目的:建立和验证一个涉及多级临床场景的白内障协作通用的人工智能(artificial intelligence,AI)管理平台,探索基于AI的医疗转诊模式,以提高协作效率和资源覆盖率。方法:训练和验证的数据集来自中国AI医学联盟,涵盖多级医疗机构和采集...目的:建立和验证一个涉及多级临床场景的白内障协作通用的人工智能(artificial intelligence,AI)管理平台,探索基于AI的医疗转诊模式,以提高协作效率和资源覆盖率。方法:训练和验证的数据集来自中国AI医学联盟,涵盖多级医疗机构和采集模式。使用三步策略对数据集进行标记:1)识别采集模式;2)白内障诊断包括正常晶体眼、白内障眼或白内障术后眼;3)从病因和严重程度检测需转诊的白内障患者。此外,将白内障AI系统与真实世界中的居家自我监测、初级医疗保健机构和专科医院等多级转诊模式相结合。结果:通用AI平台和多级协作模式在三步任务中表现出可靠的诊断性能:1)识别采集模式的受试者操作特征(receiver operating characteristic curve,ROC)曲线下面积(area under the curve,AUC)为99.28%~99.71%);2)白内障诊断对正常晶体眼、白内障或术后眼,在散瞳-裂隙灯模式下的AUC分别为99.82%、99.96%和99.93%,其他采集模式的AUC均>99%;3)需转诊白内障的检测(在所有测试中AUC>91%)。在真实世界的三级转诊模式中,该系统建议30.3%的人转诊,与传统模式相比,眼科医生与人群服务比率大幅提高了10.2倍。结论:通用AI平台和多级协作模式显示了准确的白内障诊断性能和有效的白内障转诊服务。建议AI的医疗转诊模式扩展应用到其他常见疾病和资源密集型情景当中。展开更多
Objective:To systematically evaluate the efficacy and safety of Fuke Qianjin Tablets(妇科千金片)in the treatment of chronic pelvic inflammation.Methods:A systematically and comprehensively search was conducted in 4 Ch...Objective:To systematically evaluate the efficacy and safety of Fuke Qianjin Tablets(妇科千金片)in the treatment of chronic pelvic inflammation.Methods:A systematically and comprehensively search was conducted in 4 Chinese databases of CNKI,VIP,Wan Fang and CBM and the foreign language databases of Pubmed,EMbase and The Cochrane Library.The retrieval time was from database establishment to March 2019.The randomized controlled trials of Fuke Qianjin Tablets(妇科千金片)in the treatment of chronic pelvic inflammation were selected according to the predetermined criteria.The quality of the included study was evaluated by Cochrane collaborative network bias risk evaluation tool,and the meta-analysis was performed by Rev Man5.3 software.Results:A total of 1009 related literatures were searched.After initial screening and strict evaluation,55 studies were included,with a total sample size of 6826 cases,including 3416 cases in the experiment group and 3410 cases in the control group.The results of meta-analysis showed that the total effective rate of Fuke Qianjin Tablets(妇科千金片)combined with antibiotics in the treatment of chronic pelvic inflammation was better than that of antibiotics alone(RR=1.20,95%CI[1.17,1.22],P<0.00001).Fuke Qianjin Tablets(妇科千金片)combined with antibiotics was better than that of antibiotics alone in the improvement of abdominal pain symptoms(RR=1.40,95%CI[1.04,1.88],P<0.00001),leukorrhea abnormality(RR=1.38,95%CI[1.16,1.65],P<0.0004).In terms of safety,Fuke Qianjin Tablets(妇科千金片)combined with antibiotics could reduce the incidence of adverse reactions(RR=0.67,95%CI[0.48,0.93],P<0.02).The main adverse reactions were nausea and vomiting,bitterness and astringency in the mouth,rash and so on.All of them could be tolerated and the symptoms could disappear in the short term,and had no effect on the treatment.Conclusion:Fuke Qianjin Tablets(妇科千金片)combined with antibiotics in the treatment of chronic pelvic inflammation can improve the total effective rate,relieve abdominal pain and abnormal leukorrhea and other clinical discomfort symptoms,improve the quality of life of patients to a certain extent,and no serious adverse reactions are found.Due to the limitation of the quality and quantity of the included literature,the above conclusions need to be further studied and verified by high-quality research.展开更多
