With a great difference in therapeutic effects of Mahuang(MH, the stems of Ephedra sinica) and Mahuanggen(MHG, the roots of Ephedra sinica), chemical differences between MH and MHG should be investigated. In the prese...With a great difference in therapeutic effects of Mahuang(MH, the stems of Ephedra sinica) and Mahuanggen(MHG, the roots of Ephedra sinica), chemical differences between MH and MHG should be investigated. In the present study, gas chromatography-mass spectrometry(GC-MS)-based plant metabolomics was employed to compare volatile oil profiles of MH and MHG. The antioxidant activities of volatile oils from MH and MHG were also compared. 32 differential chemical markers were identified according to the variable importance in the projection(VIP) value of orthogonal partial least squares discriminant analysis(OPLS-DA) and P value of Mann-Whitney test. Among them, chemical markers of tetramethylpyrazine(TMP) and α-terpineol were quantified. Their contents were much higher in most MH samples compared with MHG. The antioxidant assay demonstrated that MH had significantly higher free radical-scavenging activity than MHG. Although MH and MHG derived from the same medicinal plant, there was much difference in their volatile oil profiles. MH samples had significantly higher content of two reported pharmacologically important chemical markers of TMP and α-terpineol, which may account for their different antioxidant activities.展开更多
Two new complexes[Zn(nph)(bix)]n·nH2O(1)and[Zn(nba)2(bix)]n(2)(H2nph=4-nitrophthalic acid,Hnba=4-nitrobenzoic acid,bix=1,4-bis(imidazol-1-yl)-benzene)have been hydrothermally synthesized and structurally characte...Two new complexes[Zn(nph)(bix)]n·nH2O(1)and[Zn(nba)2(bix)]n(2)(H2nph=4-nitrophthalic acid,Hnba=4-nitrobenzoic acid,bix=1,4-bis(imidazol-1-yl)-benzene)have been hydrothermally synthesized and structurally characterized by elemental analysis,IR spectrum,fluorescence spectrum,single-crystal and power X-ray diffraction.Complex 1 exhibits a three-dimensional(3D)framework,which is stabilized through C–H…O hydrogen bonds andπ-πstacking interactions.Complex 2 shows a zero-dimensional structure,which is further extended into a three-dimensional supramolecular structure through C–H…O and C–H…N hydrogen bonding interactions.展开更多
基金financially supported by the National Science Foundation of China(No.81302733)the research project of Chinese Ministry of education(No.113036A)+3 种基金the Program for Jiangsu province Innovative Research Team,the Program for New Century Excellent Talents in University(No.NCET-13-1036)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Fundamental Research Funds for the Central Universities(No.JKZD2013004)the Open Project Program of State Key Laboratory of Natural Medicines,China Pharmaceutical University(Nos.SKLNMZZYQ 201303 and SKLNMKF201220)
文摘With a great difference in therapeutic effects of Mahuang(MH, the stems of Ephedra sinica) and Mahuanggen(MHG, the roots of Ephedra sinica), chemical differences between MH and MHG should be investigated. In the present study, gas chromatography-mass spectrometry(GC-MS)-based plant metabolomics was employed to compare volatile oil profiles of MH and MHG. The antioxidant activities of volatile oils from MH and MHG were also compared. 32 differential chemical markers were identified according to the variable importance in the projection(VIP) value of orthogonal partial least squares discriminant analysis(OPLS-DA) and P value of Mann-Whitney test. Among them, chemical markers of tetramethylpyrazine(TMP) and α-terpineol were quantified. Their contents were much higher in most MH samples compared with MHG. The antioxidant assay demonstrated that MH had significantly higher free radical-scavenging activity than MHG. Although MH and MHG derived from the same medicinal plant, there was much difference in their volatile oil profiles. MH samples had significantly higher content of two reported pharmacologically important chemical markers of TMP and α-terpineol, which may account for their different antioxidant activities.
基金the Science and Technology Development Plan of Jilin Province(2015052006JH)Graduate Innovation Program of Jilin Normal University(201939)。
文摘Two new complexes[Zn(nph)(bix)]n·nH2O(1)and[Zn(nba)2(bix)]n(2)(H2nph=4-nitrophthalic acid,Hnba=4-nitrobenzoic acid,bix=1,4-bis(imidazol-1-yl)-benzene)have been hydrothermally synthesized and structurally characterized by elemental analysis,IR spectrum,fluorescence spectrum,single-crystal and power X-ray diffraction.Complex 1 exhibits a three-dimensional(3D)framework,which is stabilized through C–H…O hydrogen bonds andπ-πstacking interactions.Complex 2 shows a zero-dimensional structure,which is further extended into a three-dimensional supramolecular structure through C–H…O and C–H…N hydrogen bonding interactions.
