目的探讨格列齐特联合阿卡波糖治疗2型糖尿病(T2DM)的临床效果。方法选取2019年6月~2020年7月阳江市阳东区人民医院收治的100例T2DM患者作为研究对象,采用随机数字表法将其分为对照组与观察组,每组各50例。对照组患者给予阿卡波糖治疗,...目的探讨格列齐特联合阿卡波糖治疗2型糖尿病(T2DM)的临床效果。方法选取2019年6月~2020年7月阳江市阳东区人民医院收治的100例T2DM患者作为研究对象,采用随机数字表法将其分为对照组与观察组,每组各50例。对照组患者给予阿卡波糖治疗,观察组患者在对照组的基础上联合格列齐特治疗,疗程为12周。比较治疗前及治疗后两组患者的空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、血清超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平及治疗期间不良反应发生情况。结果治疗前两组患者的FPG、2 h PG、HbA1c水平比较,差异无统计学意义(P>0.05);治疗后两组患者的FPG、2 h PG、HbA1c水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前两组患者的hs-CRP、IL-6、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后两组患者hs-CRP、IL-6、TNF-α水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论格列齐特联合阿卡波糖治疗T2DM可有效降低FPG、2 h PG、HbA1c、hs-CRP、IL-6、TNF-α水平,不增加不良反应。展开更多
Nd0.7 Sr0.3MnO3 ceramics with secondary phases were prepared by ball-milling and post heat- treatment at 1623 K for 3,7 and 13h,respectively.The results from x-ray diffraction and energy dispersed spectroscopy show th...Nd0.7 Sr0.3MnO3 ceramics with secondary phases were prepared by ball-milling and post heat- treatment at 1623 K for 3,7 and 13h,respectively.The results from x-ray diffraction and energy dispersed spectroscopy show that some secondary phases are introduced and grow gradually with sintering time.These secondary phases have significant effects on the ac transport.For all the samples,the real part of impedance (Zr) decreases with increasing frequency and the Zr peak moves to a higher temperature.Interestingly,for a given frequency the Zr peak decreases with sintering time.However,for samples B and C which were sintered for a longer time than sample A,an additional Zr peak appears at a higher temperature and gradually increases with sintering time.The reposition of trapped charges in phase/grain boundaries or secondary phases is supposed to be responsible for the unusual relaxation process.展开更多
Electrical transport properties of the interface between a Nd_(0.7)Sr_(0.3)MnO_(3) ceramic and a Ag electrode are investigated using the ac impedance over a wide temperature and frequency ranges.The ac impedance measu...Electrical transport properties of the interface between a Nd_(0.7)Sr_(0.3)MnO_(3) ceramic and a Ag electrode are investigated using the ac impedance over a wide temperature and frequency ranges.The ac impedance measurements give the compressed semicircle arcs at different temperatures,which are used for the analysis of different contributions to electrical transport based on an electrical equivalent circuit.A significant interface-dependent electroresistance effect of 530% is clearly developed around the metal-insulator transition temperature 130K,which is confirmed as the interface-layer dependent Curie temperature by the plot of interfacial conductance with frequency at different temperatures.展开更多
文摘目的探讨格列齐特联合阿卡波糖治疗2型糖尿病(T2DM)的临床效果。方法选取2019年6月~2020年7月阳江市阳东区人民医院收治的100例T2DM患者作为研究对象,采用随机数字表法将其分为对照组与观察组,每组各50例。对照组患者给予阿卡波糖治疗,观察组患者在对照组的基础上联合格列齐特治疗,疗程为12周。比较治疗前及治疗后两组患者的空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、血清超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平及治疗期间不良反应发生情况。结果治疗前两组患者的FPG、2 h PG、HbA1c水平比较,差异无统计学意义(P>0.05);治疗后两组患者的FPG、2 h PG、HbA1c水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前两组患者的hs-CRP、IL-6、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后两组患者hs-CRP、IL-6、TNF-α水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论格列齐特联合阿卡波糖治疗T2DM可有效降低FPG、2 h PG、HbA1c、hs-CRP、IL-6、TNF-α水平,不增加不良反应。
基金Supported by the Program for New Century Excellent Talents in University under Grant No NCET-08-0674.
文摘Nd0.7 Sr0.3MnO3 ceramics with secondary phases were prepared by ball-milling and post heat- treatment at 1623 K for 3,7 and 13h,respectively.The results from x-ray diffraction and energy dispersed spectroscopy show that some secondary phases are introduced and grow gradually with sintering time.These secondary phases have significant effects on the ac transport.For all the samples,the real part of impedance (Zr) decreases with increasing frequency and the Zr peak moves to a higher temperature.Interestingly,for a given frequency the Zr peak decreases with sintering time.However,for samples B and C which were sintered for a longer time than sample A,an additional Zr peak appears at a higher temperature and gradually increases with sintering time.The reposition of trapped charges in phase/grain boundaries or secondary phases is supposed to be responsible for the unusual relaxation process.
基金Supported by the National Natural Science Foundation of China under Grant Nos 10774040,11174073 and 10911120055/A0402the Program for New Century Excellent Talents in University under Grant No NCET-08-0674the Joint Chinese-Russian Project under Grant No 08-02-92205。
文摘Electrical transport properties of the interface between a Nd_(0.7)Sr_(0.3)MnO_(3) ceramic and a Ag electrode are investigated using the ac impedance over a wide temperature and frequency ranges.The ac impedance measurements give the compressed semicircle arcs at different temperatures,which are used for the analysis of different contributions to electrical transport based on an electrical equivalent circuit.A significant interface-dependent electroresistance effect of 530% is clearly developed around the metal-insulator transition temperature 130K,which is confirmed as the interface-layer dependent Curie temperature by the plot of interfacial conductance with frequency at different temperatures.
