To the Editor:Lung fibrosis is characterized by extracellular matrix accumulation and remodeling of the lung interstitium.Although lung fibrosis has been extensively studied,there is still a lack of effective anti-pul...To the Editor:Lung fibrosis is characterized by extracellular matrix accumulation and remodeling of the lung interstitium.Although lung fibrosis has been extensively studied,there is still a lack of effective anti-pulmonary fibrosis drugs at present.The pathogenesis of lung fibrosis involves many aspects in which the lung macrophages play a particularly important role.[1]It has been reported that the manipulation of the monocyte/macrophage phenotype switch might be a potential target for many macrophagemediated inflammatory disorders.In our previous study,mice that were exposed to bleomycin(BLM)showed a dynamic change of mononuclear phagocytes in the circulating system,lung alveoli,and interstitial compartments.The rapid increase of the number of circulating Ly6Chi monocytes after BLM stimulation,followed by the expansion of M2-like alveolar macrophages(AMf)numbers,is closely associated with lung inflammatory response and fibrosis.[2,3]展开更多
Objective:To investigate the constituent ratio and clinical features of diffuse interstitial lung disease(DILD)in Tianjin,and to identify the existing problems of its diagnosis and treatment.Methods:Data of all patien...Objective:To investigate the constituent ratio and clinical features of diffuse interstitial lung disease(DILD)in Tianjin,and to identify the existing problems of its diagnosis and treatment.Methods:Data of all patients diagnosed as DILD in ten comprehensive hospitals in Tianjin from 2003 to 2009 was collected.The disease constituent ratio of DILD to all kinds of diseases in the respiration department or in the whole hospital,the clinical manifestation,lung function,the result of blood gas analysis,and biopsy were analyzed.Results:A total of 804 DILD patients were included in the study aged(69.28±12.09)years with a male/female ratio of 1.32.The disease constituent ratios of DILD were 4.52‰in respiratory department and 0.31‰in the whole hospital in 2003,which increased to 35.9‰and 1.51‰respectively in 2009.Reticular abnormality(43.1%),ground glass(25.6%)and honeycombing(11.4%)were the predominant imaging manifestations.26.7%patients’lung function were tested,and 10.3%had diffusion function tests.Most patients presented with hypoxemia,and the average oxygenation index was(281±98.3)mmHg.Only 4.0%of patients underwent bronchoalveolar lavage,and 3.5%had pathologic data.Conclusion:The disease constituent ratio of DILD increased progressively from 2003 to 2009.A definite diagnosis of DILD demands cooperation of physicians,radiologists and pathologists.Doctors should attach more importance on lung function test,bronchoalveolar lavage and biopsy.展开更多
基金supported by a grant from Tianjin Municipal Science and Technology Committee(No.18JCZDJC12000).
文摘To the Editor:Lung fibrosis is characterized by extracellular matrix accumulation and remodeling of the lung interstitium.Although lung fibrosis has been extensively studied,there is still a lack of effective anti-pulmonary fibrosis drugs at present.The pathogenesis of lung fibrosis involves many aspects in which the lung macrophages play a particularly important role.[1]It has been reported that the manipulation of the monocyte/macrophage phenotype switch might be a potential target for many macrophagemediated inflammatory disorders.In our previous study,mice that were exposed to bleomycin(BLM)showed a dynamic change of mononuclear phagocytes in the circulating system,lung alveoli,and interstitial compartments.The rapid increase of the number of circulating Ly6Chi monocytes after BLM stimulation,followed by the expansion of M2-like alveolar macrophages(AMf)numbers,is closely associated with lung inflammatory response and fibrosis.[2,3]
文摘Objective:To investigate the constituent ratio and clinical features of diffuse interstitial lung disease(DILD)in Tianjin,and to identify the existing problems of its diagnosis and treatment.Methods:Data of all patients diagnosed as DILD in ten comprehensive hospitals in Tianjin from 2003 to 2009 was collected.The disease constituent ratio of DILD to all kinds of diseases in the respiration department or in the whole hospital,the clinical manifestation,lung function,the result of blood gas analysis,and biopsy were analyzed.Results:A total of 804 DILD patients were included in the study aged(69.28±12.09)years with a male/female ratio of 1.32.The disease constituent ratios of DILD were 4.52‰in respiratory department and 0.31‰in the whole hospital in 2003,which increased to 35.9‰and 1.51‰respectively in 2009.Reticular abnormality(43.1%),ground glass(25.6%)and honeycombing(11.4%)were the predominant imaging manifestations.26.7%patients’lung function were tested,and 10.3%had diffusion function tests.Most patients presented with hypoxemia,and the average oxygenation index was(281±98.3)mmHg.Only 4.0%of patients underwent bronchoalveolar lavage,and 3.5%had pathologic data.Conclusion:The disease constituent ratio of DILD increased progressively from 2003 to 2009.A definite diagnosis of DILD demands cooperation of physicians,radiologists and pathologists.Doctors should attach more importance on lung function test,bronchoalveolar lavage and biopsy.