Shear wave splitting is studied based on the digital waveforms of three seismic stations DJS, SZD and WUJ, which were set up after the Jiujiang-Ruichang MS5.7 earthquake of November 26, 2005 around the epicenter area....Shear wave splitting is studied based on the digital waveforms of three seismic stations DJS, SZD and WUJ, which were set up after the Jiujiang-Ruichang MS5.7 earthquake of November 26, 2005 around the epicenter area. The result shows that the time delays of slow shear waves of the DJS station, which is not far from the epicenter and where the distribution of faults is complex near the station, are relatively larger and the polarization directions of fast shear waves are not concentrated; the predominant polarization direction of fast shear waves of WUJ station, with single fault distributed nearby, has a difference of 35° to the strike of the fault and is inconsistent with the direction of regional principal compressive stress. The predominant polarization direction of fast shear waves of SZD station with no faults nearby is in accordance with regional principal compressive stress. There is no obvious regular relationshipship between the delay time and the focal depth.展开更多
系统评价宁泌泰胶囊治疗慢性前列腺炎的临床疗效与安全性。整合中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献数据库(SinoMed)、Cochrane Library、PubMed、EMbase、Medline、Web of Science中截至到2022年7月的宁泌泰...系统评价宁泌泰胶囊治疗慢性前列腺炎的临床疗效与安全性。整合中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献数据库(SinoMed)、Cochrane Library、PubMed、EMbase、Medline、Web of Science中截至到2022年7月的宁泌泰胶囊治疗慢性前列腺炎相关文献,最终筛选出宁泌泰胶囊治疗慢性前列腺炎的随机对照试验(RCTs),并综合采用国际Cochrane协作组提供的ROB工具与RevMan 5.3软件进行数据整合与Meta分析。共纳入21项研究,总样本量2584例,试验组1289例,对照组1295例。结果显示,宁泌泰胶囊+常规西医药物/宁泌泰胶囊单药治疗慢性前列腺炎患者的治愈率(RR=1.60,95%CI[1.28,2.00],P<0.0001;RR=1.63,95%CI[1.35,1.97],P<0.00001;RR=1.89,95%CI[1.43,2.48],P<0.00001)、白介素水平(MDIL-2=-10.09,95%CI[-14.13,-6.04],P<0.00001;MDIL-6=-35.06,95%CI[-37.44,-32.68],P<0.00001;MDIL-10=-118.59,95%CI[-124.41,-112.77],P<0.00001;MD(IL-1β(ng/L))=-17.13,95%CI[-22.31,-11.95],P<0.00001;MD(IL-1β(μg/L))=-0.48,95%CI[-0.50,-0.45],P<0.00001)、NIH-CPSI评分(MD=-3.70,95%CI[-6.04,-1.37],P=0.002;MD=-5.43,95%CI[-6.51,-4.34],P<0.00001;MD=-7.65,95%CI[-14.77,-0.52],P=0.04)、均优于仅使用常规西医药物治疗;宁泌泰胶囊+盐酸坦洛新可改善慢性前列腺炎患者的尿动力学指标(MDMFR=14.17,95%CI[13.50,14.84],P<0.00001;MDRVU=-5.05,95%CI[-5.62,-4.48],P<0.00001)。不良反应主要为胃肠道反应,均较轻微。基于现有数据分析,宁泌泰胶囊联合常规西药/单用治疗可提高慢性前列腺炎患者的治愈率,改善白介素水平、尿动力学指标、NIH-CPSI评分,且暂未发现严重的不良反应。纳入高质量文献所占比例低,提示今后研究需纳入设计严谨、样本量充足、结局指标完备的临床观察实验以更有效验证宁泌泰胶囊治疗慢性前列腺炎的临床疗效与安全性。展开更多
