。基于“湿热蕴毒”探讨持续性宫颈HR-HPV感染“炎-癌转化”进程,可为中医防治宫颈癌及中医药干预“炎-癌转化”提供思路。
基金supported by the National Key Research and Developmental Program of China(2016YFC0502303)the Special Fund for Department of Water Resources of Guizhou Province,China(KT201617)。
文摘Soil microbial communities and enzyme activities play key roles in soil ecosystems.Both are sensitive to changes in environmental factors,including seasonal temperature,precipitation variations and soil properties.To understand the interactive mechanisms of seasonal changes that affect soil microbial communities and enzyme activities in a subtropical masson pine(Pinus massoniana)forest,we investigated the soil microbial community structure and enzyme activities to identify the effect of seasonal changes on the soil microbial community for two years in Jinyun Mountain National Nature Reserve,Chongqing,China.The soil microbial community structure was investigated using phospholipid fatty acids(PLFAs).The results indicated that a total of 36 different PLFAs were identified,and 16:0 was found in the highest proportions in the four seasons,moreover,the total PLFAs abundance were highest in spring and lowest in winter.Bacteria and actinomycetes were the dominant types in the study area.Seasonal changes also had a significant(P<0.05)influence on the soil enzyme activity.The maximum and minimum values of the invertase and catalase activities were observed in autumn and winter,respectively.However,the maximum and minimum values of the urease and phosphatase acid enzymatic activities were found in spring and winter,respectively.Canonical correspondence analysis(CCA)analysis revealed that the seasonal shifts in soil community composition and enzyme activities were relatively more sensitive to soil moisture and temperature,but the microbial community structure and enzyme activity were not correlated with soil pH in the study region.This study highlights how the seasonal variations affect the microbial community and function(enzyme activity)to better understand and predict microbial responses to future climate regimes in subtropical area.