文摘目的:建立和验证一个涉及多级临床场景的白内障协作通用的人工智能(artificial intelligence,AI)管理平台,探索基于AI的医疗转诊模式,以提高协作效率和资源覆盖率。方法:训练和验证的数据集来自中国AI医学联盟,涵盖多级医疗机构和采集模式。使用三步策略对数据集进行标记:1)识别采集模式;2)白内障诊断包括正常晶体眼、白内障眼或白内障术后眼;3)从病因和严重程度检测需转诊的白内障患者。此外,将白内障AI系统与真实世界中的居家自我监测、初级医疗保健机构和专科医院等多级转诊模式相结合。结果:通用AI平台和多级协作模式在三步任务中表现出可靠的诊断性能:1)识别采集模式的受试者操作特征(receiver operating characteristic curve,ROC)曲线下面积(area under the curve,AUC)为99.28%~99.71%);2)白内障诊断对正常晶体眼、白内障或术后眼,在散瞳-裂隙灯模式下的AUC分别为99.82%、99.96%和99.93%,其他采集模式的AUC均>99%;3)需转诊白内障的检测(在所有测试中AUC>91%)。在真实世界的三级转诊模式中,该系统建议30.3%的人转诊,与传统模式相比,眼科医生与人群服务比率大幅提高了10.2倍。结论:通用AI平台和多级协作模式显示了准确的白内障诊断性能和有效的白内障转诊服务。建议AI的医疗转诊模式扩展应用到其他常见疾病和资源密集型情景当中。
基金National Key Research and Development Plan Project(2018YFC1707400)Basic Business Expense Project of Central Public Welfare Research Institutes(Z0605)。
文摘Objective:To systematically evaluate the efficacy and safety of Fuke Qianjin Tablets(妇科千金片)in the treatment of chronic pelvic inflammation.Methods:A systematically and comprehensively search was conducted in 4 Chinese databases of CNKI,VIP,Wan Fang and CBM and the foreign language databases of Pubmed,EMbase and The Cochrane Library.The retrieval time was from database establishment to March 2019.The randomized controlled trials of Fuke Qianjin Tablets(妇科千金片)in the treatment of chronic pelvic inflammation were selected according to the predetermined criteria.The quality of the included study was evaluated by Cochrane collaborative network bias risk evaluation tool,and the meta-analysis was performed by Rev Man5.3 software.Results:A total of 1009 related literatures were searched.After initial screening and strict evaluation,55 studies were included,with a total sample size of 6826 cases,including 3416 cases in the experiment group and 3410 cases in the control group.The results of meta-analysis showed that the total effective rate of Fuke Qianjin Tablets(妇科千金片)combined with antibiotics in the treatment of chronic pelvic inflammation was better than that of antibiotics alone(RR=1.20,95%CI[1.17,1.22],P<0.00001).Fuke Qianjin Tablets(妇科千金片)combined with antibiotics was better than that of antibiotics alone in the improvement of abdominal pain symptoms(RR=1.40,95%CI[1.04,1.88],P<0.00001),leukorrhea abnormality(RR=1.38,95%CI[1.16,1.65],P<0.0004).In terms of safety,Fuke Qianjin Tablets(妇科千金片)combined with antibiotics could reduce the incidence of adverse reactions(RR=0.67,95%CI[0.48,0.93],P<0.02).The main adverse reactions were nausea and vomiting,bitterness and astringency in the mouth,rash and so on.All of them could be tolerated and the symptoms could disappear in the short term,and had no effect on the treatment.Conclusion:Fuke Qianjin Tablets(妇科千金片)combined with antibiotics in the treatment of chronic pelvic inflammation can improve the total effective rate,relieve abdominal pain and abnormal leukorrhea and other clinical discomfort symptoms,improve the quality of life of patients to a certain extent,and no serious adverse reactions are found.Due to the limitation of the quality and quantity of the included literature,the above conclusions need to be further studied and verified by high-quality research.
基金sponsored by the China Spark Program of Earthquake Science and Technology(XH12027)the Three-Combination Topics of China Earthquake Administration of"Research on the Crustal Medium Anisotropy in the Jiujiang-Ruichang Earthquake Area"the Special Fund of Seismic Industry Research(201008007)
文摘Shear wave splitting is studied based on the digital waveforms of three seismic stations DJS, SZD and WUJ, which were set up after the Jiujiang-Ruichang MS5.7 earthquake of November 26, 2005 around the epicenter area. The result shows that the time delays of slow shear waves of the DJS station, which is not far from the epicenter and where the distribution of faults is complex near the station, are relatively larger and the polarization directions of fast shear waves are not concentrated; the predominant polarization direction of fast shear waves of WUJ station, with single fault distributed nearby, has a difference of 35° to the strike of the fault and is inconsistent with the direction of regional principal compressive stress. The predominant polarization direction of fast shear waves of SZD station with no faults nearby is in accordance with regional principal compressive stress. There is no obvious regular relationshipship between the delay time and the focal depth.
文摘系统评价宁泌泰胶囊治疗慢性前列腺炎的临床疗效与安全性。整合中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献数据库(SinoMed)、Cochrane Library、PubMed、EMbase、Medline、Web of Science中截至到2022年7月的宁泌泰胶囊治疗慢性前列腺炎相关文献,最终筛选出宁泌泰胶囊治疗慢性前列腺炎的随机对照试验(RCTs),并综合采用国际Cochrane协作组提供的ROB工具与RevMan 5.3软件进行数据整合与Meta分析。共纳入21项研究,总样本量2584例,试验组1289例,对照组1295例。结果显示,宁泌泰胶囊+常规西医药物/宁泌泰胶囊单药治疗慢性前列腺炎患者的治愈率(RR=1.60,95%CI[1.28,2.00],P<0.0001;RR=1.63,95%CI[1.35,1.97],P<0.00001;RR=1.89,95%CI[1.43,2.48],P<0.00001)、白介素水平(MDIL-2=-10.09,95%CI[-14.13,-6.04],P<0.00001;MDIL-6=-35.06,95%CI[-37.44,-32.68],P<0.00001;MDIL-10=-118.59,95%CI[-124.41,-112.77],P<0.00001;MD(IL-1β(ng/L))=-17.13,95%CI[-22.31,-11.95],P<0.00001;MD(IL-1β(μg/L))=-0.48,95%CI[-0.50,-0.45],P<0.00001)、NIH-CPSI评分(MD=-3.70,95%CI[-6.04,-1.37],P=0.002;MD=-5.43,95%CI[-6.51,-4.34],P<0.00001;MD=-7.65,95%CI[-14.77,-0.52],P=0.04)、均优于仅使用常规西医药物治疗;宁泌泰胶囊+盐酸坦洛新可改善慢性前列腺炎患者的尿动力学指标(MDMFR=14.17,95%CI[13.50,14.84],P<0.00001;MDRVU=-5.05,95%CI[-5.62,-4.48],P<0.00001)。不良反应主要为胃肠道反应,均较轻微。基于现有数据分析,宁泌泰胶囊联合常规西药/单用治疗可提高慢性前列腺炎患者的治愈率,改善白介素水平、尿动力学指标、NIH-CPSI评分,且暂未发现严重的不良反应。纳入高质量文献所占比例低,提示今后研究需纳入设计严谨、样本量充足、结局指标完备的临床观察实验以更有效验证宁泌泰胶囊治疗慢性前列腺炎的临床疗效与安全性。
